Search Results - "Perrimon, Norbert"

Drosophila Cytokine Unpaired 2 Regulates Physiological Homeostasis by Remotely Controlling Insulin Secretion by Rajan, Akhila, Perrimon, Norbert

“…In Drosophila, the fat body (FB), a functional analog of the vertebrate adipose tissue, is the nutrient sensor that conveys the nutrient status to the…”
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Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling by Owusu-Ansah, Edward, Song, Wei, Perrimon, Norbert

“…Mitochondrial dysfunction is usually associated with aging. To systematically characterize the compensatory stress signaling cascades triggered in response to…”
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Interorgan Communication Pathways in Physiology: Focus on Drosophila by Droujinine, Ilia A, Perrimon, Norbert

“…Studies in mammals and Drosophila have demonstrated the existence and significance of secreted factors involved in communication between distal organs. In this…”
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Wnt signaling modulates the response to DNA damage in the Drosophila wing imaginal disc by regulating the EGFR pathway by Ewen-Campen, Ben, Perrimon, Norbert

“…Despite the deep conservation of the DNA damage response (DDR) pathway, cells in different contexts vary widely in their susceptibility to DNA damage and their…”
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Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species by Parkhitko, Andrey A., Jouandin, Patrick, Mohr, Stephanie E., Perrimon, Norbert

“…Methionine restriction (MetR) extends lifespan across different species and exerts beneficial effects on metabolic health and inflammatory responses. In…”
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Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel by He, Li, Si, Guangwei, Huang, Jiuhong, Samuel, Aravinthan D. T., Perrimon, Norbert

“…Stem cells of the Drosophila midgut sense mechanical signals in vivo through the stretch-activated ion channel Piezo, which is expressed on previously…”
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The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration by Karpowicz, Phillip, Perez, Jessica, Perrimon, Norbert

“…Identification of the signaling pathways that control the proliferation of stem cells (SCs), and whether they act in a cell or non-cell autonomous manner, is…”
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Modeling metabolic homeostasis and nutrient sensing in Drosophila: implications for aging and metabolic diseases by Owusu-Ansah, Edward, Perrimon, Norbert

“…Over the past decade, numerous reports have underscored the similarities between the metabolism of Drosophila and vertebrates, with the identification of…”
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An integrative approach to ortholog prediction for disease-focused and other functional studies by Hu, Yanhui, Flockhart, Ian, Vinayagam, Arunachalam, Bergwitz, Clemens, Berger, Bonnie, Perrimon, Norbert, Mohr, Stephanie E

“…Mapping of orthologous genes among species serves an important role in functional genomics by allowing researchers to develop hypotheses about gene function in…”
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Pooled genome-wide CRISPR screening for basal and context-specific fitness gene essentiality in Drosophila cells by Viswanatha, Raghuvir, Li, Zhongchi, Hu, Yanhui, Perrimon, Norbert

“…Genome-wide screens in cells have offered numerous insights into gene function, yet a major limitation has been the inability to stably deliver large…”
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Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response by Wang, Wenjun, Li, Jianshuang, Tan, Junyang, Wang, Miaomiao, Yang, Jing, Zhang, Zhi-Min, Li, Chuanzhou, Basnakian, Alexei G., Tang, Hong-Wen, Perrimon, Norbert, Zhou, Qinghua

“…Endonuclease G (ENDOG), a mitochondrial nuclease, is known to participate in many cellular processes, including apoptosis and paternal mitochondrial…”
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Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila by Cho, Bumsik, Yoon, Sang-Ho, Lee, Daewon, Koranteng, Ferdinand, Tattikota, Sudhir Gopal, Cha, Nuri, Shin, Mingyu, Do, Hobin, Hu, Yanhui, Oh, Sue Young, Lee, Daehan, Vipin Menon, A., Moon, Seok Jun, Perrimon, Norbert, Nam, Jin-Wu, Shim, Jiwon

“…The Drosophila lymph gland, the larval hematopoietic organ comprised of prohemocytes and mature hemocytes, has been a valuable model for understanding…”
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Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila by Demontis, Fabio, Perrimon, Norbert

“…Drosophila larval skeletal muscles are single, multinucleated cells of different sizes that undergo tremendous growth within a few days. The mechanisms…”
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spenito is required for sex determination in Drosophila melanogaster by Yan, Dong, Perrimon, Norbert

“…Sex-lethal (Sxl) encodes the master regulator of the sex determination pathway in Drosophila and acts by controlling sex identity in both soma and germ line…”
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Role of autophagy in glycogen breakdown and its relevance to chloroquine myopathy by Zirin, Jonathan, Nieuwenhuis, Joppe, Perrimon, Norbert

“…Several myopathies are associated with defects in autophagic and lysosomal degradation of glycogen, but it remains unclear how glycogen is targeted to the…”
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In vivo study of gene expression with an enhanced dual-color fluorescent transcriptional timer by He, Li, Binari, Richard, Huang, Jiuhong, Falo-Sanjuan, Julia, Perrimon, Norbert

“…Fluorescent transcriptional reporters are widely used as signaling reporters and biomarkers to monitor pathway activities and determine cell type identities…”
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A single-cell survey of Drosophila blood by Tattikota, Sudhir Gopal, Cho, Bumsik, Liu, Yifang, Hu, Yanhui, Barrera, Victor, Steinbaugh, Michael J, Yoon, Sang-Ho, Comjean, Aram, Li, Fangge, Dervis, Franz, Hung, Ruei-Jiun, Nam, Jin-Wu, Ho Sui, Shannan, Shim, Jiwon, Perrimon, Norbert

“…blood cells, called hemocytes, are classified into plasmatocytes, crystal cells, and lamellocytes based on the expression of a few marker genes and cell…”
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Control of lipid metabolism by tachykinin in Drosophila by Song, Wei, Veenstra, Jan A, Perrimon, Norbert

“…The intestine is a key organ for lipid uptake and distribution, and abnormal intestinal lipid metabolism is associated with obesity and hyperlipidemia…”
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Stress Signaling Between Organs in Metazoa by Owusu-Ansah, Edward, Perrimon, Norbert

“…Many organisms have developed a robust ability to adapt and survive in the face of environmental perturbations that threaten the integrity of their genome,…”
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A gene-specific T2A-GAL4 library for Drosophila by Lee, Pei-Tseng, Zirin, Jonathan, Kanca, Oguz, Lin, Wen-Wen, Schulze, Karen L, Li-Kroeger, David, Tao, Rong, Devereaux, Colby, Hu, Yanhui, Chung, Verena, Fang, Ying, He, Yuchun, Pan, Hongling, Ge, Ming, Zuo, Zhongyuan, Housden, Benjamin E, Mohr, Stephanie E, Yamamoto, Shinya, Levis, Robert W, Spradling, Allan C, Perrimon, Norbert, Bellen, Hugo J

“…We generated a library of ~1000 stocks in which we inserted a construct in the intron of genes allowing expression of under control of endogenous promoters…”
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