Search Results - "Perrin, Florian"

Divergent Asymmetric Synthesis of Polycyclic Compounds via Vinyl Triazenes by Kossler, David, Perrin, Florian G., Suleymanov, Abdusalom A., Kiefer, Gregor, Scopelliti, Rosario, Severin, Kay, Cramer, Nicolai

“…Vinyl triazenes were obtained by enantioselective [2+2] cycloaddition reactions of bicyclic alkenes with 1‐alkynyl triazenes in the presence of a RuII catalyst…”
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Divergent Synthesis of Densely Substituted Arenes and Pyridines via Cyclotrimerization Reactions of Alkynyl Triazenes by Tan, Jin-Fay, Bormann, Carl T, Perrin, Florian G, Chadwick, F. Mark, Severin, Kay, Cramer, Nicolai

“…Densely substituted fused aromatic triazenes can be prepared by [2 + 2 + 2] cyclotrimerization reactions of 1-alkynyl triazenes. The Cp*Ru-catalyzed…”
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1-Alkynyltriazenes as Functional Analogues of Ynamides by Perrin, Florian G., Kiefer, Gregor, Jeanbourquin, Loïc, Racine, Sophie, Perrotta, Daniele, Waser, Jérôme, Scopelliti, Rosario, Severin, Kay

“…The chemical reactivity of 1‐alkynyltriazenes has been investigated and is found to parallel the reactivity of ynamides. The similarity in reactivity of these…”
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Mechanism of Cellular Formation and In Vivo Seeding Effects of Hexameric β-Amyloid Assemblies by Vrancx, Céline, Vadukul, Devkee M., Suelves, Nuria, Contino, Sabrina, D’Auria, Ludovic, Perrin, Florian, van Pesch, Vincent, Hanseeuw, Bernard, Quinton, Loïc, Kienlen-Campard, Pascal

“…The β-amyloid peptide (Aβ) is found as amyloid fibrils in senile plaques, a typical hallmark of Alzheimer’s disease (AD). However, intermediate soluble…”
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A Novel NIR-FRET Biosensor for Reporting PS/γ-Secretase Activity in Live Cells by Houser, Mei Cq, Hou, Steven S, Perrin, Florian, Turchyna, Yuliia, Bacskai, Brian J, Berezovska, Oksana, Maesako, Masato

“…Presenilin (PS)/γ-secretase plays a pivotal role in essential cellular events via proteolytic processing of transmembrane proteins that include APP and Notch…”
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CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer’s disease PSEN1 M146L mutation by Konstantinidis, Evangelos, Molisak, Agnieszka, Perrin, Florian, Streubel-Gallasch, Linn, Fayad, Sarah, Kim, Daniel Y., Petri, Karl, Aryee, Martin J., Aguilar, Ximena, György, Bence, Giedraitis, Vilmantas, Joung, J. Keith, Pattanayak, Vikram, Essand, Magnus, Erlandsson, Anna, Berezovska, Oksana, Ingelsson, Martin

“…Presenilin 1 (PS1) is a central component of γ-secretase, an enzymatic complex involved in the generation of the amyloid-β (Aβ) peptide that deposits as…”
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Glutamate Transporter 1 as a Novel Negative Regulator of Amyloid β by Sinha, Priyanka, Turchyna, Yuliia, Mitchell, Shane Patrick Clancy, Sadek, Michael, Armagan, Gokce, Perrin, Florian, Maesako, Masato, Berezovska, Oksana

“…Glutamate transporter-1 (GLT-1) dynamics are implicated in excitotoxicity and Alzheimer's disease (AD) progression. Early stages of AD are often marked by…”
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Towards a dynamic compression facility at the ESRF by Sévelin-Radiguet, Nicolas, Torchio, Raffaella, Berruyer, Gilles, Gonzalez, Hervé, Pasternak, Sébastien, Perrin, Florian, Occelli, Florent, Pépin, Charles, Sollier, Arnaud, Kraus, Dominik, Schuster, Anja, Voigt, Katja, Zhang, Min, Amouretti, Alexis, Boury, Antoine, Fiquet, Guillaume, Guyot, François, Harmand, Marion, Borri, Marcello, Groves, Janet, Helsby, William, Branly, Stéphane, Norby, James, Pascarelli, Sakura, Mathon, Olivier

“…Results of the 2018 commissioning and experimental campaigns of the new High Power Laser Facility on the Energy‐dispersive X‐ray Absorption Spectroscopy…”
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PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer's disease by Perrin, Florian, Anderson, Lauren C, Mitchell, Shane P C, Sinha, Priyanka, Turchyna, Yuliia, Maesako, Masato, Houser, Mei C Q, Zhang, Can, Wagner, Steven L, Tanzi, Rudolph E, Berezovska, Oksana

“…The recently discovered interaction between presenilin 1 (PS1), a subunit of γ-secretase involved in amyloid-β (Aβ) peptide production, and GLT-1, the major…”
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Towards a frustrated Lewis pair-ionic liquid system by Perrin, Florian G., Bobbink, Felix D., Păunescu, Emilia, Fei, Zhaofu, Scopelliti, Rosario, Laurenczy, Gabor, Katsyuba, Sergey, Dyson, Paul J.

“…[Display omitted] •An ionic liquid (IL) encompassing a tertiary amine forms adducts with B(C6F5)3.•The adducts can react with H2 and CO2.•The adducts were…”
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Limited Substrate Specificity of PS/γ-Secretase Is Supported by Novel Multiplexed FRET Analysis in Live Cells by Houser, Mei C Q, Turchyna, Yuliia, Perrin, Florian, Chibnik, Lori, Berezovska, Oksana, Maesako, Masato

“…Presenilin (PS)/γ-secretase is an aspartyl protease that processes a wide range of transmembrane proteins such as the amyloid precursor protein (APP) and…”
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Structural Determinant of β-Amyloid Formation: From Transmembrane Protein Dimerization to β-Amyloid Aggregates by Papadopoulos, Nicolas, Suelves, Nuria, Perrin, Florian, Vadukul, Devkee M, Vrancx, Céline, Constantinescu, Stefan N, Kienlen-Campard, Pascal

“…Most neurodegenerative diseases have the characteristics of protein folding disorders, i.e., they cause lesions to appear in vulnerable regions of the nervous…”
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Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization by Perrin, Florian, Papadopoulos, Nicolas, Suelves, Nuria, Opsomer, Rémi, Vadukul, Devkee M., Vrancx, Céline, Smith, Steven O., Vertommen, Didier, Kienlen-Campard, Pascal, Constantinescu, Stefan N.

“…Amyloid precursor protein (APP) cleavage by the β-secretase produces the C99 transmembrane (TM) protein, which contains three dimerization-inducing…”
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Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization by Perrin, Florian, Papadopoulos, Nicolas, Suelves, Nuria, Opsomer, Rémi, Vadukul, Devkee M., Vrancx, Céline, Smith, Steven O., Vertommen, Didier, Kienlen-Campard, Pascal, Constantinescu, Stefan N.

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Divergent Asymmetric Synthesis of Polycyclic Compounds via Vinyl Triazenes by Kossler, David, Perrin, Florian G., Suleymanov, Abdusalom A., Kiefer, Gregor, Scopelliti, Rosario, Severin, Kay, Cramer, Nicolai

“…Vinyl triazenes were obtained by enantioselective [2+2] cycloaddition reactions of bicyclic alkenes with 1‐alkynyl triazenes in the presence of a RuII catalyst…”
Get full text

1-Alkynyltriazenes as Functional Analogues of Ynamides by Perrin, Florian G., Kiefer, Gregor, Jeanbourquin, Loïc, Racine, Sophie, Perrotta, Daniele, Waser, Jérôme, Scopelliti, Rosario, Severin, Kay

“…The chemical reactivity of 1‐alkynyltriazenes has been investigated and is found to parallel the reactivity of ynamides. The similarity in reactivity of these…”
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APP TRANSMEMBRANE DOMAIN DIMERIZATION AND ORIENTATION REGULATE PROCESSING, AMYLOID PEPTIDE OLIGOMERIZATION AND APP SIGNALING by Perrin, Florian

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Identification of PS1/gamma-secretase and glutamate transporter GLT-1 interaction sites by Perrin, Florian, Sinha, Priyanka, Mitchell, Shane Patrick Clancy, Sadek, Michael, Maesako, Masato, Berezovska, Oksana

“…The recently discovered interaction between Presenilin 1 (PS1), a catalytic subunit of γ-secretase responsible for generating amyloid-β peptides, and GLT-1, a…”
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Influence of the familial Alzheimer's disease–associated T43I mutation on the transmembrane structure and γ-secretase processing of the C99 peptide by Tang, Tzu-Chun, Kienlen-Campard, Pascal, Hu, Yi, Perrin, Florian, Opsomer, Rémi, Octave, Jean-Noël, Constantinescu, Stefan N., Smith, Steven O.

“…Extracellular deposition of β-amyloid (Aβ) peptides in the brain is a hallmark of Alzheimer's disease (AD). Upon β-secretase–mediated cleavage of the β…”
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A Novel Platinum–Maurocalcine Conjugate Induces Apoptosis of Human Glioblastoma Cells by Acting through the ROS-ERK/AKT-p53 Pathway by Aroui, Sonia, Dardevet, Lucie, Ajmia, Wafa Ben, de Boisvilliers, Madryssa, Perrin, Florian, Laajimi, Amel, Boumendjel, Ahcène, Kenani, Abderraouf, Muller, Jean Marc, De Waard, Michel

“…Glioblastoma multiforme (GBM) is a highly malignant and aggressive primary brain tumor. In spite of an arsenal of therapeutic interventions, the prognosis of…”
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