Search Results - "Peter R. Rijnbeek"

The role of explainability in creating trustworthy artificial intelligence for health care: A comprehensive survey of the terminology, design choices, and evaluation strategies by Markus, Aniek F., Kors, Jan A., Rijnbeek, Peter R.

“…[Display omitted] •Comprehensive survey to provide guidance and formalize the field of explainable AI.•Assessment of quantitative evaluation metrics for…”
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External validation of existing dementia prediction models on observational health data by John, Luis H, Kors, Jan A, Fridgeirsson, Egill A, Reps, Jenna M, Rijnbeek, Peter R

“…Many dementia prediction models have been developed, but only few have been externally validated, which hinders clinical uptake and may pose a risk if models…”
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Predictive approaches to heterogeneous treatment effects: a scoping review by Rekkas, Alexandros, Paulus, Jessica K, Raman, Gowri, Wong, John B, Steyerberg, Ewout W, Rijnbeek, Peter R, Kent, David M, van Klaveren, David

“…Recent evidence suggests that there is often substantial variation in the benefits and harms across a trial population. We aimed to identify regression…”
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Thrombosis and thrombocytopenia after vaccination against and infection with SARS-CoV-2 in the United Kingdom by Burn, Edward, Li, Xintong, Delmestri, Antonella, Jones, Nathan, Duarte-Salles, Talita, Reyes, Carlen, Martinez-Hernandez, Eugenia, Marti, Edelmira, Verhamme, Katia M. C., Rijnbeek, Peter R., Strauss, Victoria Y., Prieto-Alhambra, Daniel

“…Population-based studies can provide important evidence on the safety of COVID-19 vaccines. Using data from the United Kingdom, here we compare observed rates…”
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Estimating individualized treatment effects from randomized controlled trials: a simulation study to compare risk-based approaches by Rekkas, Alexandros, Rijnbeek, Peter R, Kent, David M, Steyerberg, Ewout W, van Klaveren, David

“…Baseline outcome risk can be an important determinant of absolute treatment benefit and has been used in guidelines for "personalizing" medical decisions. We…”
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Development and validation of a patient-level model to predict dementia across a network of observational databases by John, Luis H, Fridgeirsson, Egill A, Kors, Jan A, Reps, Jenna M, Williams, Ross D, Ryan, Patrick B, Rijnbeek, Peter R

“…A prediction model can be a useful tool to quantify the risk of a patient developing dementia in the next years and take risk-factor-targeted intervention…”
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Normal Values of Corrected Heart-Rate Variability in 10-Second Electrocardiograms for All Ages by van den Berg, Marten E, Rijnbeek, Peter R, Niemeijer, Maartje N, Hofman, Albert, van Herpen, Gerard, Bots, Michiel L, Hillege, Hans, Swenne, Cees A, Eijgelsheim, Mark, Stricker, Bruno H, Kors, Jan A

“…Heart-rate variability (HRV) measured on standard 10-s electrocardiograms (ECGs) has been associated with increased risk of cardiac and all-cause mortality,…”
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Declining incidence of sudden cardiac death from 1990–2010 in a general middle-aged and elderly population: The Rotterdam Study by Niemeijer, Maartje N., MD, van den Berg, Marten E., MD, Leening, Maarten J.G., MD, Hofman, Albert, MD, PhD, Franco, Oscar H., MD, PhD, Deckers, Jaap W., MD, PhD, Heeringa, Jan, MD, PhD, Rijnbeek, Peter R., PhD, Stricker, Bruno H., MMed, PhD, Eijgelsheim, Mark, MD, PhD

“…Background Although sudden cardiac death (SCD) is relatively common, contemporary data on its incidence are lacking. Objective The purpose of this study was to…”
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Advancing the use of real world evidence in health technology assessment: insights from a multi-stakeholder workshop by Claire, Ravinder, Elvidge, Jamie, Hanif, Shahid, Goovaerts, Hannah, Rijnbeek, Peter R, Jónsson, Páll, Facey, Karen, Dawoud, Dalia

“…Real-world evidence (RWE) in health technology assessment (HTA) holds significant potential for informing healthcare decision-making. A multistakeholder…”
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Impact of random oversampling and random undersampling on the performance of prediction models developed using observational health data by Yang, Cynthia, Fridgeirsson, Egill A., Kors, Jan A., Reps, Jenna M., Rijnbeek, Peter R.

“…Background There is currently no consensus on the impact of class imbalance methods on the performance of clinical prediction models. We aimed to empirically…”
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Normal values of the electrocardiogram for ages 16–90 years by Rijnbeek, Peter R., PhD, van Herpen, Gerard, MD, PhD, Bots, Michiel L., MD, PhD, Man, Sumche, MD, Verweij, Niek, MD, Hofman, Albert, MD, PhD, Hillege, Hans, MD, PhD, Numans, Matthijs E., MD, PhD, Swenne, Cees A., PhD, Witteman, Jacqueline C.M., PhD, Kors, Jan A., PhD

“…Abstract Introduction To establish an up-to-date and comprehensive set of normal values for the clinically current measurements in the adult ECG, covering all…”
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Learning patient-level prediction models across multiple healthcare databases: evaluation of ensembles for increasing model transportability by Reps, Jenna Marie, Williams, Ross D, Schuemie, Martijn J, Ryan, Patrick B, Rijnbeek, Peter R

“…Prognostic models that are accurate could help aid medical decision making. Large observational databases often contain temporal medical data for large and…”
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Comparative safety and effectiveness of alendronate versus raloxifene in women with osteoporosis by Kim, Yeesuk, Tian, Yuxi, Yang, Jianxiao, Huser, Vojtech, Jin, Peng, Lambert, Christophe G., Park, Hojun, You, Seng Chan, Park, Rae Woong, Rijnbeek, Peter R., Van Zandt, Mui, Reich, Christian, Vashisht, Rohit, Wu, Yonghui, Duke, Jon, Hripcsak, George, Madigan, David, Shah, Nigam H., Ryan, Patrick B., Schuemie, Martijn J., Suchard, Marc A.

“…Alendronate and raloxifene are among the most popular anti-osteoporosis medications. However, there is a lack of head-to-head comparative effectiveness studies…”
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Dynamic Digital Twin: Diagnosis, Treatment, Prediction, and Prevention of Disease During the Life Course by Mulder, Skander Tahar, Omidvari, Amir-Houshang, Rueten-Budde, Anja J, Huang, Pei-Hua, Kim, Ki-Hun, Bais, Babette, Rousian, Melek, Hai, Rihan, Akgun, Can, van Lennep, Jeanine Roeters, Willemsen, Sten, Rijnbeek, Peter R, Tax, David MJ, Reinders, Marcel, Boersma, Eric, Rizopoulos, Dimitris, Visch, Valentijn, Steegers-Theunissen, Régine

“…A digital twin (DT), originally defined as a virtual representation of a physical asset, system, or process, is a new concept in health care. A DT in health…”
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Development and validation of a prognostic model predicting symptomatic hemorrhagic transformation in acute ischemic stroke at scale in the OHDSI network by Wang, Qiong, Reps, Jenna M, Kostka, Kristin Feeney, Ryan, Patrick B, Zou, Yuhui, Voss, Erica A, Rijnbeek, Peter R, Chen, RuiJun, Rao, Gowtham A, Morgan Stewart, Henry, Williams, Andrew E, Williams, Ross D, Van Zandt, Mui, Falconer, Thomas, Fernandez-Chas, Margarita, Vashisht, Rohit, Pfohl, Stephen R, Shah, Nigam H, Kasthurirathne, Suranga N, You, Seng Chan, Jiang, Qing, Reich, Christian, Zhou, Yi

“…Hemorrhagic transformation (HT) after cerebral infarction is a complex and multifactorial phenomenon in the acute stage of ischemic stroke, and often results…”
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Parasitic infections related to anti-type 2 immunity monoclonal antibodies: a disproportionality analysis in the food and drug administration’s adverse event reporting system (FAERS) by Pera, Victor, Brusselle, Guy G., Riemann, Sebastian, Kors, Jan A., Van Mulligen, Erik M., Parry, Rowan, de Wilde, Marcel, Rijnbeek, Peter R., Verhamme, Katia M. C.

“…Introduction: Monoclonal antibodies (mAbs) targeting immunoglobulin E (IgE) [omalizumab], type 2 (T2) cytokine interleukin (IL) 5 [mepolizumab, reslizumab],…”
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Factors Influencing Background Incidence Rate Calculation: Systematic Empirical Evaluation Across an International Network of Observational Databases by Ostropolets, Anna, Li, Xintong, Makadia, Rupa, Rao, Gowtham, Rijnbeek, Peter R, Duarte-Salles, Talita, Sena, Anthony G, Shaoibi, Azza, Suchard, Marc A, Ryan, Patrick B, Prieto-Alhambra, Daniel, Hripcsak, George

“…Background incidence rates are routinely used in safety studies to evaluate an association of an exposure and outcome. Systematic research on sensitivity of…”
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Design matters in patient-level prediction: evaluation of a cohort vs. case-control design when developing predictive models in observational healthcare datasets by Reps, Jenna M., Ryan, Patrick B., Rijnbeek, Peter R., Schuemie, Martijn J.

“…Background The design used to create labelled data for training prediction models from observational healthcare databases (e.g., case-control and cohort) may…”
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Characterising the treatment of thromboembolic events after COVID-19 vaccination in 4 European countries and the US: An international network cohort study by Markus, Aniek F, Strauss, Victoria Y, Burn, Edward, Li, Xintong, Delmestri, Antonella, Reich, Christian, Yin, Can, Mayer, Miguel A, Ramírez-Anguita, Juan-Manuel, Marti, Edelmira, Verhamme, Katia M C, Rijnbeek, Peter R, Prieto-Alhambra, Daniel, Jödicke, Annika M

“…Thrombosis with thrombocytopenia syndrome (TTS) has been identified as a rare adverse event following some COVID-19 vaccines. Various guidelines have been…”
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Finding a short and accurate decision rule in disjunctive normal form by exhaustive search by Rijnbeek, Peter R., Kors, Jan A.

“…Greedy approaches suffer from a restricted search space which could lead to suboptimal classifiers in terms of performance and classifier size. This study…”
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