Search Results - "Petchey, Mark"

Enzyme‐Catalysed Synthesis of Secondary and Tertiary Amides by Petchey, Mark R., Grogan, Gideon

“…The synthesis of the amide bond between an amine and a carboxylic acid is one of the most significant reactions in industrial pharmaceutical synthesis. Despite…”
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Biocatalytic Amino Acid Functionalisation by Petchey, Mark R., Schneider, Pascal, Harwood, Lucy A

“…The success of new therapeutic modalities relies on advancements in synthetic chemistry to produce compounds for evaluation throughout the drug discovery…”
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Regiodivergent Radical Termination for Intermolecular Biocatalytic C–C Bond Formation by Petchey, Mark R., Ye, Yuxuan, Spelling, Victor, Finnigan, James D., Gittings, Samantha, Johansson, Magnus J., Hayes, Martin A., Hyster, Todd K.

“…Radical hydrofunctionalizations of electronically unbiased dienes are challenging to render regioselective, because the products are nearly identical in…”
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Biocatalytic Synthesis of Moclobemide Using the Amide Bond Synthetase McbA Coupled with an ATP Recycling System by Petchey, Mark R, Rowlinson, Benjamin, Lloyd, Richard C, Fairlamb, Ian J. S, Grogan, Gideon

“…The biocatalytic synthesis of amides from carboxylic acids and primary amines in aqueous media can be achieved using the ATP-dependent amide bond synthetase…”
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A Reductive Aminase Switches to Imine Reductase Mode for a Bulky Amine Substrate by Gilio, Amelia K., Thorpe, Thomas W., Heyam, Alex, Petchey, Mark R., Pogrányi, Balázs, France, Scott P., Howard, Roger M., Karmilowicz, Michael J., Lewis, Russell, Turner, Nicholas, Grogan, Gideon

“…Imine reductases (IREDs) catalyze the asymmetric reduction of cyclic imines, but also in some cases the coupling of ketones and amines to form secondary amine…”
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Broad Spectrum Enantioselective Amide Bond Synthetase from Streptoalloteichus hindustanus by Tang, Qingyun, Petchey, Mark, Rowlinson, Benjamin, Burden, Thomas J., Fairlamb, Ian J. S., Grogan, Gideon

“…The synthesis of amide bonds is one of the most frequently performed reactions in pharmaceutical synthesis, but the requirement for stoichiometric quantities…”
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The Broad Aryl Acid Specificity of the Amide Bond Synthetase McbA Suggests Potential for the Biocatalytic Synthesis of Amides by Petchey, Mark, Cuetos, Anibal, Rowlinson, Benjamin, Dannevald, Stephanie, Frese, Amina, Sutton, Peter W., Lovelock, Sarah, Lloyd, Richard C., Fairlamb, Ian J. S., Grogan, Gideon

“…Amide bond formation is one of the most important reactions in pharmaceutical synthetic chemistry. The development of sustainable methods for amide bond…”
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Advanced Insights into Catalytic and Structural Features of the Zinc‐Dependent Alcohol Dehydrogenase from Thauera aromatica by Stark, Frances, Loderer, Christoph, Petchey, Mark, Grogan, Gideon, Ansorge‐Schumacher, Marion B.

“…The asymmetric reduction of ketones to chiral hydroxyl compounds by alcohol dehydrogenases (ADHs) is an established strategy for the provision of valuable…”
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Biocatalysis in Drug Design: Engineered Reductive Aminases (RedAms) Are Used to Access Chiral Building Blocks with Multiple Stereocenters by Casamajo, Arnau Rué, Yu, Yuqi, Schnepel, Christian, Morrill, Charlotte, Barker, Rhys, Levy, Colin W., Finnigan, James, Spelling, Victor, Westerlund, Kristina, Petchey, Mark, Sheppard, Robert J., Lewis, Richard J., Falcioni, Francesco, Hayes, Martin A., Turner, Nicholas J.

“…Novel building blocks are in constant demand during the search for innovative bioactive small molecule therapeutics by enabling the construction of…”
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The Application of Amide Bond Synthetases (Abss), of the McbA Family, to the Synthesis of Amide Pharmaceuticals by Petchey, Mark

“…Amide bond formation is one of the most important reactions in synthetic medicinal chemistry, however current methods rely on toxic or hazardous reagents and…”
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The Broad Aryl Acid Specificity of the Amide Bond Synthetase McbA Suggests Potential for the Biocatalytic Synthesis of Amides by Petchey, Mark, Cuetos, Anibal, Rowlinson, Benjamin, Dannevald, Stephanie, Frese, Amina, Sutton, Peter W., Lovelock, Sarah, Lloyd, Richard C., Fairlamb, Ian J. S., Grogan, Gideon

“…Amide bond formation is one of the most important reactions in pharmaceutical synthetic chemistry. The development of sustainable methods for amide bond…”
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