Search Results - "Peter, M.O."

Sclerocarya birrea (a. rich) hochst. ['marula'] (anacardiaceae): a review of its phytochemistry, pharmacology and toxicology and its ethnomedicinal uses by Ojewole, John A.O, Mawoza, Tariro, Chiwororo, Witness D.H, Owira, Peter M.O

“…A plethora of ethnotherapeutic properties and pharmacological actions have been attributed to Sclerocarya birrea (family: Anacardiaceae). It is one of the most…”
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'African potato' (Hypoxis hemerocallidea corm): a plant-medicine for modern and 21st century diseases of mankind? - a review by Owira, Peter M.O, Ojewole, John A.O

“…The traditional uses, therapeutic attributes, phytochemical and pharmacological profiles of 'African potato' (Hypoxis hemerocallidea corm) extracts have been…”
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Alcohol Risk Management in College Settings by Saltz, Robert F., PhD, Paschall, Mallie J., PhD, McGaffigan, Richard P., MSW, Nygaard, Peter M.O., PhD

“…Context Potentially effective environmental strategies have been recommended to reduce heavy alcohol use among college students. However, studies to date on…”
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Tenofovir alafenamide compared to tenofovir disoproxil fumarate, induces dysglycemia, and dyslipidemia in Wistar rats by Hurchund, Rajendraparsad, Sibiya, Sinegugu E, Owaga, Bernard O, Owira, Peter M O

“…To determine the metabolic effects of tenofovir alafenamide (TAF) compared to tenofovir disoproxil fumarate (TDF) in vivo . Male Wistar rats ( Rattus…”
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Antidiabetic effects of Psidium x durbanensis Baijnath & Ramcharun ined. (Myrtaceae) leaf extract on streptozotocin-induced diabetes in rats by Mbara, Kingsley C., Rambharose, Sanjeev, Baijnath, Himansu, Nlooto, Manimbulu, Owira, Peter M.O.

“…Psidium guajava L. leaves are used to treat diabetes in South African folkloric medicine and in other parts of the world. Psidium x durbanensis Baijnath &…”
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Potential Role of Polyphenolic Flavonoids as Senotherapeutic Agents in Degenerative Diseases and Geroprotection by Mbara, Kingsley C., Devnarain, Nikita, Owira, Peter M. O.

“…Cellular senescence, a hallmark of ageing, contributes to tissue or organ dysfunction and the pathophysiology of diverse age-related diseases (ARD) by various…”
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The link between relative stability constant of DNA- and BSA-chromenopyrimidine complexes and cytotoxicity towards human breast cancer cells (MCF-7) by Zamisa, Sizwe J, Adeleke, Adesola A, Devnarain, Nikita, Rhman, Mahasin Abdel, Owira, Peter M. O, Omondi, Bernard

“…In this study, we synthesized and characterized ten chromenopyrimidine derivatives using analytical and spectroscopic methods. Studies on DNA and albumin…”
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Cardioprotective Effects of Metformin by Driver, Christine, Bamitale, Kayode Dominion Samuel, Kazi, Aniessa, Olla, Mehnaaz, Nyane, Annah Ntsoaki, Owira, Peter Mark Oroma

“…ABSTRACTMetformin, routinely used as first-line drug in the treatment of type 2 diabetes has been shown to have cardioprotective effects beyond its glycemic…”
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By reducing oxidative stress, naringenin mitigates hyperglycaemia-induced upregulation of hepatic nuclear factor erythroid 2-related factor 2 protein by Kometsi, Lereko, Govender, Khmera, Mofo Mato, Edith P, Hurchund, Rajendraparsad, Owira, Peter M O

“…Abstract Objectives Antioxidant and anti-inflammatory properties of naringenin could confer hepatoprotective effects. Methods Chang cells in culture media were…”
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Naringin protects against HIV-1 protease inhibitors-induced pancreatic β-cell dysfunction and apoptosis by Nzuza, Sanelisiwe, Ndwandwe, Duduzile E., Owira, Peter M.O.

“…The protective effects of grapefruit-derived naringin against HIV-1 Protease Inhibitors (PIs)-associated oxidative damage to pancreatic β-cells and apoptosis…”
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Synergism Potentiates Oxidative Antiproliferative Effects of Naringenin and Quercetin in MCF-7 Breast Cancer Cells by Rhman, Mahasin Abdel, Devnarain, Nikita, Khan, Rene, Owira, Peter M. O

“…Breast cancer (BC) is the most frequently diagnosed type of cancer as of 2020. Quercetin (Que) and Naringenin (Nar) are predominantly found in citrus fruits…”
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Naringin Reduces Hyperglycemia-Induced Cardiac Fibrosis by Relieving Oxidative Stress by Adebiyi, Olubunmi A, Adebiyi, Oluwafeyisetan O, Owira, Peter M O

“…Hyperglycemia promotes myocardial fibrotic lesions through upregulation of PKC and p38 in response to redox changes. The effects of naringin on…”
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Naringin prevents HIV-1 protease inhibitors-induced metabolic complications in vivo by Nzuza, Sanelisiwe, Zondi, Sindiswa, Owira, Peter M O

“…Insulin resistance, glucose intolerance and overt diabetes are known metabolic complications associated with chronic use of HIV-Protease Inhibitors. Naringin…”
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Citrus fruit‐derived flavonoid naringenin and the expression of hepatic organic cation transporter 1 protein in diabetic rats treated with metformin by Mato Mofo, Edith P., Essop, M. Faadiel, Owira, Peter M. O.

“…Naringenin possesses many pharmacological effects and may modulate metformin disposition. The purpose of this study was to evaluate the role of naringenin on…”
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Naringin Mitigates Cardiac Hypertrophy by Reducing Oxidative Stress and Inactivating c-Jun Nuclear Kinase-1 Protein in Type I Diabetes by Adebiyi, A Olubunmi, Adebiyi, Oluwafeysetan O, Owira, Peter M O

“…Cardiac hypertrophy (CH) in type 1 diabetes mellitus is attributed to increased oxidative stress–associated activation of c-Jun Nuclear Kinase (JNK). We…”
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Alcohol risk management in college settings: the safer California universities randomized trial by Saltz, Robert F, Paschall, Mallie J, McGaffigan, Richard P, Nygaard, Peter M O

“…Potentially effective environmental strategies have been recommended to reduce heavy alcohol use among college students. However, studies to date on…”
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Grapefruit juice improves glucose intolerance in streptozotocin-induced diabetes by suppressing hepatic gluconeogenesis by Hayanga, Julia A, Ngubane, Senelisiwe P, Murunga, Alfred N, Owira, Peter M. O

“…PURPOSE: Hypoglycemic effects of grapefruit juice (GFJ) are widely recognized, but the mechanism(s) by which GFJ lowers blood glucose levels have not…”
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Naringin Reverses Hepatocyte Apoptosis and Oxidative Stress Associated with HIV-1 Nucleotide Reverse Transcriptase Inhibitors-Induced Metabolic Complications by Adebiyi, Oluwafeyisetan O, Adebiyi, Olubunmi A, Owira, Peter M O

“…Nucleoside Reverse Transcriptase Inhibitors (NRTIs) have not only improved therapeutic outcomes in the treatment of HIV infection but have also led to an…”
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Grapefruit Derived Flavonoid Naringin Improves Ketoacidosis and Lipid Peroxidation in Type 1 Diabetes Rat Model by Murunga, Alfred N, Miruka, David O, Driver, Christine, Nkomo, Fezile S, Cobongela, Snazo Z Z, Owira, Peter M O

“…Hypoglycemic effects of grapefruit juice are well known but the effects of naringin, its main flavonoid on glucose intolerance and metabolic complications in…”
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The grapefruit : an old wine in a new glass? Metabolic and cardiovascular perspectives : review article by Ojewole, John A.O., Owira, Peter M.O.

“…Grapefruit is a popular, tasty and nutritive fruit enjoyed globally. Biomedical evidence in the last 10 years has, however, shown that consumption of…”
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