Search Results - "Peters, Douglas G"

The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin by Peters, Douglas G, Connor, James R, Meadowcroft, Mark D

“…Abstract The dysregulation of iron metabolism in Alzheimer's disease is not accounted for in the current framework of the amyloid cascade hypothesis…”
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Lifespan trajectory of myelin integrity and maximum motor speed by Bartzokis, George, Lu, Po H, Tingus, Kathleen, Mendez, Mario F, Richard, Aurore, Peters, Douglas G, Oluwadara, Bolanle, Barrall, Katherine A, Finn, J. Paul, Villablanca, Pablo, Thompson, Paul M, Mintz, Jim

“…Abstract Objective Myelination of the human brain results in roughly quadratic trajectories of myelin content and integrity, reaching a maximum in mid-life and…”
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Brain Metal Distribution and Neuro-Inflammatory Profiles after Chronic Vanadium Administration and Withdrawal in Mice by Folarin, Oluwabusayo R, Snyder, Amanda M, Peters, Douglas G, Olopade, Funmilayo, Connor, James R, Olopade, James O

“…Vanadium is a potentially toxic environmental pollutant and induces oxidative damage in biological systems including the central nervous system (CNS). Its…”
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Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease by Fonseca, Maria I, Chu, Shu-Hui, Berci, Alisia M, Benoit, Marie E, Peters, Douglas G, Kimura, Yuko, Tenner, Andrea J

“…Complement proteins and activation products have been found associated with neuropathology in Alzheimer's disease (AD). Recently, a C5a receptor antagonist was…”
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The effect of iron in MRI and transverse relaxation of amyloid-beta plaques in Alzheimer's disease by Meadowcroft, Mark D., Peters, Douglas G., Dewal, Rahul P., Connor, James R., Yang, Qing X.

“…Dysregulation of neural iron is known to occur during the progression of Alzheimer's disease. The visualization of amyloid‐beta (Aβ) plaques with MRI has…”
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Gender and Iron Genes May Modify Associations Between Brain Iron and Memory in Healthy Aging by BARTZOKIS, George, LU, Po H, NEELY, Elizabeth, CONNOR, James R, TINGUS, Kathleen, PETERS, Douglas G, AMAR, Chetan P, TISHLER, Todd A, FINN, J. Paul, VILLABLANCA, Pablo, ALTSHULER, Lori L, MINTZ, Jim

“…Brain iron increases with age and is abnormally elevated early in the disease process in several neurodegenerative disorders that impact memory including…”
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Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice by Peters, Douglas G, Pollack, Alexis N, Cheng, Keith C, Sun, Dongxiao, Saido, Takaomi, Haaf, Michael P, Yang, Qing X, Connor, James R, Meadowcroft, Mark D

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized pathologically by amyloid beta (Aβ) deposition, microgliosis, and iron…”
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Dietary lipophilic iron accelerates regional brain iron-load in C57BL6 mice by Peters, Douglas G., Purnell, Carson J., Haaf, Michael P., Yang, Qing X., Connor, James R., Meadowcroft, Mark D.

“…Impaired brain iron homeostatic mechanisms, independent of pathological hallmarks, are harmful to the brain because excess free iron can cause DNA, protein,…”
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Prevalent iron metabolism gene variants associated with increased brain ferritin iron in healthy older men by Bartzokis, George, Lu, Po H, Tishler, Todd A, Peters, Douglas G, Kosenko, Anastasia, Barrall, Katherine A, Finn, J Paul, Villablanca, Pablo, Laub, Gerhard, Altshuler, Lori L, Geschwind, Daniel H, Mintz, Jim, Neely, Elizabeth, Connor, James R

“…Prevalent gene variants involved in iron metabolism [hemochromatosis (HFE) H63D and transferrin C2 (TfC2)] have been associated with higher risk and earlier…”
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Magnetic resonance imaging of APP/PS1/Tau mice on gradated iron diets by Meadowcroft, Mark D, Peters, Douglas G, Haaf, Michael P, Yang, Qing X, Connor, James R

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Differential MRI relaxation in Alzheimer’s patients with mutant hfe and transferrin genotypes by Meadowcroft, Mark D, Peters, Douglas G, Purnell, Carson J, Wang, Jianli, Eslinger, Paul J, Yang, Qing X, Connor, James R

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Magnetic resonance imaging of APP/PS1/Tau mice on gradated iron diets by Meadowcroft, Mark D, Peters, Douglas G, Haaf, Michael P, Yang, Qing X, Connor, James R

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Differential MRI relaxation in Alzheimer’s patients with mutant hfe and transferrin genotypes by Meadowcroft, Mark D, Peters, Douglas G, Purnell, Carson J, Wang, Jianli, Eslinger, Paul J, Yang, Qing X, Connor, James R

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Reduced white matter MRI transverse relaxation rate in cognitively normal H63D-HFE human carriers and H67D-HFE mice by Meadowcroft, Mark D., Wang, Jianli, Purnell, Carson J., Peters, Douglas G., Eslinger, Paul J., Neely, Elizabeth B., Gill, David J., Vasavada, Megha, Ali-Rahmani, Fatima, Yang, Qing X., Connor, James R.

“…Mutations within the HFE protein gene sequence have been associated with increased risk of developing a number of neurodegenerative disorders. To this effect,…”
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Incorporating Informatics for Integrating Biology and the Bedside (i2b2) into Predoctoral Trainee Curriculum to Evaluate Student‐Generated Hypotheses by Schieffer, Kathleen M., Peters, Douglas G., Richter, Chesney K., Loc, Welley S., Pawelczyk, James A.

“…As part of the Clinical and Translational Science Institute predoctoral TL1 training program at the Pennsylvania State University, a multidisciplinary team of…”
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Influence of iron genes and gender on brain iron and cognition by Bartzokis, George, Lu, Po H, Tingus, Kathleen, Tishler, Todd A, Peters, Douglas G, Richard, Aurore, Mintz, Jim, Villablanca, Pablo, Finn, J. Paul, Laub, Gerhard, Connor, James R

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Influence of iron genes and gender on brain iron and cognition by Bartzokis, George, Lu, Po H, Tingus, Kathleen, Tishler, Todd A, Peters, Douglas G, Richard, Aurore, Mintz, Jim, Villablanca, Pablo, Finn, J. Paul, Laub, Gerhard, Connor, James R

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The Effect of Iron in MR Imaging and Transverse Relaxation of Amyloid-Beta Plaques in Alzheimer’s Disease by Meadowcroft, Mark D., Peters, Douglas G., Dewal, Rahul, Connor, James R., Yang, Qing X.

“…Dysregulation of neural iron is known to occur during the progression of Alzheimer’s disease. Visualization of amyloid-beta (Aβ) plaques with magnetic…”
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P1‐162: Magnetic resonance imaging of APP/PS1/Tau mice on gradated iron diets by Meadowcroft, Mark D., Peters, Douglas G., Haaf, Michael P., Yang, Qing X., Connor, James R.

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IC‐P‐029: Magnetic resonance imaging of APP/PS1/Tau mice on gradated iron diets by Meadowcroft, Mark D., Peters, Douglas G., Haaf, Michael P., Yang, Qing X., Connor, James R.

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