Search Results - "Peter J. Murray"

Macrophage Polarization by Murray, Peter J

“…Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as macrophages are…”
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Tryptophan and indole metabolism in immune regulation by Fiore, Alessandra, Murray, Peter J

“…•Tryptophan follows three metabolic fates: incorporation into proteins, production of indoles, and breakdown into kynurenine.•IDO1 is an endogenous mechanism…”
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The JAK-STAT Signaling Pathway: Input and Output Integration by Murray, Peter J

“…Universal and essential to cytokine receptor signaling, the JAK-STAT pathway is one of the best understood signal transduction cascades. Almost 40 cytokine…”
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Protective and pathogenic functions of macrophage subsets by Murray, Peter J, Wynn, Thomas A

“…Key Points Macrophages are highly heterogenous cells that can rapidly change their function in response to local microenvironmental signals. Although distinct…”
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On macrophage diversity and inflammatory metabolic timers by Murray, Peter J.

“…Key papers were published in 2019 that solidify the notion that macrophage gene expression is remarkably diverse; single-cell sequencing combined with new…”
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Macrophages and cancer: from mechanisms to therapeutic implications by Ostuni, Renato, Kratochvill, Franz, Murray, Peter J, Natoli, Gioacchino

“…Highlights • Circulating monocytes are the primary source of TAMs in many tumors. • TAM properties are shaped by tissue- and tumor-specific microenvironmental…”
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Obstacles and opportunities for understanding macrophage polarization by Murray, Peter J., Wynn, Thomas A.

“…Review on new issues concerning macrophage polarization and the impact of polarization and categorization of macrophage subsets on immunology. Macrophages are…”
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Understanding Local Macrophage Phenotypes In Disease: Modulating macrophage function to treat cancer by Bronte, Vincenzo, Murray, Peter J

“…Recent studies have suggested that manipulating the tumor-associated macrophage phenotype is a valid therapeutic approach in cancer. In turn, these studies…”
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Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines by Murray, Peter J., Allen, Judith E., Biswas, Subhra K., Fisher, Edward A., Gilroy, Derek W., Goerdt, Sergij, Gordon, Siamon, Hamilton, John A., Ivashkiv, Lionel B., Lawrence, Toby, Locati, Massimo, Mantovani, Alberto, Martinez, Fernando O., Mege, Jean-Louis, Mosser, David M., Natoli, Gioacchino, Saeij, Jeroen P., Schultze, Joachim L., Shirey, Kari Ann, Sica, Antonio, Suttles, Jill, Udalova, Irina, van Ginderachter, Jo A., Vogel, Stefanie N., Wynn, Thomas A.

“…Description of macrophage activation is currently contentious and confusing. Like the biblical Tower of Babel, macrophage activation encompasses a panoply of…”
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Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards by Bronte, Vincenzo, Brandau, Sven, Chen, Shu-Hsia, Colombo, Mario P., Frey, Alan B., Greten, Tim F., Mandruzzato, Susanna, Murray, Peter J., Ochoa, Augusto, Ostrand-Rosenberg, Suzanne, Rodriguez, Paulo C., Sica, Antonio, Umansky, Viktor, Vonderheide, Robert H., Gabrilovich, Dmitry I.

“…Myeloid-derived suppressor cells (MDSC) are a heterogeneous population expanded in cancer and other chronic inflammatory conditions. Here the authors identify…”
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Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways by Murray, Peter J, Smale, Stephen T

“…Activation of Toll-like receptor (TLR) signaling and related pathways by microbial products drives inflammatory responses, host-defense pathways and adaptive…”
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TNF Counterbalances the Emergence of M2 Tumor Macrophages by Kratochvill, Franz, Neale, Geoffrey, Haverkamp, Jessica M., Van de Velde, Lee-Ann, Smith, Amber M., Kawauchi, Daisuke, McEvoy, Justina, Roussel, Martine F., Dyer, Michael A., Qualls, Joseph E., Murray, Peter J.

“…Cancer can involve non-resolving, persistent inflammation where varying numbers of tumor-associated macrophages (TAMs) infiltrate and adopt different…”
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Local Arginase 1 Activity Is Required for Cutaneous Wound Healing by Campbell, Laura, Saville, Charis R., Murray, Peter J., Cruickshank, Sheena M., Hardman, Matthew J.

“…Chronic nonhealing wounds in the elderly population are associated with a prolonged and excessive inflammatory response, which is widely hypothesized to impede…”
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The Primary Mechanism of the IL-10-Regulated Antiinflammatory Response Is to Selectively Inhibit Transcription by Murray, Peter J., Unanue, Emil R.

“…The antiinflammatory cytokine IL-10 inhibits the production of multiple, diverse inflammatory mediators from activated macrophages and dendritic cells, a…”
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Nucleotide Binding Oligomerization Domain 2 Deficiency Leads to Dysregulated TLR2 Signaling and Induction of Antigen-Specific Colitis by Watanabe, Tomohiro, Kitani, Atsushi, Murray, Peter J., Wakatsuki, Yoshio, Fuss, Ivan J., Strober, Warren

“…In this study, we determined conditions leading to the development of colitis in mice with nucleotide binding oligomerization domain 2 (NOD2) deficiency, a…”
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T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells by Marigo, Ilaria, Zilio, Serena, Desantis, Giacomo, Mlecnik, Bernhard, Agnellini, Andrielly H.R., Ugel, Stefano, Sasso, Maria Stella, Qualls, Joseph E., Kratochvill, Franz, Zanovello, Paola, Molon, Barbara, Ries, Carola H., Runza, Valeria, Hoves, Sabine, Bilocq, Amélie M., Bindea, Gabriela, Mazza, Emilia M.C., Bicciato, Silvio, Galon, Jérôme, Murray, Peter J., Bronte, Vincenzo

“…Effective cancer immunotherapy requires overcoming immunosuppressive tumor microenvironments. We found that local nitric oxide (NO) production by…”
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The composition and signaling of the IL-35 receptor are unconventional by Collison, Lauren W, Delgoffe, Greg M, Guy, Clifford S, Vignali, Kate M, Chaturvedi, Vandana, Fairweather, DeLisa, Satoskar, Abhay R, Garcia, K Christopher, Hunter, Christopher A, Drake, Charles G, Murray, Peter J, Vignali, Dario A A

“…IL-35 is an immunomodulatory cytokine, but the molecular details of its effects have remained obscure. Vignali and colleagues determine the IL-35 receptor and…”
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Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism by Zeitler, Leonie, Fiore, Alessandra, Meyer, Claudia, Russier, Marion, Zanella, Gaia, Suppmann, Sabine, Gargaro, Marco, Sidhu, Sachdev S, Seshagiri, Somasekar, Ohnmacht, Caspar, Köcher, Thomas, Fallarino, Francesca, Linkermann, Andreas, Murray, Peter J

“…Interleukin-4-induced-1 (IL4i1) is an amino acid oxidase secreted from immune cells. Recent observations have suggested that IL4i1 is pro-tumorigenic via…”
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Real-time monitoring of single ZTP riboswitches reveals a complex and kinetically controlled decision landscape by Hua, Boyang, Jones, Christopher P., Mitra, Jaba, Murray, Peter J., Rosenthal, Rebecca, Ferré-D’Amaré, Adrian R., Ha, Taekjip

“…RNAs begin to fold and function during transcription. Riboswitches undergo cotranscriptional switching in the context of transcription elongation, RNA folding,…”
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Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment by Steggerda, Susanne M, Bennett, Mark K, Chen, Jason, Emberley, Ethan, Huang, Tony, Janes, Julie R, Li, Weiqun, MacKinnon, Andrew L, Makkouk, Amani, Marguier, Gisele, Murray, Peter J, Neou, Silinda, Pan, Alison, Parlati, Francesco, Rodriguez, Mirna L M, Van de Velde, Lee-Ann, Wang, Tracy, Works, Melissa, Zhang, Jing, Zhang, Winter, Gross, Matthew I

“…Myeloid cells are an abundant leukocyte in many types of tumors and contribute to immune evasion. Expression of the enzyme arginase 1 (Arg1) is a defining…”
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