Search Results - "Peter M. Henson"

Cell Removal: Efferocytosis by Henson, Peter M

“…In metazoans, removal of cells in situ is involved in larval maturation, metamorphosis, and embryonic development. In adults, such cell removal plays a role in…”
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Monocyte differentiation and antigen-presenting functions by Jakubzick, Claudia V., Randolph, Gwendalyn J., Henson, Peter M.

“…Key Points Constitutively migrating LY6C + monocytes can retain their own properties without differentiating into a bone fide macrophage or dendritic cell…”
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Neutrophil clearance: when the party is over, clean-up begins by Bratton, Donna L, Henson, Peter M

“…Maintenance of circulating, functional neutrophils and their robust recruitment to tissues in response to injury and/or microbial infection are crucial for…”
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Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes by Jakubzick, Claudia, Gautier, Emmanuel L., Gibbings, Sophie L., Sojka, Dorothy K., Schlitzer, Andreas, Johnson, Theodore E., Ivanov, Stoyan, Duan, Qiaonan, Bala, Shashi, Condon, Tracy, van Rooijen, Nico, Grainger, John R., Belkaid, Yasmine, Ma’ayan, Avi, Riches, David W.H., Yokoyama, Wayne M., Ginhoux, Florent, Henson, Peter M., Randolph, Gwendalyn J.

“…It is thought that monocytes rapidly differentiate to macrophages or dendritic cells (DCs) upon leaving blood. Here we have shown that Ly-6C+ monocytes…”
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Antiinflammatory effects of apoptotic cells by Henson, Peter M, Bratton, Donna L

“…Apoptotic cells are rapidly phagocytosed by macrophages, a process that represents a critical step in tissue remodeling, immune responses, and the resolution…”
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Unbiased Quantitation of Alveolar Type II to Alveolar Type I Cell Transdifferentiation during Repair after Lung Injury in Mice by Jansing, Nicole L, McClendon, Jazalle, Henson, Peter M, Tuder, Rubin M, Hyde, Dallas M, Zemans, Rachel L

“…The alveolar epithelium consists of squamous alveolar type (AT) I and cuboidal ATII cells. ATI cells cover 95-98% of the alveolar surface, thereby playing a…”
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Modulation of macrophage efferocytosis in inflammation by Korns, Darlynn, Frasch, S Courtney, Fernandez-Boyanapalli, Ruby, Henson, Peter M, Bratton, Donna L

“…A critical function of macrophages within the inflammatory milieu is the removal of dying cells by a specialized phagocytic process called efferocytosis ("to…”
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Flow Cytometric Analysis of Mononuclear Phagocytes in Nondiseased Human Lung and Lung-Draining Lymph Nodes by Desch, A Nicole, Gibbings, Sophie L, Goyal, Rajni, Kolde, Raivo, Bednarek, Joe, Bruno, Tullia, Slansky, Jill E, Jacobelli, Jordan, Mason, Robert, Ito, Yoko, Messier, Elise, Randolph, Gwendalyn J, Prabagar, Miglena, Atif, Shaikh M, Segura, Elodie, Xavier, Ramnik J, Bratton, Donna L, Janssen, William J, Henson, Peter M, Jakubzick, Claudia V

“…The pulmonary mononuclear phagocyte system is a critical host defense mechanism composed of macrophages, monocytes, monocyte-derived cells, and dendritic…”
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Hemophagocytosis causes a consumptive anemia of inflammation by Zoller, Erin E, Lykens, Jennifer E, Terrell, Catherine E, Aliberti, Julio, Filipovich, Alexandra H, Henson, Peter M, Jordan, Michael B

“…Cytopenias of uncertain etiology are commonly observed in patients during severe inflammation. Hemophagocytosis, the histological appearance of blood-eating…”
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Apoptotic Cell Recognition: Will the Real Phosphatidylserine Receptor(s) Please Stand up? by Bratton, Donna L., Henson, Peter M.

“…The recognition of phosphatidylserine (PS) on apoptotic cells within tissues drives both their engulfment and an accompanying anti-inflammatory and tissue…”
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CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen by Desch, A Nicole, Randolph, Gwendalyn J, Murphy, Kenneth, Gautier, Emmanuel L, Kedl, Ross M, Lahoud, Mireille H, Caminschi, Irina, Shortman, Ken, Henson, Peter M, Jakubzick, Claudia V

“…Cells undergoing programmed cell death (apoptosis) are removed in situ by macrophages and dendritic cells (DCs) through a specialized form of phagocytosis…”
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Phagocytosis of microparticles by alveolar macrophages during acute lung injury requires MerTK by Mohning, Michael P, Thomas, Stacey M, Barthel, Lea, Mould, Kara J, McCubbrey, Alexandria L, Frasch, S Courtney, Bratton, Donna L, Henson, Peter M, Janssen, William J

“…Microparticles are a newly recognized class of mediators in the pathophysiology of lung inflammation and injury, but little is known about the factors that…”
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Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis by Redente, Elizabeth F, Jacobsen, Kristen M, Solomon, Joshua J, Lara, Abigail R, Faubel, Sarah, Keith, Rebecca C, Henson, Peter M, Downey, Gregory P, Riches, David W H

“…Fibrotic interstitial pneumonias are more prevalent in males of advancing age, although little is known about the underlying mechanisms. To evaluate the…”
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Neutrophil transmigration triggers repair of the lung epithelium via β-catenin signaling by Zemans, Rachel L, Briones, Natalie, Campbell, Megan, McClendon, Jazalle, Young, Scott K, Suzuki, Tomoko, Yang, Ivana V, De Langhe, Stijn, Reynolds, Susan D, Mason, Robert J, Kahn, Michael, Henson, Peter M, Colgan, Sean P, Downey, Gregory P

“…Injury to the epithelium is integral to the pathogenesis of many inflammatory lung diseases, and epithelial repair is a critical determinant of clinical…”
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Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte by Gardai, Shyra J., McPhillips, Kathleen A., Frasch, S. Courtney, Janssen, William J., Starefeldt, Anna, Murphy-Ullrich, Joanne E., Bratton, Donna L., Oldenborg, Per-Arne, Michalak, Marek, Henson, Peter M.

“…Apoptotic-cell removal is critical for development, tissue homeostasis, and resolution of inflammation. Although many candidate systems exist, only…”
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A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation by Sather, Susan, Kenyon, Karla D., Lefkowitz, Jerry B., Liang, Xiayuan, Varnum, Brian C., Henson, Peter M., Graham, Douglas K.

“…Membrane-bound receptors generate soluble ligand-binding domains either by proteolytic cleavage of the extracellular domain or alternative mRNA splicing…”
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Lung environment determines unique phenotype of alveolar macrophages by Guth, Amanda M, Janssen, William J, Bosio, Catharine M, Crouch, Erika C, Henson, Peter M, Dow, Steven W

“…Alveolar macrophages (AM) are the most abundant antigen-presenting cells in the lungs, and they play a critical role in regulating pulmonary immune responses…”
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Recognition ligands on apoptotic cells: a perspective by Gardai, Shyra J., Bratton, Donna L., Ogden, Carole Anne, Henson, Peter M.

“…The process of apoptosis includes critically important changes on the cell surface that lead to its recognition and removal. The recognition also generates a…”
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TNFα: TNFR1 signaling inhibits maturation and maintains the pro-inflammatory programming of monocyte-derived macrophages in murine chronic granulomatous disease by Gibbings, Sophie L, Haist, Kelsey C, Redente, Elizabeth F, Henson, Peter M, Bratton, Donna L

“…Loss of NADPH oxidase activity results in proinflammatory macrophages that contribute to hyperinflammation in Chronic Granulomatous Disease (CGD). Previously,…”
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Epithelial Cells Remove Apoptotic Epithelial Cells During Post-Lactation Involution of the Mouse Mammary Gland by Monks, Jenifer, Smith-Steinhart, Christine, Kruk, Ellen R, Fadok, Valerie A, Henson, Peter M

“…Following the cessation of lactation, the mammary gland undergoes a physiologic process of tissue remodeling called involution in which glandular structures…”
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