Search Results - "Persengiev, Stephan"

Dynamic Assembly of End-Joining Complexes Requires Interaction between Ku70/80 and XRCC4 by Mari, Pierre-Olivier, Florea, Bogdan I., Persengiev, Stephan P., Verkaik, Nicole S., Brüggenwirth, Hennie T., Modesti, Mauro, Giglia-Mari, Giuseppina, Bezstarosti, Karel, Demmers, Jeroen A. A., Luider, Theo M., Houtsmuller, Adriaan B., van Gent, Dik C.

“…DNA double-strand break (DSB) repair by nonhomologous end joining (NHEJ) requires the assembly of several proteins on DNA ends. Although biochemical studies…”
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Epigenomic annotation of gene regulatory alterations during evolution of the primate brain by Vermunt, Marit W, Tan, Sander C, Castelijns, Bas, Geeven, Geert, Reinink, Peter, de Bruijn, Ewart, Kondova, Ivanela, Persengiev, Stephan, Bontrop, Ronald, Cuppen, Edwin, de Laat, Wouter, Creyghton, Menno P

“…Gene-regulatory elements are drivers of evolutionary divergence, yet where these are located and which are evolutionarily relevant is unclear. In this work,…”
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Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs) by Persengiev, Stephan P, Zhu, Xiaochun, Green, Michael R

“…RNA interference is an evolutionarily conserved process in which expression of a specific gene is post-transcriptionally inhibited by a small interfering RNA…”
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Evolution and diversity of copy number variation in the great ape lineage by Sudmant, Peter H, Huddleston, John, Catacchio, Claudia R, Malig, Maika, Hillier, Ladeana W, Baker, Carl, Mohajeri, Kiana, Kondova, Ivanela, Bontrop, Ronald E, Persengiev, Stephan, Antonacci, Francesca, Ventura, Mario, Prado-Martinez, Javier, Marques-Bonet, Tomas, Eichler, Evan E

“…Copy number variation (CNV) contributes to disease and has restructured the genomes of great apes. The diversity and rate of this process, however, have not…”
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MicroRNA‐mediated gene silencing modulates the UV‐induced DNA‐damage response by Pothof, Joris, Verkaik, Nicole S, van IJcken, Wilfred, Wiemer, Erik A C, Ta, Van T B, van der Horst, Gijsbertus T J, Jaspers, Nicolaas G J, van Gent, Dik C, Hoeijmakers, Jan H J, Persengiev, Stephan P

“…DNA damage provokes DNA repair, cell‐cycle regulation and apoptosis. This DNA‐damage response encompasses gene‐expression regulation at the transcriptional and…”
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miRNAs at the crossroad between hematopoietic malignancies and autoimmune pathogenesis by Persengiev, Stephan P

“…The study of microRNA (miRNA) regulation in the pathogenesis of autoimmune diseases and hematopoietic malignancies provides new understanding of the mechanisms…”
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MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response by Pothof, Joris, Verkaik, Nicole S, van IJcken, Wilfred, Wiemer, Erik A C, Ta, Van T B, van der Horst, Gijsbertus T J, Jaspers, Nicolaas G J, van Gent, Dik C, Hoeijmakers, Jan H J, Persengiev, Stephan P

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The Impact of MicroRNAs on Brain Aging and Neurodegeneration by Persengiev, Stephan P., Kondova, Ivanela I., Bontrop, Ronald E.

“…The molecular instructions that govern gene expression regulation are encoded in the genome and ultimately determine the morphology and functional…”
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Inhibition of apoptosis by ATFx: a novel role for a member of the ATF/CREB family of mammalian bZIP transcription factors by Persengiev, Stephan P, Devireddy, Laxminarayana R, Green, Michael R

“…The mammalian ATF/CREB family of transcription factors comprises a large group of basic-region leucine zipper (bZIP) proteins whose members mediate diverse…”
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Functional Annotation of Small Noncoding RNAs Target Genes Provides Evidence for a Deregulated Ubiquitin-Proteasome Pathway in Spinocerebellar Ataxia Type 1 by Persengiev, Stephan P., Kondova, Ivanela I., Bontrop, Ronald E.

“…Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disorder caused by the expansion of CAG repeats in the ataxin 1 (ATXN1) gene. In affected…”
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TRF3, a TATA-Box-Binding Protein-Related Factor, Is Vertebrate-Specific and Widely Expressed by Persengiev, Stephan P., Zhu, Xiaochun, Dixit, Bharat L., Maston, Glenn A., Ellen L. W. Kittler, Green, Michael R.

“…TATA-box-binding protein (TBP) is a highly conserved RNA polymerase II general transcription factor that binds to the core promoter and initiates assembly of…”
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Association analysis of myosin IXB and type 1 diabetes by Persengiev, Stephan, Koeleman, Bobby P.C, Downes, Kate, Valdigem, Gustavo, van der Slik, Arno R, Eerligh, Peter, Monsuur, Alienke, Bruining, G. Jan, Wijmenga, Cisca, Todd, John A, Roep, Bart O, Alizadeh, Behrooz Z

“…Abstract To date, seven studies have provided evidence for an association between the gene encoding for myosin IXB ( MYO9B ) and celiac disease (CD), and…”
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The neuroprotective and antiapoptotic effects of melatonin in cerebellar neurons involve glucocorticoid receptor and p130 signal pathways by Persengiev, Stephan P.

“…Melatonin is an endocrine factor known to affect a number of physiological functions. The present studies have demonstrated an additional activity for pineal…”
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E2F2 converts reversibly differentiated PC12 cells to an irreversible, neurotrophin-dependent state by PERSENGIEV, Stephan P, JUNQING LI, POULIN, Matthew L, KILPATRICK, Daniel L

“…E2Fs play a central role in cell proliferation and growth arrest through their ability to regulate genes involved in cell cycle progression, arrest and…”
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Genome-wide analysis of miRNA expression reveals a potential role for miR-144 in brain aging and spinocerebellar ataxia pathogenesis by Persengiev, Stephan, Kondova, Ivanela, Otting, Nel, Koeppen, Arnulf H, Bontrop, Ronald E

“…Abstract Neurodegenerative pathologies associated with aging exhibit clinical and morphological features that are relatively specific to humans. To gain…”
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Multiple domains of melatonin receptor are involved in the regulation of glucocorticoid receptor-induced gene expression by Persengiev, Stephan P

“…Melatonin, the principal hormone of the pineal gland, elicits potent anti-stress, anti-aging and oncostatic properties and influences various immunological and…”
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E2F4 Actively Promotes the Initiation and Maintenance of Nerve Growth Factor-Induced Cell Differentiation by Persengiev, Stephan P., Kondova, Ivanela I., Kilpatrick, Daniel L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The DNA methyltransferase inhibitor 5-azacytidine specifically alters the expression of helix–loop–helix proteins Id1, Id2 and Id3 during neuronal differentiation by Persengiev, Stephan P, Kilpatrick, Daniel L

“…IN mammals, cytosine methylation is important for the regulation of gene expression and chromatin structure. Recently, we have found evidence indicating that…”
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Gli family members are differentially expressed during the mitotic phase of spermatogenesis by PERSENGIEV, S. P, KONDOVA, I. I, MILLETTE, C. F, KILPATRICK, D. L

“…The Gli family of DNA binding proteins has been implicated in multiple neoplasias and developmental abnormalities, suggesting a primary involvement in cell…”
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Nerve growth factor induced differentiation of neuronal cells requires gene methylation by Persengiev, Stephan P, Kilpatrick, Daniel L

“…CELL differentiation in the nervous system is dictated by specific patterns of gene expression. We have investigated the role of gene methylation during…”
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