Search Results - "Pertwee, Roger"

Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities by Pertwee, Roger G.

“…Human tissues express cannabinoid CB1 and CB2 receptors that can be activated by endogenously released ‘endocannabinoids’ or exogenously administered compounds…”
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Emerging strategies for exploiting cannabinoid receptor agonists as medicines by Pertwee, Roger G

“…Mandarin translation of Medicines that activate cannabinoid CB1 and CB2 receptor are already in the clinic. These are Cesamet® (nabilone), Marinol®…”
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Endocannabinoids and Their Pharmacological Actions by Pertwee, Roger G

“…The endocannabinoid system consists of G protein-coupled cannabinoid CB(1) and CB(2) receptors, of endogenous compounds known as endocannabinoids that can…”
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Are cannabidiol and Δ(9) -tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review by McPartland, John M, Duncan, Marnie, Di Marzo, Vincenzo, Pertwee, Roger G

“…Based upon evidence that the therapeutic properties of Cannabis preparations are not solely dependent upon the presence of Δ(9) -tetrahydrocannabinol (THC),…”
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Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications by Pertwee, Roger G.

“…The endocannabinoid system consists of cannabinoid CB1 and CB2 receptors, of endogenous agonists for these receptors known as ‘endocannabinoids’, and of…”
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Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond by Pertwee, Roger G.

“…ABSTRACT A major finding—that (–)‐trans‐Δ9‐tetrahydrocannabinol (Δ9‐THC) is largely responsible for the psychotropic effects of cannabis—prompted research in…”
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Cannabinoid pharmacology: the first 66 years by Pertwee, Roger G

“…Research into the pharmacology of individual cannabinoids that began in the 1940s, several decades after the presence of a cannabinoid was first detected in…”
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The 90th Birthday of Professor Raphael Mechoulam, a Top Cannabinoid Scientist and Pioneer by Pertwee, Roger G.

“…n/a…”
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Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence by Slivicki, Richard A., Xu, Zhili, Kulkarni, Pushkar M., Pertwee, Roger G., Mackie, Ken, Thakur, Ganesh A., Hohmann, Andrea G.

“…Activation of cannabinoid CB1 receptors suppresses pathological pain but also produces unwanted central side effects. We hypothesized that a positive…”
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Effect of cannabis on glutamate signalling in the brain: A systematic review of human and animal evidence by Colizzi, Marco, McGuire, Philip, Pertwee, Roger G, Bhattacharyya, Sagnik

“…Use of cannabis or delta-9-tetrahydrocannabinol (Δ9-THC), its main psychoactive ingredient, is associated with psychotic symptoms or disorder. However, the…”
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The Plant Derived 3-3′-Diindolylmethane (DIM) Behaves as CB2 Receptor Agonist in Prostate Cancer Cellular Models by Tucci, Paolo, Brown, Iain, Bewick, Guy S., Pertwee, Roger G., Marini, Pietro

“…3-3′-Diindolylmethane (DIM) is a biologically active dimer derived from the endogenous conversion of indole-3-carbinol (I3C), a naturally occurring…”
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Inverse agonism and neutral antagonism at cannabinoid CB1 receptors by Pertwee, Roger G

“…There are at least two types of cannabinoid receptor, CB1 and CB2, both G protein coupled. CB1 receptors are expressed predominantly at nerve terminals and…”
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Phytocannabinoids beyond the Cannabis plant – do they exist? by Gertsch, Jürg, Pertwee, Roger G, Di Marzo, Vincenzo

“…It is intriguing that during human cultural evolution man has detected plant natural products that appear to target key protein receptors of important…”
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M3 Receptor Pathway Stimulates Rapid Transcription of the CB1 Receptor Activation through Calcium Signalling and the CNR1 Gene Promoter by Marini, Pietro, Cowie, Philip, Ayar, Ahmet, Bewick, Guy S, Barrow, John, Pertwee, Roger G, MacKenzie, Alasdair, Tucci, Paolo

“…In this study, we have investigated a possible mechanism that enables CB /M receptor cross-talk, using SH-SY5Y cells as a model system. Our results show that M…”
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Identification of the First Synthetic Allosteric Modulator of the CB 2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief by Gado, Francesca, Di Cesare Mannelli, Lorenzo, Lucarini, Elena, Bertini, Simone, Cappelli, Elena, Digiacomo, Maria, Stevenson, Lesley A, Macchia, Marco, Tuccinardi, Tiziano, Ghelardini, Carla, Pertwee, Roger G, Manera, Clementina

“…The direct activation of cannabinoid receptors (CBRs) results in several beneficial effects; therefore several CBRs ligands have been synthesized and tested in…”
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Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief by Gado, Francesca, Di Cesare Mannelli, Lorenzo, Lucarini, Elena, Bertini, Simone, Cappelli, Elena, Digiacomo, Maria, Stevenson, Lesley A, Macchia, Marco, Tuccinardi, Tiziano, Ghelardini, Carla, Pertwee, Roger G, Manera, Clementina

“…The direct activation of cannabinoid receptors (CBRs) results in several beneficial effects; therefore several CBRs ligands have been synthesized and tested in…”
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Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2+ Levels by Ryan, Duncan, Drysdale, Alison J, Lafourcade, Carlos, Pertwee, Roger G, Platt, Bettina

“…Cannabinoids and the endocannabinoid system have attracted considerable interest for therapeutic applications. Nevertheless, the mechanism of action of one of…”
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Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5‐HT1A receptor‐mediated suppression of nausea and anxiety in rats by Pertwee, Roger G, Rock, Erin M, Guenther, Kelsey, Limebeer, Cheryl L, Stevenson, Lesley A, Haj, Christeene, Smoum, Reem, Parker, Linda A, Mechoulam, Raphael

“…Background and Purpose The aim of this study was to compare the abilities of cannabidiolic acid methyl ester (HU‐580) and cannabidiolic acid (CBDA) to enhance…”
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The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids by Pertwee, Roger G

“…There are at least 2 types of cannabinoid receptor, CB(1) and CB(2), both G protein coupled. CB(1) receptors are expressed predominantly at nerve terminals and…”
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Lipoxin A₄ is an allosteric endocannabinoid that strengthens anandamide-induced CB₁ receptor activation by Pertwee, Roger G.

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