Search Results - "Peter, Matthias"

Dynamic ubiquitin signaling in cell cycle regulation by Gilberto, Samuel, Peter, Matthias

“…The cell division cycle is driven by a collection of enzymes that coordinate DNA duplication and separation, ensuring that genomic information is faithfully…”
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Endosome and Golgi‐associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism by Schmidt, Oliver, Weyer, Yannick, Baumann, Verena, Widerin, Michael A, Eising, Sebastian, Angelova, Mihaela, Schleiffer, Alexander, Kremser, Leopold, Lindner, Herbert, Peter, Matthias, Fröhlich, Florian, Teis, David

“…Cellular homeostasis requires the ubiquitin‐dependent degradation of membrane proteins. This was assumed to be mediated exclusively either by endoplasmic…”
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Substrate recognition in selective autophagy and the ubiquitin-proteasome system by Schreiber, Anne, Peter, Matthias

“…Dynamic protein turnover through regulated protein synthesis and degradation ensures cellular growth, proliferation, differentiation and adaptation. Eukaryotic…”
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Frequency modulation of ERK activation dynamics rewires cell fate by Ryu, Hyunryul, Chung, Minhwan, Dobrzyński, Maciej, Fey, Dirk, Blum, Yannick, Lee, Sung Sik, Peter, Matthias, Kholodenko, Boris N, Jeon, Noo Li, Pertz, Olivier

“…Transient versus sustained ERK MAP kinase (MAPK) activation dynamics induce proliferation versus differentiation in response to epidermal (EGF) or nerve (NGF)…”
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Modular microfluidics enables kinetic insight from time-resolved cryo-EM by Mäeots, Märt-Erik, Lee, Byungjin, Nans, Andrea, Jeong, Seung-Geun, Esfahani, Mohammad M. N., Ding, Shan, Smith, Daniel J., Lee, Chang-Soo, Lee, Sung Sik, Peter, Matthias, Enchev, Radoslav I.

“…Mechanistic understanding of biochemical reactions requires structural and kinetic characterization of the underlying chemical processes. However, no single…”
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A mechanism for the suppression of homologous recombination in G1 cells by Orthwein, Alexandre, Noordermeer, Sylvie M., Wilson, Marcus D., Landry, Sébastien, Enchev, Radoslav I., Sherker, Alana, Munro, Meagan, Pinder, Jordan, Salsman, Jayme, Dellaire, Graham, Xia, Bing, Peter, Matthias, Durocher, Daniel

“…A mechanism for the repression of homologous recombination in G1, the stage of the cell cycle preceding replication, is determined; the critical aspects are…”
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Functional mapping of yeast genomes by saturated transposition by Michel, Agnès H, Hatakeyama, Riko, Kimmig, Philipp, Arter, Meret, Peter, Matthias, Matos, Joao, De Virgilio, Claudio, Kornmann, Benoît

“…Yeast is a powerful model for systems genetics. We present a versatile, time- and labor-efficient method to functionally explore the genome using saturated…”
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Moment-based inference predicts bimodality in transient gene expression by Zechner, Christoph, Ruess, Jakob, Krenn, Peter, Pelet, Serge, Peter, Matthias, Lygeros, John, Koeppl, Heinz

“…Recent computational studies indicate that the molecular noise of a cellular process may be a rich source of information about process dynamics and parameters…”
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Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family by Pintard, Lionel, Willems, Andrew, Peter, Matthias

“…Cullin‐based E3 ligases target substrates for ubiquitin‐dependent degradation by the 26S proteasome. The SCF (Skp1–Cul1–F‐box) and ECS (ElonginC–Cul2–SOCS box)…”
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The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation by Lampert, Fabienne, Stafa, Diana, Goga, Algera, Soste, Martin Varis, Gilberto, Samuel, Olieric, Natacha, Picotti, Paola, Stoffel, Markus, Peter, Matthias

“…In yeast, the glucose-induced degradation-deficient (GID) E3 ligase selectively degrades superfluous gluconeogenic enzymes. Here, we identified all subunits of…”
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The human GID complex engages two independent modules for substrate recruitment by Mohamed, Weaam I, Park, Sophia L, Rabl, Julius, Leitner, Alexander, Boehringer, Daniel, Peter, Matthias

“…The human GID (hGID) complex is a conserved E3 ubiquitin ligase regulating diverse biological processes, including glucose metabolism and cell cycle…”
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Cytosolic pH is a second messenger for glucose and regulates the PKA pathway through V-ATPase by Dechant, Reinhard, Binda, Matteo, Lee, Sung Sik, Pelet, Serge, Winderickx, Joris, Peter, Matthias

“…Glucose is the preferred carbon source for most cell types and a major determinant of cell growth. In yeast and certain mammalian cells, glucose activates the…”
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Mre11-Rad50 oligomerization promotes DNA double-strand break repair by Kissling, Vera M., Reginato, Giordano, Bianco, Eliana, Kasaciunaite, Kristina, Tilma, Janny, Cereghetti, Gea, Schindler, Natalie, Lee, Sung Sik, Guérois, Raphaël, Luke, Brian, Seidel, Ralf, Cejka, Petr, Peter, Matthias

“…The conserved Mre11-Rad50 complex is crucial for the detection, signaling, end tethering and processing of DNA double-strand breaks. While it is known that…”
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Regulatory control of DNA end resection by Sae2 phosphorylation by Cannavo, Elda, Johnson, Dominic, Andres, Sara N., Kissling, Vera M., Reinert, Julia K., Garcia, Valerie, Erie, Dorothy A., Hess, Daniel, Thomä, Nicolas H., Enchev, Radoslav I., Peter, Matthias, Williams, R. Scott, Neale, Matt J., Cejka, Petr

“…DNA end resection plays a critical function in DNA double-strand break repair pathway choice. Resected DNA ends are refractory to end-joining mechanisms and…”
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Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery by Fumagalli, Fiorenza, Noack, Julia, Bergmann, Timothy J., Cebollero, Eduardo, Pisoni, Giorgia Brambilla, Fasana, Elisa, Fregno, Ilaria, Galli, Carmela, Loi, Marisa, Soldà, Tatiana, D’Antuono, Rocco, Raimondi, Andrea, Jung, Martin, Melnyk, Armin, Schorr, Stefan, Schreiber, Anne, Simonelli, Luca, Varani, Luca, Wilson-Zbinden, Caroline, Zerbe, Oliver, Hofmann, Kay, Peter, Matthias, Quadroni, Manfredo, Zimmermann, Richard, Molinari, Maurizio

“…The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing ER homeostasis activates stress programs collectively called the…”
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Cytosolic pH Regulates Cell Growth through Distinct GTPases, Arf1 and Gtr1, to Promote Ras/PKA and TORC1 Activity by Dechant, Reinhard, Saad, Shady, Ibáñez, Alfredo J., Peter, Matthias

“…Regulation of cell growth by nutrients is governed by highly conserved signaling pathways, yet mechanisms of nutrient sensing are still poorly understood…”
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Local sampling paints a global picture: Local concentration measurements sense direction in complex chemical gradients by Hegemann, Björn, Peter, Matthias

“…Detecting and interpreting extracellular spatial signals is essential for cellular orientation within complex environments, such as during directed cell…”
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Phosphorylation‐linked complex profiling identifies assemblies required for Hippo signal integration by Uliana, Federico, Ciuffa, Rodolfo, Mishra, Ranjan, Fossati, Andrea, Frommelt, Fabian, Keller, Sabrina, Mehnert, Martin, Birkeland, Eivind Salmorin, van Drogen, Frank, Srejic, Nevena, Peter, Matthias, Tapon, Nicolas, Aebersold, Ruedi, Gstaiger, Matthias

“…While several computational methods have been developed to predict the functional relevance of phosphorylation sites, experimental analysis of the…”
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Transient Activation of the HOG MAPK Pathway Regulates Bimodal Gene Expression by Pelet, Serge, Rudolf, Fabian, Nadal-Ribelles, Mariona, de Nadal, Eulàlia, Posas, Francesc, Peter, Matthias

“…Mitogen-activated protein kinase (MAPK) cascades are conserved signaling modules that control many cellular processes by integrating intra- and extracellular…”
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High-Power and High-Efficiency InGaN-Based Light Emitters by Laubsch, A., Sabathil, M., Baur, J., Peter, M., Hahn, B.

“…In this paper, we report on the latest advancements in improving AlGaInN-based visible-light-emitting-diode (LED) efficiency in epitaxy, chip, and package…”
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