Search Results - "Peshenko, Igor V."

A G86R mutation in the calcium-sensor protein GCAP1 alters regulation of retinal guanylyl cyclase and causes dominant cone-rod degeneration by Peshenko, Igor V., Cideciyan, Artur V., Sumaroka, Alexander, Olshevskaya, Elena V., Scholten, Alexander, Abbas, Seher, Koch, Karl-Wilhelm, Jacobson, Samuel G., Dizhoor, Alexander M.

“…The guanylyl cyclase-activating protein, GCAP1, activates photoreceptor membrane guanylyl cyclase (RetGC) in the light, when free Ca2+ concentrations decline,…”
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cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function by Xu, Jianhua, Morris, Lynsie, Thapa, Arjun, Ma, Hongwei, Michalakis, Stylianos, Biel, Martin, Baehr, Wolfgang, Peshenko, Igor V, Dizhoor, Alexander M, Ding, Xi-Qin

“…Photoreceptor cyclic nucleotide-gated (CNG) channels regulate Ca(2+) influx in rod and cone photoreceptors. cGMP, the native ligand of the photoreceptor CNG…”
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Structure of Guanylyl Cyclase Activator Protein 1 (GCAP1) Mutant V77E in a Ca2+-free/Mg2+-bound Activator State by Lim, Sunghyuk, Peshenko, Igor V., Olshevskaya, Elena V., Dizhoor, Alexander M., Ames, James B.

“…GCAP1, a member of the neuronal calcium sensor subclass of the calmodulin superfamily, confers Ca2+-sensitive activation of retinal guanylyl cyclase 1…”
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Mg²⁺/Ca²⁺ cation binding cycle of guanylyl cyclase activating proteins (GCAPs): role in regulation of photoreceptor guanylyl cyclase by Dizhoor, Alexander M, Olshevskaya, Elena V, Peshenko, Igor V

“…Photon absorption by photoreceptors activates hydrolysis of cGMP, which shuts down cGMP-gated channels and decreases free Ca²⁺ concentrations in outer segment…”
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Enzymatic Properties and Regulation of the Native Isozymes of Retinal Membrane Guanylyl Cyclase (RetGC) from Mouse Photoreceptors by Peshenko, Igor V, Olshevskaya, Elena V, Savchenko, Andrey B, Karan, Sukanya, Palczewski, Krzysztof, Baehr, Wolfgang, Dizhoor, Alexander M

“…Mouse photoreceptor function and survival critically depend on Ca2+-regulated retinal membrane guanylyl cyclase (RetGC), comprised of two isozymes, RetGC1 and…”
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Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice by Makino, Clint L, Wen, Xiao-Hong, Olshevskaya, Elena V, Peshenko, Igor V, Savchenko, Andrey B, Dizhoor, Alexander M

“…Regulation of cGMP synthesis by retinal membrane guanylyl cyclase isozymes (RetGC1 and RetGC2) in rod and cone photoreceptors by calcium-sensitive guanylyl…”
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Structural insights for activation of retinal guanylate cyclase by GCAP1 by Lim, Sunghyuk, Peshenko, Igor V, Dizhoor, Alexander M, Ames, James B

“…Guanylyl cyclase activating protein 1 (GCAP1), a member of the neuronal calcium sensor (NCS) subclass of the calmodulin superfamily, confers Ca(2+)-sensitive…”
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Safety and improved efficacy signals following gene therapy in childhood blindness caused by GUCY2D mutations by Jacobson, Samuel G., Cideciyan, Artur V., Ho, Allen C., Peshenko, Igor V., Garafalo, Alexandra V., Roman, Alejandro J., Sumaroka, Alexander, Wu, Vivian, Krishnan, Arun K., Sheplock, Rebecca, Boye, Sanford L., Cheang, Bee-Lin, Davidson, Vanessa, O'Riordan, Catherine R., Dizhoor, Alexander M., Boye, Shannon E.

“…A first-in-human clinical trial of gene therapy in Leber congenital amaurosis due to mutations in the GUCY2D gene is underway, and early results are…”
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Night vision restored in days after decades of congenital blindness by Jacobson, Samuel G., Cideciyan, Artur V., Ho, Allen C., Roman, Alejandro J., Wu, Vivian, Garafalo, Alexandra V., Sumaroka, Alexander, Krishnan, Arun K., Swider, Malgorzata, Mascio, Abraham A., Kay, Christine N., Yoon, Dan, Fujita, Kenji P., Boye, Sanford L., Peshenko, Igor V., Dizhoor, Alexander M., Boye, Shannon E.

“…Signaling of vision to the brain starts with the retinal phototransduction cascade which converts visible light from the environment into chemical changes…”
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Oxidation of active center cysteine of bovine 1-Cys peroxiredoxin to the cysteine sulfenic acid form by peroxide and peroxynitrite by Peshenko, Igor V, Shichi, Hitoshi

“…Peroxiredoxins are antioxidant enzymes whose peroxidase activity depends on a redox-sensitive cysteine residue at the active center. In this study we…”
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Modulation of Phosphodiesterase6 Turnoff during Background Illumination in Mouse Rod Photoreceptors by Woodruff, Michael L, Janisch, Kerstin M, Peshenko, Igor V, Dizhoor, Alexander M, Tsang, Stephen H, Fain, Gordon L

“…In rod photoreceptors of wild-type mice, background light produces an acceleration of the decay of responses to brief flashes, accompanied by a decrease in the…”
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Regulation of retinal membrane guanylyl cyclase (RetGC) by negative calcium feedback and RD3 protein by Dizhoor, Alexander M., Peshenko, Igor V.

“…This article presents a brief overview of the main biochemical and cellular processes involved in regulation of cyclic GMP production in photoreceptors. The…”
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Two clusters of surface-exposed amino acid residues enable high-affinity binding of retinal degeneration-3 (RD3) protein to retinal guanylyl cyclase by Peshenko, Igor V., Dizhoor, Alexander M.

“…Retinal degeneration-3 (RD3) protein protects photoreceptors from degeneration by preventing retinal guanylyl cyclase (RetGC) activation via calcium-sensing…”
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GUCY2D mutations in retinal guanylyl cyclase 1 provide biochemical reasons for dominant cone–rod dystrophy but not for stationary night blindness by Peshenko, Igor V., Olshevskaya, Elena V., Dizhoor, Alexander M.

“…Mutations in the GUCY2D gene coding for the dimeric human retinal membrane guanylyl cyclase (RetGC) isozyme RetGC1 cause various forms of blindness, ranging…”
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Retinal degeneration-3 protein attenuates photoreceptor degeneration in transgenic mice expressing dominant mutation of human retinal guanylyl cyclase by Peshenko, Igor V., Olshevskaya, Elena V., Dizhoor, Alexander M.

“…Different forms of photoreceptor degeneration cause blindness. Retinal degeneration-3 protein (RD3) deficiency in photoreceptors leads to recessive congenital…”
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The Y99C Mutation in Guanylyl Cyclase-Activating Protein 1 Increases Intracellular Ca2+ and Causes Photoreceptor Degeneration in Transgenic Mice by Olshevskaya, Elena V, Calvert, Peter D, Woodruff, Michael L, Peshenko, Igor V, Savchenko, Andrey B, Makino, Clint L, Ho, Ye-Shih, Fain, Gordon L, Dizhoor, Alexander M

“…Guanylyl cyclase-activating proteins (GCAPs) are Ca2+-binding proteins that activate guanylyl cyclase when free Ca2+ concentrations in retinal rods and cones…”
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Correction to: Regulation of retinal membrane guanylyl cyclase (RetGC) by negative calcium feedback and RD3 protein by Dizhoor, Alexander M., Peshenko, Igor V.

“…A Correction to this paper has been published: https://doi.org/10.1007/s00424-021-02547-w…”
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Retinal guanylyl cyclase activation by calcium sensor proteins mediates photoreceptor degeneration in an rd3 mouse model of congenital human blindness by Dizhoor, Alexander M., Olshevskaya, Elena V., Peshenko, Igor V.

“…Deficiency of RD3 (retinal degeneration 3) protein causes recessive blindness and photoreceptor degeneration in humans and in the rd3 mouse strain, but the…”
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Functional Study and Mapping Sites for Interaction with the Target Enzyme in Retinal Degeneration 3 (RD3) Protein by Peshenko, Igor V., Olshevskaya, Elena V., Dizhoor, Alexander M.

“…Retinal degeneration 3 (RD3) protein, essential for normal expression of retinal membrane guanylyl cyclase (RetGC) in photoreceptor cells, blocks RetGC…”
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Retinal degeneration-3 protein promotes photoreceptor survival by suppressing activation of guanylyl cyclase rather than accelerating GMP recycling by Dizhoor, Alexander M., Olshevskaya, Elena V., Peshenko, Igor V.

“…Retinal degeneration-3 protein (RD3) deficiency causes photoreceptor dysfunction and rapid degeneration in the rd3 mouse strain and in human Leber’s congenital…”
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