Search Results - "Pessah, Neta"

Bioactivation of carbamate-based 20( S)-camptothecin prodrugs by Pessah, Neta, Reznik, Mika, Shamis, Marina, Yantiri, Ferda, Xin, Hong, Bowdish, Katherine, Shomron, Noam, Ast, Gil, Shabat, Doron

“…Two new prodrugs of CPT were synthesized, based on carbamate linkages between the 20-hydroxy group of CPT and a linker designed to be enzymatically removed by…”
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Self-Immolative Dendrimers by Amir, Roey J., Pessah, Neta, Shamis, Marina, Shabat, Doron

“…Docking the tails: The triggering of a single cleavage at the core of a new class of dendrimers (see, for example, the second generation dendron) results in a…”
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α-Fluoro-2,2,3,3-Tetramethylcyclopropanecarboxamide, a Novel Potent Anticonvulsant Derivative of a Cyclic Analogue of Valproic Acid by Pessah, Neta, Bialer, Meir, Wlodarczyk, Bogdan, Finnell, Richard H, Yagen, Boris

“…2,2,3,3-Tetramethylcyclopropanecarboxylic acid (TMCA, 4) is a cyclic analogue of the antiepileptic drug (AED) valproic acid (VPA) (1). α-F, α-Cl, α-Br, and…”
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Optimization of Liganded Polyethylenimine Polyethylene Glycol Vector for Nucleic Acid Delivery by Joubran, Salim, Zigler, Maya, Pessah, Neta, Klein, Shoshana, Shir, Alexei, Edinger, Nufar, Sagalov, Anna, Razvag, Yair, Reches, Meital, Levitzki, Alexander

“…The delivery of nucleic acids into cells is an attractive approach for cancer therapy. Polyethylenimine (PEI) is among the most efficient nonviral carriers…”
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Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3‐tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acid by Pessah, Neta, Kaufmann, Dan, Yagen, Boris, Hen, Naama, Wlodarczyk, Bogdan, Finnell, Richard H., Bialer, Meir

“…Summary Purpose:  α‐Fluoro‐2,2,3,3‐tetramethylcyclopropanecarboxamide (α‐F‐TMCD) and α‐Cl‐TMCD, are α‐halo derivatives of TMCD, the corresponding amide of a…”
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A Chemical Adaptor System Designed To Link a Tumor-Targeting Device with a Prodrug and an Enzymatic Trigger by Gopin, Anna, Pessah, Neta, Shamis, Marina, Rader, Christoph, Shabat, Doron

“…Targeting tumors can be achieved by using a novel chemical adaptor system (see picture) comprising, for example, the anticancer drug epotoside, an…”
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Design and pharmacological activity of glycinamide and N -methoxy amide derivatives of analogs and constitutional isomers of valproic acid by Pessah, Neta, Yagen, Boris, Hen, Naama, Shimshoni, Jakob A, Wlodarczyk, Bogdan, Finnell, Richard H, Bialer, Meir

“…Abstract A series of glycinamide conjugates and N -methoxy amide derivatives of valproic acid (VPA) analogs and constitutional isomers were synthesized and…”
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Chemical Adaptor Systems by Shabat, Doron, Amir, Roey J., Gopin, Anna, Pessah, Neta, Shamis, Marina

“…“Chemical adaptor systems” are molecules used to link different functionalities, based on unique reactivity that allows controlled fragmentation. Two different…”
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Anticonvulsant profile and teratogenicity of 3,3‐dimethylbutanoylurea: A potential for a second generation drug to valproic acid by Shimshoni, Jakob Avi, Yagen, Boris, Pessah, Neta, Wlodarczyk, Bogdan, Finnell, Richard H., Bialer, Meir

“…Summary Purpose: The purpose of this study was to evaluate the anticonvulsant activity and teratogenic potential of branched aliphatic acylureas represented by…”
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Cover Picture: "Cascade-Release Dendrimers" Liberate All End Groups upon a Single Triggering Event in the Dendritic Core / Self-Immolative Dendrimers (Angew. Chem. Int. Ed. 37/2003) by de Groot, Franciscus M. H., Albrecht, Carsten, Koekkoek, Ralph, Beusker, Patrick H., Scheeren, Hans W., Amir, Roey J., Pessah, Neta, Shamis, Marina, Shabat, Doron

“…Cascade‐release dendrimers or self‐immolative dendrimers, as shown in the cover picture, spontaneously release all the end‐group molecules following a single…”
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Self-Immolative Dendrimers by Amir, Roey J., Pessah, Neta, Shamis, Marina, Shabat, Doron

“…Zersetzung auf Kommando: Die Spaltung einer einzigen Bindung im Zentrum einer neuen Klasse von Dendrimeren (das Bild zeigt ein Dendron der zweiten Generation)…”
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A Chemical Adaptor System Designed To Link a Tumor-Targeting Device with a Prodrug and an Enzymatic Trigger by Gopin, Anna, Pessah, Neta, Shamis, Marina, Rader, Christoph, Shabat, Doron

“…Das Bekämpfen von Tumoren kann mithilfe eines neuartigen chemischen Adaptersystems (siehe Bild) durchgeführt werden. Darin sind beispielsweise der…”
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Titelbild: “Cascade‐Release Dendrimers” Liberate All End Groups upon a Single Triggering Event in the Dendritic Core / Self‐Immolative Dendrimers (Angew. Chem. 37/2003) by de Groot, Franciscus M. H., Albrecht, Carsten, Koekkoek, Ralph, Beusker, Patrick H., Scheeren, Hans W., Amir, Roey J., Pessah, Neta, Shamis, Marina, Shabat, Doron

“…Dendrimere die sich selbst “opfern”, um aus ihren Endgruppen in einer selbstzerstörerischen Kaskadenreaktion funktionelle Moleküle freizusetzen, zeigt das…”
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Self‐Immolative Dendrimers by Amir, Roey J., Pessah, Neta, Shamis, Marina, Shabat, Doron

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A Chemical Adaptor System Designed To Link a Tumor‐Targeting Device with a Prodrug and an Enzymatic Trigger by Gopin, Anna, Pessah, Neta, Shamis, Marina, Rader, Christoph, Shabat, Doron

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Titelbild: "Cascade-Release Dendrimers" Liberate All End Groups upon a Single Triggering Event in the Dendritic Core / Self-Immolative Dendrimers (Angew. Chem. 37/2003) by de Groot, Franciscus M. H., Albrecht, Carsten, Koekkoek, Ralph, Beusker, Patrick H., Scheeren, Hans W., Amir, Roey J., Pessah, Neta, Shamis, Marina, Shabat, Doron

“…Dendrimere die sich selbst “opfern”, um aus ihren Endgruppen in einer selbstzerstörerischen Kaskadenreaktion funktionelle Moleküle freizusetzen, zeigt das…”
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