Search Results - "Persson, Jenny L."

role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer by Semenas, Julius, Hedblom, Andreas, Miftakhova, Regina R, Sarwar, Martuza, Larsson, Rikard, Shcherbina, Liliya, Johansson, Martin E, Härkönen, Pirkko, Sterner, Olov, Persson, Jenny L

“…Nitrogen-containing heterocyclic compounds are an important class of molecules that are commonly used for the synthesis of candidate drugs…”
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The interplay between AR, EGF receptor and MMP-9 signaling pathways in invasive prostate cancer by Mandel, Anna, Larsson, Per, Sarwar, Martuza, Semenas, Julius, Syed Khaja, Azharuddin Sajid, Persson, Jenny L

“…Metastatic Prostate cancer (PCa) cells have gained survival and invasive advantages. Epidermal growth factor (EGF) receptor is a receptor tyrosine kinase,…”
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Heme detoxification by heme oxygenase-1 reinstates proliferative and immune balances upon genotoxic tissue injury by Hedblom, Andreas, Hejazi, Seyed M., Canesin, Giacomo, Choudhury, Reeham, Hanafy, Khalid A., Csizmadia, Eva, Persson, Jenny L., Wegiel, Barbara

“…Phenotypic changes of myeloid cells are critical to the regulation of premature aging, development of cancer, and responses to infection. Heme metabolism has a…”
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Epitranscriptomic mechanisms of androgen signalling and prostate cancer by Patke, Rodhan, Harris, Anna E., Woodcock, Corinne L., Thompson, Rachel, Santos, Rute, Kumari, Amber, Allegrucci, Cinzia, Archer, Nathan, Gudas, Lorraine J., Robinson, Brian D., Persson, Jenny L., Fray, Rupert, Jeyapalan, Jennie, Rutland, Catrin S., Rakha, Emad, Madhusudan, Srinivasan, Emes, Richard D., Muyangwa-Semenova, Musalwa, Alsaleem, Mansour, de Brot, Simone, Green, William, Ratan, Hari, Mongan, Nigel P., Lothion-Roy, Jennifer

“…Prostate cancer (PCa) is the second most common cancer diagnosed in men. While radical prostatectomy and radiotherapy are often successful in treating…”
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Targeted inhibition of ERα signaling and PIP5K1α/Akt pathways in castration‐resistant prostate cancer by Semenas, Julius, Wang, Tianyan, Sajid Syed Khaja, Azharuddin, Firoj Mahmud, AKM, Simoulis, Athanasios, Grundström, Thomas, Fällman, Maria, Persson, Jenny L.

“…In the present study, we unrevealed the effect of tamoxifen on ERα and PIP5K1α/AKT that are responsible for prostate cancer growth and invasion. Tamoxifen in…”
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Cell-autonomous IL6ST activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment by Sternberg, Christina, Raigel, Martin, Limberger, Tanja, Trachtová, Karolína, Schlederer, Michaela, Lindner, Desiree, Kodajova, Petra, Yang, Jiaye, Ziegler, Roman, Kalla, Jessica, Stoiber, Stefan, Dey, Saptaswa, Zwolanek, Daniela, Neubauer, Heidi A, Oberhuber, Monika, Redmer, Torben, Hejret, Václav, Tichy, Boris, Tomberger, Martina, Harbusch, Nora S, Pencik, Jan, Tangermann, Simone, Bystry, Vojtech, Persson, Jenny L, Egger, Gerda, Pospisilova, Sarka, Eferl, Robert, Wolf, Peter, Sternberg, Felix, Högler, Sandra, Lagger, Sabine, Rose-John, Stefan, Kenner, Lukas

“…Prostate cancer ranks as the second most frequently diagnosed cancer in men worldwide. Recent research highlights the crucial roles IL6ST-mediated signaling…”
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Bacterial protein MakA causes suppression of tumour cell proliferation via inhibition of PIP5K1α/Akt signalling by Toh, Eric, Baryalai, Palwasha, Nadeem, Aftab, Aung, Kyaw Min, Chen, Sa, Persson, Karina, Persson, Jenny L., Uhlin, Bernt Eric, Wai, Sun Nyunt

“…Recently, we demonstrated that a novel bacterial cytotoxin, the protein MakA which is released by Vibrio cholerae , is a virulence factor, causing killing of…”
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Development and validation of a 25-Gene Panel urine test for prostate cancer diagnosis and potential treatment follow-up by Johnson, Heather, Guo, Jinan, Zhang, Xuhui, Zhang, Heqiu, Simoulis, Athanasios, Wu, Alan H B, Xia, Taolin, Li, Fei, Tan, Wanlong, Johnson, Allan, Dizeyi, Nishtman, Abrahamsson, Per-Anders, Kenner, Lukas, Feng, Xiaoyan, Zou, Chang, Xiao, Kefeng, Persson, Jenny L, Chen, Lingwu

“…Heterogeneity of prostate cancer (PCa) contributes to inaccurate cancer screening and diagnosis, unnecessary biopsies, and overtreatment. We intended to…”
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JUN mediates the senescence associated secretory phenotype and immune cell recruitment to prevent prostate cancer progression by Redmer, Torben, Raigel, Martin, Sternberg, Christina, Ziegler, Roman, Probst, Clara, Lindner, Desiree, Aufinger, Astrid, Limberger, Tanja, Trachtova, Karolina, Kodajova, Petra, Högler, Sandra, Schlederer, Michaela, Stoiber, Stefan, Oberhuber, Monika, Bolis, Marco, Neubauer, Heidi A, Miranda, Sara, Tomberger, Martina, Harbusch, Nora S, Garces de Los Fayos Alonso, Ines, Sternberg, Felix, Moriggl, Richard, Theurillat, Jean-Philippe, Tichy, Boris, Bystry, Vojtech, Persson, Jenny L, Mathas, Stephan, Aberger, Fritz, Strobl, Birgit, Pospisilova, Sarka, Merkel, Olaf, Egger, Gerda, Lagger, Sabine, Kenner, Lukas

“…Prostate cancer develops through malignant transformation of the prostate epithelium in a stepwise, mutation-driven process. Although activator protein-1…”
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Single-cell heterogeneity in Sézary syndrome by Buus, Terkild Brink, Willerslev-Olsen, Andreas, Fredholm, Simon, Blümel, Edda, Nastasi, Claudia, Gluud, Maria, Hu, Tengpeng, Lindahl, Lise M., Iversen, Lars, Fogh, Hanne, Gniadecki, Robert, Litvinov, Ivan V., Persson, Jenny L., Bonefeld, Charlotte Menné, Geisler, Carsten, Christensen, Jan Pravsgaard, Krejsgaard, Thorbjørn, Litman, Thomas, Woetmann, Anders, Ødum, Niels

“…Sézary syndrome (SS) is an aggressive leukemic variant of cutaneous T-cell lymphoma (CTCL) with a median life expectancy of less than 4 years. Although initial…”
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Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer by Harris, Anna E., Metzler, Veronika M., Lothion-Roy, Jennifer, Varun, Dhruvika, Woodcock, Corinne L., Haigh, Daisy B., Endeley, Chantelle, Haque, Maria, Toss, Michael S., Alsaleem, Mansour, Persson, Jenny L., Gudas, Lorraine J., Rakha, Emad, Robinson, Brian D., Khani, Francesca, Martin, Laura M., Moyer, Jenna E., Brownlie, Juliette, Madhusudan, Srinivasan, Allegrucci, Cinzia, James, Victoria H., Rutland, Catrin S., Fray, Rupert G., Ntekim, Atara, de Brot, Simone, Mongan, Nigel P., Jeyapalan, Jennie N.

“…Androgen deprivation therapies (ADTs) are important treatments which inhibit androgen-induced prostate cancer (PCa) progression by either preventing androgen…”
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Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4 + T cells in cutaneous T-cell lymphoma by Blümel, Edda, Willerslev-Olsen, Andreas, Gluud, Maria, Lindahl, Lise M, Fredholm, Simon, Nastasi, Claudia, Krejsgaard, Thorbjørn, Surewaard, Bas G J, Koralov, Sergei B, Hu, Tengpeng, Persson, Jenny L, Bonefeld, Charlotte Menné, Geisler, Carsten, Iversen, Lars, Becker, Jürgen C, Andersen, Mads Hald, Woetmann, Anders, Buus, Terkild Brink, Ødum, Niels

“…is implicated in disease progression in cutaneous T-cell lymphoma (CTCL). Here, we demonstrate that malignant T cell lines derived from CTCL patients as well…”
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Induction of Apoptosis by Staurosporine Involves the Inhibition of Expression of the Major Cell Cycle Proteins at the G2/M Checkpoint Accompanied by Alterations in Erk and Akt Kinase Activities by ANTONSSON, Andreas, PERSSON, Jenny L

“…Background: Staurosporine is a therapeutic agent that inhibits tumor cell growth by inducing cell death via intrinsic apoptotic pathways. Our previous studies…”
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GLUL Ablation Can Confer Drug Resistance to Cancer Cells via a Malate-Aspartate Shuttle-Mediated Mechanism by Muthu, Magesh, Kumar, Ranjeet, Syed Khaja, Azharuddin Sajid, Gilthorpe, Jonathan D, Persson, Jenny L, Nordström, Anders

“…Glutamate-ammonia ligase (GLUL) is important for acid-base homeostasis, ammonia detoxification, cell signaling, and proliferation. Here, we reported that…”
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FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer by Larsson, Per Flodbring, Karlsson, Richard, Sarwar, Martuza, Miftakhova, Regina, Wang, Tianyan, Syed Khaja, Azharuddin Sajid, Semenas, Julius, Chen, Sa, Hedblom, Andreas, Ali, Amjad, Ekström‐Holka, Kristina, Simoulis, Athanasios, Kumar, Anjani, Wingren, Anette Gjörloff, Robinson, Brian, Nyunt Wai, Sun, Mongan, Nigel P., Heery, David M., Öhlund, Daniel, Grundström, Thomas, Ødum, Niels, Persson, Jenny L.

“…Low‐affinity immunoglobulin gamma Fc region receptor III‐A (FcγRIIIa) is a cell surface protein that belongs to a family of Fc receptors that facilitate the…”
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Circulating Tumor Cell Models Mimicking Metastasizing Cells In Vitro: Discrimination of Colorectal Cancer Cells and White Blood Cells Using Digital Holographic Cytometry by Feith, Marek, Zhang, Yuecheng, Persson, Jenny L, Balvan, Jan, El-Schich, Zahra, Wingren, Anette Gjörloff

“…Colorectal cancer (CRC) is the second most metastatic disease with the majority of cases detected in Western countries. Metastases are formed by circulating…”
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Discrimination between Breast Cancer Cells and White Blood Cells by Non-Invasive Measurements: Implications for a Novel In Vitro-Based Circulating Tumor Cell Model Using Digital Holographic Cytometry by El-Schich, Zahra, Janicke, Birgit, Alm, Kersti, Dizeyi, Nishtman, L. Persson, Jenny, Gjörloff Wingren, Anette

“…Breast cancer is the second most common cancer worldwide. Metastasis is the main reason for death in breast cancer, and today, there is a lack of methods to…”
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ISA-2011B, a Phosphatidylinositol 4-Phosphate 5-Kinase α Inhibitor, Impairs CD28-Dependent Costimulatory and Pro-inflammatory Signals in Human T Lymphocytes by Kunkl, Martina, Porciello, Nicla, Mastrogiovanni, Marta, Capuano, Cristina, Lucantoni, Federica, Moretti, Chiara, Persson, Jenny L, Galandrini, Ricciarda, Buzzetti, Raffaella, Tuosto, Loretta

“…Phosphatidylinositol 4,5-biphosphate (PIP2) is a membrane phospholipid that controls the activity of several proteins regulating cytoskeleton reorganization,…”
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Sialic Acid as a Biomarker Studied in Breast Cancer Cell Lines In Vitro Using Fluorescent Molecularly Imprinted Polymers by El-Schich, Zahra, Zhang, Yuecheng, Göransson, Tommy, Dizeyi, Nishtman, Persson, Jenny L., Johansson, Emil, Caraballo, Remi, Elofsson, Mikael, Shinde, Sudhirkumar, Sellergren, Börje, Wingren, Anette Gjörloff

“…Sialylations are post-translational modifications of proteins and lipids that play important roles in many cellular events, including cell-cell interactions,…”
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Protein kinase A (PKA) pathway is functionally linked to androgen receptor (AR) in the progression of prostate cancer by Sarwar, Martuza, Sandberg, Sabina, Abrahamsson, Per-Anders, M.D., Ph.D, Persson, Jenny L., Ph.D

“…Abstract Objectives In the present study, we investigated whether the cyclic adenosine monophosphate (cAMP)-activated protein kinase A (PKA) pathway may…”
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