Search Results - "Persico, F J"

Antinociceptive action of McN-5195 in rodents: a structurally novel (indolizine) analgesic with a nonopioid mechanism of action by Vaught, J L, Carson, J R, Carmosin, R J, Blum, P S, Persico, F J, Hageman, W E, Shank, R P, Raffa, R B

“…McN-5195 [(+/-)-trans-3-(2-bromophenyl)-octahydroindolizine] inhibited at nontoxic doses the nociceptive response in tail-pinch, tail-flick and 48 degrees C…”
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Effect of tolmetin glycine amide (McN-4366), a prodrug of tolmetin sodium, on adjuvant arthritis in the rat by Persico, F J, Pritchard, J F, Fisher, M C, Yorgey, K, Wong, S, Carson, J

“…The glycine amide of tolmetin sodium (TGA) functions as a prodrug and was demonstrated to be more potent than the parent compound as an inhibitor of developing…”
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Benzothiazole hydroxy ureas as inhibitors of 5-lipoxygenase: use of the hydroxyurea moiety as a replacement for hydroxamic acid by Greco, Michael N, Hageman, William E, Powell, Eugene T, Tighe, Joseph J, Persico, Francis J

“…A novel series of N-[(2-benzothiazolylthio)alkyl]-N'-hydroxyurea derivatives (9-25) was synthesized and evaluated for biological activity as inhibitors of…”
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Indolo[2,1-c][1,4]benzodiazepines: a new class of antiallergic agents by Ho, Chih Y, Hageman, William E, Persico, Francis J

“…A series of 12-(cyclic alkylamino)-6H-indolo[2,1-c][1,4]benzodiazepines were synthesized that possess antihistamine and antiserotonin activities as well as…”
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Substance P, neurokinin A, and neurokinin B induce generation of IL-1- like activity in P388D1 cells. Possible relevance to arthritic disease by Kimball, ES, Persico, FJ, Vaught, JL

“…Near nanomolar concentrations of substance P induce production of IL-1 or an IL-1-like activity in the mouse macrophage cell line P388D1. Moreover, this could…”
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Potentiation of Balb/3T3 fibroblast proliferative response by interleukin-1 and epidermal growth factor by Kimball, E S, Fisher, M C, Persico, F J

“…Balb/3T3 fibroblasts respond to interleukin-1 (IL-1) by proliferating in a dose-dependent fashion. Increasing proliferative responses were observed with…”
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Antagonism by ETYA of the effects of leukotrienes on ileum and lung parenchymal strips independent of effects on arachidonic acid metabolism by Hageman, W E, Rose, M P, Persico, F J

“…5,8,11,14-Eicosatetraynoic acid (ETYA), a compound which inhibits both the cyclooxygenase and lipoxygenase pathways of arachidonic acid metabolism, antagonized…”
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Enhancement of in vitro lipopolysaccharide-stimulated interleukin-1 production by levamisole by Kimball, E S, Clark, M C, Schneider, C R, Persico, F J

“…The production of interleukin-1 (IL-1) by the P388D1 mouse macrophage cell line and by adherent peritoneal exudate cells (PMs) was examined. In vitro IL-1…”
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Identification of some interleukin-1 (IL-1) sensitive organs in vivo using the induction of ornithine decarboxylase (ODC) following injection of recombinant IL-1 beta in mice by End, D W, Look, R A, Garrabrant, T, Persico, F J

“…Intraperitoneal (i.p.) and intravenous (i.v.) injection of human recombinant interleukin-1 beta (rIL-1 beta) in mice produced a 2-4 fold induction of ornithine…”
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Non-selective inhibition of mammalian protein kinases by flavinoids in vitro by End, D W, Look, R A, Shaffer, N L, Balles, E A, Persico, F J

“…In vitro, the flavinoids quercetin, morin, and rutin produced comparable inhibition of protein kinase C prepared from bovine brain, the epidermal growth factor…”
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Isolation and partial characterization of multiple DNA polymerases of the murine myeloma, MOPC-21 by Persico, F J, Nicholson, D E, Gottlieb, A A

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An inhibitor of DNA polymerase which appears after inoculation of BALB-c mice with syngeneic tumors by Gottlieb, A A, Plescia, O J, Smith, A H, Persico, F J, Nicholson, D E

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Inhibitor of DNA Polymerase in Sera of Tumour-bearing Mice by GOTTLIEB, A. ARTHUR, SMITH, ALAN H, PLESCIA, OTTO J, PERSICO, FRANCIS J, NICHOLSON, DIARMUID E

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Substance PO, neurokinin A, and neurokinin B induced generation of IL-1-like activity in P388D1 cells: possible relevance to arthritic disease by KIMBALL, E. S, PERSICO, F. J, VAUGHT, J. L

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Neurokinin-induced generation of interleukin-1 in a macrophage cell line by Kimball, E S, Persico, F J, Vaught, J L

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Erythrocyte sedimentation rate quantitation in MRL/MpM-lpr/lpr mice by Stim, T B, Persico, F J, Garrabrant, T A

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Replacement of aromatic or heteroaromatic groups in nonsteroidal antiinflammatory agents with the ferrocene group by Maryanoff, Bruce E, Keeley, Stanley L, Persico, Frank J

“…Ferrocene analogues of the antiinflammatory agents tolmetin (1), fenbufen (2), flurbiprofen (3), and fenclofenac (4) were synthesized and tested for biological…”
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Two ribonuclease H activities from the murine myeloma, MOPC-21 by O'Cuinn, G, Persico, F J, Gottlieb, A A

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Erythrocyte sedimentation rate as a parameter for drug evaluation in the MRL/l autoimmune mouse by Stim, T B, Garrabrant, T A, Kimball, E S, Persico, F J

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DNA Polymerases of Myeloma: Template and Primer Specificities of Two Enzymes by PERSICO, FRANCIS J, GOTTLIEB, A. ARTHUR

“…INTEREST in the viral RNA-dependent DNA polymerases1,2 has led to an examination of mammalian DNA polymerases and to the characterization in certain systems of…”
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