Search Results - "Peter MacPherson"

mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism by Tang, Huibin, Inoki, Ken, Brooks, Susan V., Okazawa, Hideki, Lee, Myung, Wang, Junying, Kim, Michael, Kennedy, Catherine L., Macpherson, Peter C. D., Ji, Xuhuai, Van Roekel, Sabrina, Fraga, Danielle A., Wang, Kun, Zhu, Jinguo, Wang, Yoyo, Sharp, Zelton D., Miller, Richard A., Rando, Thomas A., Goldman, Daniel, Guan, Kun‐Liang, Shrager, Joseph B.

“…Aging leads to skeletal muscle atrophy (i.e., sarcopenia), and muscle fiber loss is a critical component of this process. The mechanisms underlying these…”
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Neuron‐specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice by Bhaskaran, Shylesh, Pollock, Natalie, Macpherson, Peter, Ahn, Bumsoo, Piekarz, Katarzyna M., Staunton, Caroline A., Brown, Jacob L., Qaisar, Rizwan, Vasilaki, Aphrodite, Richardson, Arlan, McArdle, Anne, Jackson, Malcolm J., Brooks, Susan V., Van Remmen, Holly

“…Age‐associated loss of muscle mass and function (sarcopenia) has a profound effect on the quality of life in the elderly. Our previous studies show that…”
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Dach2-Hdac9 signaling regulates reinnervation of muscle endplates by Macpherson, Peter C D, Farshi, Pershang, Goldman, Daniel

“…Muscle denervation resulting from injury, disease or aging results in impaired motor function. Restoring neuromuscular communication requires axonal regrowth…”
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Metabolipidomic profiling reveals an age‐related deficiency of skeletal muscle pro‐resolving mediators that contributes to maladaptive tissue remodeling by Markworth, James F., Brown, Lemuel A., Lim, Eunice, Castor‐Macias, Jesus A., Larouche, Jacqueline, Macpherson, Peter C. D., Davis, Carol, Aguilar, Carlos A., Maddipati, Krishna Rao, Brooks, Susan V.

“…Specialized pro‐resolving mediators actively limit inflammation and support tissue regeneration, but their role in age‐related muscle dysfunction has not been…”
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Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle by Macpherson, Peter C. D., Wang, Xun, Goldman, Daniel

“…Muscle inactivity due to injury or disease results in muscle atrophy. The molecular mechanisms contributing to muscle atrophy are poorly understood. However,…”
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Sex Differences in Tuberculosis Burden and Notifications in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis by Horton, Katherine C, MacPherson, Peter, Houben, Rein M G J, White, Richard G, Corbett, Elizabeth L

“…Tuberculosis (TB) case notification rates are usually higher in men than in women, but notification data are insufficient to measure sex differences in disease…”
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Eccentric Exercise as a Potent Prescription for Muscle Weakness After Joint Injury by Lepley, Lindsey K., Stoneback, Luke, Macpherson, Peter C.D., Butterfield, Timothy A.

“…Lengthening contractions (i.e., eccentric contractions) are capable of uniquely triggering the nervous system and signaling pathways to promote tissue…”
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Transgenic expression of SOD1 specifically in neurons of Sod1 deficient mice prevents defects in muscle mitochondrial function and calcium handling by Su, Yu, Ahn, Bumsoo, Macpherson, Peter C.D., Ranjit, Rojina, Claflin, Dennis R., Van Remmen, Holly, Brooks, Susan V.

“…Aging is accompanied by loss of muscle mass and force, known as sarcopenia. Muscle atrophy, weakness, and neuromuscular junction (NMJ) degeneration reminiscent…”
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Uptake, Accuracy, Safety, and Linkage into Care over Two Years of Promoting Annual Self-Testing for HIV in Blantyre, Malawi: A Community-Based Prospective Study by Choko, Augustine T, MacPherson, Peter, Webb, Emily L, Willey, Barbara A, Feasy, Helena, Sambakunsi, Rodrick, Mdolo, Aaron, Makombe, Simon D, Desmond, Nicola, Hayes, Richard, Maheswaran, Hendramoorthy, Corbett, Elizabeth L

“…Home-based HIV testing and counselling (HTC) achieves high uptake, but is difficult and expensive to implement and sustain. We investigated a novel alternative…”
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Oxidative stress induced by UVA photoactivation of the tryptophan UVB photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) inhibits nucleotide excision repair in human cells by Brem, Reto, Macpherson, Peter, Guven, Melisa, Karran, Peter

“…Potentially mutagenic DNA lesions induced by UVB (wavelengths 280–320 nm) are important risk factors for solar ultraviolet (UV) radiation-induced skin cancer…”
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Deletion of Neuronal CuZnSOD Accelerates Age-Associated Muscle Mitochondria and Calcium Handling Dysfunction That Is Independent of Denervation and Precedes Sarcopenia by Su, Yu, Claflin, Dennis R., Huang, Meixiang, Davis, Carol S., Macpherson, Peter C. D., Richardson, Arlan, Van Remmen, Holly, Brooks, Susan V.

“…Skeletal muscle suffers atrophy and weakness with aging. Denervation, oxidative stress, and mitochondrial dysfunction are all proposed as contributors to…”
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Oxidative Damage to RPA Limits the Nucleotide Excision Repair Capacity of Human Cells by Guven, Melisa, Brem, Reto, Macpherson, Peter, Peacock, Matthew, Karran, Peter

“…Nucleotide excision repair (NER) protects against sunlight-induced skin cancer. Defective NER is associated with photosensitivity and a high skin cancer…”
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Maintenance of subsynaptic myonuclei number is not driven by neural input by Ruiz, Lloyd P, Macpherson, Peter C, Brooks, Susan V

“…The development and maintenance of neuromuscular junctions (NMJ) are supported by a specialized population of myonuclei that are referred to as the subsynaptic…”
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Computer-aided X-ray screening for tuberculosis and HIV testing among adults with cough in Malawi (the PROSPECT study): A randomised trial and cost-effectiveness analysis by MacPherson, Peter, Webb, Emily L, Kamchedzera, Wala, Joekes, Elizabeth, Mjoli, Gugu, Lalloo, David G, Divala, Titus H, Choko, Augustine T, Burke, Rachael M, Maheswaran, Hendramoorthy, Pai, Madhukar, Squire, S Bertel, Nliwasa, Marriott, Corbett, Elizabeth L

“…Suboptimal tuberculosis (TB) diagnostics and HIV contribute to the high global burden of TB. We investigated costs and yield from systematic HIV-TB screening,…”
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Pre-treatment loss to follow-up in tuberculosis patients in low- and lower-middle-income countries and high-burden countries: a systematic review and meta-analysis by MACPHERSON, Peter, HOUBEN, Rein M.G.J, GLYNN, Judith R, CORBETT, Elizabeth L, KRANZER, Katharina

“…To assess the magnitude of loss to follow-up in smear- or culture-positive tuberculosis patients before treatment initiation and outcomes among patients who…”
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Tuberculosis Immunoreactivity Surveillance in Malawi (Timasamala)-A protocol for a cross-sectional Mycobacterium tuberculosis immunoreactivity survey in Blantyre, Malawi by Rickman, Hannah M, Phiri, Mphatso D, Feasey, Helena R A, Mbale, Hannah, Nliwasa, Marriott, Semphere, Robina, Chagaluka, George, Fielding, Katherine, Mwandumba, Henry C, Horton, Katherine C, Nightingale, Emily S, Henrion, Marc Y R, Mbendera, Kuzani, Mpunga, James A, Corbett, Elizabeth L, MacPherson, Peter

“…Tuberculosis (TB) transmission and prevalence are dynamic over time, and heterogeneous within populations. Public health programmes therefore require…”
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Schwann Cell Derived Signals Enhance AChR Clustering in C2C12 Myotubes by Guzman, Steve D., Abu‐Mahfouz, Ahmad, Macpherson, Peter C., Brooks, Susan V.

“…The neuromuscular junction (NMJ) is a tripartite structure made up of the pre‐synaptic motor neuron terminal, the post‐synaptic muscle end plate, and the…”
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Repairing Volumetric Muscle Loss in the Ovine Peroneus Tertius Following a 6-Month Recovery by Rodriguez, Brittany L, Novakova, Stoyna S, Vega-Soto, Emmanuel E, Nutter, Genevieve P, Macpherson, Peter C D, Larkin, Lisa M

“…Tissue-engineered skeletal muscle is a promising novel therapy for the treatment of volumetric muscle loss (VML). Our laboratory has developed…”
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Effects of Coronavirus Disease Pandemic on Tuberculosis Notifications, Malawi by Soko, Rebecca Nzawa, Burke, Rachael M, Feasey, Helena R A, Sibande, Wakumanya, Nliwasa, Marriott, Henrion, Marc Y R, Khundi, McEwen, Dodd, Peter J, Ku, Chu Chang, Kawalazira, Gift, Choko, Augustine T, Divala, Titus H, Corbett, Elizabeth L, MacPherson, Peter

“…The coronavirus disease (COVID-19) pandemic might affect tuberculosis (TB) diagnosis and patient care. We analyzed a citywide electronic TB register in…”
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Effect of patient-delivered household contact tracing and prevention for tuberculosis: A household cluster-randomised trial in Malawi by Kaswaswa, Kruger, MacPherson, Peter, Kumwenda, Moses, Mpunga, James, Thindwa, Deus, Nliwasa, Marriott, Mwapasa, Mphatso, Odland, Jon, Tomoka, Tamiwe, Chipungu, Geoffrey, Mukaka, Mavuto, Corbett, Elizabeth L

“…Household contact tracing provides TB screening and TB preventive therapy (TPT) to contacts at high risk of TB disease. However, it is resource intensive,…”
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