Search Results - "Peskar, Bernhard A."

Anti-inflammatory effects of aspirin and sodium salicylate by Amann, Rainer, Peskar, Bernhard A

“…Aspirin (acetylsalicylic acid) is one of the most widely used drugs worldwide. It acetylates cyclooxygenases thereby irreversibly blocking the conversion of…”
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Endothelial E-type prostanoid 4 receptors promote barrier function and inhibit neutrophil trafficking by Konya, Viktoria, PhD, Üllen, Andreas, PhD, Kampitsch, Nora, BSc, Theiler, Anna, BSc, Philipose, Sonia, PhD, Parzmair, Gerald P., BSc, Marsche, Gunther, PhD, Peskar, Bernhard A., MD, Schuligoi, Rufina, PhD, Sattler, Wolfgang, PhD, Heinemann, Akos, MD

“…Background Increased vascular permeability is a fundamental characteristic of inflammation. Substances that are released during inflammation, such as…”
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Prostaglandin E2 Inhibits Eosinophil Trafficking through E-Prostanoid 2 Receptors by Sturm, Eva M, Schratl, Petra, Schuligoi, Rufina, Konya, Viktoria, Sturm, Gunter J, Lippe, Irmgard Th, Peskar, Bernhard A, Heinemann, Akos

“…The accumulation of eosinophils in lung tissue is a hallmark of asthma, and it is believed that eosinophils play a crucial pathogenic role in allergic…”
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CRTH2 and D-type prostanoid receptor antagonists as novel therapeutic agents for inflammatory diseases by Schuligoi, Rufina, Sturm, Eva, Luschnig, Petra, Konya, Viktoria, Philipose, Sonia, Sedej, Miriam, Waldhoer, Maria, Peskar, Bernhard A, Heinemann, Akos

“…Accumulation of type 2 T helper (Th2) lymphocytes and eosinophils is a hallmark of bronchial asthma and other allergic diseases, and it is believed that these…”
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EP4 receptor stimulation down-regulates human eosinophil function by Luschnig-Schratl, Petra, Sturm, Eva M., Konya, Viktoria, Philipose, Sonia, Marsche, Gunther, Fröhlich, Eleonore, Samberger, Claudia, Lang-Loidolt, Doris, Gattenlöhner, Stefan, Lippe, Irmgard Th, Peskar, Bernhard A., Schuligoi, Rufina, Heinemann, Akos

“…Accumulation of eosinophils in tissue is a hallmark of allergic inflammation. Here we observed that a selective agonist of the PGE 2 receptor EP4, ONO AE1-329,…”
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The Role of the Prostaglandin D2 Receptor, DP, in Eosinophil Trafficking by Schratl, Petra, Royer, Julia F, Kostenis, Evi, Ulven, Trond, Sturm, Eva M, Waldhoer, Maria, Hoefler, Gerald, Schuligoi, Rufina, Lippe, Irmgard Th, Peskar, Bernhard A, Heinemann, Akos

“…Prostaglandin (PG) D2 is a major mast cell product that acts via two receptors, the D-type prostanoid (DP) and the chemoattractant receptor-homologous molecule…”
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Laropiprant attenuates EP3 and TP prostanoid receptor-mediated thrombus formation by Philipose, Sonia, Konya, Viktoria, Lazarevic, Mirjana, Pasterk, Lisa M, Marsche, Gunther, Frank, Sasa, Peskar, Bernhard A, Heinemann, Akos, Schuligoi, Rufina

“…The use of the lipid lowering agent niacin is hampered by a frequent flush response which is largely mediated by prostaglandin (PG) D(2). Therefore,…”
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Role of ATP-sensitive potassium channels in prostaglandin-mediated gastroprotection in the rat by Peskar, Brigitta M, Ehrlich, Karlheinz, Peskar, Bernhard A

“…This study compares the involvement of ATP-sensitive potassium (K(ATP)) channels and prostaglandins in various forms of gastroprotection in the rat…”
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11-Dehydro-thromboxane B2, a Stable Thromboxane Metabolite, Is a Full Agonist of Chemoattractant Receptor-homologous Molecule Expressed on TH2 Cells (CRTH2) in Human Eosinophils and Basophils by Böhm, Eva, Sturm, Gunter J., Weiglhofer, Iris, Sandig, Hilary, Shichijo, Michitaka, McNamee, Anne, Pease, James E., Kollroser, Manfred, Peskar, Bernhard A., Heinemann, Akos

“…Thromboxane (TX) A2, a cyclooxygenase-derived mediator involved in allergic responses, is rapidly converted in vivo to a stable metabolite, 11-dehydro-TXB2,…”
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Hierarchy of eosinophil chemoattractants: role of p38 mitogen‐activated protein kinase by Schratl, Petra, Sturm, Eva M., Royer, Julia F., Sturm, Gunter J., Lippe, Irmgard T., Peskar, Bernhard A., Heinemann, Akos

“…Several chemoattractants can regulate the recruitment of eosinophils to sites of inflammation, but the hierarchy among them is unknown. We observed here that…”
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Prostaglandin H2 induces the migration of human eosinophils through the chemoattractant receptor homologous molecule of Th2 cells, CRTH2 by Schuligoi, Rufina, Sedej, Miriam, Waldhoer, Maria, Vukoja, Anela, Sturm, Eva M., Lippe, Irmgard T., Peskar, Bernhard A., Heinemann, Akos

“…The major mast cell product PGD2 is released during the allergic response and stimulates the chemotaxis of eosinophils, basophils, and Th2‐type T lymphocytes…”
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Sequential induction of prostaglandin E and D synthases in inflammation by Schuligoi, Rufina, Grill, Magdalena, Heinemann, Akos, Peskar, Bernhard A., Amann, Rainer

“…Enhanced biosynthesis of prostaglandin (PG)D 2 and subsequent formation of 15-deoxy-Δ 12,14-PGJ 2 has been suggested to contribute to resolution of…”
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Stem cell factor stimulates the chemotaxis, integrin upregulation, and survival of human basophils by Heinemann, Akos, Sturm, Gunter J., Ofner, Martina, Sturm, Eva M., Weller, Charlotte, Peskar, Bernhard A., Hartnell, Adele

“…Little is known about the mechanisms that regulate the selective recruitment of basophils to sites of allergic inflammation. Here we examine the role of stem…”
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The Prostaglandin E2 Receptor EP4 Is Expressed by Human Platelets and Potently Inhibits Platelet Aggregation and Thrombus Formation by Philipose, Sonia, Konya, Viktoria, Sreckovic, Ivana, Marsche, Gunther, Lippe, Irmgard T, Peskar, Bernhard A, Heinemann, Akos, Schuligoi, Rufina

“…OBJECTIVE—Low concentrations of prostaglandin (PG) E2 enhance platelet aggregation, whereas high concentrations inhibit it. The effects of PGE2 are mediated…”
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PGD2 metabolism in plasma: kinetics and relationship with bioactivity on DP1 and CRTH2 receptors by Schuligoi, Rufina, Schmidt, Ronald, Geisslinger, Gerd, Kollroser, Manfred, Peskar, Bernhard A, Heinemann, Akos

“…Prostaglandin (PG)D(2), an important mediator in allergic diseases, is rapidly transformed in plasma to active metabolites that bind and activate two distinct…”
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Role of cyclooxygenase-1 and -2, phospholipase C, and protein kinase C in prostaglandin-mediated gastroprotection by Peskar, Brigitta M, Sawka, Nadia, Ehrlich, Karlheinz, Peskar, Bernhard A

“…Oral administration of the nonselective cyclooxygenase (COX) inhibitor indomethacin (20 mg/kg), the COX-1 inhibitor…”
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Effect of endotoxin treatment on the expression and localization of spinal cyclooxygenase, prostaglandin synthases, and PGD₂ receptors by Grill, Magdalena, Heinemann, Akos, Hoefler, Gerald, Peskar, Bernhard A, Schuligoi, Rufina

“…Systemic inflammation leads to increased expression of spinal cyclooxygenase (COX)-2 and to a subsequent increase of prostaglandin (PG) biosynthesis, which…”
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Interaction of eosinophils with endothelial cells is modulated by prostaglandin EP4 receptors by Konya, Viktoria, Philipose, Sonia, Bálint, Zoltán, Olschewski, Andrea, Marsche, Gunther, Sturm, Eva M., Schicho, Rudolf, Peskar, Bernhard A., Schuligoi, Rufina, Heinemann, Akos

“…Eosinophil extravasation across the endothelium is a key feature of allergic inflammation. Here, we investigated the role of PGE2 and its receptor, E‐type…”
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Endothelium-derived prostaglandin I2 controls the migration of eosinophils by Konya, Viktoria, MSc, Sturm, Eva M., PhD, Schratl, Petra, PhD, Beubler, Eckhard, PhD, Marsche, Gunther, PhD, Schuligoi, Rufina, PhD, Lippe, Irmgard Th., PhD, Peskar, Bernhard A., MD, Heinemann, Akos, MD

“…Background Enhanced eosinophil migration from the blood into the tissue is a hallmark of allergic diseases. Prostaglandin (PG) I2 is the major prostanoid…”
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Muscular Side Effects of Statins by Sinzinger, Helmut, Wolfram, Roswitha, Peskar, Bernhard A

“…Lipid lowering has been shown to be effective in preventing primary and recurrent cardiovascular events and to save life. Statins almost exclusively used for…”
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