Search Results - "Pestana, Karen Goldsmith"

Murine visceral leishmaniasis: IgM and polyclonal B-cell activation lead to disease exacerbation by Deak, Eszter, Jayakumar, Asha, Cho, Ka Wing, Goldsmith-Pestana, Karen, Dondji, Blaise, Lambris, John D, McMahon-Pratt, Diane

“…In visceral leishmaniasis, the draining LN (DLN) is the initial site for colonization and establishment of infection after intradermal transmission by the sand…”
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Leishmania pifanoi Proteoglycolipid Complex P8 Induces Macrophage Cytokine Production through Toll-Like Receptor 4 by Whitaker, Shanta M, Colmenares, Maria, Pestana, Karen Goldsmith, McMahon-Pratt, Diane

“…The P8 proteoglycolipid complex (P8 PGLC) is a glyconjugate expressed by Leishmania mexicana complex parasites. We previously have shown that vaccination with…”
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The Wnt Antagonist Dickkopf-1 Promotes Pathological Type 2 Cell-Mediated Inflammation by Chae, Wook-Jin, Ehrlich, Allison K., Chan, Pamela Y., Teixeira, Alexandra M., Henegariu, Octavian, Hao, Liming, Shin, Jae Hun, Park, Jong-Hyun, Tang, Wai Ho, Kim, Sang-Taek, Maher, Stephen E., Goldsmith-Pestana, Karen, Shan, Peiying, Hwa, John, Lee, Patty J., Krause, Diane S., Rothlin, Carla V., McMahon-Pratt, Diane, Bothwell, Alfred L.M.

“…Exposure to a plethora of environmental challenges commonly triggers pathological type 2 cell-mediated inflammation. Here we report the pathological role of…”
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Murine model of chronic L. (Viannia) panamensis infection: Role of IL-13 in disease by Castilho, Tiago M, Goldsmith-Pestana, Karen, Lozano, Caterin, Valderrama, Liliana, Saravia, Nancy G, McMahon-Pratt, Diane

“…Leishmania (Viannia) organisms are the most prevalent etiologic agents of human cutaneous leishmaniasis in the Americas. Nevertheless, our knowledge of the…”
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TLR1/2 activation during heterologous prime-boost vaccination (DNA-MVA) enhances CD8+ T Cell responses providing protection against Leishmania (Viannia) by Jayakumar, Asha, Castilho, Tiago M, Park, Esther, Goldsmith-Pestana, Karen, Blackwell, Jenefer M, McMahon-Pratt, Diane

“…Leishmania (Viannia) parasites present particular challenges, as human and murine immune responses to infection are distinct from other Leishmania species,…”
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Intradermal NKT cell activation during DNA priming in heterologous prime-boost vaccination enhances T cell responses and protection against Leishmania by Dondji, Blaise, Deak, Eszter, Goldsmith-Pestana, Karen, Perez-Jimenez, Eva, Esteban, Mariano, Miyake, Sachiko, Yamamura, Takashi, McMahon-Pratt, Diane

“…Heterologous prime-boost vaccination employing DNA-vaccinia virus (VACV) modality using the Leishmania homologue of receptors for activated C kinase (LACK)…”
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Heterologous Prime-Boost Vaccination with the LACK Antigen Protects against Murine Visceral Leishmaniasis by Dondji, Blaise, Pérez-Jimenez, Eva, Goldsmith-Pestana, Karen, Esteban, Mariano, McMahon-Pratt, Diane

“…This study reports the efficacy of a heterologous prime-boost vaccination using DNA and vaccinia viruses (Western Reserve [WR] virus and modified [attenuated]…”
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Mechanisms of pathogenesis: differences amongst Leishmania species by Colmenares, Maria, Kar, Sujata, Goldsmith-Pestana, Karen, McMahon-Pratt, Diane

“…One of the features of the genus Leishmania is the diversity of tropism/disease resulting from infection. With notable exceptions, the form (visceral,…”
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The Immunologically Protective P-4 Antigen ofLeishmania Amastigotes by Kar, Sujata, Soong, Lynn, Colmenares, Maria, Goldsmith-Pestana, Karen, McMahon-Pratt, Diane

“…The purified membrane-associated Leishmania pifanoi amastigote protein P-4 has been shown to induce protective immunity against infection and to elicit…”
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Immunomodulatory nanoparticles ameliorate disease in the Leishmania (Viannia) panamensis mouse model by Siefert, Alyssa L, Ehrlich, Allison, Corral, María Jesús, Goldsmith-Pestana, Karen, McMahon-Pratt, Diane, Fahmy, Tarek M

“…Abstract Leishmania (Viannia) panamensis ( L. (V.) panamensis ) is a species of protozoan parasites that causes New World leishmaniasis, which is characterized…”
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The immunotherapeutic role of regulatory T cells in Leishmania (Viannia) panamensis infection by Ehrlich, Allison, Castilho, Tiago Moreno, Goldsmith-Pestana, Karen, Chae, Wook-Jin, Bothwell, Alfred L M, Sparwasser, Tim, McMahon-Pratt, Diane

“…Leishmania (Viannia) parasites are etiological agents of cutaneous leishmaniasis in the New World. Infection is characterized by a mixed Th1/Th2 inflammatory…”
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Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness by Abdeen, Sanofar, Salim, Nilshad, Mammadova, Najiba, Summers, Corey M., Goldsmith-Pestana, Karen, McMahon-Pratt, Diane, Schultz, Peter G., Horwich, Arthur L., Chapman, Eli, Johnson, Steven M.

“…[Display omitted] Trypanosoma brucei are protozoan parasites that cause African sleeping sickness in humans (also known as Human African Trypanosomiasis—HAT)…”
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Local Delivery of the Toll-Like Receptor 9 Ligand CpG Downregulates Host Immune and Inflammatory Responses, Ameliorating Established Leishmania (Viannia) panamensis Chronic Infection by Ehrlich, Allison K, Fernández, Olga L, Rodriguez-Pinto, Daniel, Castilho, Tiago M, Corral Caridad, Maria J, Goldsmith-Pestana, Karen, Saravia, Nancy Gore, McMahon-Pratt, Diane

“…Infection by ( ) , the predominant etiologic agent for cutaneous leishmaniasis in Colombia, is characterized by a chronic mixed inflammatory response. Current…”
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A Scaffold Protein, AHNAK1, Is Required for Calcium Signaling during T Cell Activation by Matza, Didi, Badou, Abdallah, Kobayashi, Koichi S., Goldsmith-Pestana, Karen, Masuda, Yutaka, Komuro, Akihiko, McMahon-Pratt, Diane, Marchesi, Vincent T., Flavell, Richard A.

“…Engagement of the T cell antigen receptor (TCR) during antigen presentation initiates a coordinated action of a large number of signaling proteins and ion…”
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Cutaneous leishmaniasis is regulated by Wnt antagonist Dkk-1 from activated platelets (MPF7P.715) by Bothwell, Alfred, Chae, WookJin, Ehrlich, Allison, Teixeira, Alexandra, Goldsmith-Pestana, Karen, Maher, Stephen, Hwa, John, Krause, Diane, McMahon-Pratt, Diane

“…Cutaneous leishmaniasis is a chronic non-healing skin inflammatory disease present in many countries. Here we show that the Wnt antagonist Dkk-1 is secreted…”
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The role of regulatory T cells in the Leishmania (Viannia) panamensis mouse model: a target for immunotherapy. (P3091) by Ehrlich, Allison, Castilho, Tiago, Goldsmith-Pestana, Karen, Sparwasser, Tim, McMahon-Pratt, Diane

“…Leishmania (Viannia) parasites are etiological agents of cutaneous leishmaniasis in the New World. Infection in humans is characterized by mixed Th1/Th2 and…”
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TLR1/2 activation during heterologous prime-boost vaccination by Jayakumar, Asha, Castilho, Tiago M, Park, Esther, Goldsmith-Pestana, Karen, Blackwell, Jenefer M, McMahon-Pratt, Diane

“…Background: Leishmania (Viannia) parasites present particular challenges, as human and murine immune responses to infection are distinct from other Leishmania…”
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NKTi cell activation during DNA priming in heterologous prime-boost vaccination enhances T cell responses and protection against Leishmania by Dondji, Blaise, Deak, Eszter, Goldsmith-Pestana, Karen, Perez-Jimenez, Eva, Esteban, Mariano, Miyake, Sachiko, Yamamura, Takashi, McMahon-Pratt, Diane

“…Heterologous prime-boost vaccination employing DNA-vaccinia virus (VACV) modality using the LACK (p36) antigen ( Leishmania homologue of receptors for…”
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The immunologically protective P-4 antigen of Leishmania amastigotes. A developmentally regulated single strand-specific nuclease associated with the endoplasmic reticulum by Kar, S, Soong, L, Colmenares, M, Goldsmith-Pestana, K, McMahon-Pratt, D

“…The purified membrane-associated Leishmania pifanoi amastigote protein P-4 has been shown to induce protective immunity against infection and to elicit…”
Get full text