Search Results - "Pertovaara, A"

Oxidative Stress in the Amygdala Contributes to Neuropathic Pain by Sagalajev, B., Wei, H., Chen, Z., Albayrak, I., Koivisto, A., Pertovaara, A.

“…[Display omitted] •Amygdaloid administration of antioxidants or TRPA1 antagonists attenuated nociception and affective pain in neuropathy.•Blocking spinal…”
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Influence of peripheral nerve injury on response properties of locus coeruleus neurons and coeruleospinal antinociception in the rat by Viisanen, H, Pertovaara, A

“…Abstract Noradrenergic locus coeruleus (LC) is involved in pain regulation. We studied whether response properties of LC neurons or coeruleospinal…”
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Bidirectional amygdaloid control of neuropathic hypersensitivity mediated by descending serotonergic pathways acting on spinal 5-HT3 and 5-HT1A receptors by Sagalajev, B., Bourbia, N., Beloushko, E., Wei, H., Pertovaara, A.

“…•Amygdaloid glutamate modulates neuropathic hypersensitivity bidirectionally.•A low glutamate dose increases neuropathic hypersensitivity.•The increase of…”
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Involvement of the periaqueductal gray in the descending antinociceptive effect induced by the central nucleus of amygdala by Bourbia, N, Pertovaara, A

“…Here we studied whether descending control of mechanical nociception by glutamate in the central nucleus of the amygdala (CeA) of healthy control animals is…”
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Neurotransmitters behind pain relief with transcranial magnetic stimulation – positron emission tomography evidence for release of endogenous opioids by Lamusuo, S., Hirvonen, J., Lindholm, P., Martikainen, I. K., Hagelberg, N., Parkkola, R., Taiminen, T., Hietala, J., Helin, S., Virtanen, A., Pertovaara, A., Jääskeläinen, S.K.

“…Background Repetitive transcranial magnetic stimulation (rTMS) at M1/S1 cortex has been shown to alleviate neuropathic pain. Objectives To investigate the…”
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Reduction of BDNF expression in Fmr1 knockout mice worsens cognitive deficits but improves hyperactivity and sensorimotor deficits by Uutela, M., Lindholm, J., Louhivuori, V., Wei, H., Louhivuori, L. M., Pertovaara, A., Åkerman, K., Castrén, E., Castrén, M. L.

“…Fragile X syndrome (FXS) is a common cause of inherited intellectual disability and a well‐characterized form of autism spectrum disorder. As brain‐derived…”
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Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis by Amorim, D., David-Pereira, A., Pertovaara, A., Almeida, A., Pinto-Ribeiro, F.

“…•Mood disorders in monoarthritic rats mimic those in osteoarthritic patients.•Monoarthritic rodents display mechanical hyperalgesia and mood-like…”
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Dose-related effects of memantine on a mismatch negativity-like response in anesthetized rats by Tikhonravov, D, Neuvonen, T, Pertovaara, A, Savioja, K, Ruusuvirta, T, Näätänen, R, Carlson, S

“…Abstract Memantine is a low-affinity NMDA receptor antagonist that is used in the treatment of Alzheimer's disease to alleviate the cognitive symptoms of the…”
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Metabotropic glutamate 5 receptor in the infralimbic cortex contributes to descending pain facilitation in healthy and arthritic animals by David-Pereira, A, Puga, S, Gonçalves, S, Amorim, D, Silva, C, Pertovaara, A, Almeida, A, Pinto-Ribeiro, F

“…Highlights • The infralimbic and prelimbic cortices tonically promote spinal antinociception. • Glutamate in the infralimbic cortex enhances behavioral…”
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Exploration of supraspinal mechanisms in effects of spinal cord stimulation: Role of the locus coeruleus by Song, Z, Ansah, O.B, Meyerson, B.A, Pertovaara, A, Linderoth, B

“…Highlights • SCS increased discharge rate of LC neurons only in SCS responding rats. • Unilateral silencing of the LC with lidocaine failed to influence the…”
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The rostroventromedial medulla is engaged in the effects of spinal cord stimulation in a rodent model of neuropathic pain by Song, Z, Ansah, O.B, Meyerson, B.A, Pertovaara, A, Linderoth, B

“…Highlights • Spinal cord stimulation involves pain controls in the rostroventromedial medulla. • OFF- and 5HT-like cells in the RVM are selectively activated…”
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Differential microglial inflammatory responses in the spinal cord and brain towards the chronic neuropathic pain in rats by Li, Z, Wei, H, Kalso, E, Pertovaara, A, Tian, L

“…Accumulating evidences suggest the involvement of immune cells, especially microglia, in development of the central nervous system and persistence of…”
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Differential microglial inflammatory responses in the spinal cord and brain towards chronic neuropathic pain in rats by Li, Z, Wei, H, Piirainen, S, Chen, Z, Kalso, E, Pertovaara, A, Tian, L

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Pronociceptive effects induced by cutaneous application of a transient receptor potential ankyrin 1 (TRPA1) channel agonist methylglyoxal in diabetic animals: comparison with tunicamycin-induced endoplastic reticulum stress by Viisanen, H, Chapman, H, Wei, H, Lasierra Losada, M, Koivisto, A, Akerman, K E, Pertovaara, A

“…Methylglyoxal (MG) is a reactive carbonyl compound generated in diabetes mellitus. MG is an established transient receptor potential ankyrin 1 (TRPA1) channel…”
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113 MODULATION OF PAIN BY THE STRIATUM, A POTENTIAL CULPRIT IN RLS by Pertovaara, A.

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Spinal transient receptor potential ankyrin 1 channel induces mechanical hypersensitivity, increases cutaneous blood flow, and mediates the pronociceptive action of dynorphin A by Wei, H, Saarnilehto, M, Falck, L, Viisanen, H, Lasierra, M, Koivisto, A, Pertovaara, A

“…We characterized pain behavior and cutaneous blood flow response induced by activation of the spinal transient receptor potential ankyrin 1 (TRPA1) channel…”
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A dissociative change in the efficacy of supraspinal versus spinal morphine in the neuropathic rat by Pertovaara, Antti, Wei, Hong

“…The efficacy of spinally versus supraspinally administered morphine was studied in rats with a spinal nerve ligation-induced neuropathy. Behavioural assessment…”
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S.02.02 Dopamine D2 and serotonin 5-HT1A receptors of the brain in processing of pain by Pertovaara, A, Martikainen, I.K, Hagelberg, N, Hirvonen, J, Scheinin, H, Hietala, J

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P656: S2 cortex – a promising novel target for the treatment of neuropathic pain with rTMS by Jaeaeskelaeinen, S, Lindholm, P, Lamusuo, S, Lahti, A, Pesonen, U, Taiminen, T, Virtanen, A, Forssell, H, Hietala, J, Hagelberg, N, Parkkola, R, Pertovaara, A

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Noradrenergic pain modulation by Pertovaara, Antti

“…Norepinephrine is involved in intrinsic control of pain. Main sources of norepinephrine are sympathetic nerves peripherally and noradrenergic brainstem nuclei…”
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