Search Results - "Pestova, Tatyana V."

Reinitiation and Other Unconventional Posttermination Events during Eukaryotic Translation by Skabkin, Maxim A., Skabkina, Olga V., Hellen, Christopher U.T., Pestova, Tatyana V.

“…During ribosome recycling, posttermination complexes are dissociated by ABCE1 and eRF1 into 60S and tRNA/mRNA-associated 40S subunits, after which tRNA and…”
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Release of Ubiquitinated and Non-ubiquitinated Nascent Chains from Stalled Mammalian Ribosomal Complexes by ANKZF1 and Ptrh1 by Kuroha, Kazushige, Zinoviev, Alexandra, Hellen, Christopher U.T., Pestova, Tatyana V.

“…The ribosome-associated quality control (RQC) pathway degrades nascent chains (NCs) arising from interrupted translation. First, recycling factors split…”
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Structure of mammalian eIF3 in the context of the 43S preinitiation complex by des Georges, Amedee, Dhote, Vidya, Kuhn, Lauriane, Hellen, Christopher U. T., Pestova, Tatyana V., Frank, Joachim, Hashem, Yaser

“…During eukaryotic translation initiation, 43S complexes, comprising a 40S ribosomal subunit, initiator transfer RNA and initiation factors (eIF) 2, 3, 1 and…”
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Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29 by Hashem, Yaser, des Georges, Amedee, Dhote, Vidya, Langlois, Robert, Liao, Hstau Y., Grassucci, Robert A., Hellen, Christopher U.T., Pestova, Tatyana V., Frank, Joachim

“…Eukaryotic translation initiation begins with assembly of a 43S preinitiation complex. First, methionylated initiator methionine transfer RNA (Met-tRNAiMet),…”
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Toward the mechanism of eIF4F-mediated ribosomal attachment to mammalian capped mRNAs by Kumar, Parimal, Hellen, Christopher U T, Pestova, Tatyana V

“…Ribosomal attachment to mammalian capped mRNAs is achieved through the cap-eukaryotic initiation factor 4E (eIF4E)-eIF4G-eIF3-40S chain of interactions, but…”
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Multiple Mechanisms of Reinitiation on Bicistronic Calicivirus mRNAs by Zinoviev, Alexandra, Hellen, Christopher U.T., Pestova, Tatyana V.

“…Reinitiation is a strategy used by viruses to express several cistrons from one mRNA. Although extremely weak after translation of long open reading frames…”
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Ribosomal collision is not a prerequisite for ZNF598-mediated ribosome ubiquitination and disassembly of ribosomal complexes by ASCC by Miścicka, Anna, Bulakhov, Alexander G, Kuroha, Kazushige, Zinoviev, Alexandra, Hellen, Christopher U T, Pestova, Tatyana V

“…Ribosomal stalling induces the ribosome-associated quality control (RQC) pathway targeting aberrant polypeptides. RQC is initiated by K63-polyubiquitination of…”
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Termination and post-termination events in eukaryotic translation by Jackson, Richard J., Hellen, Christopher U.T., Pestova, Tatyana V.

“…Translation termination in eukaryotes occurs in response to a stop codon in the ribosomal A-site and requires two release factors (RFs), eRF1 and eRF3, which…”
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Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes by Pisareva, Vera P, Skabkin, Maxim A, Hellen, Christopher U T, Pestova, Tatyana V, Pisarev, Andrey V

“…No‐go decay (NGD) and non‐stop decay (NSD) are eukaryotic surveillance mechanisms that target mRNAs on which elongation complexes (ECs) are stalled by, for…”
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Functional role and ribosomal position of the unique N-terminal region of DHX29, a factor required for initiation on structured mammalian mRNAs by Sweeney, Trevor R, Dhote, Vidya, Guca, Ewelina, Hellen, Christopher U T, Hashem, Yaser, Pestova, Tatyana V

“…Abstract Translation initiation on structured mammalian mRNAs requires DHX29, a DExH protein that comprises a unique 534-aa-long N-terminal region (NTR) and a…”
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Extraction of mRNA from Stalled Ribosomes by the Ski Complex by Zinoviev, Alexandra, Ayupov, Rustam K., Abaeva, Irina S., Hellen, Christopher U.T., Pestova, Tatyana V.

“…The evolutionarily conserved Ski2-Ski3-Ski8 (Ski) complex containing the 3′→5′ RNA helicase Ski2 binds to 80S ribosomes near the mRNA entrance and facilitates…”
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The structure and mechanism of action of a distinct class of dicistrovirus intergenic region IRESs by Abaeva, Irina S, Young, Christina, Warsaba, Reid, Khan, Nadiyah, Tran, Lan Vy, Jan, Eric, Pestova, Tatyana V, Hellen, Christopher U T

“…Abstract Internal ribosomal entry sites (IRESs) engage with the eukaryotic translation apparatus to promote end-independent initiation. We identified a…”
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Cryo-EM of Ribosomal 80S Complexes with Termination Factors Reveals the Translocated Cricket Paralysis Virus IRES by Muhs, Margarita, Hilal, Tarek, Mielke, Thorsten, Skabkin, Maxim A., Sanbonmatsu, Karissa Y., Pestova, Tatyana V., Spahn, Christian M.T.

“…The cricket paralysis virus (CrPV) uses an internal ribosomal entry site (IRES) to hijack the ribosome. In a remarkable RNA-based mechanism involving neither…”
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Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling by Skabkin, Maxim A, Skabkina, Olga V, Dhote, Vidya, Komar, Anton A, Hellen, Christopher U T, Pestova, Tatyana V

“…Eukaryotic translation initiation begins with ribosomal recruitment of aminoacylated initiator tRNA (Met-tRNA(Met)(i)) by eukaryotic initiation factor eIF2. In…”
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The Role of ABCE1 in Eukaryotic Posttermination Ribosomal Recycling by Pisarev, Andrey V., Skabkin, Maxim A., Pisareva, Vera P., Skabkina, Olga V., Rakotondrafara, Aurélie M., Hentze, Matthias W., Hellen, Christopher U.T., Pestova, Tatyana V.

“…After termination, eukaryotic 80S ribosomes remain associated with mRNA, P-site deacylated tRNA, and release factor eRF1 and must be recycled by dissociating…”
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Translation of Overlapping Open Reading Frames Promoted by Type 2 IRESs in Avian Calicivirus Genomes by Arhab, Yani, Pestova, Tatyana V, Hellen, Christopher U T

“…Caliciviruses have positive-sense RNA genomes, typically with short 5'-untranslated regions (5'UTRs) that precede the long open reading frame 1 (ORF1)…”
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Dissemination of Internal Ribosomal Entry Sites (IRES) Between Viruses by Horizontal Gene Transfer by Arhab, Yani, Bulakhov, Alexander G, Pestova, Tatyana V, Hellen, Christopher U T

“…Members of and of the , and genera of all contain an internal ribosomal entry site (IRES) in the 5'-untranslated region (5'UTR) of their genomes. Each class of…”
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Functions of unconventional mammalian translational GTPases GTPBP1 and GTPBP2 by Zinoviev, Alexandra, Goyal, Akanksha, Jindal, Supriya, LaCava, John, Komar, Anton A, Rodnina, Marina V, Hellen, Christopher U T, Pestova, Tatyana V

“…GTP-binding protein 1 (GTPBP1) and GTPBP2 comprise a divergent group of translational GTPases with obscure functions, which are most closely related to eEF1A,…”
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Two classes of EF1-family translational GTPases encoded by giant viruses by Zinoviev, Alexandra, Kuroha, Kazushige, Pestova, Tatyana V, Hellen, Christopher U T

“…Giant viruses have extraordinarily large dsDNA genomes, and exceptionally, they encode various components of the translation apparatus, including tRNAs,…”
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Translational Control by a Small RNA: Dendritic BC1 RNA Targets the Eukaryotic Initiation Factor 4A Helicase Mechanism by Lin, Daisy, Pestova, Tatyana V., Hellen, Christopher U. T., Tiedge, Henri

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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