Search Results - "Peters, J H."

Templated Enzymatic Synthesis of δ‑Cyclodextrin by Erichsen, Andreas, Peters, Günther H. J., Beeren, Sophie R.

“…While α-, β-, and γ-cyclodextrin (CD) are ubiquitous hosts employed by supramolecular chemists, δ-CD (formed from nine α-1,4-linked glucopyranose units) has…”
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pH- and concentration-dependent supramolecular assembly of a fungal defensin plectasin variant into helical non-amyloid fibrils by Pohl, Christin, Effantin, Gregory, Kandiah, Eaazhisai, Meier, Sebastian, Zeng, Guanghong, Streicher, Werner, Segura, Dorotea Raventos, Mygind, Per H., Sandvang, Dorthe, Nielsen, Line Anker, Peters, Günther H. J., Schoehn, Guy, Mueller-Dieckmann, Christoph, Noergaard, Allan, Harris, Pernille

“…Self-assembly and fibril formation play important roles in protein behaviour. Amyloid fibril formation is well-studied due to its role in neurodegenerative…”
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Dynamics of Human Serum Transferrin in Varying Physicochemical Conditions Explored by Using Molecular Dynamics Simulations by Indrakumar, Sowmya, Kulakova, Alina, Harris, Pernille, Peters, Günther H. J.

“…Conformational stability of human serum transferrin (Tf) at varying pH values and salt and excipient concentrations were investigated using molecular dynamics…”
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Advancing Therapeutic Protein Discovery and Development through Comprehensive Computational and Biophysical Characterization by Gentiluomo, Lorenzo, Svilenov, Hristo L, Augustijn, Dillen, El Bialy, Inas, Greco, Maria Laura, Kulakova, Alina, Indrakumar, Sowmya, Mahapatra, Sujata, Morales, Marcello Martinez, Pohl, Christin, Roche, Aisling, Tosstorff, Andreas, Curtis, Robin, Derrick, Jeremy P, Nørgaard, Allan, Khan, Tarik A, Peters, Günther H. J, Pluen, Alain, Rinnan, Åsmund, Streicher, Werner W, van der Walle, Christopher F, Uddin, Shahid, Winter, Gerhard, Roessner, Dierk, Harris, Pernille, Frieß, Wolfgang

“…Therapeutic protein candidates should exhibit favorable properties that render them suitable to become drugs. Nevertheless, there are no well-established…”
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Physical constraints and functional plasticity of cellulases by Kari, Jeppe, Molina, Gustavo A., Schaller, Kay S., Schiano-di-Cola, Corinna, Christensen, Stefan J., Badino, Silke F., Sørensen, Trine H., Røjel, Nanna S., Keller, Malene B., Sørensen, Nanna Rolsted, Kolaczkowski, Bartlomiej, Olsen, Johan P., Krogh, Kristian B. R. M., Jensen, Kenneth, Cavaleiro, Ana M., Peters, Günther H. J., Spodsberg, Nikolaj, Borch, Kim, Westh, Peter

“…Enzyme reactions, both in Nature and technical applications, commonly occur at the interface of immiscible phases. Nevertheless, stringent descriptions of…”
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Self-Interactions of Two Monoclonal Antibodies: Small-Angle X‑ray Scattering, Light Scattering, and Coarse-Grained Modeling by Mahapatra, Sujata, Polimeni, Marco, Gentiluomo, Lorenzo, Roessner, Dierk, Frieß, Wolfgang, Peters, Günther H. J, Streicher, Werner W, Lund, Mikael, Harris, Pernille

“…Using light scattering (LS), small-angle X-ray scattering (SAXS), and coarse-grained Monte Carlo (MC) simulations, we studied the self-interactions of two…”
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Universal Scaling in the Dynamic Hysteresis, and Non-Markovian Dynamics, of a Tunable Optical Cavity by Geng, Z, Peters, K J H, Trichet, A A P, Malmir, K, Kolkowski, R, Smith, J M, Rodriguez, S R K

“…We investigate, experimentally and theoretically, the dynamics of a laser-driven cavity with noninstantaneous effective photon-photon interactions. Scanning…”
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Aluminium corrosion in power semiconductor devices by Leppänen, J., Ingman, J., Peters, J.-H., Hanf, M., Ross, R., Koopmans, G., Jormanainen, J., Forsström, A., Ross, G., Kaminski, N., Vuorinen, V.

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Small-Angle X‑ray Scattering Data in Combination with RosettaDock Improves the Docking Energy Landscape by Sønderby, Pernille, Rinnan, Åsmund, Madsen, Jesper J, Harris, Pernille, Bukrinski, Jens T, Peters, Günther H. J

“…We have performed a benchmark to evaluate the relative success of using small-angle X-ray scattering (SAXS) data as constraints (hereafter termed…”
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Evaluation of esophageal motor function in clinical practice by Gyawali, C. P., Bredenoord, A. J., Conklin, J. L., Fox, M., Pandolfino, J. E., Peters, J. H., Roman, S., Staiano, A., Vaezi, M. F.

“…Esophageal motor function is highly coordinated between central and enteric nervous systems and the esophageal musculature, which consists of proximal skeletal…”
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Investigations of Albumin–Insulin Detemir Complexes Using Molecular Dynamics Simulations and Free Energy Calculations by Ryberg, Line A, Sønderby, Pernille, Bukrinski, Jens T, Harris, Pernille, Peters, Günther H. J

“…Insulin detemir is a lipidated insulin analogue that obtains a half-life extension by oligomerization and reversible binding to human serum albumin. In the…”
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Water Distribution and Clustering on the Lyophilized IgG1 Surface: Insight from Molecular Dynamics Simulations by Feng, Shaoxin, Peters, Günther H. J, Ohtake, Satoshi, Schöneich, Christian, Shalaev, Evgenyi

“…Water has a critical role in the stability of the higher-order structure of proteins. In addition, it is considered to be a major destabilization factor for…”
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Combining Molecular Dynamics Simulations and Biophysical Characterization to Investigate Protein-Specific Excipient Effects on Reteplase during Freeze Drying by Ko, Suk Kyu, Björkengren, Gabriella, Berner, Carolin, Winter, Gerhard, Harris, Pernille, Peters, Günther H J

“…We performed molecular dynamics simulations of Reteplase in the presence of different excipients to study the stabilizing mechanisms and to identify the role…”
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The Effect of Point Mutations on the Biophysical Properties of an Antimicrobial Peptide: Development of a Screening Protocol for Peptide Stability Screening by Pohl, Christin, Zalar, Matja, Bialy, Inas El, Indrakumar, Sowmya, Peters, Günther H. J, Friess, Wolfgang, Golovanov, Alexander P, Streicher, Werner W, Noergaard, Allan, Harris, Pernille

“…Therapeutic peptides and proteins show enormous potential in the pharmaceutical market, but high costs in discovery and development are limiting factors so…”
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Albumin-neprilysin fusion protein: understanding stability using small angle X-ray scattering and molecular dynamic simulations by Kulakova, Alina, Indrakumar, Sowmya, Sønderby Tuelung, Pernille, Mahapatra, Sujata, Streicher, Werner W., Peters, Günther H. J., Harris, Pernille

“…Fusion technology is widely used in protein-drug development to increase activity, stability, and bioavailability of protein therapeutics. Fusion proteins,…”
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Glucagon-like Peptide 1 Conjugated to Recombinant Human Serum Albumin Variants with Modified Neonatal Fc Receptor Binding Properties. Impact on Molecular Structure and Half-Life by Bukrinski, Jens T, Sønderby, Pernille, Antunes, Filipa, Andersen, Birgitte, Schmidt, Esben G. W, Peters, Günther H. J, Harris, Pernille

“…Glucagon-like peptide 1 (GLP-1) is a small incretin hormone stimulated by food intake, resulting in an amplification of the insulin response. Though GLP-1 is…”
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Revealing the Compact Structure of Lactic Acid Bacterial Heteroexopolysaccharides by SAXS and DLS by Khan, Sanaullah, Birch, Johnny, Harris, Pernille, Van Calsteren, Marie-Rose, Ipsen, Richard, Peters, Günther H. J, Svensson, Birte, Almdal, Kristoffer

“…Molecular structures of exopolysaccharides are required to understand their functions and the relationships between the structure and physical and rheological…”
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Evaluation of a concerted vs. sequential oxygen activation mechanism in α-ketoglutarate–dependent nonheme ferrous enzymes by Goudarzi, Serra, Iyer, Shyam R., Babicz, Jeffrey T., Yan, James J., Peters, Günther H. J., Christensen, Hans E. M., Hedman, Britt, Hodgson, Keith O., Solomon, Edward I.

“…Determining the requirements for efficient oxygen (O₂) activation is key to understanding how enzymes maintain efficacy and mitigate unproductive, often…”
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Chemometrics in Protein Formulation: Stability Governed by Repulsion and Protein Unfolding by Kulakova, Alina, Augustijn, Dillen, El Bialy, Inas, Gentiluomo, Lorenzo, Greco, Maria Laura, Hervø-Hansen, Stefan, Indrakumar, Sowmya, Mahapatra, Sujata, Martinez Morales, Marcello, Pohl, Christin, Polimeni, Marco, Roche, Aisling, Svilenov, Hristo L., Tosstorff, Andreas, Zalar, Matja, Curtis, Robin, Derrick, Jeremy P., Frieß, Wolfgang, Golovanov, Alexander P., Lund, Mikael, Nørgaard, Allan, Khan, Tarik A., Peters, Günther H. J., Pluen, Alain, Roessner, Dierk, Streicher, Werner W., van der Walle, Christopher F., Warwicker, Jim, Uddin, Shahid, Winter, Gerhard, Bukrinski, Jens Thostrup, Rinnan, Åsmund, Harris, Pernille

“…Therapeutic proteins can be challenging to develop due to their complexity and the requirement of an acceptable formulation to ensure patient safety and…”
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Leptin and CCK selectively activate vagal afferent neurons innervating the stomach and duodenum by Peters, J H, Ritter, R C, Simasko, S M

“…The hormone leptin and the gut peptide CCK synergistically interact to enhance the process of satiation. Although this interaction may occur at several levels…”
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