Search Results - "Perrien, D S"

The effect of an inhibitor of gut serotonin (LP533401) during the induction of periodontal disease by Lima, G. M. G., Corazza, B. J. M., Moraes, R. M., de Oliveira, F. E., de Oliveira, L. D., Franco, G. C. N., Perrien, D. S., Elefteriou, F., Anbinder, A. L.

“…Background and Objective LP533401 is an inhibitor of tryptophan hydroxylase 1, which regulates serotonin production in the gut. Previous work indicates that…”
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IL-1 and TNF Antagonists Prevent Inhibition of Fracture Healing by Ethanol in Rats by Perrien, Daniel S., Wahl, Elizabeth C., Hogue, William R., Feige, Ulrich, Aronson, James, Ronis, Martin J. J., Badger, Thomas M., Lumpkin, Charles K.

“…We tested the hypothesis that combined administration of IL-1 and TNF antagonists would protect fracture healing from inhibition by chronic ethanol exposure…”
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Improving bone formation in a rat femur segmental defect by controlling bone morphogenetic protein-2 release by Brown, Kate V, Li, Bing, Guda, Teja, Perrien, Daniel S, Guelcher, Scott A, Wenke, Joseph C

“…Nonunion is a common complication in open fractures and other severe bone injuries. Recombinant human bone morphogenetic protein-2 (rhBMP-2) delivered on a…”
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Chronic ethanol exposure is associated with a local increase in TNF-α and decreased proliferation in the rat distraction gap by Perrien, Daniel S., Liu, Zhendong, Wahl, Elizabeth C., Bunn, Robert C., Skinner, Robert A., Aronson, James, Fowlkes, John, Badger, Thomas M., Lumpkin, Charles K.

“…Chronic alcohol consumption is a risk factor for osteoporosis and inhibits osseous repair and regeneration. We investigated the hypothesis that chronic ethanol…”
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Differential effects between the loss of MMP‐2 and MMP‐9 on structural and tissue‐level properties of bone by Nyman, Jeffry S, Lynch, Conor C, Perrien, Daniel S, Thiolloy, Sophie, O'Quinn, Elizabeth C, Patil, Chetan A, Bi, Xiaohong, Pharr, George M, Mahadevan‐Jansen, Anita, Mundy, Gregory R

“…Matrix metalloproteinases (MMPs) are capable of processing certain components of bone tissue, including type 1 collagen, a determinant of the biomechanical…”
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Silent Information Regulator (Sir)T1 Inhibits NF- theta B Signaling to Maintain Normal Skeletal Remodeling by Edwards, J R, Perrien, D S, Fleming, N, Nyman, J S, Ono, K, Connelly, L, Moore, M M, Lwin, ST, Yull, F E, Mundy, G R, Elefteriou, F

“…Silent information regulator T1 (SirT1) is linked to longevity and negatively controls NF- Kappa B signaling, a crucial mediator of survival and regulator of…”
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Effects of Systemic and Local Administration of Recombinant Human IGF‐I (rhIGF‐I) on De Novo Bone Formation in an Aged Mouse Model by Fowlkes, John L, Thrailkill, Kathryn M, Liu, Lichu, Wahl, Elizabeth C, Bunn, Robert C, Cockrell, Gael E, Perrien, Daniel S, Aronson, James, Lumpkin, Charles K

“…DO was used in an aged mouse model to determine if systemically and/or locally administered rhIGF‐I improved osteoblastogenesis and new bone formation. Local…”
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Chronic Ethanol Consumption Inhibits Postlactational Anabolic Bone Rebuilding in Female Rats by Shankar, Kartik, Hidestrand, Mats, Liu, Xiaoli, Chen, Jin Ran, Haley, Rani, Perrien, Daniel S, Skinner, Robert A, Lumpkin, Charles K, Badger, Thomas M, Ronis, Martin J J

“…EtOH consumption significantly impaired anabolic rebuilding of bone after lactation. Lower BMD and BMC in EtOH‐fed rats were associated with decreased bone…”
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A novel rat model for the study of deficits in bone formation in type-2 diabetes by Liu, Zhendong, Aronson, James, Wahl, Elizabeth C, Liu, Lichu, Perrien, Daniel S, Kern, Phillip A, Fowlkes, John L, Thrailkill, Kathryn M, Bunn, Robert C, Cockrell, Gael E, Skinner, Robert A, Lumpkin, Jr, Charles K

“…There is evidence to suggest that impairment in bone formation and/or turnover is associated with the metabolic abnormalities characteristic of type-2 diabetes…”
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Chronic ethanol exposure inhibits distraction osteogenesis in a mouse model: Role of the TNF signaling axis by Wahl, Elizabeth C., Aronson, James, Liu, Lichu, Liu, Zhendong, Perrien, Daniel S., Skinner, Robert A., Badger, Thomas M., Ronis, Martin J.J., Lumpkin, Charles K.

“…Tumor necrosis factor-alpha (TNF-α) is an inflammatory cytokine that modulates osteoblastogenesis. In addition, the demonstrated inhibitory effects of chronic…”
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Bone Turnover across the Menopause Transition: Correlations with Inhibins and Follicle-Stimulating Hormone by Perrien, Daniel S., Achenbach, Sara J., Bledsoe, Samuel E., Walser, Brandon, Suva, Larry J., Khosla, Sundeep, Gaddy, Dana

“…Context: Longitudinal clinical studies demonstrate that increases in bone turnover that occur in perimenopausal women correlate better with elevated serum FSH…”
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Bone Formation Is Impaired in a Model of Type 1 Diabetes by THRAILKILL, Kathryn M, LICHU LIU, ARONSON, James, LUMPKIN, Charles K, WAHL, Elizabeth C, BUNN, Robert C, PERRIEN, Daniel S, COCKRELL, Gael E, SKINNER, Robert A, HOGUE, William R, CARVER, Adam A, FOWLKES, John L

“…Bone Formation Is Impaired in a Model of Type 1 Diabetes Kathryn M. Thrailkill 1 , Lichu Liu 2 , Elizabeth C. Wahl 2 , Robert C. Bunn 1 , Daniel S. Perrien 3 4…”
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Interleukin-1 and tumor necrosis factor antagonists attenuate ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis by Perrien, Daniel S, Brown, Elizabeth C, Fletcher, Terry W, Irby, David J, Aronson, James, Gao, Guan G, Skinner, Robert A, Hogue, William R, Feige, Ulrich, Suva, Larry J, Ronis, Martin J J, Badger, Thomas M, Lumpkin, Jr, Charles K

“…Chronic ethanol exposure inhibits rapid bone formation during distraction osteogenesis (DO; fracture and limb lengthening) and decreases volumetric bone…”
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Immunohistochemical Study of Osteopontin Expression During Distraction Osteogenesis in the Rat by Perrien, Daniel S, Brown, Elizabeth C, Aronson, James, Skinner, Robert A, Montague, Donna C, Badger, Thomas M, Lumpkin, Charles K., Jr

“…Distraction osteogenesis (DO) is a limb-lengthening procedure that combines mechanical tension stress with fracture healing to provide a unique opportunity for…”
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Ethanol-Induced Inhibition of Bone Formation in a Rat Model of Distraction Osteogenesis: A Role for the Tumor Necrosis Factor Signaling Axis by Wahl, Elizabeth C., Perrien, Daniel S., Aronson, James, Liu, Zhendong, Fletcher, Terry W., Skinner, Robert A., Feige, Ulrich, Suva, Larry J., Badger, Thomas M., Lumpkin Jr, Charles K.

“…Background: Chronic ethanol exposure inhibits the rapid bone formation demonstrated during limb lengthening by distraction osteogenesis (DO). This inhibition…”
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Skeletal toxicity associated with chronic ethanol exposure in a rat model using total enteral nutrition by Brown, Elizabeth C, Perrien, Daniel S, Fletcher, Terry W, Irby, David J, Aronson, James, Gao, Guan G, Hogue, William J, Skinner, Robert A, Suva, Larry J, Ronis, Martin J J, Hakkak, Reza, Badger, Thomas M, Lumpkin, Jr, Charles K

“…Chronic alcohol abuse decreases bone mass, inhibits osteoblast differentiation and function, increases fracture incidence, and delays fracture healing. Four…”
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