Search Results - "Perry, V.H"
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Systemic infection and inflammation in acute CNS injury and chronic neurodegeneration: Underlying mechanisms
Published in Neuroscience (06-02-2009)“…Abstract We have all at some time experienced the non-specific symptoms that arise from being ill following a systemic infection. These symptoms, such as…”
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Proinflammatory cytokines, sickness behavior, and Alzheimer disease
Published in Neurology (19-07-2011)“…In Alzheimer disease (AD), systemic inflammation is known to give rise to a delirium. However, systemic inflammation also gives rise to other centrally…”
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The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA (poly I:C)
Published in Brain, behavior, and immunity (01-05-2007)“…Abstract Poly inosinic:poly cytidylic acid (poly I:C) is a synthetic double-stranded RNA and is a ligand for the Toll like receptor-3. This receptor is…”
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The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: Implications for a role of COX-1
Published in Brain, behavior, and immunity (01-03-2010)“…Abstract Systemic inflammation gives rise to metabolic and behavioural changes, largely mediated by pro-inflammatory cytokines and prostaglandin production…”
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Mechanisms to explain the reverse perivascular transport of solutes out of the brain
Published in Journal of theoretical biology (21-02-2006)“…Experimental studies and observations in the human brain indicate that interstitial fluid and solutes, such as amyloid- β ( A β ) , are eliminated from grey…”
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Sub-pyrogenic systemic inflammation impacts on brain and behavior, independent of cytokines
Published in Brain, behavior, and immunity (01-08-2007)“…Abstract Systemic inflammation impacts on the brain and gives rise to behavioral changes, often referred to as ‘sickness behavior’. These symptoms are thought…”
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Selective and compartmentalized myelin expression of HspB5
Published in Neuroscience (01-03-2016)“…Graphical abstract…”
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66. Evidence for neuroplastic changes in the brainstem following TH2 lung inflammation: A role for the central nervous system in contributing to the symptoms of asthma and investigating a potential target for therapy
Published in Brain, behavior, and immunity (01-09-2012)“…Inflammatory events in the lung, such as atopic asthma, induce changes in neuronal activity of afferent airway vagal fibres and neurons in the brainstem, as…”
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36. Immune adaptation in the central nervous system in response to systemic infection
Published in Brain, behavior, and immunity (01-09-2012)“…Introduction: Acute systemic inflammation leads to production of inflammatory mediators and transient metabolic and behavioural changes. In models of chronic…”
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Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood–brain barrier breakdown in vivo
Published in Neuroscience (01-10-1998)“…The tight junctions found between cerebral vascular endothelial cells form the basis of the blood–brain barrier. Breakdown of the blood–brain barrier is a…”
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Alpha-synuclein deficiency in the C57BL/6JOlaHsd strain does not modify disease progression in the ME7-model of prion disease
Published in Neuroscience (03-02-2010)“…Abstract We previously detailed how intrahippocampal inoculation of C57BL/6J mice with murine modified scrapie (ME7) leads to chronic neurodegeneration…”
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MCP-1 and murine prion disease: Separation of early behavioural dysfunction from overt clinical disease
Published in Neurobiology of disease (01-11-2005)“…Prion diseases are chronic, fatal neurodegenerative conditions of the CNS. We have investigated the role of monocyte chemoattractant protein-1 (MCP-1) in the…”
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Neuropathologically distinct prion strains give rise to similar temporal profiles of behavioral deficits
Published in Neurobiology of disease (01-03-2005)“…Mouse-adapted scrapie strains have been characterized by vacuolation profiles and incubation times, but the behavioral consequences have not been well studied…”
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Immune adaptation in the central nervous system in response to systemic infections
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Turnover of resident microglia in the normal adult mouse brain
Published in Neuroscience (1992)“…We undertook this study to determine whether the microglia, the resident macrophages of the central nervous system, turn over in the steady-state. The turnover…”
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Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
Published in Neuroscience (1990)“…We have examined the distribution of microglia in the normal adult mouse brain using immunocytochemical detection of the macrophage specific plasma membrane…”
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Demyelination in the central nervous system following a delayed-type hypersensitivity response to bacillus Calmette-Guérin
Published in Neuroscience (01-02-1995)“…We describe here a model of delayed-type hypersensitivity response in the CNS directed against a non-CNS antigen. The results presented in this paper show that…”
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The kinetics and morphological characteristics of the macrophage-microglial response to kainic acid-induced neuronal degeneration
Published in Neuroscience (1991)“…Outside the nervous system myelomonocytic cells are known to play an important role in the inflammatory response and tissue repair after injury. In this study…”
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Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain
Published in Neuroscience (01-06-1985)“…Macrophages and microglia in the developing and adult mouse brain have been identified by immunohistochemical localization of the macrophage-specific antigen…”
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