Search Results - "Pest, Michael A."

Recent developments in emerging therapeutic targets of osteoarthritis by Sun, Margaret Man-Ger, Beier, Frank, Pest, Michael A

“…PURPOSE OF REVIEWDespite the tremendous individual suffering and socioeconomic burden caused by osteoarthritis, there are currently no effective…”
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Atoh1+ secretory progenitors possess renewal capacity independent of Lgr5+ cells during colonic regeneration by Castillo‐Azofeifa, David, Fazio, Elena N, Nattiv, Roy, Good, Hayley J, Wald, Tomas, Pest, Michael A, de Sauvage, Frederic J, Klein, Ophir D, Asfaha, Samuel

“…During homeostasis, the colonic epithelium is replenished every 3–5 days by rapidly cycling Lgr5 + stem cells. However, various insults can lead to depletion…”
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Overexpression of MIG-6 in the cartilage induces an osteoarthritis-like phenotype in mice by Bellini, Melina, Pest, Michael A, Miranda-Rodrigues, Manuela, Qin, Ling, Jeong, Jae-Wook, Beier, Frank

“…Osteoarthritis (OA) is the most common form of arthritis and characterized by degeneration of the articular cartilage. Mitogen-inducible gene 6 (Mig-6) has…”
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Transforming growth factor alpha controls the transition from hypertrophic cartilage to bone during endochondral bone growth by Usmani, Shirine E, Pest, Michael A, Kim, Gunwoo, Ohora, Sara N, Qin, Ling, Beier, Frank

“…Abstract We have recently identified transforming growth factor alpha (TGFα) as a novel growth factor involved in the joint disease osteoarthritis. The role of…”
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Disturbed Cartilage and Joint Homeostasis Resulting From a Loss of Mitogen‐Inducible Gene 6 in a Mouse Model of Joint Dysfunction by Pest, Michael A., Russell, Bailey A., Zhang, Yu‐Wen, Jeong, Jae‐Wook, Beier, Frank

“…Objective Mitogen‐inducible gene 6 (MIG‐6) regulates epidermal growth factor receptor (EGFR) signaling in synovial joint tissues. Whole‐body knockout of the…”
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Anabolic phenotype in cartilage-specific mitogen-inducible gene-6 knockout mice is independent of transforming growth factor-α by Hadzic, Ermina, To, Bethia, Pest, Michael A., Qin, Ling, Beier, Frank

“…Osteoarthritis (OA) is a whole joint disorder with no disease modifying treatment currently available. The Epidermal Growth Factor Receptor (EGFR) signaling…”
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Reduction in Disease Progression by Inhibition of Transforming Growth Factor α–CCL2 Signaling in Experimental Posttraumatic Osteoarthritis by Appleton, C. Thomas G., Usmani, Shirine E., Pest, Michael A., Pitelka, Vasek, Mort, John S., Beier, Frank

“…Objective Transforming growth factor α (TGFα) is increased in osteoarthritic (OA) cartilage in rats and humans and modifies chondrocyte phenotype. CCL2 is…”
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Reduction in Disease Progression by Inhibition of Transforming Growth Factor [alpha]-CCL2 Signaling in Experimental Posttraumatic Osteoarthritis by Appleton, C Thomas G, Usmani, Shirine E, Pest, Michael A, Pitelka, Vasek, Mort, John S, Beier, Frank

“…Objective Transforming growth factor [alpha] (TGF[alpha]) is increased in osteoarthritic (OA) cartilage in rats and humans and modifies chondrocyte phenotype…”
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Context-specific protection of TGFα null mice from osteoarthritis by Usmani, Shirine E., Ulici, Veronica, Pest, Michael A., Hill, Tracy L., Welch, Ian D., Beier, Frank

“…Transforming growth factor alpha (TGFα) is a growth factor involved in osteoarthritis (OA). TGFα induces an OA-like phenotype in articular chondrocytes, by…”
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Developmental biology: Is there such a thing as a cartilage-specific knockout mouse? by Pest, Michael A, Beier, Frank

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Repeated Exposure to High‐Frequency Low‐Amplitude Vibration Induces Degeneration of Murine Intervertebral Discs and Knee Joints by McCann, Matthew R., Patel, Priya, Pest, Michael A., Ratneswaran, Anusha, Lalli, Gurkeet, Beaucage, Kim L., Backler, Garth B., Kamphuis, Meg P., Esmail, Ziana, Lee, Jimin, Barbalinardo, Michael, Mort, John S., Holdsworth, David W., Beier, Frank, Dixon, S. Jeffrey, Séguin, Cheryle A.

“…Objective High‐frequency, low‐amplitude whole‐body vibration (WBV) is being used to treat a range of musculoskeletal disorders; however, there is surprisingly…”
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Is there such a thing as a cartilage-specific knockout mouse? by Pest, Michael A., Beier, Frank

“…The strongest evidence yet that hypertrophic chondrocytes can turn into osteoblasts could affect not only our understanding of skeletal development, but also…”
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Whole-body vibration of mice induces articular cartilage degeneration with minimal changes in subchondral bone by McCann, Matthew R, Yeung, Cynthia, Pest, Michael A, Ratneswaran, Anusha, Pollmann, Steven I, Holdsworth, David W, Beier, Frank, Dixon, S. Jeffrey, Séguin, Cheryle A., Dr

“…Summary Objective Low-amplitude, high-frequency whole-body vibration (WBV) has been adopted for the treatment of musculoskeletal diseases including…”
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C57BL/6 mice are resistant to joint degeneration induced by whole-body vibration by Kerr, Geoffrey J, McCann, Matthew R, Branch, Jennifer K, Ratneswaran, Anusha, Pest, Michael A, Holdsworth, David W, Beier, Frank, Dixon, S. Jeffrey, Séguin, Cheryle A

“…Summary Objective Whole-body vibration (WBV) platforms are commercially available devices that are used clinically as potential treatments for numerous…”
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