Neointimized gore-tex graft for ureteral prosthesis in the dog

Neointimized gore-tex graft for ureteral prosthesis in the dog

Abstract To determine the feasibility of replacing a ureteral segment with a neointimized Gore-Tex graft. Methods. Seven adult mongrel dogs underwent a two-stage operative procedure. The first procedure involved arterializing the graft to stimulate spread of a luminal neoendothelium by transmural ca...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) Vol. 48; no. 3; pp. 379 - 382
Main Authors: Peters, Jeffry J., Bruce Shingleton, W., Morgan, David, Allen, Brett, Fowler, Jackson E.
Format: Journal Article
Language:English
Published: New York, NY Elsevier Inc 01-09-1996
Elsevier Science
Subjects:
Animals
Artificial Organs
Biological and medical sciences
Capillaries
Dogs
Medical sciences
Polytetrafluoroethylene
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Ureter - surgery
Fissipedia
Animal model
Carnivora
Urinary system disease
Prosthesis
Exploration
Ureteral disease
Histology
Urinary tract disease
Plasty
Vertebrata
Mammalia
Treatment
Surgery
Animal
Intima
Technique
Ureter
Dog
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Summary:Abstract To determine the feasibility of replacing a ureteral segment with a neointimized Gore-Tex graft. Methods. Seven adult mongrel dogs underwent a two-stage operative procedure. The first procedure involved arterializing the graft to stimulate spread of a luminal neoendothelium by transmural capillary growth. Eight weeks after the initial procedure, a segment of the ipsilateral ureter was replaced with a segment of the neointimized graft. Histologic evaluation of a portion of the graft removed during the second procedure demonstrated transmural neocapillary ingrowth in all grafts; however, there was no neoendothelial growth on the luminal surface. In 5 dogs the graft was occluded with blood clot and was not suitable for a ureteral prosthesis. In 2 dogs the graft was patent and was successfully incorporated into the urinary system. After 1 year of observation, both of these dogs maintained a patent ureter and had no evidence of hydronephrosis on intravenous urogram. These data demonstrate that a Gore-Tex graft can be used as a ureteral prosthesis in the dog. The importance of preliminary arterialization, however, remains to be determined.
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ISSN:0090-4295
1527-9995
DOI:10.1016/S0090-4295(96)00163-X