Search Results - "Peterhoff, David"

New case of HIV cure: joined forces of haploidentical stem cells and HLA-mismatched cord blood by Peterhoff, David

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Analysis of modular bioengineered antimicrobial lanthipeptides at nanoliter scale by Schmitt, Steven, Montalbán-López, Manuel, Peterhoff, David, Deng, Jingjing, Wagner, Ralf, Held, Martin, Kuipers, Oscar P., Panke, Sven

“…The rise of antibiotic resistance demands the acceleration of molecular diversification strategies to inspire new chemical entities for antibiotic medicines…”
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Association between Reactogenicity and Immunogenicity after Vaccination with BNT162b2 by Bauernfeind, Stilla, Salzberger, Bernd, Hitzenbichler, Florian, Scigala, Karolina, Einhauser, Sebastian, Wagner, Ralf, Gessner, André, Koestler, Josef, Peterhoff, David

“…It is not clear whether there is an association between adverse reactions and immune response after vaccination. Seven hundred and thirty-five vaccinees from…”
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Targeted escape of SARS-CoV-2 in vitro from monoclonal antibody S309, the precursor of sotrovimab by Magnus, Clara Luzia, Hiergeist, Andreas, Schuster, Philipp, Rohrhofer, Anette, Medenbach, Jan, Gessner, André, Peterhoff, David, Schmidt, Barbara

“…Class 1 and 2 monoclonal antibodies inhibit SARS-CoV-2 entry by blocking the interaction of the viral receptor-binding domain with angiotensin-converting…”
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A Multi-Faceted Binding Assessment of Aptamers Targeting the SARS-CoV-2 Spike Protein by Civit, Laia, Moradzadeh, Nima, Jonczyk, Anna, Neckermann, Patrick, Asbach, Benedikt, Peterhoff, David, Wagner, Ralf, Famulok, Michael, Mayer, Günter, Kjems, Jørgen, Valero, Julián

“…The COVID-19 pandemic has underscored the critical need for the advancement of diagnostic and therapeutic platforms. These platforms rely on the rapid…”
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DNA extraction from clotted blood in genotyping quality by Stanzick, Kira J, Simon, Josef, Zimmermann, Martina E, Schachtner, Michael, Peterhoff, David, Niller, Hans-Helmut, Überla, Klaus, Wagner, Ralf, Heid, Iris M, Stark, Klaus J

“…DNA extraction from frozen blood clots is challenging. Here, the authors applied QIAGEN Clotspin Baskets and the Gentra Puregene Blood Kit for DNA extraction…”
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ECMO in COVID-19—prolonged therapy needed? A retrospective analysis of outcome and prognostic factors by Dreier, Esther, Malfertheiner, Maximilian Valentin, Dienemann, Thomas, Fisser, Christoph, Foltan, Maik, Geismann, Florian, Graf, Bernhard, Lunz, Dirk, Maier, Lars Siegfried, Müller, Thomas, Offner, Robert, Peterhoff, David, Philipp, Alois, Salzberger, Bernd, Schmidt, Barbara, Sinner, Barbara, Lubnow, Matthias

“…Background: The role of venovenous extracorporeal membrane oxygenation (VV ECMO) in patients with COVID-19-induced acute respiratory distress syndrome (ARDS)…”
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Manufacturing of convalescent plasma of COVID-19 patients: Aspects of quality by Hähnel, Viola, Peterhoff, David, Bäuerlein, Veronika, Brosig, Andreas-Michael, Pamler, Irene, Johnson, Christian, Bica, Adelina, Totir, Monica, Ossner, Thomas, Stemmer, Barbara, Toelge, Martina, Schütz, Anja, Niller, Hans-Helmut, Schmidt, Barbara, Wagner, Ralf, Gessner, André, Burkhard, Ralph, Offner, Robert

“…The ongoing coronavirus disease 2019 (COVID-19) pandemic emerged in December 2019. Convalescent plasma represents a promising COVID-19 treatment. Here, we…”
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Analysis of Serological Biomarkers of SARS-CoV-2 Infection in Convalescent Samples From Severe, Moderate and Mild COVID-19 Cases by Castillo-Olivares, Javier, Wells, David A, Ferrari, Matteo, Chan, Andrew C Y, Smith, Peter, Nadesalingam, Angalee, Paloniemi, Minna, Carnell, George W, Ohlendorf, Luis, Cantoni, Diego, Mayora-Neto, Martin, Palmer, Phil, Tonks, Paul, Temperton, Nigel J, Peterhoff, David, Neckermann, Patrick, Wagner, Ralf, Doffinger, Rainer, Kempster, Sarah, Otter, Ashley D, Semper, Amanda, Brooks, Tim, Albecka, Anna, James, Leo C, Page, Mark, Schwaeble, Wilhelm, Baxendale, Helen, Heeney, Jonathan L

“…Precision monitoring of antibody responses during the COVID-19 pandemic is increasingly important during large scale vaccine rollout and rise in prevalence of…”
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Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis by Holzinger, Jonas Maurice, Toelge, Martina, Werner, Maren, Ederer, Katharina Ursula, Siegmund, Heiko Ingo, Peterhoff, David, Blaas, Stefan Helmut, Gisch, Nicolas, Brochhausen, Christoph, Gessner, André, Bülow, Sigrid

“…Chronic pulmonary infection is a hallmark of cystic fibrosis (CF) and requires continuous antibiotic treatment. In this context, ( ) is of special concern…”
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Population-based study of the durability of humoral immunity after SARS-CoV-2 infection by Peterhoff, David, Wiegrebe, Simon, Einhauser, Sebastian, Patt, Arisha J., Beileke, Stephanie, Günther, Felix, Steininger, Philipp, Niller, Hans H., Burkhardt, Ralph, Küchenhoff, Helmut, Gefeller, Olaf, Überla, Klaus, Heid, Iris M., Wagner, Ralf

“…SARS-CoV-2 antibody quantity and quality are key markers of humoral immunity. However, there is substantial uncertainty about their durability. We investigated…”
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Expanding the Genetic Code of Lactococcus lactis and Escherichia coli to Incorporate Non-canonical Amino Acids for Production of Modified Lantibiotics by Bartholomae, Maike, Baumann, Tobias, Nickling, Jessica H, Peterhoff, David, Wagner, Ralf, Budisa, Nediljko, Kuipers, Oscar P

“…The incorporation of non-canonical amino acids (ncAAs) into ribosomally synthesized and post-translationally modified peptides, e.g., nisin from the…”
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Glycan masking of a non-neutralising epitope enhances neutralising antibodies targeting the RBD of SARS-CoV-2 and its variants by Carnell, George W, Billmeier, Martina, Vishwanath, Sneha, Suau Sans, Maria, Wein, Hannah, George, Charlotte L, Neckermann, Patrick, Del Rosario, Joanne Marie M, Sampson, Alexander T, Einhauser, Sebastian, Aguinam, Ernest T, Ferrari, Matteo, Tonks, Paul, Nadesalingam, Angalee, Schütz, Anja, Huang, Chloe Qingzhou, Wells, David A, Paloniemi, Minna, Jordan, Ingo, Cantoni, Diego, Peterhoff, David, Asbach, Benedikt, Sandig, Volker, Temperton, Nigel, Kinsley, Rebecca, Wagner, Ralf, Heeney, Jonathan L

“…The accelerated development of the first generation COVID-19 vaccines has saved millions of lives, and potentially more from the long-term sequelae of…”
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Estimates and Determinants of SARS-Cov-2 Seroprevalence and Infection Fatality Ratio Using Latent Class Analysis: The Population-Based Tirschenreuth Study in the Hardest-Hit German County in Spring 2020 by Wagner, Ralf, Peterhoff, David, Beileke, Stephanie, Günther, Felix, Berr, Melanie, Einhauser, Sebastian, Schütz, Anja, Niller, Hans Helmut, Steininger, Philipp, Knöll, Antje, Tenbusch, Matthias, Maier, Clara, Korn, Klaus, Stark, Klaus J., Gessner, André, Burkhardt, Ralph, Kabesch, Michael, Schedl, Holger, Küchenhoff, Helmut, Pfahlberg, Annette B., Heid, Iris M., Gefeller, Olaf, Überla, Klaus

“…SARS-CoV-2 infection fatality ratios (IFR) remain controversially discussed with implications for political measures. The German county of Tirschenreuth…”
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Potency and durability of T and B cell immune responses after homologous and heterologous vector delivery of a trimer-stabilized, membrane-displayed HIV-1 clade ConC Env protein by Perdiguero, Beatriz, Hauser, Alexandra, Gómez, Carmen Elena, Peterhoff, David, Sideris, Elefthéria, Sorzano, Carlos Óscar S, Wilmschen, Sarah, Schaber, Marion, Stengel, Laura, Asbach, Benedikt, Ding, Song, Von Laer, Dorothee, Levy, Yves, Pantaleo, Giuseppe, Kimpel, Janine, Esteban, Mariano, Wagner, Ralf

“…The generation of an HIV-1 vaccine able to induce long-lasting protective immunity remains a main challenge. Here, we aimed to modify next-generation soluble,…”
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Omicron’s binding to sotrovimab, casirivimab, imdevimab, CR3022, and sera from previously infected or vaccinated individuals by Mader, Anna-Lena, Tydykov, Leonid, Glück, Vivian, Bertok, Manuela, Weidlich, Tanja, Gottwald, Christine, Stefl, Alexa, Vogel, Matthias, Plentz, Annelie, Köstler, Josef, Salzberger, Bernd, Wenzel, Jürgen J., Niller, Hans Helmut, Jantsch, Jonathan, Wagner, Ralf, Schmidt, Barbara, Glück, Thomas, Gessner, André, Peterhoff, David

“…SARS-CoV-2 Omicron is the first pandemic variant of concern exhibiting an abrupt accumulation of mutations particularly in the receptor-binding domain that is…”
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Secondary hemophagocytic lymphohistiocytosis and severe liver injury induced by hepatic SARS-CoV-2 infection unmasking Wilson’s disease: Balancing immunosuppression by Lubnow, Matthias, Schmidt, Barbara, Fleck, Martin, Salzberger, Bernd, Müller, Thomas, Peschel, Georg, Schneckenpointner, Roland, Lange, Tobias, Hitzenbichler, Florian, Kieninger, Martin, Lunz, Dirk, Graf, Bernhard, Brochhausen, Christoph, Weber, Florian, Lüke, Florian, Peterhoff, David, Schuster, Philipp, Hiergeist, Andreas, Offner, Robert, Hehr, Ute, Wallner, Stefan, Hanses, Frank, Schmid, Stephan, Weigand, Kilian, Geismann, Florian, Poeck, Hendrik, Pukrop, Tobias, Evert, Matthias, Gessner, Andre, Burkhardt, Ralph, Herr, Wolfgang, Maier, Lars S., Heudobler, Daniel

“…•We present an unusual case of a young COVID-19 patient presenting with hyperinflammation and severe liver injury.•The underlying causative events were sHLH,…”
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Case report: Local bacteriophage therapy for fracture-related infection with polymicrobial multi-resistant bacteria: hydrogel application and postoperative phage analysis through metagenomic sequencing by Alt, Volker, Gessner, André, Merabishvili, Maya, Hitzenbichler, Florian, Mannala, Gopala Krishna, Peterhoff, David, Walter, Nike, Pirnay, Jean-Paul, Hiergeist, Andreas, Rupp, Markus

“…Fracture-related infections can be challenging, particularly with concomitant severe bone defects and multi-resistant microorganisms. We present a case of a…”
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Spectrum Bias and Individual Strengths of SARS-CoV-2 Serological Tests—A Population-Based Evaluation by Einhauser, Sebastian, Peterhoff, David, Niller, Hans Helmut, Beileke, Stephanie, Günther, Felix, Steininger, Philipp, Burkhardt, Ralph, Heid, Iris M., Pfahlberg, Annette B., Überla, Klaus, Gefeller, Olaf, Wagner, Ralf

“…Antibody testing for determining the SARS-CoV-2 serostatus was rapidly introduced in early 2020 and since then has been gaining special emphasis regarding…”
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Increased neutralization of SARS-CoV-2 Delta variant after heterologous ChAdOx1 nCoV-19/BNT162b2 versus homologous BNT162b2 vaccination by Bauswein, Markus, Peterhoff, David, Plentz, Annelie, Hiergeist, Andreas, Wagner, Ralf, Gessner, André, Salzberger, Bernd, Schmidt, Barbara, Bauernfeind, Stilla

“…Heterologous SARS-CoV-2 vaccine approaches with a second mRNA-based vaccine have been favored in the recommendations of many countries over homologous…”
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