Search Results - "Pesaresi, Maria Grazia"

Cysteine 111 Affects Aggregation and Cytotoxicity of Mutant Cu,Zn-superoxide Dismutase Associated with Familial Amyotrophic Lateral Sclerosis by Cozzolino, Mauro, Amori, Ilaria, Pesaresi, Maria Grazia, Ferri, Alberto, Nencini, Monica, Carrì, Maria Teresa

“…Converging evidence indicates that aberrant aggregation of mutant Cu,Zn-superoxide dismutase (mutSOD1) is strongly implicated in familial amyotrophic lateral…”
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Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity by Ferri, Alberto, Fiorenzo, Paolo, Nencini, Monica, Cozzolino, Mauro, Pesaresi, Maria Grazia, Valle, Cristiana, Sepe, Sara, Moreno, Sandra, Carrì, Maria Teresa

“…Vulnerability of motoneurons in amyotrophic lateral sclerosis (ALS) arises from a combination of several mechanisms, including protein misfolding and…”
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Apaf1 plays a pro-survival role by regulating centrosome morphology and function by Ferraro, Elisabetta, Pesaresi, Maria Grazia, De Zio, Daniela, Cencioni, Maria Teresa, Gortat, Anne, Cozzolino, Mauro, Berghella, Libera, Salvatore, Anna Maria, Oettinghaus, Bjorn, Scorrano, Luca, Pérez-Payà, Enrique, Cecconi, Francesco

“…The apoptotic protease activating factor 1 (Apaf1) is the main component of the apoptosome, and a crucial factor in the mitochondria-dependent death pathway…”
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Mutant SOD1 and mitochondrial damage alter expression and splicing of genes controlling neuritogenesis in models of neurodegeneration by Lenzken, Silvia C, Romeo, Valentina, Zolezzi, Francesca, Cordero, Francesca, Lamorte, Giuseppe, Bonanno, Davide, Biancolini, Donatella, Cozzolino, Mauro, Pesaresi, Maria Grazia, Maracchioni, Alessia, Sanges, Remo, Achsel, Tilmann, Carrì, Maria Teresa, Calogero, Raffaele A, Barabino, Silvia M.L

“…Mitochondrial dysfunction has been implicated in the pathogenesis of a number of neurodegenerative disorders including Parkinson, Alzheimer, and Amyotrophic…”
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The NADPH oxidase pathway is dysregulated by the P2X7 receptor in the SOD1-G93A microglia model of amyotrophic lateral sclerosis by Apolloni, Savina, Parisi, Chiara, Pesaresi, Maria Grazia, Rossi, Simona, Carrì, Maria Teresa, Cozzolino, Mauro, Volonté, Cinzia, D'Ambrosi, Nadia

“…Inflammation and oxidative stress are thought to play determinant roles in the pathogenesis of amyotrophic lateral sclerosis (ALS). Degenerating motor neurons…”
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Amyotrophic lateral sclerosis: new insights into underlying molecular mechanisms and opportunities for therapeutic intervention by Cozzolino, Mauro, Pesaresi, Maria Grazia, Gerbino, Valeria, Grosskreutz, Julian, Carrì, Maria Teresa

“…Recent years have witnessed a renewed interest in the pathogenic mechanisms of amyotrophic lateral sclerosis (ALS), a late-onset progressive degeneration of…”
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Oligomerization of mutant SOD1 in mitochondria of motoneuronal cells drives mitochondrial damage and cell toxicity by Cozzolino, Mauro, Pesaresi, Maria Grazia, Amori, Ilaria, Crosio, Claudia, Ferri, Alberto, Nencini, Monica, Carrì, Maria Teresa

“…Increasing evidence indicates that the accumulation and aggregation of mutant Cu,Zn superoxide dismutase (mutSOD1) in spinal cord mitochondria is implicated in…”
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Mitochondrial redox signalling by p66Shc mediates ALS-like disease through Rac1 inactivation by Pesaresi, Maria Grazia, Amori, Ilaria, Giorgi, Carlotta, Ferri, Alberto, Fiorenzo, Paolo, Gabanella, Francesca, Salvatore, Anna Maria, Giorgio, Marco, Pelicci, Pier Giuseppe, Pinton, Paolo, Carrì, Maria Teresa, Cozzolino, Mauro

“…Increased oxidative stress and mitochondrial damage are among the mechanisms whereby mutant SOD1 (mutSOD1) associated with familial forms of amyotrophic…”
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