Search Results - "Perry, Kathy M"

Structure-Based Discovery of Inhibitors of Thymidylate Synthase by Shoichet, Brian K., Stroud, Robert M., Santi, Daniel V., Kuntz, Irwin D., Perry, Kathy M.

“…A molecular docking computer program (DOCK) was used to screen the Fine Chemical Directory, a database of commercially available compounds, for molecules that…”
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Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate by Montfort, William R, Perry, Kathy M, Fauman, Eric B, Finer-Moore, Janet S, Maley, Gladys F, Hardy, Larry, Maley, Frank, Stroud, Robert M

“…The structure of Escherichia coli thymidylate synthase (TS) complexed with the substrate dUMP and an analogue of the cofactor methylenetetrahydrofolate was…”
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Folding of dihydrofolate reductase from Escherichia coli by Touchette, Nancy A, Perry, Kathy M, Matthews, C. Robert

“…The urea-induced equilibrium unfolding transition of dihydrofolate reductase from Escherichia coli was monitored by UV difference, circular dichroism (CD), and…”
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The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design by Anderson, Amy C, Perry, Kathy M, Freymann, Douglas M, Stroud, Robert M

“…Thymidylate synthase from Pneumocystis carinii (PcTS) is an especially important drug target, since P. carinii is a fungus that causes opportunistic pneumonia…”
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Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei by Finer-Moore, J, Fauman, E B, Foster, P G, Perry, K M, Santi, D V, Stroud, R M

“…Crystal structures of two crystal forms of the complex of Lactobacillus casei (TS) with its substrate dUMP have been solved and refined at 2.55 A resolution…”
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Structures of thymidylate synthase with a C-terminal deletion: Role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate by Perry, Kathy M, Carreras, Christopher W, Chang, Louise C, Santi, Daniel V, Stroud, Robert M

“…Thymidylate synthase undergoes a major conformational change upon ligand binding, where the carboxyl terminus displays the largest movement (approximately 4…”
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Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate [Erratum to document cited in CA113(7):54978v] by Montfort, William R, Perry, Kathy M, Fauman, Eric B, Finer-Moore, Janet S, Maley, Gladys F, Hardy, Larry, Maley, Frank, Stroud, Robert M

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Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases by Perry, K M, Fauman, E B, Finer-Moore, J S, Montfort, W R, Maley, G F, Maley, F, Stroud, R M

“…The structure of thymidylate synthase (TS) from Escherichia coli was solved from cubic crystals with a = 133 A grown under reducing conditions at pH 7.0, and…”
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Reversible dissociation and unfolding of the dimeric protein thymidylate synthase by Perry, Kathy M., Pookanjanatavip, Manee, Zhao, Jia, Santi, Daniel V., Stroud, Robert M.

“…Conditions for in vitro unfolding and refolding of dimeric thymidylate synthase from Lactobacillus casei were found. Ultraviolet difference and circular…”
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