Search Results - "Peters, James E."

Longitudinal plasma proteomics reveals biomarkers of alveolar-capillary barrier disruption in critically ill COVID-19 patients by Duijvelaar, Erik, Gisby, Jack, Peters, James E., Bogaard, Harm Jan, Aman, Jurjan

“…The pathobiology of respiratory failure in COVID-19 consists of a complex interplay between viral cytopathic effects and a dysregulated host immune response…”
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Systematic Mendelian randomization using the human plasma proteome to discover potential therapeutic targets for stroke by Chen, Lingyan, Peters, James E., Prins, Bram, Persyn, Elodie, Traylor, Matthew, Surendran, Praveen, Karthikeyan, Savita, Yonova-Doing, Ekaterina, Di Angelantonio, Emanuele, Roberts, David J., Watkins, Nicholas A., Ouwehand, Willem H., Danesh, John, Lewis, Cathryn M., Bronson, Paola G., Markus, Hugh S., Burgess, Stephen, Butterworth, Adam S., Howson, Joanna M. M.

“…Stroke is the second leading cause of death with substantial unmet therapeutic needs. To identify potential stroke therapeutic targets, we estimate the causal…”
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Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death by Gisby, Jack, Clarke, Candice L, Medjeral-Thomas, Nicholas, Malik, Talat H, Papadaki, Artemis, Mortimer, Paige M, Buang, Norzawani B, Lewis, Shanice, Pereira, Marie, Toulza, Frederic, Fagnano, Ester, Mawhin, Marie-Anne, Dutton, Emma E, Tapeng, Lunnathaya, Richard, Arianne C, Kirk, Paul Dw, Behmoaras, Jacques, Sandhu, Eleanor, McAdoo, Stephen P, Prendecki, Maria F, Pickering, Matthew C, Botto, Marina, Willicombe, Michelle, Thomas, David C, Peters, James E

“…End-stage kidney disease (ESKD) patients are at high risk of severe COVID-19. We measured 436 circulating proteins in serial blood samples from hospitalised…”
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Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence by Gisby, Jack S., Buang, Norzawani B., Papadaki, Artemis, Clarke, Candice L., Malik, Talat H., Medjeral-Thomas, Nicholas, Pinheiro, Damiola, Mortimer, Paige M., Lewis, Shanice, Sandhu, Eleanor, McAdoo, Stephen P., Prendecki, Maria F., Willicombe, Michelle, Pickering, Matthew C., Botto, Marina, Thomas, David C., Peters, James E.

“…Patients with end-stage kidney disease (ESKD) are at high risk of severe COVID-19. Here, we perform longitudinal blood sampling of ESKD haemodialysis patients…”
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Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease by Peters, James E, Lyons, Paul A, Lee, James C, Richard, Arianne C, Fortune, Mary D, Newcombe, Paul J, Richardson, Sylvia, Smith, Kenneth G C

“…Genome-wide association studies (GWAS) have transformed our understanding of the genetics of complex traits such as autoimmune diseases, but how risk variants…”
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Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease by Richard, Arianne C, Peters, James E, Savinykh, Natalia, Lee, James C, Hawley, Eric T, Meylan, Françoise, Siegel, Richard M, Lyons, Paul A, Smith, Kenneth G C

“…Chronic inflammation in inflammatory bowel disease (IBD) results from a breakdown of intestinal immune homeostasis and compromise of the intestinal barrier…”
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A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology by Akbari, Parsa, Vuckovic, Dragana, Stefanucci, Luca, Jiang, Tao, Kundu, Kousik, Kreuzhuber, Roman, Bao, Erik L., Collins, Janine H., Downes, Kate, Grassi, Luigi, Guerrero, Jose A., Kaptoge, Stephen, Knight, Julian C., Meacham, Stuart, Sambrook, Jennifer, Seyres, Denis, Stegle, Oliver, Verboon, Jeffrey M., Walter, Klaudia, Watkins, Nicholas A., Danesh, John, Roberts, David J., Di Angelantonio, Emanuele, Sankaran, Vijay G., Frontini, Mattia, Burgess, Stephen, Kuijpers, Taco, Peters, James E., Butterworth, Adam S., Ouwehand, Willem H., Soranzo, Nicole, Astle, William J.

“…Blood cells contain functionally important intracellular structures, such as granules, critical to immunity and thrombosis. Quantitative variation in these…”
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Integrated analyses of growth differentiation factor-15 concentration and cardiometabolic diseases in humans by Lemmelä, Susanna, Wigmore, Eleanor M, Benner, Christian, Havulinna, Aki S, Ong, Rachel M Y, Kempf, Tibor, Wollert, Kai C, Blankenberg, Stefan, Zeller, Tanja, Peters, James E, Salomaa, Veikko, Fritsch, Maria, March, Ruth, Palotie, Aarno, Daly, Mark, Butterworth, Adam S, Kinnunen, Mervi, Paul, Dirk S, Matakidou, Athena

“…Growth differentiation factor-15 (GDF15) is a stress response cytokine that is elevated in several cardiometabolic diseases and has attracted interest as a…”
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Severe localised granulomatosis with polyangiitis (Wegener's granulomatosis) manifesting with extensive cranial nerve palsies and cranial diabetes insipidus: a case report and literature review by Peters, James E, Gupta, Vivek, Saeed, Ibtisam T, Offiah, Curtis, Jawad, Ali S M

“…Granulomatosis with polyangiitis (GPA, formerly Wegener's granulomatosis) is a multisystem vasculitis of small- to medium-sized blood vessels. Cranial…”
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Plasma Lectin Pathway Complement Proteins in Patients With COVID-19 and Renal Disease by Medjeral-Thomas, Nicholas R, Troldborg, Anne, Hansen, Annette G, Gisby, Jack, Clarke, Candice L, Prendecki, Maria, McAdoo, Stephen P, Sandhu, Eleanor, Lightstone, Liz, Thomas, David C, Willicombe, Michelle, Botto, Marina, Peters, James E, Pickering, Matthew C, Thiel, Steffen

“…We do not understand why non-white ethnicity and chronic kidney disease increase susceptibility to COVID-19. The lectin pathway of complement activation is a…”
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Interleukin-6 Receptor Signaling and Abdominal Aortic Aneurysm Growth Rates by Paige, Ellie, Clément, Marc, Lareyre, Fabien, Sweeting, Michael, Raffort, Juliette, Grenier, Céline, Finigan, Alison, Harrison, James, Peters, James E, Sun, Benjamin B, Butterworth, Adam S, Harrison, Seamus C, Bown, Matthew J, Lindholt, Jes S, Badger, Stephen A, Kullo, Iftikhar J, Powell, Janet, Norman, Paul E, Scott, D Julian A, Bailey, Marc A, Rose-John, Stefan, Danesh, John, Freitag, Daniel F, Paul, Dirk S, Mallat, Ziad

“…The Asp358Ala variant (rs2228145; A>C) in the IL (interleukin)-6 receptor ( IL6R) gene has been implicated in the development of abdominal aortic aneurysms…”
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Genomic atlas of the human plasma proteome by Sun, Benjamin B., Maranville, Joseph C., Peters, James E., Stacey, David, Staley, James R., Blackshaw, James, Burgess, Stephen, Jiang, Tao, Paige, Ellie, Surendran, Praveen, Oliver-Williams, Clare, Kamat, Mihir A., Prins, Bram P., Wilcox, Sheri K., Zimmerman, Erik S., Chi, An, Bansal, Narinder, Spain, Sarah L., Wood, Angela M., Morrell, Nicholas W., Bradley, John R., Janjic, Nebojsa, Roberts, David J., Ouwehand, Willem H., Todd, John A., Soranzo, Nicole, Suhre, Karsten, Paul, Dirk S., Fox, Caroline S., Plenge, Robert M., Danesh, John, Runz, Heiko, Butterworth, Adam S.

“…Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control…”
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Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease by Vijayakumar, Bavithra, Boustani, Karim, Ogger, Patricia P., Papadaki, Artemis, Tonkin, James, Orton, Christopher M., Ghai, Poonam, Suveizdyte, Kornelija, Hewitt, Richard J., Desai, Sujal R., Devaraj, Anand, Snelgrove, Robert J., Molyneaux, Philip L., Garner, Justin L., Peters, James E., Shah, Pallav L., Lloyd, Clare M., Harker, James A.

“…Some patients hospitalized with acute COVID-19 suffer respiratory symptoms that persist for many months. We delineated the immune-proteomic landscape in the…”
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Tuberculosis and anti-TNF treatment: experience of a central London hospital by Mankia, Satveer, Peters, James E, Kang, Swan, Moore, Samantha, Ehrenstein, Michael R

“…Reactivation of latent tuberculosis (TB) is an established risk of anti-tumour necrosis factor α (anti-TNF) therapy. We report five cases of active TB…”
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Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis by Burgess, Stephen, Ference, Brian A, Staley, James R, Freitag, Daniel F, Mason, Amy M, Nielsen, Sune F, Willeit, Peter, Young, Robin, Surendran, Praveen, Karthikeyan, Savita, Bolton, Thomas R, Peters, James E, Kamstrup, Pia R, Tybjærg-Hansen, Anne, Benn, Marianne, Langsted, Anne, Schnohr, Peter, Vedel-Krogh, Signe, Kobylecki, Camilla J, Ford, Ian, Packard, Chris, Trompet, Stella, Jukema, J Wouter, Sattar, Naveed, Di Angelantonio, Emanuele, Saleheen, Danish, Howson, Joanna M M, Nordestgaard, Børge G, Butterworth, Adam S, Danesh, John

“…Human genetic studies have indicated that plasma lipoprotein(a) (Lp[a]) is causally associated with the risk of coronary heart disease (CHD), but randomized…”
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An atlas of genetic scores to predict multi-omic traits by Xu, Yu, Ritchie, Scott C., Liang, Yujian, Timmers, Paul R. H. J., Pietzner, Maik, Lannelongue, Loïc, Lambert, Samuel A., Tahir, Usman A., May-Wilson, Sebastian, Foguet, Carles, Johansson, Åsa, Surendran, Praveen, Nath, Artika P., Persyn, Elodie, Peters, James E., Oliver-Williams, Clare, Deng, Shuliang, Prins, Bram, Luan, Jian’an, Bomba, Lorenzo, Soranzo, Nicole, Di Angelantonio, Emanuele, Pirastu, Nicola, Tai, E. Shyong, van Dam, Rob M., Parkinson, Helen, Davenport, Emma E., Paul, Dirk S., Yau, Christopher, Gerszten, Robert E., Mälarstig, Anders, Danesh, John, Sim, Xueling, Langenberg, Claudia, Wilson, James F., Butterworth, Adam S., Inouye, Michael

“…The use of omic modalities to dissect the molecular underpinnings of common diseases and traits is becoming increasingly common. But multi-omic traits can be…”
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Somatostatin Receptor PET/MR Imaging of Inflammation in Patients With Large Vessel Vasculitis and Atherosclerosis by Ćorović, Andrej, Wall, Christopher, Nus, Meritxell, Gopalan, Deepa, Huang, Yuan, Imaz, Maria, Zulcinski, Michal, Peverelli, Marta, Uryga, Anna, Lambert, Jordi, Bressan, Dario, Maughan, Robert T., Pericleous, Charis, Dubash, Suraiya, Jordan, Natasha, Jayne, David R., Hoole, Stephen P., Calvert, Patrick A., Dean, Andrew F., Rassl, Doris, Barwick, Tara, Iles, Mark, Frontini, Mattia, Hannon, Greg, Manavaki, Roido, Fryer, Tim D., Aloj, Luigi, Graves, Martin J., Gilbert, Fiona J., Dweck, Marc R., Newby, David E., Fayad, Zahi A., Reynolds, Gary, Morgan, Ann W., Aboagye, Eric O., Davenport, Anthony P., Jørgensen, Helle F., Mallat, Ziad, Bennett, Martin R., Peters, James E., Rudd, James H.F., Mason, Justin C., Tarkin, Jason M.

“…Assessing inflammatory disease activity in large vessel vasculitis (LVV) can be challenging by conventional measures. We aimed to investigate somatostatin…”
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MT-HESS: an efficient Bayesian approach for simultaneous association detection in OMICS datasets, with application to eQTL mapping in multiple tissues by Lewin, Alex, Saadi, Habib, Peters, James E, Moreno-Moral, Aida, Lee, James C, Smith, Kenneth G C, Petretto, Enrico, Bottolo, Leonardo, Richardson, Sylvia

“…Analysing the joint association between a large set of responses and predictors is a fundamental statistical task in integrative genomics, exemplified by…”
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Association of Histologic Parameters with Outcome in C3 Glomerulopathy and Idiopathic Immunoglobulin-Associated Membranoproliferative Glomerulonephritis by Lomax-Browne, Hannah J, Medjeral-Thomas, Nicholas R, Barbour, Sean J, Gisby, Jack, Han, Heedeok, Bomback, Andrew S, Fervenza, Fernando C, Cairns, Thomas H, Szydlo, Richard, Tan, Sven-Jean, Marks, Stephen D, Waters, Aoife M, Appel, Gerald B, D'Agati, Vivette D, Sethi, Sanjeev, Nast, Cynthia C, Bajema, Ingeborg, Alpers, Charles E, Fogo, Agnes B, Licht, Christoph, Fakhouri, Fadi, Cattran, Daniel C, Peters, James E, Cook, H Terence, Pickering, Matthew C

“…C3 glomerulopathy and idiopathic Ig-associated membranoproliferative GN are kidney diseases characterized by abnormal glomerular complement C3 deposition…”
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Novel Approach to Imaging Active Takayasu Arteritis Using Somatostatin Receptor Positron Emission Tomography/Magnetic Resonance Imaging by Tarkin, Jason M., Wall, Christopher, Gopalan, Deepa, Aloj, Luigi, Manavaki, Roido, Fryer, Tim D., Aboagye, Eric O., Bennett, Martin R., Peters, James E., Rudd, James H.F., Mason, Justin C.

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