Search Results - "Peters, Joseph"

Targeted transposition with Tn7 elements: safe sites, mobile plasmids, CRISPR/Cas and beyond by Peters, Joseph E.

“…Summary Transposon Tn7 is notable for the control it exercises over where transposition events are directed. One Tn7 integration pathways recognizes a highly…”
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Natural and Engineered Guide RNA–Directed Transposition with CRISPR-Associated Tn7-Like Transposons by Hsieh, Shan-Chi, Peters, Joseph E

“…CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR-associated nuclease) defense systems have been naturally coopted for guide…”
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Recruitment of CRISPR-Cas systems by Tn7-like transposons by Peters, Joseph E., Makarova, Kira S., Shmakov, Sergey, Koonin, Eugene V.

“…A survey of bacterial and archaeal genomes shows that many Tn7-like transposons contain minimal type I-F CRISPR-Cas systems that consist of fused cas8f and…”
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Guide RNA Categorization Enables Target Site Choice in Tn7-CRISPR-Cas Transposons by Petassi, Michael T., Hsieh, Shan-Chi, Peters, Joseph E.

“…CRISPR-Cas defense systems have been coopted multiple times in nature for guide RNA-directed transposition by Tn7-like elements. Prototypic Tn7 uses dedicated…”
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Discovery and characterization of novel type I-D CRISPR-guided transposons identified among diverse Tn7-like elements in cyanobacteria by Hsieh, Shan-Chi, Peters, Joseph E

“…CRISPR-Cas defense systems have been naturally coopted for guide RNA-directed transposition by Tn7 family bacterial transposons. We find cyanobacterial genomes…”
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CRISPR–Cas in mobile genetic elements: counter-defence and beyond by Faure, Guilhem, Shmakov, Sergey A., Yan, Winston X., Cheng, David R., Scott, David A., Peters, Joseph E., Makarova, Kira S., Koonin, Eugene V.

“…The principal function of CRISPR–Cas systems in archaea and bacteria is defence against mobile genetic elements (MGEs), including viruses, plasmids and…”
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Transposition with Tn3-family elements occurs through interaction with the host β-sliding clamp processivity factor by Tang, Yu, Zhang, Jianfeng, Guan, Jiahao, Liang, Wei, Petassi, Michael T, Zhang, Yumeng, Jiang, Xiaofei, Wang, Minggui, Wu, Wenjuan, Ou, Hong-Yu, Peters, Joseph E

“…Tn3 family transposons are a widespread group of replicative transposons, notorious for contributing to the dissemination of antibiotic resistance,…”
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Widespread CRISPR-derived RNA regulatory elements in CRISPR-Cas systems by Shmakov, Sergey A, Barth, Zachary K, Makarova, Kira S, Wolf, Yuri I, Brover, Vyacheslav, Peters, Joseph E, Koonin, Eugene V

“…Abstract CRISPR-cas loci typically contain CRISPR arrays with unique spacers separating direct repeats. Spacers along with portions of adjacent repeats are…”
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Structural basis for DNA targeting by the Tn7 transposon by Shen, Yao, Gomez-Blanco, Josue, Petassi, Michael T., Peters, Joseph E., Ortega, Joaquin, Guarné, Alba

“…Tn7 transposable elements are unique for their highly specific, and sometimes programmable, target-site selection mechanisms and precise insertions. All the…”
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Tn7 by Peters, Joseph E

“…The bacterial transposon Tn7 is distinguished by the levels of control it displays over transposition and its capacity to utilize different kinds of target…”
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Evidence that spillover from Marine Protected Areas benefits the spiny lobster (Panulirus interruptus) fishery in southern California by Lenihan, Hunter S., Gallagher, Jordan P., Peters, Joseph R., Stier, Adrian C., Hofmeister, Jennifer K. K., Reed, Daniel C.

“…Marine Protected Areas (MPAs) are designed to enhance biodiversity and ecosystem services. Some MPAs are also established to benefit fisheries through…”
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Increased Endoplasmic Reticulum Stress in Human Glaucomatous Trabecular Meshwork Cells and Tissues by Peters, Joseph C, Bhattacharya, Sanjoy, Clark, Abbot F, Zode, Gulab S

“…Primary open-angle glaucoma (POAG) is the most common form of glaucoma and is accompanied by elevated intraocular pressure (IOP) resulting from increased…”
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Novel mechanisms of diversity generation in Acinetobacter baumannii resistance islands driven by Tn7-like elements by Correa, 3rd, Alberto, Shehreen, Saadlee, Machado, Laura Chacon, Thesier, Jordan, Cunic, Lille M, Petassi, Michael T, Chu, Joshua, Kapili, Bennett J, Jia, Yu, England, Kevin A, Peters, Joseph E

“…Mobile genetic elements play an important role in the acquisition of antibiotic and biocide resistance, especially through the formation of resistance islands…”
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Mechanistic details of CRISPR-associated transposon recruitment and integration revealed by cryo-EM by Park, Jung-Un, Tsai, Amy Wei-Lun, Chen, Tiffany H, Peters, Joseph E, Kellogg, Elizabeth H

“…CRISPR-associated transposons (CASTs) are Tn7-like elements that are capable of RNA-guided DNA integration. Although structural data are known for nearly all…”
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Optimization of T4 phage engineering via CRISPR/Cas9 by Duong, Michelle M., Carmody, Caitlin M., Ma, Qinqin, Peters, Joseph E., Nugen, Sam R.

“…A major limitation hindering the widespread use of synthetic phages in medical and industrial settings is the lack of an efficient phage-engineering platform…”
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Structural basis for target site selection in RNA-guided DNA transposition systems by Park, Jung-Un, Tsai, Amy Wei-Lun, Mehrotra, Eshan, Petassi, Michael T, Hsieh, Shan-Chi, Ke, Ailong, Peters, Joseph E, Kellogg, Elizabeth H

“…CRISPR-associated transposition systems allow guide RNA-directed integration of a single DNA cargo in one orientation at a fixed distance from a programmable…”
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A View From Both Ends: Shifts in Herbivore Assemblages Impact Top-Down and Bottom-Up Processes on Coral Reefs by Munsterman, Katrina S., Allgeier, Jacob E., Peters, Joseph R., Burkepile, Deron E.

“…A fundamental goal in ecology is to understand the role of consumers in top-down (TD) and bottom-up (BU) processes that affect the functioning of ecosystems…”
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Long-term exposure to fluoxetine reduces growth and reproductive potential in the dominant rocky intertidal mussel, Mytilus californianus by Peters, Joseph R., Granek, Elise F.

“…Environmental stressors shape community composition and ecosystem functioning. Contaminants such as pharmaceuticals are of increasing concern as an…”
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A characterization of oblivious message adversaries for which Consensus is solvable by Coulouma, Étienne, Godard, Emmanuel, Peters, Joseph

“…We consider the Consensus problem on arbitrary oblivious message adversaries. A message adversary models a communication network whose topology evolves from…”
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Climate and fishing drive regime shifts in consumer‐mediated nutrient cycling in kelp forests by Peters, Joseph R., Reed, Daniel C., Burkepile, Deron E.

“…Globally, anthropogenic pressures are reducing the abundances of marine species and altering ecosystems through modification of trophic interactions. Yet,…”
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