Search Results - "Pesce, Emanuela"

The outcome of peripheral T-cell lymphoma patients failing first-line therapy: a report from the prospective, International T-Cell Project by Bellei, Monica, Foss, Francine M, Shustov, Andrei R, Horwitz, Steven M, Marcheselli, Luigi, Kim, Won Seog, Cabrera, Maria E, Dlouhy, Ivan, Nagler, Arnon, Advani, Ranjana H, Pesce, Emanuela A, Ko, Young-Hyeh, Martinez, Virginia, Montoto, Silvia, Chiattone, Carlos, Moskowitz, Alison, Spina, Michele, Biasoli, Irene, Manni, Martina, Federico, Massimo

“…This analysis explored factors influencing survival of patients with primary refractory and relapsed peripheral T-cell lymphomas enrolled in the prospective…”
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Incidence and outcomes of rare T cell lymphomas from the T Cell Project: hepatosplenic, enteropathy associated and peripheral gamma delta T cell lymphomas by Foss, Francine M., Horwitz, Steven M., Civallero, Monica, Bellei, Monica, Marcheselli, Luigi, Kim, Won Seog, Cabrera, Maria E., Dlouhy, Ivan, Nagler, Arnon, Advani, Ranjana H., Pesce, Emanuela A., Ko, Young‐Hyeh, Montoto, Silvia, Chiattone, Carlos, Moskowitz, Alison, Spina, Michele, Cesaretti, Marina, Biasoli, Irene, Federico, Massimo

“…The T Cell Project was the largest prospective trial to explore the incidence, treatment patterns, and outcomes for T cell lymphomas. The rare subtypes of T…”
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RNF5, DAB2 and Friends: Novel Drug Targets for Cystic Fibrosis by Sondo, Elvira, Pesce, Emanuela, Tomati, Valeria, Marini, Monica, Pedemonte, Nicoletta

“…Deletion of phenylalanine 508 is the most frequent mutation causing cystic fibrosis. It causes multiple defects: 1) misfolding of the protein causing retention…”
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The L467F-F508del Complex Allele Hampers Pharmacological Rescue of Mutant CFTR by Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Patients: The Value of the Ex Vivo Nasal Epithelial Model to Address Non-Responders to CFTR-Modulating Drugs by Sondo, Elvira, Cresta, Federico, Pastorino, Cristina, Tomati, Valeria, Capurro, Valeria, Pesce, Emanuela, Lena, Mariateresa, Iacomino, Michele, Baffico, Ave Maria, Coviello, Domenico, Bandiera, Tiziano, Zara, Federico, Galietta, Luis J V, Bocciardi, Renata, Castellani, Carlo, Pedemonte, Nicoletta

“…Loss-of-function mutations of the gene cause cystic fibrosis (CF) through a variety of molecular mechanisms involving altered expression, trafficking, and/or…”
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Clinical Consequences and Functional Impact of the Rare S737F CFTR Variant and Its Responsiveness to CFTR Modulators by Terlizzi, Vito, Pesce, Emanuela, Capurro, Valeria, Tomati, Valeria, Lena, Mariateresa, Pastorino, Cristina, Bocciardi, Renata, Zara, Federico, Centrone, Claudia, Taccetti, Giovanni, Castellani, Carlo, Pedemonte, Nicoletta

“…S737F is a Cystic Fibrosis (CF) transmembrane conductance regulator (CFTR) missense variant. The aim of our study was to describe the clinical features of a…”
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Virtual Drug Repositioning as a Tool to Identify Natural Small Molecules That Synergize with Lumacaftor in F508del-CFTR Binding and Rescuing by Fossa, Paola, Uggeri, Matteo, Orro, Alessandro, Urbinati, Chiara, Rondina, Alessandro, Milanesi, Maria, Pedemonte, Nicoletta, Pesce, Emanuela, Padoan, Rita, Ford, Robert C., Meng, Xin, Rusnati, Marco, D’Ursi, Pasqualina

“…Cystic fibrosis is a hereditary disease mainly caused by the deletion of the Phe 508 (F508del) of the cystic fibrosis transmembrane conductance regulator…”
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High-Content Screening Identifies Vanilloids as a Novel Class of Inhibitors of NET Formation by Sondo, Elvira, Bertelli, Roberta, Pesce, Emanuela, Ghiggeri, Gian Marco, Pedemonte, Nicoletta

“…Neutrophils migrate to sites of infection where they phagocytose, degranulate, and/or, in the presence of appropriate stimuli, release decondensed chromatin…”
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GM1 as Adjuvant of Innovative Therapies for Cystic Fibrosis Disease by Mancini, Giulia, Loberto, Nicoletta, Olioso, Debora, Dechecchi, Maria Cristina, Cabrini, Giulio, Mauri, Laura, Bassi, Rosaria, Schiumarini, Domitilla, Chiricozzi, Elena, Lippi, Giuseppe, Pesce, Emanuela, Sonnino, Sandro, Pedemonte, Nicoletta, Tamanini, Anna, Aureli, Massimo

“…Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein is expressed at the apical plasma membrane (PM) of different epithelial cells. The most…”
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Probing Allosteric Hsp70 Inhibitors by Molecular Modelling Studies to Expedite the Development of Novel Combined F508del CFTR Modulators by Sabbadini, Roberto, Pesce, Emanuela, Parodi, Alice, Mustorgi, Eleonora, Bruzzone, Santina, Pedemonte, Nicoletta, Casale, Monica, Millo, Enrico, Cichero, Elena

“…Cystic fibrosis (CF) is caused by different mutations related to the cystic fibrosis transmembrane regulator protein (CFTR), with F508del being the most…”
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Pharmacological rescue of the G85E CFTR variant by preclinical and approved modulators by Tomati, Valeria, Capurro, Valeria, Pesce, Emanuela, Pastorino, Cristina, Sondo, Elvira, Lena, Mariateresa, Borrelli, Anna, Cresta, Federico, Pantano, Stefano, Collini, Francesca, Ripani, Pietro, Terlizzi, Vito, Fevola, Cristina, Costa, Stefano, Lucanto, Maria Cristina, Zara, Federico, Bandiera, Tiziano, Bocciardi, Renata, Castellani, Carlo, Galietta, Luis J. V., Pedemonte, Nicoletta

“…Introduction Cystic Fibrosis (CF) is a genetic disease due to loss-of-function mutations of the CFTR channel. F508del is the most frequent mutation (70% of…”
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Nonpegylated liposomal doxorubicin combination regimen in patients with diffuse large B‐cell lymphoma and cardiac comorbidity. Results of the HEART01 phase II trial conducted by the Fondazione Italiana Linfomi by Luminari, Stefano, Viel, Elda, Ferreri, Andrés José Maria, Zaja, Francesco, Chimienti, Emanuela, Musuraca, Gerardo, Tucci, Alessandra, Balzarotti, Monica, Tani, Monica, Salvi, Francesca, Pesce, Emanuela A., Ferrari, Angela, Liberati, Anna M., Spadea, Antonio, Marino, Dario, Bruno‐Ventre, Maria, Volpetti, Stefano, Bottelli, Chiara, Ravaioli, Elena, Merli, Francesco, Spina, Michele

“…The purpose of this phase 2, multicenter study was to determine the activity and safety of nonpegylated liposomal doxorubicin as part of “R‐COMP” combination…”
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Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation by Tomati, Valeria, Sondo, Elvira, Armirotti, Andrea, Caci, Emanuela, Pesce, Emanuela, Marini, Monica, Gianotti, Ambra, Ju Jeon, Young, Cilli, Michele, Pistorio, Angela, Mastracci, Luca, Ravazzolo, Roberto, Scholte, Bob, Ronai, Ze’ev, Galietta, Luis J. V., Pedemonte, Nicoletta

“…Cystic fibrosis (CF) is caused by mutations in the CFTR chloride channel. Deletion of phenylalanine 508 (F508del), the most frequent CF mutation, impairs CFTR…”
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Distinctive lipid signatures of bronchial epithelial cells associated with cystic fibrosis drugs, including Trikafta by Liessi, Nara, Pesce, Emanuela, Braccia, Clarissa, Bertozzi, Sine Mandrup, Giraudo, Alessandro, Bandiera, Tiziano, Pedemonte, Nicoletta, Armirotti, Andrea

“…In recent years, a number of drugs have been approved for the treatment of cystic fibrosis (CF). Among them, newly released Trikafta, a combination of 3 drugs…”
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Journey on VX-809-Based Hybrid Derivatives towards Drug-like F508del-CFTR Correctors: From Molecular Modeling to Chemical Synthesis and Biological Assays by Parodi, Alice, Righetti, Giada, Pesce, Emanuela, Salis, Annalisa, Tomati, Valeria, Pastorino, Cristina, Tasso, Bruno, Benvenuti, Mirko, Damonte, Gianluca, Pedemonte, Nicoletta, Cichero, Elena, Millo, Enrico

“…Cystic fibrosis (CF) is a genetic disease affecting the lungs and pancreas and causing progressive damage. CF is caused by mutations abolishing the function of…”
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The Autophagy Inhibitor Spautin-1 Antagonizes Rescue of Mutant CFTR Through an Autophagy-Independent and USP13-Mediated Mechanism by Pesce, Emanuela, Sondo, Elvira, Ferrera, Loretta, Tomati, Valeria, Caci, Emanuela, Scudieri, Paolo, Musante, Ilaria, Renda, Mario, Baatallah, Nesrine, Servel, Nathalie, Hinzpeter, Alexandre, di Bernardo, Diego, Pedemonte, Nicoletta, Galietta, Luis J V

“…The mutation F508del, responsible for a majority of cystic fibrosis cases, provokes the instability and misfolding of the CFTR chloride channel…”
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Rituximab plus bendamustine as front-line treatment in frail elderly (>70 years) patients with diffuse large B-cell non-Hodgkin lymphoma: a phase II multicenter study of the Fondazione Italiana Linfomi by Storti, Sergio, Spina, Michele, Pesce, Emanuela Anna, Salvi, Flavia, Merli, Michele, Ruffini, Alessia, Cabras, Giuseppina, Chiappella, Annalisa, Angelucci, Emanuele, Fabbri, Alberto, Liberati, Anna Marina, Tani, Monica, Musuraca, Gerardo, Molinari, Annalia, Petrilli, Maria Pia, Palladino, Carmela, Ciancia, Rosanna, Ferrario, Andrea, Gasbarrino, Cristiana, Monaco, Federico, Fraticelli, Vincenzo, De Vellis, Annalisa, Merli, Francesco, Luminari, Stefano

“…We conducted a phase II study to assess activity and safety profile of bendamustine and rituximab in elderly patients with untreated diffuse large B-cell…”
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Is ZAP70 still a key prognostic factor in early stage chronic lymphocytic leukaemia? Results of the analysis from a prospective multicentre observational study by Morabito, Fortunato, Cutrona, Giovanna, Gentile, Massimo, Fabris, Sonia, Matis, Serena, Vigna, Ernesto, Todoerti, Katia, Colombo, Monica, Recchia, Anna G., Bossio, Sabrina, De Stefano, Laura, Ilariucci, Fiorella, Cortelezzi, Agostino, Consoli, Ugo, Vincelli, Iolanda, Pesce, Emanuela A., Musolino, Caterina, Molica, Stefano, Di Raimondo, Francesco, Neri, Antonino, Ferrarini, Manlio

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Relevance of stereotyped B-cell receptors in the context of the molecular, cytogenetic and clinical features of chronic lymphocytic leukemia by Maura, Francesco, Cutrona, Giovanna, Fabris, Sonia, Colombo, Monica, Tuana, Giacomo, Agnelli, Luca, Matis, Serena, Lionetti, Marta, Gentile, Massimo, Recchia, Anna Grazia, Di Raimondo, Francesco, Musolino, Caterina, Ilariucci, Fiorella, Di Renzo, Nicola, Pesce, Emanuela, Molica, Stefano, Federico, Massimo, Cortelezzi, Agostino, Morabito, Fortunato, Ferrarini, Manlio, Neri, Antonino

“…Highly homologous B-cell receptors, characterized by non-random combinations of immunoglobulin heavy-chain variable (IGHV) genes and heavy-chain…”
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Watchful Waiting in Low–Tumor Burden Follicular Lymphoma in the Rituximab Era: Results of an F2-Study Database by SOLAL-CELIGNY, Philippe, BELLEI, Monica, DECONINCK, Eric, MILPIED, Noel, GORDON, Leo I, FEDERICO, Massimo, MARCHESELLI, Luigi, PESCE, Emanuela Anna, PILERI, Stefano, MCLAUGHLIN, Peter, LUMINARI, Stefano, PRO, Barbara, MONTOTO, Silvia, FERRERI, Andrés J. M

“…Patients with follicular lymphoma (FL) registered in the F2-study and initially managed without treatment were analyzed to describe the presentation and…”
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Chromosome 2p gain in monoclonal B‐cell lymphocytosis and in early stage chronic lymphocytic leukemia by Fabris, Sonia, Mosca, Laura, Cutrona, Giovanna, Lionetti, Marta, Agnelli, Luca, Ciceri, Gabriella, Barbieri, Marzia, Maura, Francesco, Matis, Serena, Colombo, Monica, Gentile, Massimo, Recchia, Anna Grazia, Anna Pesce, Emanuela, Di Raimondo, Francesco, Musolino, Caterina, Gobbi, Marco, Di Renzo, Nicola, Mauro, Francesca Romana, Brugiatelli, Maura, Ilariucci, Fiorella, Lipari, Maria Grazia, Angrilli, Francesco, Consoli, Ugo, Fragasso, Alberto, Molica, Stefano, Festini, Gianluca, Vincelli, Iolanda, Cortelezzi, Agostino, Federico, Massimo, Morabito, Fortunato, Ferrarini, Manlio, Neri, Antonino

“…Recent studies have described chromosome 2p gain as a recurrent lesion in chronic lymphocytic leukemia (CLL). We investigated the 2p gain and its relationship…”
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