Search Results - "Pestell, Timothy"

Cancer stem cells by Yu, Zuoren, Pestell, Timothy G., Lisanti, Michael P., Pestell, Richard G.

“…Cancer stem cells (CSCs) are a small subpopulation of cells within tumors with capabilities of self-renewal, differentiation, and tumorigenicity when…”
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CCR5 Antagonist Blocks Metastasis of Basal Breast Cancer Cells by VELASCO-VELAZQUEZ, Marco, XUANMAO JIAO, DE LA FUENTE, Marisol, PESTELL, Timothy G, ERTEL, Adam, LISANTI, Michael P, PESTELL, Richard G

“…The roles of the chemokine CCL5 and its receptor CCR5 in breast cancer progression remain unclear. Here, we conducted microarray analysis on 2,254 human breast…”
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CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis by Capparelli, Claudia, Chiavarina, Barbara, Whitaker-Menezes, Diana, Pestell, Timothy G., Pestell, Richard G., Hulit, James, Andò, Sebastiano, Howell, Anthony, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.

“…Here, we investigated the compartment-specific role of cell cycle arrest and senescence in breast cancer tumor growth. For this purpose, we generated a number…”
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Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis, via glycolysis and ketone production by Capparelli, Claudia, Guido, Carmela, Whitaker-Menezes, Diana, Bonuccelli, Gloria, Balliet, Renee, Pestell, Timothy G., Goldberg, Allison F., Pestell, Richard G., Howell, Anthony, Sneddon, Sharon, Birbe, Ruth, Tsirigos, Aristotelis, Martinez-Outschoorn, Ubaldo, Sotgia, Federica, Lisanti, Michael P.

“…Senescent fibroblasts are known to promote tumor growth. However, the exact mechanism remains largely unknown. An important clue comes from recent studies…”
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CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth by Capparelli, Claudia, Whitaker-Menezes, Diana, Guido, Carmela, Balliet, Renee, Pestell, Timothy G., Howell, Anthony, Sneddon, Sharon, Pestell, Richard G., Martinez-Outschoorn, Ubaldo, Lisanti, Michael P., Sotgia, Federica

“…Previous studies have demonstrated that loss of caveolin-1 (Cav-1) in stromal cells drives the activation of the TGF-β signaling, with increased transcription…”
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Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: Understanding the aging and cancer connection by Balliet, Renee M., Capparelli, Claudia, Guido, Carmela, Pestell, Timothy G., Martinez-Outschoorn, Ubaldo E., Lin, Zhao, Whitaker-Menezes, Diana, Chiavarina, Barbara, Pestell, Richard G., Howell, Anthony, Sotgia, Federica, Lisanti, Michael P.

“…Increasing chronological age is the most significant risk factor for cancer. Recently, we proposed a new paradigm for understanding the role of the aging and…”
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Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation by Chen, Ke, Jiao, Xuanmao, Di Rocco, Agnese, Shen, Duanwen, Xu, Shaohua, Ertel, Adam, Yu, Zuoren, Di Sante, Gabriele, Wang, Min, Li, Zhiping, Pestell, Timothy G., Casimiro, Mathew C., Skordalakes, Emmanuel, Achilefu, Samuel, Pestell, Richard G.

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Loss of Sirt1 Promotes Prostatic Intraepithelial Neoplasia, Reduces Mitophagy, and Delays Park2 Translocation to Mitochondria by Di Sante, Gabriele, Pestell, Timothy G, Casimiro, Mathew C, Bisetto, Sara, Powell, Michael J, Lisanti, Michael P, Cordon-Cardo, Carlos, Castillo-Martin, Mireia, Bonal, Dennis M, Debattisti, Valentina, Chen, Ke, Wang, Liping, He, Xiaohong, McBurney, Michael W, Pestell, Richard G

“…Prostatic intraepithelial neoplasia is a precursor to prostate cancer. Herein, deletion of the NAD+ -dependent histone deacetylase Sirt1 induced histological…”
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Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis by Casimiro, Mathew C, Di Sante, Gabriele, Di Rocco, Agnese, Loro, Emanuele, Pupo, Claudia, Pestell, Timothy G, Bisetto, Sara, Velasco-Velázquez, Marco A, Jiao, Xuanmao, Li, Zhiping, Kusminski, Christine M, Seifert, Erin L, Wang, Chenguang, Ly, Daniel, Zheng, Bin, Shen, Che-Hung, Scherer, Philipp E, Pestell, Richard G

“…Autophagy activated after DNA damage or other stresses mitigates cellular damage by removing damaged proteins, lipids, and organelles. Activation of the master…”
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Hormonal Control of Androgen Receptor Function through SIRT1 by Fu, Maofu, Liu, Manran, Sauve, Anthony A., Jiao, Xuanmao, Zhang, Xueping, Wu, Xiaofang, Powell, Michael J., Yang, Tianle, Gu, Wei, Avantaggiati, Maria Laura, Pattabiraman, Nagarajan, Pestell, Timothy G., Wang, Fang, Quong, Andrew A., Wang, Chenguang, Pestell, Richard G.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation by Chen, Ke, Jiao, Xuanmao, Di Rocco, Agnese, Shen, Duanwen, Xu, Shaohua, Ertel, Adam, Yu, Zuoren, Di Sante, Gabriele, Wang, Min, Li, Zhiping, Pestell, Timothy G., Casimiro, Mathew C., Skordalakes, Emmanuel, Achilefu, Samuel, Pestell, Richard G.

“…Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates RB and functions as a collaborative nuclear oncogene. The serine threonine kinase…”
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Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth by Pestell, Timothy G, Jiao, Xuanmao, Kumar, Mukesh, Peck, Amy R, Prisco, Marco, Deng, Shengqiong, Li, Zhiping, Ertel, Adam, Casimiro, Mathew C, Ju, Xiaoming, Di Rocco, Agnese, Di Sante, Gabriele, Katiyar, Sanjay, Shupp, Alison, Lisanti, Michael P, Jain, Pooja, Wu, Kongming, Rui, Hallgeir, Hooper, Douglas C, Yu, Zuoren, Goldman, Aaron R, Speicher, David W, Laury-Kleintop, Lisa, Pestell, Richard G

“…The gene encodes the regulatory subunit of a holoenzyme that drives cell autonomous cell cycle progression and proliferation. Herein we show cyclin D1…”
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The membrane-associated form of cyclin D1 enhances cellular invasion by Chen, Ke, Jiao, Xuanmao, Ashton, Anthony, Di Rocco, Agnese, Pestell, Timothy G., Sun, Yunguang, Zhao, Jun, Casimiro, Mathew C., Li, Zhiping, Lisanti, Michael P., McCue, Peter A., Shen, Duanwen, Achilefu, Samuel, Rui, Hallgeir, Pestell, Richard G.

“…The essential G 1 -cyclin, CCND1 , is a collaborative nuclear oncogene that is frequently overexpressed in cancer. D-type cyclins bind and activate CDK4 and…”
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Sirt1-Deficient Mice Have Hypogonadotropic Hypogonadism due to Defective GnRH Neuronal Migration by Di Sante, Gabriele, Wang, Liping, Wang, Chenguang, Jiao, Xuanmiao, Casimiro, Mathew C, Chen, Ke, Pestell, Timothy G, Yaman, Ismail, Di Rocco, Agnese, Sun, Xin, Horio, Yoshiyuki, Powell, Michael J, He, Xiaohong, McBurney, Michael W, Pestell, Richard G

“…Hypogonadatropic hypogonadism (HH) can be acquired through energy restriction or may be inherited as congenital hypogonadotropic hypogonadism and its…”
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CAPER, a novel regulator of human breast cancer progression by Mercier, Isabelle, Gonzales, Donna M, Quann, Kevin, Pestell, Timothy G, Molchansky, Alexander, Sotgia, Federica, Hulit, James, Gandara, Ricardo, Wang, Chenguang, Pestell, Richard G, Lisanti, Michael P, Jasmin, Jean-François

“…CAPER is an estrogen receptor (ER) co-activator that was recently shown to be involved in human breast cancer pathogenesis. Indeed, we reported increased…”
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Time-Lapse Video Microscopy for Assessment of EYFP-Parkin Aggregation as a Marker for Cellular Mitophagy by Di Sante, Gabriele, Casimiro, Mathew C, Pestell, Timothy G, Pestell, Richard G

“…Time-lapse video microscopy can be defined as the real time imaging of living cells. This technique relies on the collection of images at different time…”
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Disruption of c-Jun reduces cellular migration and invasion through inhibition of c-Src and hyperactivation of ROCK II kinase by Jiao, Xuanmao, Katiyar, Sanjay, Liu, Manran, Mueller, Susette C, Lisanti, Michael P, Li, Anping, Pestell, Timothy G, Wu, Kongming, Ju, Xiaoming, Li, Zhiping, Wagner, Erwin F, Takeya, Tatsuo, Wang, Chenguang, Pestell, Richard G

“…The spread of metastatic tumors to different organs is associated with poor prognosis. The metastatic process requires migration and cellular invasion. The…”
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Abstract B10: Cyclin D1 restrains oncogene-induced autophagy via phosphorylation of LKB1 by Casimiro, Mathew, Sante, Gabriele Di, Loro, Emanuele, Pestell, Timothy, Bisetto, Sara, Velasco-Velázquez, Marco, Jiao, Xuanmao, Li, Zhiping, Wang, Chenguang, Ly, Daniel, Zheng, Bin, Che-Hung, Shen, Ertel, Adam, Pestell, Richard G.

“…Abstract Cyclin D1 is an important molecular driver of many human cancers. The cyclin D1 gene is amplified or overexpressed in up to half of human breast…”
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Time-Lapse Video Microscopy for Assessment of EYFP-Parkin Aggregation as a Marker for Cellular Mitophagy by Di Sante, Gabriele, Casimiro, Mathew C., Pestell, Timothy G., Pestell, Richard G.

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Abstract B33: The membrane associated cyclin D1 promotes contact-independent growth via phosphorylation of Akt1 Ser 473 by Jiao, Xuanmao, Chen, Ke, Xu, Shaohua, Ju, Xiaoming, Ertel, Adam, Tian, Lifeng, Yu, Zuoren, Sante, Gabriele Di, Wang, Min, Li, Zhiping, Pestell, Timothy, Casimiro, Mathew, Shen, Duanwen, Achilefu, Samuel, Pestell, Richard

“…Abstract The serine threonine kinase Akt plays a pivotal role in the control of cellular metabolism, survival, growth and cellular migration. Cyclin D1 encodes…”
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