Search Results - "Peters, Cole"

Combinatorial Effects of VEGFR Kinase Inhibitor Axitinib and Oncolytic Virotherapy in Mouse and Human Glioblastoma Stem-Like Cell Models by Saha, Dipongkor, Wakimoto, Hiroaki, Peters, Cole W, Antoszczyk, Slawomir J, Rabkin, Samuel D, Martuza, Robert L

“…Glioblastoma (GBM), a fatal brain cancer, contains a subpopulation of GBM stem-like cells (GSCs) that contribute to resistance to current therapy. Angiogenesis…”
Get full text

Immunomodulatory Arming Factors—The Current Paradigm for Oncolytic Vectors Relies on Immune Stimulating Molecules by Peters, Cole W. D., Nigim, Fares

“…The dogma of engineering oncolytic viral vectors has shifted from emphasizing the viral lysis of individual cancer cells to the recruitment and coordination of…”
Get full text

Delivering AAV to the Central Nervous and Sensory Systems by Peters, Cole W., Maguire, Casey A., Hanlon, Killian S.

“…As gene therapy enters mainstream medicine, it is more important than ever to have a grasp of exactly how to leverage it for maximum benefit. The development…”
Get full text

Mini-PCDH15 gene therapy rescues hearing in a mouse model of Usher syndrome type 1F by Ivanchenko, Maryna V., Hathaway, Daniel M., Klein, Alex J., Pan, Bifeng, Strelkova, Olga, De-la-Torre, Pedro, Wu, Xudong, Peters, Cole W., Mulhall, Eric M., Booth, Kevin T., Goldstein, Corey, Brower, Joseph, Sotomayor, Marcos, Indzhykulian, Artur A., Corey, David P.

“…Usher syndrome type 1 F (USH1F), caused by mutations in the protocadherin-15 gene ( PCDH15 ), is characterized by congenital deafness, lack of balance, and…”
Get full text

Rescue of hearing by adenine base editing in a humanized mouse model of Usher syndrome type 1F by Peters, Cole W., Hanlon, Killian S., Ivanchenko, Maryna V., Zinn, Eric, Linarte, Elizabeth F., Li, Yaqiao, Levy, Jonathan M., Liu, David R., Kleinstiver, Benjamin P., Indzhykulian, Artur A., Corey, David P.

“…Usher syndrome type 1F (USH1F), characterized by congenital lack of hearing and balance and progressive loss of vision, is caused by mutations in the PCDH15…”
Get full text

Designing herpes viruses as oncolytics by Peters, Cole, Rabkin, Samuel D

“…Oncolytic herpes simplex virus (oHSV) was one of the first genetically-engineered oncolytic viruses. Because HSV is a natural human pathogen that can cause…”
Get full text

Intrapleural transplantation of allogeneic pancreatic islets achieves glycemic control in a diabetic non‐human primate by Lei, Ji, Zhang, Alexander, Deng, Hongping, Yang, Zhihong, Peters, Cole W., Lee, Kang M., Wang, Zhenjuan, Rosales, Ivy A., Rickert, Charles G., Markmann, James F.

“…Clinical islet transplantation has relied almost exclusively on intraportal administration of pancreatic islets, as it has been the only consistent approach to…”
Get full text

AAV-S: A versatile capsid variant for transduction of mouse and primate inner ear by Ivanchenko, Maryna V., Hanlon, Killian S., Hathaway, Daniel M., Klein, Alex J., Peters, Cole W., Li, Yaqiao, Tamvakologos, Panos I., Nammour, Josette, Maguire, Casey A., Corey, David P.

“…Gene therapy strategies using adeno-associated virus (AAV) vectors to treat hereditary deafnesses have shown remarkable efficacy in some mouse models of…”
Get full text

Updates on Oncolytic Virus Immunotherapy for Cancers by Peters, Cole, Grandi, Paola, Nigim, Fares

“…The 2018 annual Cambridge Healthtech Institute’s International Immuno-Oncology Summit in Boston, MA convened late August, and academic and industry researchers…”
Get full text

Hypophosphatemia Due to Increased Effector Cell Metabolic Activity Is Associated with Neurotoxicity Symptoms in CD19-Targeted CAR T-cell Therapy by Tang, Jack Pengfei, Peters, Cole W, Quiros, Crystal, Wang, Xiaoyan, Klomhaus, Alexandra M, Yamada, Reiko E, Timmerman, John M, Moore, Theodore B, Nowicki, Theodore S

“…A major complication of chimeric antigen receptor (CAR) T-cell therapy is immune effector cell-associated neurotoxicity syndrome (ICANS), which presents as…”
Get more information

Infusion Product TNFα, Th2, and STAT3 Activities Are Associated with Clinical Responses to Transgenic T-cell Receptor Cell Therapy by Nowicki, Theodore S, Peters, Cole W, Quiros, Crystal, Kidd, Conner K, Kawakami, Moe, Klomhaus, Alexandra M, Baselga-Carretero, Ignacio, Kaplan-Lefko, Paula, Macabali, Mignonette H, Perez Garcilazo, Ivan, Berent-Maoz, Beata, Comin-Anduix, Begoña, Ribas, Antoni

“…Transgenic T-cell receptor (TCR) T cell-based adoptive cell therapies for solid tumors are associated with dramatic initial response rates, but there remain…”
Get more information

Immunotherapy resistance driven by loss of NY-ESO-1 expression in response to transgenic adoptive cellular therapy with PD-1 blockade by Frankiw, Luke, Singh, Arun, Peters, Cole, Comin-Anduix, Begoña, Berent-Maoz, Beata, Macabali, Mignonette, Shammaie, Kiana, Quiros, Crystal, Kaplan-Lefko, Paula, Baselga Carretero, Ignacio, Ribas, Antoni, Nowicki, Theodore Scott

“…BackgroundThe tumor antigen NY-ESO-1 has been shown to be an effective target for transgenic adoptive cell therapy (ACT) for the treatment of sarcoma and…”
Get full text

FasL microgels induce immune acceptance of islet allografts in nonhuman primates by Lei, Ji, Coronel, María M, Yolcu, Esma S, Deng, Hongping, Grimany-Nuno, Orlando, Hunckler, Michael D, Ulker, Vahap, Yang, Zhihong, Lee, Kang M, Zhang, Alexander, Luo, Hao, Peters, Cole W, Zou, Zhongliang, Chen, Tao, Wang, Zhenjuan, McCoy, Colleen S, Rosales, Ivy A, Markmann, James F, Shirwan, Haval, García, Andrés J

“…Islet transplantation to treat insulin-dependent diabetes is greatly limited by the need for maintenance immunosuppression. We report a strategy through which…”
Get full text

Construction of a Sonchus Yellow Net Virus Minireplicon: a Step toward Reverse Genetic Analysis of Plant Negative-Strand RNA Viruses by Ganesan, Uma, Bragg, Jennifer N, Deng, Min, Marr, Sharon, Lee, Mi Yeon, Qian, Shasha, Shi, Manling, Kappel, Justin, Peters, Cole, Lee, Yeon, Goodin, Michael M, Dietzgen, Ralf G, Li, Zhenghe, Jackson, Andrew O

“…Erratum ( vol. 87 , p. 13081 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
Get full text

PCDH15 Dual-AAV Gene Therapy for Deafness and Blindness in Usher Syndrome Type 1F Models by Ivanchenko, Maryna V, Hathaway, Daniel M, Mulhall, Eric M, Booth, Kevin Ta, Wang, Mantian, Peters, Cole W, Klein, Alex J, Chen, Xinlan, Li, Yaqiao, György, Bence, Corey, David P

“…Usher syndrome type 1F (USH1F), resulting from mutations in the protocadherin-15 (PCDH15) gene, is characterized by congenital lack of hearing and balance, and…”
Get full text

Oncolytic Herpes Simplex Viruses as a Paradigm for the Treatment of Cancer by Bommareddy, Praveen K, Peters, Cole, Saha, Dipongkor, Rabkin, Samuel D, Kaufman, Howard L

“…Oncolytic viruses are native or modified viruses that directly kill tumor cells but spare normal tissue and promote host antitumor immunity. Recently, an…”
Get full text

Bioengineered omental transplant site promotes pancreatic islet allografts survival in non-human primates by Deng, Hongping, Zhang, Alexander, Pang, Dillon Ren Rong, Xi, Yinsheng, Yang, Zhihong, Matheson, Rudy, Li, Guoping, Luo, Hao, Lee, Kang M., Fu, Qiang, Zou, Zhongliang, Chen, Tao, Wang, Zhenjuan, Rosales, Ivy A., Peters, Cole W., Yang, Jibing, Coronel, María M., Yolcu, Esma S., Shirwan, Haval, García, Andrés J., Markmann, James F., Lei, Ji

“…The transplanting islets to the liver approach suffers from an immediate posttransplant loss of islets of more than 50%, progressive graft dysfunction over…”
Get full text

Oncolytic viruses on the cusp of success?: proceedings of the 9th International Conference on Oncolytic Virus Therapeutics by Peters, Cole, Nigim, Fares, Chiocca, E Antonio, Rabkin, Samuel D

“…Boston, Massachusetts, was the site of the 9th International Conference on Oncolytic Virus Therapeutics held 13–16 June 2015. An overarching theme of the…”
Get full text

Rad51 Degradation: Role in Oncolytic Virus-Poly(ADP-Ribose) Polymerase Inhibitor Combination Therapy in Glioblastoma by Ning, Jianfang, Wakimoto, Hiroaki, Peters, Cole, Martuza, Robert L, Rabkin, Samuel D

“…Clinical success of poly(ADP-ribose) polymerase inhibitors (PARP i ) has been limited to repair-deficient cancers and by resistance. Oncolytic herpes simplex…”
Get full text

334.3: Presentation of FasL Protein by PEG Microgels Within Graft Site Leads to Survival of Pancreatic Islets in Nonhuman Primates Without the Need for Chronic Immunosuppression by Yolcu, Esma, Lei, Ji, Coronel, Maria M, Deng, Hongping, Yang, Zhihong, Zhang, Alexander, Chen, Tao, Mi Lee, Kang, Peters, Cole W, Rosales, Ivy A, Wang, Zhenjuan, Ulker, Vahap, Markmann, James F, García, Andres J, Shirwan, Haval

Get full text