Search Results - "Peter, Marcus E"

Let-7 and miR-200 microRNAs: Guardians against pluripotency and cancer progression by Peter, Marcus E.

“…Micro (mi)RNAs are emerging as important regulators of cellular differentiation, their importance underscored by the fact that they are often dysregulated…”
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Cancer kill code extension by Peter, Marcus E.

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The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2 by Park, Sun-Mi, Gaur, Arti B, Lengyel, Ernst, Peter, Marcus E

“…Cancer progression has similarities with the process of epithelial-to-mesenchymal transition (EMT) found during embryonic development, during which cells…”
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The role of let-7 in cell differentiation and cancer by Boyerinas, Benjamin, Park, Sun-Mi, Hau, Annika, Murmann, Andrea E, Peter, Marcus E

“…MicroRNAs (miRNAs or miRs) are small noncoding RNAs capable of regulating gene expression at the translational level. Current evidence suggests that a…”
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Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth by Nieman, Kristin M, Kenny, Hilary A, Penicka, Carla V, Ladanyi, Andras, Buell-Gutbrod, Rebecca, Zillhardt, Marion R, Romero, Iris L, Carey, Mark S, Mills, Gordon B, Hotamisligil, Gökhan S, Yamada, S Diane, Peter, Marcus E, Gwin, Katja, Lengyel, Ernst

“…Ovarian tumors preferentially metastasize to the omentum, a peritoneal fat layer. This report proposes that the reasons for this predilection stem from the…”
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Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing by Xu, Yilin, Gao, Xin D, Lee, Jae-Hyung, Huang, Huilin, Tan, Haiyan, Ahn, Jaegyoon, Reinke, Lauren M, Peter, Marcus E, Feng, Yue, Gius, David, Siziopikou, Kalliopi P, Peng, Junmin, Xiao, Xinshu, Cheng, Chonghui

“…Tumor metastasis remains the major cause of cancer-related death, but its molecular basis is still not well understood. Here we uncovered a splicing-mediated…”
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SPOROS: A pipeline to analyze DISE/6mer seed toxicity by Bartom, Elizabeth T, Kocherginsky, Masha, Paudel, Bidur, Vaidyanathan, Aparajitha, Haluck-Kangas, Ashley, Patel, Monal, O'Shea, Kaitlyn L, Murmann, Andrea E, Peter, Marcus E

“…microRNAs (miRNAs) are (18-22nt long) noncoding short (s)RNAs that suppress gene expression by targeting the 3' untranslated region of target mRNAs. This…”
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Genomics of Ovarian Cancer Progression Reveals Diverse Metastatic Trajectories Including Intraepithelial Metastasis to the Fallopian Tube by Eckert, Mark A, Pan, Shawn, Hernandez, Kyle M, Loth, Rachel M, Andrade, Jorge, Volchenboum, Samuel L, Faber, Pieter, Montag, Anthony, Lastra, Ricardo, Peter, Marcus E, Yamada, S Diane, Lengyel, Ernst

“…Accumulating evidence has supported the fallopian tube rather than the ovary as the origin for high-grade serous ovarian cancer (HGSOC). To understand the…”
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Coordinated epigenetic repression of the miR‐200 family and miR‐205 in invasive bladder cancer by Wiklund, Erik D., Bramsen, Jesper B., Hulf, Toby, Dyrskjøt, Lars, Ramanathan, Ramshanker, Hansen, Thomas B., Villadsen, Sune B., Gao, Shan, Ostenfeld, Marie S., Borre, Michael, Peter, Marcus E., Ørntoft, Torben F., Kjems, Jørgen, Clark, Susan J.

“…MicroRNAs (miRNA) are small noncoding RNAs commonly deregulated in cancer. The miR‐200 family (miR‐200a, ‐200b, ‐200c, ‐141 and ‐429) and miR‐205 are…”
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Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation by Calvert, Andrea E., Chalastanis, Alexandra, Wu, Yongfei, Hurley, Lisa A., Kouri, Fotini M., Bi, Yingtao, Kachman, Maureen, May, Jasmine L., Bartom, Elizabeth, Hua, Youjia, Mishra, Rama K., Schiltz, Gary E., Dubrovskyi, Oleksii, Mazar, Andrew P., Peter, Marcus E., Zheng, Hongwu, James, C. David, Burant, Charles F., Chandel, Navdeep S., Davuluri, Ramana V., Horbinski, Craig, Stegh, Alexander H.

“…Oncogenic mutations in two isocitrate dehydrogenase (IDH)-encoding genes (IDH1 and IDH2) have been identified in acute myelogenous leukemia, low-grade glioma,…”
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Let-7 Expression Defines Two Differentiation Stages of Cancer by Shell, Scott, Park, Sun-Mi, Radjabi, Amir Reza, Schickel, Robert, Kistner, Emily O., Jewell, David A., Feig, Christine, Lengyel, Ernst, Peter, Marcus E.

“…The early phases of carcinogenesis resemble embryonic development, often involving the reexpression of embryonic mesenchymal genes. The NCI60 panel of human…”
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Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1 by Boyerinas, Benjamin, Park, Sun-Mi, Murmann, Andrea E., Gwin, Katja, Montag, Anton G., Zillhardt, Marion, Hua, You-Jia, Lengyel, Ernst, Peter, Marcus E.

“…Ovarian cancer patients frequently develop resistance to chemotherapy regiments using Taxol and carboplatin. One of the resistance factors that protects cancer…”
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CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response by Qadir, Abdul S., Ceppi, Paolo, Brockway, Sonia, Law, Calvin, Mu, Liang, Khodarev, Nikolai N., Kim, Jung, Zhao, Jonathan C., Putzbach, William, Murmann, Andrea E., Chen, Zhuo, Chen, Wenjing, Liu, Xia, Salomon, Arthur R., Liu, Huiping, Weichselbaum, Ralph R., Yu, Jindan, Peter, Marcus E.

“…Stimulation of CD95/Fas drives and maintains cancer stem cells (CSCs). We now report that this involves activation of signal transducer and activator of…”
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Loss of E-Cadherin Promotes Ovarian Cancer Metastasis via α5-Integrin, which Is a Therapeutic Target by SAWADA, Kenjiro, MITRA, Anirban K, PETER, Marcus E, RAMAKRISHNAN, Vanitha, YAMADA, S. Diane, LENGYEL, Ernst, REZA RADJABI, A, BHASKAR, Vinay, KISTNER, Emily O, TRETIAKOVA, Maria, JAGADEESWARAN, Sujatha, MONTAG, Anthony, BECKER, Amy, KENNY, Hilary A

“…Abstract E-cadherin loss is frequently associated with ovarian cancer metastasis. Given that adhesion to the abdominal peritoneum is the first step in ovarian…”
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CD95 and CD95L promote and protect cancer stem cells by Ceppi, Paolo, Hadji, Abbas, Kohlhapp, Frederick J., Pattanayak, Abhinandan, Hau, Annika, Liu, Xia, Liu, Huiping, Murmann, Andrea E., Peter, Marcus E.

“…CD95 (APO-1/Fas) is a death receptor used by immune cells to kill cancer cells through induction of apoptosis. However, the elimination of CD95 or its ligand,…”
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DISE/6mer seed toxicity-a powerful anti-cancer mechanism with implications for other diseases by Haluck-Kangas, Ashley, Patel, Monal, Paudel, Bidur, Vaidyanathan, Aparajitha, Murmann, Andrea E, Peter, Marcus E

“…micro(mi)RNAs are short noncoding RNAs that through their seed sequence (pos. 2-7/8 of the guide strand) regulate cell function by targeting complementary…”
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Identification of the toxic 6mer seed consensus for human cancer cells by Patel, Monal, Bartom, Elizabeth T., Paudel, Bidur, Kocherginsky, Masha, O’Shea, Kaitlyn L., Murmann, Andrea E., Peter, Marcus E.

“…6mer seed toxicity is a novel cell death mechanism that kills cancer cells by triggering death induced by survival gene elimination (DISE). It is based on si-…”
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6mer seed toxicity in tumor suppressive microRNAs by Gao, Quan Q., Putzbach, William E., Murmann, Andrea E., Chen, Siquan, Sarshad, Aishe A., Peter, Johannes M., Bartom, Elizabeth T., Hafner, Markus, Peter, Marcus E.

“…Many small-interfering (si)RNAs are toxic to cancer cells through a 6mer seed sequence (positions 2–7 of the guide strand). Here we performed an siRNA screen…”
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The flip side of FLIP by Peter, Marcus E

“…Two major pathways regulate apoptosis induction in mammalian cells. In the extrinsic pathway, apoptosis is induced through specialized surface receptors,…”
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Death Induced by Survival gene Elimination (DISE) correlates with neurotoxicity in Alzheimer’s disease and aging by Paudel, Bidur, Jeong, Si-Yeon, Martinez, Carolina Pena, Rickman, Alexis, Haluck-Kangas, Ashley, Bartom, Elizabeth T., Fredriksen, Kristina, Affaneh, Amira, Kessler, John A., Mazzulli, Joseph R., Murmann, Andrea E., Rogalski, Emily, Geula, Changiz, Ferreira, Adriana, Heckmann, Bradlee L., Green, Douglas R., Sadleir, Katherine R., Vassar, Robert, Peter, Marcus E.

“…Alzheimer’s disease (AD) is characterized by progressive neurodegeneration, but the specific events that cause cell death remain poorly understood. Death…”
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