Search Results - "Perry, S.A"

Distinct Contributions of Aire and Antigen-Presenting-Cell Subsets to the Generation of Self-Tolerance in the Thymus by Perry, Justin S.A., Lio, Chan-Wang J., Kau, Andrew L., Nutsch, Katherine, Yang, Zhuo, Gordon, Jeffrey I., Murphy, Kenneth M., Hsieh, Chyi-Song

“…The contribution of thymic antigen-presenting-cell (APC) subsets in selecting a self-tolerant T cell population remains unclear. We show that bone marrow (BM)…”
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Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth by Yao, Maojin, Ventura, P. Britten, Jiang, Ying, Rodriguez, Fausto J., Wang, Lixin, Perry, Justin S.A., Yang, Yibo, Wahl, Kelsey, Crittenden, Rowena B., Bennett, Mariko L., Qi, Lin, Gong, Cong-Cong, Li, Xiao-Nan, Barres, Ben A., Bender, Timothy P., Ravichandran, Kodi S., Janes, Kevin A., Eberhart, Charles G., Zong, Hui

“…The tumor microenvironment (TME) is critical for tumor progression. However, the establishment and function of the TME remain obscure because of its complex…”
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Metabolites released from apoptotic cells act as tissue messengers by Medina, Christopher B., Mehrotra, Parul, Arandjelovic, Sanja, Perry, Justin S. A., Guo, Yizhan, Morioka, Sho, Barron, Brady, Walk, Scott F., Ghesquière, Bart, Krupnick, Alexander S., Lorenz, Ulrike, Ravichandran, Kodi S.

“…Caspase-dependent apoptosis accounts for approximately 90% of homeostatic cell turnover in the body 1 , and regulates inflammation, cell proliferation, and…”
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Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release by Morioka, Sho, Perry, Justin S. A., Raymond, Michael H., Medina, Christopher B., Zhu, Yunlu, Zhao, Liyang, Serbulea, Vlad, Onengut-Gumuscu, Suna, Leitinger, Norbert, Kucenas, Sarah, Rathmell, Jeffrey C., Makowski, Liza, Ravichandran, Kodi S.

“…Development and routine tissue homeostasis require a high turnover of apoptotic cells. These cells are removed by professional and non-professional phagocytes…”
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A role for interleukin-2 trans-presentation in dendritic cell–mediated T cell activation in humans, as revealed by daclizumab therapy by Wuest, Simone C, Edwan, Jehad H, Martin, Jayne F, Han, Sungpil, Perry, Justin S A, Cartagena, Casandra M, Matsuura, Eiji, Maric, Dragan, Waldmann, Thomas A, Bielekova, Bibiana

“…Dendritic cells produce interleukin-2 (IL-2) and express the IL-2 receptor subunit CD25. Bibiana Bielekova and her colleagues show that dendritic cells, upon…”
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Intrinsic Functional Connectivity of Amygdala-Based Networks in Adolescent Generalized Anxiety Disorder by Roy, Amy K., Ph.D, Fudge, Julie L., M.D, Kelly, Clare, Ph.D, Perry, Justin S.A., B.A, Daniele, Teresa, B.A, Carlisi, Christina, B.A, Benson, Brenda, Ph.D, Xavier Castellanos, F., M.D, Milham, Michael P., M.D., Ph.D, Pine, Daniel S., M.D, Ernst, Monique, M.D., Ph.D

“…Objective Generalized anxiety disorder (GAD) typically begins during adolescence and can persist into adulthood. The pathophysiological mechanisms underlying…”
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Polypedilum nubifer, a Chironomid Midge (Diptera: Chironomidae) new to Florida that has nuisance potential by Jacobsen, R.E., Perry, S.A.

“…We document the first record of Polypedilum nubifer in Pan-America. This eurytopic species often reaches severe nuisance population sizes in Australia, Asia,…”
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Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity by Chow, Andrew, Schad, Sara, Green, Michael D., Hellmann, Matthew D., Allaj, Viola, Ceglia, Nicholas, Zago, Giulia, Shah, Nisargbhai S., Sharma, Sai Kiran, Mattar, Marissa, Chan, Joseph, Rizvi, Hira, Zhong, Hong, Liu, Cailian, Bykov, Yonina, Zamarin, Dmitriy, Shi, Hongyu, Budhu, Sadna, Wohlhieter, Corrin, Uddin, Fathema, Gupta, Aditi, Khodos, Inna, Waninger, Jessica J., Qin, Angel, Markowitz, Geoffrey J., Mittal, Vivek, Balachandran, Vinod, Durham, Jennifer N., Le, Dung T., Zou, Weiping, Shah, Sohrab P., McPherson, Andrew, Panageas, Katherine, Lewis, Jason S., Perry, Justin S.A., de Stanchina, Elisa, Sen, Triparna, Poirier, John T., Wolchok, Jedd D., Rudin, Charles M., Merghoub, Taha

“…Immune checkpoint blockade (ICB) has been a remarkable clinical advance for cancer; however, the majority of patients do not respond to ICB therapy. We show…”
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Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments by Wang, Ya-Ting, Trzeciak, Alissa J., Rojas, Waleska Saitz, Saavedra, Pedro, Chen, Yan-Ting, Chirayil, Rachel, Etchegaray, Jon Iker, Lucas, Christopher D., Puleston, Daniel J., Keshari, Kayvan R., Perry, Justin S.A.

“…Apoptotic cell (AC) clearance (efferocytosis) is performed by phagocytes, such as macrophages, that inhabit harsh physiological environments. Here, we find…”
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Live cell tracking of macrophage efferocytosis during Drosophila embryo development in vivo by Raymond, Michael H, Davidson, Andrew J, Shen, Yi, Tudor, Daniel R, Lucas, Christopher D, Morioka, Sho, Perry, Justin S A, Krapivkina, Julia, Perrais, David, Schumacher, Linus J, Campbell, Robert E, Wood, Will, Ravichandran, Kodi S

“…Apoptosis of cells and their subsequent removal through efferocytosis occurs in nearly all tissues during development, homeostasis, and disease. However, it…”
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Microbes exploit death-induced nutrient release by gut epithelial cells by Anderson, Christopher J., Medina, Christopher B., Barron, Brady J., Karvelyte, Laura, Aaes, Tania Løve, Lambertz, Irina, Perry, Justin S. A., Mehrotra, Parul, Gonçalves, Amanda, Lemeire, Kelly, Blancke, Gillian, Andries, Vanessa, Ghazavi, Farzaneh, Martens, Arne, van Loo, Geert, Vereecke, Lars, Vandenabeele, Peter, Ravichandran, Kodi S.

“…Regulated cell death is an integral part of life, and has broad effects on organism development and homeostasis 1 . Malfunctions within the regulated cell…”
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Maternal diet during early gestation influences postnatal taste activity–dependent pruning by microglia by Sun, Chengsan, Zheng, Shuqiu, Perry, Justin S.A., Norris, Geoffrey T., Cheng, Mei, Kong, Fanzhen, Skyberg, Rolf, Cang, Jianhua, Erisir, Alev, Kipnis, Jonathan, Hill, David L.

“…A key process in central sensory circuit development involves activity-dependent pruning of exuberant terminals. Here, we studied gustatory terminal field…”
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Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway by Perry, Justin S. A., Morioka, Sho, Medina, Christopher B., Iker Etchegaray, J., Barron, Brady, Raymond, Michael H., Lucas, Christopher D., Onengut-Gumuscu, Suna, Delpire, Eric, Ravichandran, Kodi S.

“…Apoptotic cell clearance (efferocytosis) elicits an anti-inflammatory response by phagocytes, but the mechanisms that underlie this response are still being…”
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Community structure of fishes inhabiting aquatic refuges in a threatened Karst wetland and its implications for ecosystem management by Kobza, R.M., Trexler, J.C., Loftus, W.F., Perry, S.A.

“…We illustrate the importance of subsurface refuges for conservation of aquatic fauna with our studies of karstic wetlands in Everglades National Park, Florida,…”
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Development of T-cell tolerance utilizes both cell-autonomous and cooperative presentation of self-antigen by Perry, Justin S. A., Hsieh, Chyi-Song

“…Summary The development of T‐cell self‐tolerance in the thymus is important for establishing immune homeostasis and preventing autoimmunity. Here, we review…”
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Inhibition of LTi cell development by CD25 blockade is associated with decreased intrathecal inflammation in multiple sclerosis by Perry, Justin S A, Han, Sungpil, Xu, Quangang, Herman, Matthew L, Kennedy, Lucy B, Csako, Gyorgy, Bielekova, Bibiana

“…Genetic polymorphisms in the interleukin-2 receptor α (IL-2Rα) chain (CD25) locus are associated with several human autoimmune diseases, including multiple…”
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An IL-2 paradox: blocking CD25 on T cells induces IL-2-driven activation of CD56(bright) NK cells by Martin, Jayne F, Perry, Justin S A, Jakhete, Neha R, Wang, Xiang, Bielekova, Bibiana

“…Daclizumab (Dac), an Ab against the IL-2R alpha-chain, inhibits brain inflammation in patients with multiple sclerosis, while expanding CD56(bright)…”
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A Single-Agent Dual-Specificity Targeting of FOLR1 and DR5 as an Effective Strategy for Ovarian Cancer by Shivange, Gururaj, Urbanek, Karol, Przanowski, Piotr, Perry, Justin S.A., Jones, James, Haggart, Robert, Kostka, Christina, Patki, Tejal, Stelow, Edward, Petrova, Yuliya, Llaneza, Danielle, Mayo, Marty, Ravichandran, Kodi S., Landen, Charles N., Bhatnagar, Sanchita, Tushir-Singh, Jogender

“…Therapeutic antibodies targeting ovarian cancer (OvCa)-enriched receptors have largely been disappointing due to limited tumor-specific antibody-dependent…”
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ELMO1 signaling is a promoter of osteoclast function and bone loss by Arandjelovic, Sanja, Perry, Justin S. A., Zhou, Ming, Ceroi, Adam, Smirnov, Igor, Walk, Scott F., Shankman, Laura S., Cambré, Isabelle, Onengut-Gumuscu, Suna, Elewaut, Dirk, Conrads, Thomas P., Ravichandran, Kodi S.

“…Osteoporosis affects millions worldwide and is often caused by osteoclast induced bone loss. Here, we identify the cytoplasmic protein ELMO1 as an important…”
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The effects of interleukin-2 on immune response regulation by Waters, Ryan S, Perry, Justin S A, Han, SunPil, Bielekova, Bibiana, Gedeon, Tomas

“…Abstract The immune system has many adaptive and dynamic components that are regulated to ensure appropriate, precise and rapid response to a foreign pathogen…”
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