Search Results - "Peter Tilston"

Chronic Rhinovirus Infection in an Adult with Cystic Fibrosis by Flight, William G, Bright-Thomas, Rowland J, Tilston, Peter, Mutton, Kenneth J, Guiver, Malcolm, Webb, A Kevin, Jones, Andrew M

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Incidence and clinical impact of respiratory viruses in adults with cystic fibrosis by Flight, William G, Bright-Thomas, Rowland J, Tilston, Peter, Mutton, Kenneth J, Guiver, Malcolm, Morris, Julie, Webb, A Kevin, Jones, Andrew M

“…Viral respiratory infection (VRI) is a common cause of pulmonary exacerbations in children with cystic fibrosis (CF). The importance of VRI in adult CF…”
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Real-world SARS CoV-2 testing in Northern England during the first wave of the COVID-19 pandemic by Farooq, Hamzah Z., Davies, Emma, Brown, Benjamin, Whitfield, Thomas, Tilston, Peter, McEwan, Ashley, Birtles, Andrew, O'Hara, Robert, Spencer, Hannah, Hesketh, Louise, Ahmad, Shazaad, Guiver, Malcolm, Machin, Nicholas

“…•Nasal swabs are the optimum samples for diagnosing SARS-CoV-2 via PCR in this dataset.•None of the faecal, fluid or CSF samples were positive for…”
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An Overview of SARS-CoV-2 Molecular Diagnostics in Europe by Davies, Emma, Farooq, Hamzah Z., Brown, Benjamin, Tilston, Peter, McEwan, Ashley, Birtles, Andrew, O’Hara, Robert William, Ahmad, Shazaad, Machin, Nicholas, Hesketh, Louise, Guiver, Malcolm

“…The COVID-19 pandemic has led to the rapid development of a plethora of molecular diagnostic assays with real-time polymerase chain reaction (RT-PCR) at the…”
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Persistence of HIV-1 Transmitted Drug Resistance Mutations by Castro, Hannah, Pillay, Deenan, Cane, Patricia, Asboe, David, Cambiano, Valentina, Phillips, Andrew, Dunn, David T.

“…There are few data on the persistence of individual human immunodeficiency virus type 1 (HIV-1) transmitted drug resistance (TDR) mutations in the absence of…”
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Recent trends and patterns in HIV‐1 transmitted drug resistance in the United Kingdom by Tostevin, A, White, E, Dunn, D, Croxford, S, Delpech, V, Williams, I, Asboe, D, Pozniak, A, Churchill, D, Geretti, AM, Pillay, D, Sabin, C, Leigh‐Brown, A, Smit, E, Aitken, Celia, Cane, Patricia, Chadwick, David, Clark, Duncan, Collins, Simon, Douthwaite, Samuel, Fearnhill, Esther, Porter, Kholoud, Fraser, Christophe, Hale, Antony, Hué, Stéphane, Kaye, Steve, Kellam, Paul, Lazarus, Linda, Mbisa, Tamyo, Mackie, Nicola, Moses, Samuel, Orkin, Chloe, Nastouli, Eleni, Phillips, Andrew, Templeton, Kate, Tilston, Peter, Zhang, Hongyi, Fairbrother, Keith, Greatorex, Jane, O'Shea, Siobhan, Mullen, Jane, Cox, Alison, Tandy, Richard, Fawcett, Tracy, Hopkins, Mark, Ashton, Lynne, Booth, Clare, Garcia‐Diaz, Ana, Shepherd, Jill, Schmid, Matthias L., Payne, Brendan, Pereira, Spiro, Hubb, Jonathan, Kirk, Stuart, Gunson, Rory, Bradley‐Stewart, Amanda

“…Objectives Transmission of drug‐resistant HIV‐1 has decreased in the UK since the early 2000s. This analysis reports recent trends and characteristics of…”
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Determining the Origins of Human Immunodeficiency Virus Type 1 Drug-resistant Minority Variants in People Who Are Recently Infected Using Phylogenetic Reconstruction by Mbisa, Jean L, Kirwan, Peter, Tostevin, Anna, Ledesma, Juan, Bibby, David F, Brown, Alison, Myers, Richard, Hassan, Amin S, Murphy, Gary, Asboe, David, Pozniak, Anton, Kirk, Stuart, Gill, O Noel, Sabin, Caroline, Delpech, Valerie, Dunn, David T

“…Drug-resistant minority variants (DRMinVs) detected in patients who recently acquired human immunodeficiency virus type 1 (HIV-1) can be transmitted, generated…”
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HIV-1 drug resistance mutations emerging on darunavir therapy in PI-naive and -experienced patients in the UK by El Bouzidi, Kate, White, Ellen, Mbisa, Jean L, Sabin, Caroline A, Phillips, Andrew N, Mackie, Nicola, Pozniak, Anton L, Tostevin, Anna, Pillay, Deenan, Dunn, David T

“…Darunavir is considered to have a high genetic barrier to resistance. Most darunavir-associated drug resistance mutations (DRMs) have been identified through…”
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The impact of HIV-1 reverse transcriptase polymorphisms on responses to first-line nonnucleoside reverse transcriptase inhibitor-based therapy in HIV-1-infected adults by MACKIE, Nicola E, DUNN, David T, DOLLING, David, GARVEY, Lucy, HARRISON, Linda, FEARNHILL, Esther, TILSTON, Peter, SABIN, Caroline, GERETTI, Anna M

“…HIV-1 genetic variability may influence antiretroviral therapy (ART) outcomes. The study aim was to determine the impact of polymorphisms in regions known to…”
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Virological outcomes of boosted protease inhibitor-based first-line ART in subjects harbouring thymidine analogue-associated mutations as the sole form of transmitted drug resistance by Geretti, Anna Maria, White, Ellen, Orkin, Chloe, Tostevin, Anna, Tilston, Peter, Chadwick, David, Leen, Clifford, Sabin, Caroline, Dunn, David T

“…Abstract Objectives In subjects with transmitted thymidine analogue mutations (TAMs), boosted PIs (PI/b) are often chosen to overcome possible resistance to…”
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Evaluation of the artus® Prep&Amp UM RT-PCR for detection of SARS-CoV-2 from nasopharyngeal swabs without prior nucleic acid eluate extraction by O'Hara, Robert William, Brown, Benjamin, Hughes, Angela, McEwan, Ashley, Birtles, Andrew, Hawker, Adam, Davies, Emma, Farooq, Hamzah Z, Tilston, Peter, Haigh, Dominic, Hesketh, Louise, Dodgson, Andrew, Dodgson, Kirsty, Shazaad, Ahmad, Guiver, Malcolm, Machin, Nicholas

“…Here we describe a retrospective clinical evaluation of the QIAGEN artus® SARS-CoV-2 Prep&Amp UM RT-PCR assay that detects SARS-CoV-2 RNA without the need for…”
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Evaluation of the artus® Prep Amp UM RT-PCR for detection of SARS-CoV-2 from nasopharyngeal swabs without prior nucleic acid eluate extraction by Robert William O'Hara, Benjamin Brown, Angela Hughes, Ashley McEwan, Andrew Birtles, Adam Hawker, Emma Davies, Hamzah Z Farooq, Peter Tilston, Dominic Haigh, Louise Hesketh, Andrew Dodgson, Kirsty Dodgson, Ahmad Shazaad, Malcolm Guiver, Nicholas Machin

“…Here we describe a retrospective clinical evaluation of the QIAGEN artus® SARS-CoV-2 Prep&Amp UM RT-PCR assay that detects SARS-CoV-2 RNA without the need for…”
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The contribution of viral genotype to plasma viral set-point in HIV infection by Hodcroft, Emma, Hadfield, Jarrod D, Fearnhill, Esther, Phillips, Andrew, Dunn, David, O'Shea, Siobhan, Pillay, Deenan, Leigh Brown, Andrew J

“…Disease progression in HIV-infected individuals varies greatly, and while the environmental and host factors influencing this variation have been widely…”
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Intercontinental dispersal of HIV-1 subtype B associated with transmission among men who have sex with men in Japan by Takebe, Yutaka, Naito, Yuki, Raghwani, Jayna, Fearnhill, Esther, Sano, Takako, Kusagawa, Shigeru, Mbisa, Jean L, Zhang, Hongyi, Matano, Tetsuro, Brown, Andrew J Leigh, Pybus, Oliver G, Dunn, David, Kondo, Makiko

“…Transmission clusters of HIV-1 subtype B uniquely associated with the epidemic among men who have sex with men (MSM) in East Asia have recently been…”
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Long-Term Probability of Detecting Drug-Resistant HIV in Treatment-Naive Patients Initiating Combination Antiretroviral Therapy by Cozzi-Lepri, A

“…Background. Robust long-term estimates of the risk of development of drug resistance are needed for human immunodeficiency virus (HIV)-infected patients…”
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Frequency and patterns of protease gene resistance mutations in HIV-infected patients treated with lopinavir/ritonavir as their first protease inhibitor by Barber, Tristan J., Harrison, Linda, Asboe, David, Williams, Ian, Kirk, Stuart, Gilson, Richard, Bansi, Loveleen, Pillay, Deenan, Dunn, David

“…Background Selection of protease mutations on antiretroviral therapy (ART) including a ritonavir-boosted protease inhibitor (PI) has been reported…”
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Low frequency of genotypic resistance in HIV-1-infected patients failing an atazanavir-containing regimen: a clinical cohort study by Dolling, David I, Dunn, David T, Sutherland, Katherine A, Pillay, Deenan, Mbisa, Jean L, Parry, Chris M, Post, Frank A, Sabin, Caroline A, Cane, Patricia A

“…To determine protease mutations that develop at viral failure for protease inhibitor (PI)-naive patients on a regimen containing the PI atazanavir. Resistance…”
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Evidence of a decline in transmitted HIV-1 drug resistance in the united Kingdom by Dunn, D

“…To examine recent trends in transmitted drug resistance (TDR) in the United Kingdom. Analysis of results of genotypic resistance tests reported to the UK HIV…”
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Associations between baseline characteristics, CD4 cell count response and virological failure on first-line efavirenz + tenofovir + emtricitabine for HIV by Stirrup, Oliver T, Sabin, Caroline A, Phillips, Andrew N, Williams, Ian, Churchill, Duncan, Tostevin, Anna, Hill, Teresa, Dunn, David T

“…Objectives: The aim of this study was to investigate associations between baseline characteristics and CD4 cell count response on first-line antiretroviral…”
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Virological failure and development of new resistance mutations according to CD4 count at combination antiretroviral therapy initiation by Jose, S, Dunn, D, Cox, A, Fidler, S, Ainsworth, Jonathan, Allan, Sris, Anderson, Jane, Delpech, Valerie, Fisher, Martin, Gazzard, Brian, Gilson, Richard, Gompels, Mark, Hay, Phillip, Hill, Teresa, Johnson, Margaret, Leen, Clifford, Martin, Fabiola, Nelson, Mark, Palfreeman, Adrian, Pillay, Deenan, Sachikonye, Memory, Schwenk, Achim, Tariq, Anjum, Thornton, Alicia, Perry, N, Tilbury, S, Youssef, E, Everett, R, Asboe, D, Taylor, C, Gleisner, Z, Ibrahim, F, Campbell, L, Brima, N, Williams, I, Youle, M, Lampe, F, Smith, C, Tsintas, R, Chaloner, C, Hutchinson, S, Huntington, S, Winston, A, Weber, J, Ramzan, F, Carder, M, Hand, J, Souza, C, Miller, S, Wilson, A, Morris, S, Allan, S, Palfreeman, A, ewszuk, A, Chadwick, D, Cope, E, Gibson, J, Kegg, S, Mitchell, Dr, Hay, P, Martin, F, Russell‐Sharpe, S, Harte, A, Spencer, H, Jones, R, Atkinson, C, Sachikonye, M, Aitken, Celia, Pozniak, Anton, Cane, Patricia, Clark, Duncan, Collins, Simon, Douthwaite, Samuel, Fraser, Christophe, Geretti, Anna Maria, Hué, Stéphane, Kaye, Steve, Kellam, Paul, Lazarus, Linda, Leigh‐Brown, Andrew, Mbisa, Tamyo, Moses, Samuel, Nastouli, Eleni, Smit, Erasmus, Templeton, Kate, Tilston, Peter, Webster, Daniel, Zhang, Hongyi, Greatorex, Jane, Hopkins, Mark, Ashton, Lynn, Booth, Claire, Garcia‐Diaz, Ana, Shepherd, Jill, Schmid, Matthias L, Payne, Brendan, Pere, Spiro, Hubb, Jonathan, Kirk, Stuart, Gunson, Rory

“…Objectives No randomized controlled trials have yet reported an individual patient benefit of initiating combination antiretroviral therapy (cART) at CD4…”
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