Search Results - "Peters, Colin"

Cardiac Pacemaker Activity and Aging by Peters, Colin H, Sharpe, Emily J, Proenza, Catherine

“…A progressive decline in maximum heart rate (mHR) is a fundamental aspect of aging in humans and other mammals. This decrease in mHR is independent of gender,…”
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Depolarization of the conductance-voltage relationship in the NaV1.5 mutant, E1784K, is due to altered fast inactivation by Peters, Colin H, Yu, Alec, Zhu, Wandi, Silva, Jonathan R, Ruben, Peter C

“…E1784K is the most common mixed long QT syndrome/Brugada syndrome mutant in the cardiac voltage-gated sodium channel NaV1.5. E1784K shifts the midpoint of the…”
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Calcium inhibits the funny current (If)in sinoatrial myocytes by Peters, Colin H., Peraza, Diego A., Blecker, Lucas M., Bankston, John, Proenza, Cathy

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Functional characterization of a metal ion coordination site in HCN4 by Blecker, Lucas M., Peters, Colin H., Peraza, Diego A., Bankston, John, Proenza, Cathy

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Defining the interactions between HCN4 and the regulatory proteins IRAG and LRMP by Singh, Rohit K., Langley, Avery A., Peters, Colin H., Bankston, John, Proenza, Cathy

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Bidirectional flow of the funny current (If) during the pacemaking cycle in murine sinoatrial node myocytes by Peters, Colin H., Liu, Pin W., Morotti, Stefano, Gantz, Stephanie C., Grandi, Eleonora, Bean, Bruce P., Proenza, Catherine

“…Sinoatrial node myocytes (SAMs) act as cardiac pacemaker cells by firing spontaneous action potentials (APs) that initiate each heartbeat. The funny current…”
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Regulation of HCN Channels by Protein Interactions by Peters, Colin H, Singh, Rohit K, Bankston, John R, Proenza, Catherine

“…Hyperpolarization-activated, cyclic nucleotide-sensitive (HCN) channels are key regulators of subthreshold membrane potentials in excitable cells. The four…”
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Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins by Peters, Colin H., Myers, Mallory E., Juchno, Julie, Haimbaugh, Charlie, Bichraoui, Hicham, Du, Yanmei, Bankston, John R., Walker, Lori A., Proenza, Catherine

“…Ion channels in excitable cells function in macromolecular complexes in which auxiliary proteinsmodulate the biophysical properties of the pore-forming…”
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The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells by Peters, Colin H, Rickert, Christian, Morotti, Stefano, Grandi, Eleonora, Aronow, Kurt A, Beam, Kurt G, Proenza, Catherine

“…The sympathetic nervous system fight-or-flight response is characterized by a rapid increase in heart rate, which is mediated by an increase in the spontaneous…”
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Differential thermosensitivity in mixed syndrome cardiac sodium channel mutants by Abdelsayed, Mena, Peters, Colin H., Ruben, Peter C.

“…Key points The E1784K mixed syndrome mutant of the cardiac voltage‐gated sodium channel, NaV1.5, responds differently to temperature changes compared to the…”
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E1784K, the most common Brugada syndrome and long-QT syndrome type 3 mutant, disrupts sodium channel inactivation through two separate mechanisms by Peters, Colin H, Watkins, Abeline R, Poirier, Olivia L, Ruben, Peter C

“…Inheritable and de novo variants in the cardiac voltage-gated sodium channel, Nav1.5, are responsible for both long-QT syndrome type 3 (LQT3) and Brugada…”
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Intracellular Na + Modulates Pacemaking Activity in Murine Sinoatrial Node Myocytes: An In Silico Analysis by Morotti, Stefano, Ni, Haibo, Peters, Colin H, Rickert, Christian, Asgari-Targhi, Ameneh, Sato, Daisuke, Glukhov, Alexey V, Proenza, Catherine, Grandi, Eleonora

“…: The mechanisms underlying dysfunction in the sinoatrial node (SAN), the heart's primary pacemaker, are incompletely understood. Electrical and Ca -handling…”
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LRMP inhibits cAMP potentiation of HCN4 channels by disrupting intramolecular signal transduction by Peters, Colin H, Singh, Rohit K, Langley, Avery A, Nichols, William G, Ferris, Hannah R, Jeffrey, Danielle A, Proenza, Catherine, Bankston, John R

“…Lymphoid restricted membrane protein (LRMP) is a specific regulator of the hyperpolarization-activated cyclic nucleotide-sensitive isoform 4 (HCN4) channel…”
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Triggers for arrhythmogenesis in the Brugada and long QT 3 syndromes by Peters, Colin H., Abdelsayed, Mena, Ruben, Peter C.

“…Cardiac arrhythmias are a prevalent cause of morbidity and mortality. In many cases, inheritable mutations in the genes encoding cardiac ion channels are the…”
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Case studies in neuroscience: a novel amino acid duplication in the NH2-terminus of the brain sodium channel NaV1.1 underlying Dravet syndrome by Angus, Madeline, Peters, Colin H, Poburko, Damon, Brimble, Elise, Spelbrink, Emily M, Ruben, Peter C

“…Dravet syndrome is a severe form of childhood epilepsy characterized by frequent temperature-sensitive seizures and delays in cognitive development. In the…”
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Case studies in neuroscience: a novel amino acid duplication in the NH 2 -terminus of the brain sodium channel Na V 1.1 underlying Dravet syndrome by Angus, Madeline, Peters, Colin H, Poburko, Damon, Brimble, Elise, Spelbrink, Emily M, Ruben, Peter C

“…Dravet syndrome is a severe form of childhood epilepsy characterized by frequent temperature-sensitive seizures and delays in cognitive development. In the…”
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A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH-Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels by Ghovanloo, Mohammad-Reza, Abdelsayed, Mena, Peters, Colin H., Ruben, Peter C.

“…Skeletal muscle channelopathies, many of which are inherited as autosomal dominant mutations, include myotonia and periodic paralysis. Myotonia is defined by a…”
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Functional Genomics of Epilepsy and Associated Neurodevelopmental Disorders Using Simple Animal Models: From Genes, Molecules to Brain Networks by Rosch, Richard, Burrows, Dominic R W, Jones, Laura B, Peters, Colin H, Ruben, Peter, Samarut, Éric

“…The genetic diagnosis of patients with seizure disorders has been improved significantly by the development of affordable next-generation sequencing…”
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The L1624Q Variant in SCN1A Causes Familial Epilepsy Through a Mixed Gain and Loss of Channel Function by Jones, Laura B, Peters, Colin H, Rosch, Richard E, Owers, Maxine, Hughes, Elaine, Pal, Deb K, Ruben, Peter C

“…Variants of the gene encoding the neuronal voltage-gated sodium channel Na 1.1 cause over 85% of all cases of Dravet syndrome, a severe and often…”
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Effects of acidosis on neuronal voltage-gated sodium channels: Nav1.1 and Nav1.3 by Ghovanloo, Mohammad-Reza, Peters, Colin H., Ruben, Peter C.

“…Voltage-gated sodium channels are key contributors to membrane excitability. These channels are expressed in a tissue-specific manner. Mutations and modulation…”
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