Search Results - "Perrin, Dimitri"

Advanced CUBIC protocols for whole-brain and whole-body clearing and imaging by Susaki, Etsuo A, Tainaka, Kazuki, Perrin, Dimitri, Yukinaga, Hiroko, Kuno, Akihiro, Ueda, Hiroki R

“…This protocol describes how to perform CUBIC (Clear, Unobstructed Brain/Body Imaging Cocktails and Computational analysis), a simple and efficient method for…”
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A benchmark of computational CRISPR-Cas9 guide design methods by Bradford, Jacob, Perrin, Dimitri

“…The popularity of CRISPR-based gene editing has resulted in an abundance of tools to design CRISPR-Cas9 guides. This is also driven by the fact that designing…”
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Improving CRISPR guide design with consensus approaches by Bradford, Jacob, Perrin, Dimitri

“…CRISPR-based systems are playing an important role in modern genome engineering. A large number of computational methods have been developed to assist in the…”
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Neural network analysis of sleep stages enables efficient diagnosis of narcolepsy by Stephansen, Jens B., Olesen, Alexander N., Olsen, Mads, Ambati, Aditya, Leary, Eileen B., Moore, Hyatt E., Carrillo, Oscar, Lin, Ling, Han, Fang, Yan, Han, Sun, Yun L., Dauvilliers, Yves, Scholz, Sabine, Barateau, Lucie, Hogl, Birgit, Stefani, Ambra, Hong, Seung Chul, Kim, Tae Won, Pizza, Fabio, Plazzi, Giuseppe, Vandi, Stefano, Antelmi, Elena, Perrin, Dimitri, Kuna, Samuel T., Schweitzer, Paula K., Kushida, Clete, Peppard, Paul E., Sorensen, Helge B. D., Jennum, Poul, Mignot, Emmanuel

“…Analysis of sleep for the diagnosis of sleep disorders such as Type-1 Narcolepsy (T1N) currently requires visual inspection of polysomnography records by…”
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Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep by Niwa, Yasutaka, Kanda, Genki N., Yamada, Rikuhiro G., Shi, Shoi, Sunagawa, Genshiro A., Ukai-Tadenuma, Maki, Fujishima, Hiroshi, Matsumoto, Naomi, Masumoto, Koh-hei, Nagano, Mamoru, Kasukawa, Takeya, Galloway, James, Perrin, Dimitri, Shigeyoshi, Yasufumi, Ukai, Hideki, Kiyonari, Hiroshi, Sumiyama, Kenta, Ueda, Hiroki R.

“…Sleep regulation involves interdependent signaling among specialized neurons in distributed brain regions. Although acetylcholine promotes wakefulness and…”
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Mammalian Reverse Genetics without Crossing Reveals Nr3a as a Short-Sleeper Gene by Sunagawa, Genshiro A., Sumiyama, Kenta, Ukai-Tadenuma, Maki, Perrin, Dimitri, Fujishima, Hiroshi, Ukai, Hideki, Nishimura, Osamu, Shi, Shoi, Ohno, Rei-ichiro, Narumi, Ryohei, Shimizu, Yoshihiro, Tone, Daisuke, Ode, Koji L., Kuraku, Shigehiro, Ueda, Hiroki R.

“…The identification of molecular networks at the system level in mammals is accelerated by next-generation mammalian genetics without crossing, which requires…”
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Metagenomic Geolocation Using Read Signatures by Chappell, Timothy, Geva, Shlomo, Hogan, James M, Lovell, David, Trotman, Andrew, Perrin, Dimitri

“…We present a novel approach to the Metagenomic Geolocation Challenge based on random projection of the sample reads from each location. This approach explores…”
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Recursive module extraction using Louvain and PageRank by Perrin, Dimitri, Zuccon, Guido

“…Biological networks are highly modular and contain a large number of clusters, which are often associated with a specific biological function or disease…”
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A Mammalian Circadian Clock Model Incorporating Daytime Expression Elements by Jolley, Craig C., Ukai-Tadenuma, Maki, Perrin, Dimitri, Ueda, Hiroki R.

“…Models of the mammalian clock have traditionally been based around two feedback loops—the self-repression of Per/Cry by interfering with activation by…”
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Predicting Carcass Weight of Grass-Fed Beef Cattle before Slaughter Using Statistical Modelling by Duwalage, Kalpani Ishara, Wynn, Moe Thandar, Mengersen, Kerrie, Nyholt, Dale, Perrin, Dimitri, Robert, Paul Frederic

“…Gaining insights into the utilization of farm-level data for decision-making within the beef industry is vital for improving production and profitability. In…”
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Rapid analysis of metagenomic data using signature-based clustering by Chappell, Timothy, Geva, Shlomo, Hogan, James M, Huygens, Flavia, Rathnayake, Irani U, Rudd, Stephen, Kelly, Wayne, Perrin, Dimitri

“…Sequencing highly-variable 16S regions is a common and often effective approach to the study of microbial communities, and next-generation sequencing (NGS)…”
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Computational micromodel for epigenetic mechanisms by Raghavan, Karthika, Ruskin, Heather J, Perrin, Dimitri, Goasmat, Francois, Burns, John

“…Characterization of the epigenetic profile of humans since the initial breakthrough on the human genome project has strongly established the key role of…”
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Reduced thermal tolerance in a coral carrying CRISPR-induced mutations in the gene for a heat-shock transcription factor by Cleves, Phillip A., Tinoco, Amanda I., Bradford, Jacob, Perrin, Dimitri, Bay, Line K., Pringle, John R.

“…Reef-building corals are keystone species that are threatened by anthropogenic stresses including climate change. To investigate corals’ responses to stress…”
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Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis by Susaki, Etsuo A., Tainaka, Kazuki, Perrin, Dimitri, Kishino, Fumiaki, Tawara, Takehiro, Watanabe, Tomonobu M., Yokoyama, Chihiro, Onoe, Hirotaka, Eguchi, Megumi, Yamaguchi, Shun, Abe, Takaya, Kiyonari, Hiroshi, Shimizu, Yoshihiro, Miyawaki, Atsushi, Yokota, Hideo, Ueda, Hiroki R.

“…Systems-level identification and analysis of cellular circuits in the brain will require the development of whole-brain imaging with single-cell resolution. To…”
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Comparison of independent, participant-led, high-resolution studies of pitch-matching in post-lingual single-sided cochlear implant recipients by Lovell, David, Martens, William, Bradford, Jake, Bradley, Andrew, Crowe, Anne-Marie, McKague, Matthew, Perrin, Dimitri

“…Understanding “what the world sounds like to someone else“ is fundamental to developing technologies and therapies to improve auditory perception for people…”
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Promises and Challenges in the Use of Consumer-Grade Devices for Sleep Monitoring by Roomkham, Sirinthip, Lovell, David, Cheung, Joseph, Perrin, Dimitri

“…The market for smartphones, smartwatches, and wearable devices is booming. In recent years, individuals and researchers have used these devices as additional…”
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Whole-body imaging with single-cell resolution by tissue decolorization by Tainaka, Kazuki, Kubota, Shimpei I, Suyama, Takeru Q, Susaki, Etsuo A, Perrin, Dimitri, Ukai-Tadenuma, Maki, Ukai, Hideki, Ueda, Hiroki R

“…The development of whole-body imaging at single-cell resolution enables system-level approaches to studying cellular circuits in organisms. Previous clearing…”
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Involvement of Ca(2+)-Dependent Hyperpolarization in Sleep Duration in Mammals by Tatsuki, Fumiya, Sunagawa, Genshiro A, Shi, Shoi, Susaki, Etsuo A, Yukinaga, Hiroko, Perrin, Dimitri, Sumiyama, Kenta, Ukai-Tadenuma, Maki, Fujishima, Hiroshi, Ohno, Rei-ichiro, Tone, Daisuke, Ode, Koji L, Matsumoto, Katsuhiko, Ueda, Hiroki R

“…The detailed molecular mechanisms underlying the regulation of sleep duration in mammals are still elusive. To address this challenge, we constructed a simple…”
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Rapid Whole-Genome Identification of High Quality CRISPR Guide RNAs with the Crackling Method by Bradford, Jacob, Chappell, Timothy, Perrin, Dimitri

“…The design of CRISPR-Cas9 guide RNAs is not trivial and is a computationally demanding task. Design tools need to identify target sequences that will maximize…”
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Circadian ribosome profiling reveals a role for the Period2 upstream open reading frame in sleep by Millius, Arthur, Yamada, Rikuhiro G., Fujishima, Hiroshi, Maeda, Kazuhiko, Standley, Daron M., Sumiyama, Kenta, Perrin, Dimitri, Ueda, Hiroki R.

“…Many mammalian proteins have circadian cycles of production and degradation, and many of these rhythms are altered posttranscriptionally. We used ribosome…”
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