Search Results - "Pesola, M."

Neuronal miR-9 promotes HSV-1 epigenetic silencing and latency by repressing Oct-1 and Onecut family genes by Deng, Yue, Lin, Yuqi, Chen, Siyu, Xiang, Yuhang, Chen, Hongjia, Qi, Shuyuan, Oh, Hyung Suk, Das, Biswajit, Komazin-Meredith, Gloria, Pesola, Jean M., Knipe, David M., Coen, Donald M., Pan, Dongli

“…Herpes simplex virus 1 (HSV-1) latent infection entails repression of viral lytic genes in neurons. By functional screening using luciferase-expressing HSV-1,…”
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A Neuron-Specific Host MicroRNA Targets Herpes Simplex Virus-1 ICP0 Expression and Promotes Latency by Pan, Dongli, Flores, Omar, Umbach, Jennifer L., Pesola, Jean M., Bentley, Peris, Rosato, Pamela C., Leib, David A., Cullen, Bryan R., Coen, Donald M.

“…After infecting peripheral sites, herpes simplex virus (HSV) invades the nervous system and initiates latent infection in sensory neurons. Establishment and…”
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Human cytomegalovirus UL97 phosphorylates the viral nuclear egress complex by Sharma, Mayuri, Bender, Brian J, Kamil, Jeremy P, Lye, Ming F, Pesola, Jean M, Reim, Natalia I, Hogle, James M, Coen, Donald M

“…Herpesvirus nucleocapsids exit the host cell nucleus in an unusual process known as nuclear egress. The human cytomegalovirus (HCMV) UL97 protein kinase is…”
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A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex by Chen, Han, Lye, Ming F, Gorgulla, Christoph, Ficarro, Scott B, Cuny, Gregory D, Scott, David A, Wu, Fan, Rothlauf, Paul W, Wang, Xiaoou, Fernandez, Rosio, Pesola, Jean M, Draga, Sorin, Marto, Jarrod A, Hogle, James M, Arthanari, Haribabu, Coen, Donald M

“…Human cytomegalovirus (HCMV) is an important pathogen for which new antiviral drugs are needed. HCMV, like other herpesviruses, encodes a nuclear egress…”
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CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection by Lee, Jennifer S, Raja, Priya, Pan, Dongli, Pesola, Jean M, Coen, Donald M, Knipe, David M

“…Herpes simplex virus 1 (HSV-1) establishes latent infection in neurons via a variety of epigenetic mechanisms that silence its genome. The cellular…”
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Human Cytomegalovirus Nuclear Egress Complex Subunit, UL53, Associates with Capsids and Myosin Va, but Is Not Important for Capsid Localization towards the Nuclear Periphery by Wilkie, Adrian R, Sharma, Mayuri, Coughlin, Margaret, Pesola, Jean M, Ericsson, Maria, Lawler, Jessica L, Fernandez, Rosio, Coen, Donald M

“…After herpesviruses encapsidate their genomes in replication compartments (RCs) within the nuclear interior, capsids migrate to the inner nuclear membrane…”
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Expression of Herpes Simplex Virus 1 MicroRNAs in Cell Culture Models of Quiescent and Latent Infection by Jurak, Igor, Hackenberg, Michael, Kim, Ju Youn, Pesola, Jean M, Everett, Roger D, Preston, Chris M, Wilson, Angus C, Coen, Donald M

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A Herpesviral Lytic Protein Regulates the Structure of Latent Viral Chromatin by Raja, Priya, Lee, Jennifer S, Pan, Dongli, Pesola, Jean M, Coen, Donald M, Knipe, David M

“…Latent infections by viruses usually involve minimizing viral protein expression so that the host immune system cannot recognize the infected cell through the…”
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Roles of conserved residues within the pre-NH2-terminal domain of herpes simplex virus 1 DNA polymerase in replication and latency in mice by Terrell, Shariya L, Pesola, Jean M, Coen, Donald M

“…The catalytic subunit of the herpes simplex virus 1 DNA polymerase (HSV-1 Pol) is essential for viral DNA synthesis and production of infectious virus in cell…”
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Inactivation of Retinoblastoma Protein Does Not Overcome the Requirement for Human Cytomegalovirus UL97 in Lamina Disruption and Nuclear Egress by Reim, Natalia I, Kamil, Jeremy P, Wang, Depeng, Lin, Alison, Sharma, Mayuri, Ericsson, Maria, Pesola, Jean M, Golan, David E, Coen, Donald M

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High-throughput real-time quantitative reverse transcription PCR by Bookout, Angie L, Cummins, Carolyn L, Mangelsdorf, David J, Pesola, Jean M, Kramer, Martha F

“…Extensive detail on the application of the real-time quantitative polymerase chain reaction (QPCR) for the analysis of gene expression is provided in this…”
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A Mutation Deleting Sequences Encoding the Amino Terminus of Human Cytomegalovirus UL84 Impairs Interaction with UL44 and Capsid Localization by STRANG, Blair L, BENDER, Brian J, SHARMA, Mayuri, PESOLA, Jean M, SANDERS, Rebecca L, SPECTOR, Deborah H, COEN, Donald M

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Herpes Simplex Virus 1 Immediate-Early and Early Gene Expression during Reactivation from Latency under Conditions That Prevent Infectious Virus Production by PESOLA, Jean M, JIA ZHU, KNIPE, David M, COEN, Donald M

“…Author's Correction ( vol. 80 , p. 6196 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike…”
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The Effect Of Different Bearing Surfaces On Metal Ion Levels In Urine Following 28 Mm Metal-On-Metal And 28 Mm Metal-On-Polyethylene Total Hip Arthroplasty by Tiusanen, H., Mäkelä, K., Kiilunen, M., Sarantsin, P., Sipola, E., Pesola, M.

“…Background and Aims: Recent advancements in manufacturing technology have enabled more precise tolerances and surface finishes using metal-on-metal bearing…”
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Mutations Inactivating Herpes Simplex Virus 1 MicroRNA miR-H2 Do Not Detectably Increase ICP0 Gene Expression in Infected Cultured Cells or Mouse Trigeminal Ganglia by Pan, Dongli, Pesola, Jean M, Li, Gang, McCarron, Seamus, Coen, Donald M

“…Herpes simplex virus 1 (HSV-1) latency entails the repression of productive ("lytic") gene expression. An attractive hypothesis to explain some of this…”
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A Role for Myosin Va in Human Cytomegalovirus Nuclear Egress by Wilkie, Adrian R, Sharma, Mayuri, Pesola, Jean M, Ericsson, Maria, Fernandez, Rosio, Coen, Donald M

“…Herpesviruses replicate and package their genomes into capsids in replication compartments within the nuclear interior. Capsids then move to the inner nuclear…”
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Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity by Patel, Chaya D, Backes, Iara M, Taylor, Sean A, Jiang, Yike, Marchant, Arnaud, Pesola, Jean M, Coen, Donald M, Knipe, David M, Ackerman, Margaret E, Leib, David A

“…Neonatal herpes simplex virus (nHSV) infections cause devastating morbidity and mortality in infants. Most nHSV cases are associated with primary maternal…”
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Aggregation kinetics of thermal double donors in silicon by Lee, Y J, von Boehm, J, Pesola, M, Nieminen, R M

“…A general kinetic model based on accurate density-functional-theoretic total-energy calculations is introduced to describe the aggregation kinetics of…”
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Neuronal IFN signaling is dispensable for the establishment of HSV-1 latency by Rosato, Pamela C, Katzenell, Sarah, Pesola, Jean M, North, Brian, Coen, Donald M, Leib, David A

“…Abstract IFN responses control acute HSV infection, but their role in regulating HSV latency is poorly understood. To address this we used mice lacking IFN…”
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Herpes simplex virus 1 microRNAs expressed abundantly during latent infection are not essential for latency in mouse trigeminal ganglia by Kramer, Martha F, Jurak, Igor, Pesola, Jean M, Boissel, Sandrine, Knipe, David M, Coen, Donald M

“…Abstract Several herpes simplex virus 1 microRNAs are encoded within or near the latency associated transcript ( LAT ) locus, and are expressed abundantly…”
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