Search Results - "Peter L. A. Giesen"

Release of Active Tissue Factor by Human Arterial Smooth Muscle Cells by Schecter, Alison D, Spirn, Benjamin, Rossikhina, Maria, Giesen, Peter L. A, Bogdanov, Vladimir, Fallon, John T, Fisher, Edward A, Schnapp, Lynn M, Nemerson, Yale, Taubman, Mark B

“…Tissue factor (TF), the initiator of coagulation, is thought to function predominantly at the cell surface. Recent data have suggested that active TF is…”
Get full text

Low Molecular Weight Activated Protein C Inhibitors as a Potential Treatment for Hemophilic Disorders by De Nanteuil, Guillaume, Gloanec, Philippe, Béguin, Suzette, Giesen, Peter L. A, Hemker, H. Coenraad, Mennecier, Philippe, Rupin, Alain, Verbeuren, Tony J

“…The synthesis and evaluation of inhibitors of activated protein C (aPC) are reported. This serine protease is partly responsible for the degradation of factor…”
Get full text

Blood-Borne Tissue Factor: Another View of Thrombosis by Peter L. A. Giesen, Rauch, Ursula, Bohrmann, Bernd, Kling, Dorothee, Roque, Merce, Fallon, John T., Badimon, Juan J., Himber, Jacques, Riederer, Markus A., Nemerson, Yale

“…Arterial thrombosis is considered to arise from the interaction of tissue factor (TF) in the vascular wall with platelets and coagulation factors in…”
Get full text

Cell Surface Platelet Tissue Factor Expression: Regulation by P2Y12 and Link to Residual Platelet Reactivity by Brambilla, Marta, Becchetti, Alessia, Rovati, Gian Enrico, Cosentino, Nicola, Conti, Maria, Canzano, Paola, Giesen, Peter L A, Loffreda, Alessia, Bonomi, Alice, Cattaneo, Marco, De Candia, Erica, Podda, Gian Marco, Trabattoni, Daniela, Werba, Pablo Josè, Campodonico, Jeness, Pinna, Christian, Marenzi, Giancarlo, Tremoli, Elena, Camera, Marina

“…BACKGROUNDADP-induced platelet activation leads to cell surface expression of several proteins, including TF (tissue factor). The role of ADP receptors in…”
Get full text

Do methodological differences account for the current controversy on tissue factor expression in platelets? by Brambilla, Marta, Rossetti, Laura, Zara, Chiara, Canzano, Paola, Giesen, Peter L.A., Tremoli, Elena, Camera, Marina

“…Tissue factor (TF), the key activator of the blood coagulation cascade and of thrombus formation, is also expressed by circulating human platelets. Despite the…”
Get full text

Thrombin generation assessed as endogenous thrombin potential in patients with hyper- or hypo-coagulability by Chantarangkul, V, Clerici, M, Bressi, C, Giesen, PL, Tripodi, A

“…Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy. BACKGROUND AND…”
Get full text

Regulation of tissue factor-induced coagulation and platelet aggregation in flowing whole blood by Kuijpers, Marijke J E, Nieuwenhuys, Cécile M A, Feijge, Marion A H, Kloots, Willem, Giesen, Peter L A, Jerling, Johann C, oude Egbrink, Mirjam G A, Heemskerk, Johan W M

“…Photochemically induced thrombosis (a thrombin-dependent process) was measured in rats treated with moderate doses of anticoagulants, but which appeared to be…”
Get more information

Platelet P2Y12 receptors enhance signalling towards procoagulant activity and thrombin generation. A study with healthy subjects and patients at thrombotic risk by van der Meijden, Paola E J, Feijge, Marion A H, Giesen, Peter L A, Huijberts, Maya, van Raak, Lisette P M, Heemskerk, Johan W M

“…Activated platelets participate in arterial thrombosis by forming aggregates and potentiating the coagulation through exposure of procoagulant…”
Get more information

Variable Hypocoagulant Effect of Fish Oil Intake in Humans: Modulation of Fibrinogen Level and Thrombin Generation by Vanschoonbeek, Kristof, Feijge, Marion A.H, Paquay, Martine, Rosing, Jan, Saris, Wim, Kluft, Cornelis, Giesen, Peter L.A, de Maat, Moniek P.M, Heemskerk, Johan W.M

“…OBJECTIVE—The beneficial effect of dietary fish oil, rich in omega-3 polyunsaturated fatty acids (PUFAs), on cardiovascular disease is multifactorial and may…”
Get full text

Decreased responsiveness and development of activation markers of PLTs stored in plasma by Curvers, Joyce, Van Pampus, Elisabeth C.M., Feijge, Marion A.H., Rombout-Sestrienkova, Eva, Giesen, Peter L.A., Heemskerk, Johan W.M.

“…BACKGROUND:  Circulating PLTs have a low activation state and high responsiveness, which ensures adequate hemostatic activity at sites of vessel wall damage…”
Get full text

The thrombogram: monitoring thrombin generation in platelet-rich plasma by Hemker, H C, Giesen, P L, Ramjee, M, Wagenvoord, R, Béguin, S

“…A method is described in which thrombin activity in clotting plasma can be monitored through the continuous measurement of the fluorescent split-product of the…”
Get more information

Tissue Factor Is Induced by Monocyte Chemoattractant Protein-1 in Human Aortic Smooth Muscle and THP-1 Cells by Schecter, Alison D., Rollins, Barrett J., Zhang, Yujun J., Charo, Israel F., Fallon, John T., Rossikhina, Maria, Giesen, Peter L.A., Nemerson, Yale, Taubman, Mark B.

“…Monocyte chemoattractant protein-1 (MCP-1) is a C-C chemokine thought to play a major role in recruiting monocytes to the atherosclerotic plaque. Tissue factor…”
Get full text

Cooperation Between VEGF and TNF-alpha Is Necessary for Exposure of Active Tissue Factor on the Surface of Human Endothelial Cells by Camera, Marina, Giesen, Peter L.A, Fallon, Jay, Aufiero, Barbara M, Taubman, Mark, Tremoli, Elena, Nemerson, Yale

“…This study was undertaken to characterize tissue factor (TF) induction, localization, and functional activity in cultured human umbilical vein endothelial…”
Get full text

Intimal tissue factor activity is released from the arterial wall after injury by Giesen, P L, Fyfe, B S, Fallon, J T, Roque, M, Mendlowitz, M, Rossikhina, M, Guha, A, Badimon, J J, Nemerson, Y, Taubman, M B

“…Tissue factor (TF), the initiator of coagulation, has been implicated as a critical mediator of arterial thrombosis. Previous studies have demonstrated that TF…”
Get more information

Cooperation between VEGF and (TNF-alpha) is necessary for exposure of active tissue factor on the surface of human endothelial cells by Camera, Marina, Giesen, Peter L A, Fallon, Jay, Aufiero, Barbara M

“…This study was undertaken to characterize tissue factor (TF) induction, localization, and functional activity in cultured human umbilical vein endothelial…”
Get full text

Thrombin generation in platelet-poor plasma is normal in patients with hereditary mucocutaneous haemorrhages by Quiroga, Teresa, Goycoolea, Manuela, Giesen, Peter L A, Morales, María, Muñoz, Blanca, Aranda, Eduardo, Rodríguez, Soledad, Panes, Olga, Martínez, Carlos, Pereira, Jaime, Mezzano, Diego

“…Mild hereditary bleeding disorders presenting with mucocutaneous haemorrhages are usually difficult to diagnose. We measured thrombin generation in…”
Get more information