Search Results - "Peters, Dorien JM"

Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling by Calcagnì, Alessia, Kors, Lotte, Verschuren, Eric, De Cegli, Rossella, Zampelli, Nicolina, Nusco, Edoardo, Confalonieri, Stefano, Bertalot, Giovanni, Pece, Salvatore, Settembre, Carmine, Malouf, Gabriel G, Leemans, Jaklien C, de Heer, Emile, Salvatore, Marco, Peters, Dorien Jm, Di Fiore, Pier Paolo, Ballabio, Andrea

“…-fusion renal cell carcinomas ( -fusion ) are caused by chromosomal translocations that lead to overexpression of the and genes (Kauffman et al., 2014). The…”
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Quantification of Cre-mediated recombination by a novel strategy reveals a stable extra-chromosomal deletion-circle in mice by Leonhard, Wouter N, Roelfsema, Jeroen H, Lantinga-van Leeuwen, Irma S, Breuning, Martijn H, Peters, Dorien J M

“…Inducible conditional knockout animals are widely used to get insight in the function of genes and the pathogenesis of human diseases. These models frequently…”
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Autosomal dominant polycystic kidney disease: modification of disease progression by Peters, Dorien JM, Breuning, Martijn H

“…Autosomal dominant polycystic kidney disease is a common inherited disorder, which is characterised by the formation of fluid-filled cysts in both kidneys that…”
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The expression of somatostatin receptor 2 decreases during cyst growth in mice with polycystic kidney disease by Lin, Cong, Happé, Hester, Veraar, Kimberley, Scharpfenecker, Marion, Peters, Dorien JM

“…Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive renal cyst formation and expansion. Several clinical trials show that…”
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Altered Hippo signalling in polycystic kidney disease by Happé, Hester, van der Wal, Annemieke M, Leonhard, Wouter N, Kunnen, Steven J, Breuning, Martijn H, de Heer, Emile, Peters, Dorien JM

“…Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive deterioration of renal function and formation of cysts, and is an…”
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Four‐jointed knock‐out delays renal failure in an ADPKD model with kidney injury by Formica, Chiara, Happé, Hester, Veraar, Kimberley AM, Vortkamp, Andrea, Scharpfenecker, Marion, McNeill, Helen, Peters, Dorien JM

“…Autosomal Dominant Polycystic Kidney Disease is characterised by the development of fluid‐filled cysts in the kidneys which lead to end‐stage renal disease…”
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Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2) by Veldhuisen, B, Spruit, L, Dauwerse, H G, Breuning, M H, Peters, D J

“…Autosomal Dominant Polycystic Kidney Disease (ADPKD), a common inherited disease leading to progressive renal failure, can be caused by a mutation in either…”
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Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation by Streets, Andrew J, Wessely, Oliver, Peters, Dorien J M, Ong, Albert C M

“…Mutations in PKD1 (85%) or PKD2 (15%) account for almost all cases of autosomal dominant polycystic kidney disease (ADPKD). The ADPKD proteins, termed as…”
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Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice by Lantinga-van Leeuwen, Irma S., Leonhard, Wouter N., van der Wal, Annemieke, Breuning, Martijn H., de Heer, Emile, Peters, Dorien J.M.

“…Autosomal dominant polycystic kidney disease, caused by mutations in the PKD1 gene, is characterized by progressive deterioration of kidney function due to the…”
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Elevated TGFβ-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease by Hassane, Sabrine, Leonhard, Wouter N, van der Wal, Annemieke, Hawinkels, Lukas JAC, Lantinga-van Leeuwen, Irma S, Dijke, Peter ten, Breuning, Martijn H, Heer, Emile de, Peters, Dorien JM

“…Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited renal disease characterized by many fluid‐filled cysts and interstitial fibrosis in…”
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LRP5 variants may contribute to ADPKD by Cnossen, Wybrich R, te Morsche, René H M, Hoischen, Alexander, Gilissen, Christian, Venselaar, Hanka, Mehdi, Soufi, Bergmann, Carsten, Losekoot, Monique, Breuning, Martijn H, Peters, Dorien J M, Veltman, Joris A, Drenth, Joost P H

“…Mutations in Polycystic Kidney Disease proteins (PKD1 or PKD2) are causative for autosomal dominant polycystic kidney disease (ADPKD). However, a small subset…”
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Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways by Happé, Hester, Leonhard, Wouter N., van der Wal, Annemieke, van de Water, Bob, Lantinga-van Leeuwen, Irma S., Breuning, Martijn H., de Heer, Emile, Peters, Dorien J.M.

“…Autosomal dominant polycystic kidney disease (ADPKD) is characterized by large fluid-filled cysts and progressive deterioration of renal function necessitating…”
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CREBBP mutations in individuals without Rubinstein-Taybi syndrome phenotype by Menke, Leonie A., van Belzen, Martine J., Alders, Marielle, Cristofoli, Francesca, Ehmke, Nadja, Fergelot, Patricia, Foster, Alison, Gerkes, Erica H., Hoffer, Mariëtte J. V., Horn, Denise, Kant, Sarina G., Lacombe, Didier, Leon, Eyby, Maas, Saskia M., Melis, Daniela, Muto, Valentina, Park, Soo-Mi, Peeters, Hilde, Peters, Dorien J. M., Pfundt, Rolph, van Ravenswaaij-Arts, Conny M. A., Tartaglia, Marco, Hennekam, Raoul C. M.

“…Mutations in CREBBP cause Rubinstein–Taybi syndrome. By using exome sequencing, and by using Sanger in one patient, CREBBP mutations were detected in 11…”
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P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells by Kraus, Andre, Grampp, Steffen, Goppelt-Struebe, Margarete, Schreiber, Rainer, Kunzelmann, Karl, Peters, Dorien J.M., Leipziger, Jens, Schley, Gunnar, Schödel, Johannes, Eckardt, Kai-Uwe, Buchholz, Bjoern

“…Polycystic kidney diseases are characterized by numerous renal cysts that continuously enlarge resulting in compression of intact nephrons and tissue hypoxia…”
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Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease by Leeuwen, Irma S. Lantinga-van, Dauwerse, Johannes G., Baelde, Hans J., Leonhard, Wouter N., van de Wal, Annemieke, Ward, Christopher J., Verbeek, Sjef, DeRuiter, Marco C., Breuning, Martijn H., de Heer, Emile, Peters, Dorien J.M.

“…Autosomal dominant polycystic kidney disease (ADPKD) is a major cause of renal failure and is characterized by the formation of many fluid-filled cysts in the…”
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Pericentrin Forms a Complex with Intraflagellar Transport Proteins and Polycystin-2 and Is Required for Primary Cilia Assembly by Jurczyk, Agata, Gromley, Adam, Redick, Sambra, San Agustin, Jovenal, Witman, George, Pazour, Gregory J., Dorien J. M. Peters, Doxsey, Stephen

“…Primary cilia are nonmotile microtubule structures that assemble from basal bodies by a process called intraflagellar transport (IFT) and are associated with…”
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Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression by Piazzon, Nathalie, Bernet, Florian, Guihard, Linda, Leonhard, Wouter N, Urfer, Séverine, Firsov, Dmitri, Chehade, Hassib, Vogt, Bruno, Piergiovanni, Sophia, Peters, Dorien J M, Bonny, Olivier, Constam, Daniel B

“…Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by numerous fluid-filled cysts that frequently result in end-stage…”
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Pkd1-inactivation in vascular smooth muscle cells and adaptation to hypertension by Hassane, Sabrine, Claij, Nanna, Jodar, Martine, Dedman, Alexandra, Lauritzen, Inger, Duprat, Fabrice, Koenderman, Jorine S, van der Wal, Annemieke, Breuning, Martijn H, de Heer, Emile, Honore, Eric, DeRuiter, Marco C, Peters, Dorien J M

“…Autosomal dominant polycystic kidney disease (ADPKD) is a multisystem disorder characterized by renal, hepatic and pancreatic cyst formation and cardiovascular…”
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SuO040EFFECT OF DOSE TITRATION OF A VASOPRESSIN V2 RECEPTOR ANTAGONIST TO IMPROVE RENOPROTECTION IN EXPERIMENTAL POLYCYSTIC KIDNEY DISEASE by Zittema, Debbie, Versteeg, Irina, Meijer, Esther, van Goor, Harry, Peters, Dorien JM, Gansevoort, Ron T

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Transgenic mice expressing tamoxifen-inducible Cre for somatic gene modification in renal epithelial cells by Lantinga-van Leeuwen, Irma S., Leonhard, Wouter N., van de Wal, Annemieke, Breuning, Martijn H., Verbeek, Sjef, de Heer, Emile, Peters, Dorien J.M.

“…Gene inactivation often leads to an embryonic‐lethal phenotype. In focal diseases like renal cell carcinomas and polycystic kidney disease, somatic gene…”
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