Search Results - "Pesce, Amadeo J"
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Age-related changes in plasma coenzyme Q10 concentrations and redox state in apparently healthy children and adults
Published in Clinica chimica acta (01-09-2004)“…Coenzyme Q10 (CoQ) is an endogenous enzyme cofactor, which may provide protective benefits as an antioxidant. Because age-related CoQ changes and deficiency…”
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A chimeric human/murine anticocaine monoclonal antibody inhibits the distribution of cocaine to the brain in mice
Published in The Journal of pharmacology and experimental therapeutics (01-01-2007)“…The predominantly human sequence, high-affinity anticocaine monoclonal antibody (mAb) 2E2 was cleared slowly from mouse blood by a first-order process with an…”
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Observations on the effects of buprenorphine and methadone on illicit drug use
Published in Journal of opioid management (01-05-2024)“…To determine if the agonistic effects of buprenorphine and methadone affect drug use. Quantitative examination of urine drug concentrations of patients treated…”
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A sensitive assay for urinary cocaine metabolite benzoylecgonine shows more positive results and longer half‐lives than those using traditional cut‐offs
Published in Drug testing and analysis (01-08-2017)“…Cocaine is a common drug of abuse. To detect its use, a screening detection concentration for the cocaine metabolite benzoylecgonine is commonly set at…”
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Reference intervals: an update
Published in Clinica Chimica Acta (01-08-2003)“…Reference intervals serve as the basis of laboratory testing and aid the physician in differentiating between the healthy and diseased patient. Standard…”
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Therapeutic monitoring of benzodiazepines in the management of pain: Current limitations of point of care immunoassays suggest testing by mass spectrometry to assure accuracy and improve patient safety
Published in Clinica chimica acta (16-08-2012)“…Concomitant use of opioids and benzodiazepines can result in significant untoward effects. Point of care (POC) urine testing devices are commonly used tools to…”
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Evaluation of High-Resolution Mass Spectrometry for Urine Toxicology Screening in a Pain Management Setting
Published in Journal of analytical toxicology (01-11-2012)“…To evaluate liquid chromatography-high-resolution mass spectrometry (LC-HR-MS) for urine toxicology screening, 29 analytes were quantitated in 152 urine…”
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Relationship between the Concentration of Hydrocodone and its Conversion to Hydromorphone in Chronic Pain Patients Using Urinary Excretion Data
Published in Journal of analytical toxicology (01-05-2012)“…Hydrocodone in combination with acetaminophen is commonly used to control moderate pain and is metabolized by cytochrome P4502D6 to form the active metabolite,…”
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Effect of Outliers and Nonhealthy Individuals on Reference Interval Estimation
Published in Clinical chemistry (Baltimore, Md.) (01-12-2001)“…Improvement in reference interval estimation using a new outlier detection technique, even with a physician-determined healthy sample, is examined. The effect…”
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Ethyl Glucuronide, Ethyl Sulfate, and Ethanol in Urine after Sustained Exposure to an Ethanol-Based Hand Sanitizer
Published in Journal of analytical toxicology (01-03-2011)“…To assess the degree of ethanol absorption and subsequent formation of urinary ethyl glucuronide (EtG) and ethyl sulfate (EtS) following sustained application…”
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Determination of illicit drug cutoff values in a pain patient population
Published in Clinica chimica acta (17-08-2011)“…When properly selected, cutoff levels minimize the reporting of false negative and false positive test results and allow the laboratory to accurately determine…”
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Anomalous observations of hydrocodone in patients on oxycodone
Published in Clinica chimica acta (14-01-2011)“…Urine drug monitoring is used by physicians treating chronic pain patients with opioid therapy. Patients are tested in part to insure that they are not taking…”
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Variability of transdermal fentanyl metabolism and excretion in pain patients
Published in Journal of opioid management (01-01-2010)“…The rising popularity of the fentanyl transdermal patch and the striking number of deaths attributed to its prescribed use have brought attention to the large…”
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Observations on the Metabolism of Morphine to Hydromorphone in Pain Patients
Published in Journal of analytical toxicology (01-05-2012)“…Morphine is one of several opioids used to treat chronic pain. Because of its high abuse potential, urine drug tests can confirm "consistency with prescribed…”
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Interpretation of Pain Management Testing Results Using Case Examples
Published in The journal of applied laboratory medicine (01-01-2018)“…Because of the increasing volume of opiate-related overdoses, clinical testing of urine for drugs and related compounds in pain management clinics has become…”
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Evaluating the Relationship of Methadone Concentrations and EDDP Formation in Chronic Pain Patients
Published in Journal of analytical toxicology (01-05-2012)“…Methadone is used to treat moderate to severe pain in patients not responsive to non-narcotic analgesics and for maintenance treatment of opioid addiction…”
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Ethyl Glucuronide, Ethyl Sulfate, and Ethanol in Urine after Intensive Exposure to High Ethanol Content Mouthwash
Published in Journal of analytical toxicology (01-06-2011)“…To determine the degree of ethanol absorption and the resultant formation and urinary excretion of its conjugated metabolites following intensive use of high…”
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Dilute and Shoot: Analysis of Drugs of Abuse Using Selected Reaction Monitoring for Quantification and Full Scan Product Ion Spectra for Identification
Published in Journal of analytical toxicology (01-03-2012)“…Our objective was to develop a "dilute and shoot" liquid chromatography-tandem mass spectrometry confirmatory procedure that uses full scan product ion spectra…”
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Observations on the Urine Metabolic Ratio of Oxymorphone to Oxycodone in Pain Patients
Published in Journal of analytical toxicology (01-05-2012)“…The object of this study was to evaluate the metabolism of oxycodone to oxymorphone in a pain patient population using a quantitative liquid…”
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