Search Results - "Perri, Patrizia"

Targeting Macrophages as a Potential Therapeutic Intervention: Impact on Inflammatory Diseases and Cancer by Ponzoni, Mirco, Pastorino, Fabio, Di Paolo, Daniela, Perri, Patrizia, Brignole, Chiara

“…Macrophages, cells belonging to the innate immune system, present a high plasticity grade, being able to change their phenotype in response to environmental…”
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Recent advances in the developmental origin of neuroblastoma: an overview by Ponzoni, Mirco, Bachetti, Tiziana, Corrias, Maria Valeria, Brignole, Chiara, Pastorino, Fabio, Calarco, Enzo, Bensa, Veronica, Giusto, Elena, Ceccherini, Isabella, Perri, Patrizia

“…Neuroblastoma (NB) is a pediatric tumor that originates from neural crest-derived cells undergoing a defective differentiation due to genomic and epigenetic…”
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Identification of ALK as a major familial neuroblastoma predisposition gene by Mossé, Yaël P., Laudenslager, Marci, Longo, Luca, Cole, Kristina A., Wood, Andrew, Attiyeh, Edward F., Laquaglia, Michael J., Sennett, Rachel, Lynch, Jill E., Perri, Patrizia, Laureys, Geneviève, Speleman, Frank, Kim, Cecilia, Hou, Cuiping, Hakonarson, Hakon, Torkamani, Ali, Schork, Nicholas J., Brodeur, Garrett M., Tonini, Gian P., Rappaport, Eric, Devoto, Marcella, Maris, John M.

“…Neuroblastoma is a childhood cancer that can be inherited, but the genetic aetiology is largely unknown. Here we show that germline mutations in the anaplastic…”
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A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A by Zeybel, Müjdat, Luli, Saimir, Sabater, Laura, Hardy, Timothy, Oakley, Fiona, Leslie, Jack, Page, Agata, Moran Salvador, Eva, Sharkey, Victoria, Tsukamoto, Hidekazu, Chu, David C.K., Singh, Uma Sharan, Ponzoni, Mirco, Perri, Patrizia, Di Paolo, Daniela, Mendivil, Edgar J., Mann, Jelena, Mann, Derek A.

“…The progression of fibrosis in chronic liver disease is dependent upon hepatic stellate cells (HSCs) transdifferentiating to a myofibroblast-like phenotype…”
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The Olive Leaves Extract Has Anti-Tumor Effects against Neuroblastoma through Inhibition of Cell Proliferation and Induction of Apoptosis by Morandi, Fabio, Bensa, Veronica, Calarco, Enzo, Pastorino, Fabio, Perri, Patrizia, Corrias, Maria Valeria, Ponzoni, Mirco, Brignole, Chiara

“…Neuroblastoma (NB) is the most common extra-cranial solid tumor of pediatric age. The prognosis for high-risk NB patients remains poor, and new treatment…”
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Cotargeting of miR‐126‐3p and miR‐221‐3p inhibits PIK3R2 and PTEN, reducing lung cancer growth and metastasis by blocking AKT and CXCR4 signalling by Di Paolo, Daniela, Pontis, Francesca, Moro, Massimo, Centonze, Giovanni, Bertolini, Giulia, Milione, Massimo, Mensah, Mavis, Segale, Miriam, Petraroia, Ilaria, Borzi, Cristina, Suatoni, Paola, Brignole, Chiara, Perri, Patrizia, Ponzoni, Mirco, Pastorino, Ugo, Sozzi, Gabriella, Fortunato, Orazio

“…Lung cancer is the leading cause of cancer‐related death worldwide. Late diagnosis and metastatic dissemination contribute to its low survival rate. Since…”
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Retinoids Delivery Systems in Cancer: Liposomal Fenretinide for Neuroectodermal-Derived Tumors by Bensa, Veronica, Calarco, Enzo, Giusto, Elena, Perri, Patrizia, Corrias, Maria Valeria, Ponzoni, Mirco, Brignole, Chiara, Pastorino, Fabio

“…Retinoids are a class of natural and synthetic compounds derived from vitamin A. They are involved in several biological processes like embryogenesis,…”
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Tumor vascular targeted liposomal-bortezomib minimizes side effects and increases therapeutic activity in human neuroblastoma by Zuccari, Guendalina, Milelli, Andrea, Pastorino, Fabio, Loi, Monica, Petretto, Andrea, Parise, Amelia, Marchetti, Chiara, Minarini, Anna, Cilli, Michele, Emionite, Laura, Di Paolo, Daniela, Brignole, Chiara, Piaggio, Francesca, Perri, Patrizia, Tumiatti, Vincenzo, Pistoia, Vito, Pagnan, Gabriella, Ponzoni, Mirco

“…Neuroblastoma is a childhood cancer with poor long-term prognosis in advanced stages. A major aim in neuroblastoma therapy is to develop targeted drug delivery…”
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Enhancement of Tumor Homing by Chemotherapy‐Loaded Nanoparticles by Ponzoni, Mirco, Curnis, Flavio, Brignole, Chiara, Bruno, Silvia, Guarnieri, Daniela, Sitia, Leopoldo, Marotta, Roberto, Sacchi, Angelina, Bauckneht, Matteo, Buschiazzo, Ambra, Rossi, Andrea, Di Paolo, Daniela, Perri, Patrizia, Gori, Alessandro, Sementa, Angela R., Emionite, Laura, Cilli, Michele, Tamma, Roberto, Ribatti, Domenico, Pompa, Pier Paolo, Marini, Cecilia, Sambuceti, Gianmario, Corti, Angelo, Pastorino, Fabio

“…Targeted delivery of anticancer drugs with nanocarriers can reduce side effects and ameliorate therapeutic efficacy. However, poorly perfused and dysfunctional…”
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Cell surface Nucleolin represents a novel cellular target for neuroblastoma therapy by Brignole, Chiara, Bensa, Veronica, Fonseca, Nuno A, Del Zotto, Genny, Bruno, Silvia, Cruz, Ana F, Malaguti, Fabiana, Carlini, Barbara, Morandi, Fabio, Calarco, Enzo, Perri, Patrizia, Moura, Vera, Emionite, Laura, Cilli, Michele, De Leonardis, Francesco, Tondo, Annalisa, Amoroso, Loredana, Conte, Massimo, Garaventa, Alberto, Sementa, Angela R, Corrias, Maria V, Ponzoni, Mirco, Moreira, Joao N, Pastorino, Fabio

“…Neuroblastoma (NB) represents the most frequent and aggressive form of extracranial solid tumor of infants. Nucleolin (NCL) is a protein overexpressed and…”
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MiR-486-5p Targets CD133+ Lung Cancer Stem Cells through the p85/AKT Pathway by Moro, Massimo, Fortunato, Orazio, Bertolini, Giulia, Mensah, Mavis, Borzi, Cristina, Centonze, Giovanni, Andriani, Francesca, Di Paolo, Daniela, Perri, Patrizia, Ponzoni, Mirco, Pastorino, Ugo, Sozzi, Gabriella, Boeri, Mattia

“…Despite improvements in therapies and screening strategies, lung cancer prognosis still remains dismal, especially for metastatic tumors. Cancer stem cells…”
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Enhanced anti-tumor and anti-angiogenic efficacy of a novel liposomal fenretinide on human neuroblastoma by Di Paolo, Daniela, Pastorino, Fabio, Zuccari, Guendalina, Caffa, Irene, Loi, Monica, Marimpietri, Danilo, Brignole, Chiara, Perri, Patrizia, Cilli, Michele, Nico, Beatrice, Ribatti, Domenico, Pistoia, Vito, Ponzoni, Mirco, Pagnan, Gabriella

“…Neuroblastoma is an embryonal tumor originating from the simpatico-adrenal lineage of the neural crest. It approximately accounts for about 15% of all…”
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Antitumor activity of the investigational B7-H3 antibody-drug conjugate, vobramitamab duocarmazine, in preclinical models of neuroblastoma by Brignole, Chiara, Calarco, Enzo, Bensa, Veronica, Giusto, Elena, Perri, Patrizia, Ciampi, Eleonora, Corrias, Maria Valeria, Astigiano, Simonetta, Cilli, Michele, Loo, Derik, Bonvini, Ezio, Pastorino, Fabio, Ponzoni, Mirco

“…Introduction B7-H3 is a potential target for pediatric cancers, including neuroblastoma (NB). Vobramitamab duocarmazine (also referred to as MGC018 and herein…”
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Therapeutic Targeting of TLR9 Inhibits Cell Growth and Induces Apoptosis in Neuroblastoma by BRIGNOLE, Chiara, MARIMPIETRI, Danilo, ERMINIO, Giovanni, HAUPT, Riccardo, GAMBINI, Claudio, PISTOIA, Vito, PONZONI, Mirco, DI PAOLO, Daniela, PERRI, Patrizia, MORANDI, Fabio, PASTORINO, Fabio, ZORZOLI, Alessia, PAGNAN, Gabriella, LOI, Monica, CAFFA, Irene

“…The Toll-like receptor 9 (TLR9) evolved to cope with pathogens, but it is expressed in a variety of tumors for reasons that are unclear. In this study, we…”
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Neuroblastoma-targeted Nanoparticles Entrapping siRNA Specifically Knockdown ALK by Di Paolo, Daniela, Brignole, Chiara, Pastorino, Fabio, Carosio, Roberta, Zorzoli, Alessia, Rossi, Marzia, Loi, Monica, Pagnan, Gabriella, Emionite, Laura, Cilli, Michele, Bruno, Silvia, Chiarle, Roberto, Allen, Theresa M, Ponzoni, Mirco, Perri, Patrizia

“…RNA interference molecules have some advantages as cancer therapeutics, including a proved efficacy on both wild-type (WT) and mutated transcripts and an…”
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Combined targeting of perivascular and endothelial tumor cells enhances anti-tumor efficacy of liposomal chemotherapy in neuroblastoma by Loi, Monica, Marchiò, Serena, Becherini, Pamela, Di Paolo, Daniela, Soster, Marco, Curnis, Flavio, Brignole, Chiara, Pagnan, Gabriella, Perri, Patrizia, Caffa, Irene, Longhi, Renato, Nico, Beatrice, Bussolino, Federico, Gambini, Claudio, Ribatti, Domenico, Cilli, Michele, Arap, Wadih, Pasqualini, Renata, Allen, Theresa M., Corti, Angelo, Ponzoni, Mirco, Pastorino, Fabio

“…The therapeutic index of anti-cancer drugs is increased when encapsulating them in tumor-targeted liposomes. Liposome-entrapped doxorubicin (DXR), targeting…”
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Quiescent hepatic stellate cells functionally contribute to the hepatic innate immune response via TLR3 by Wilson, Caroline L, Mann, Jelena, Walsh, Meagan, Perrugoria, Maria J, Oakley, Fiona, Wright, Matthew C, Brignole, Chiara, Di Paolo, Daniela, Perri, Patrizia, Ponzoni, Mirco, Karin, Michael, Mann, Derek A

“…Toll-like Receptor 3 (TLR3) is a pathogen pattern recognition receptor that plays a key role in innate immunity. TLR3 signalling has numerous functions in…”
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Nucleolin expression has prognostic value in neuroblastoma patients by Cangelosi, Davide, Brignole, Chiara, Bensa, Veronica, Tamma, Roberto, Malaguti, Fabiana, Carlini, Barbara, Giusto, Elena, Calarco, Enzo, Perri, Patrizia, Ribatti, Domenico, Fonseca, Nuno André, Moreira, Joao Nuno, Eva, Alessandra, Amoroso, Loredana, Conte, Massimo, Garaventa, Alberto, Sementa, Angela Rita, Corrias, Maria Valeria, Ponzoni, Mirco, Pastorino, Fabio

“…Neuroblastoma (NB) represents the most frequent form of extra-cranial solid tumour of infants, responsible for 15% of childhood cancer deaths. Nucleolin (NCL)…”
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PHOX2B-mediated regulation of ALK expression: in vitro identification of a functional relationship between two genes involved in neuroblastoma by Bachetti, Tiziana, Di Paolo, Daniela, Di Lascio, Simona, Mirisola, Valentina, Brignole, Chiara, Bellotti, Marta, Caffa, Irene, Ferraris, Chiara, Fiore, Michele, Fornasari, Diego, Chiarle, Roberto, Borghini, Silvia, Pfeffer, Ulrich, Ponzoni, Mirco, Ceccherini, Isabella, Perri, Patrizia

“…Neuroblastoma (NB) is a severe pediatric tumor originating from neural crest derivatives and accounting for 15% of childhood cancer mortality. The…”
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Combined Therapeutic Effects of Vinblastine and Rapamycin on Human Neuroblastoma Growth, Apoptosis, and Angiogenesis by MARIMPIETRI, Danilo, BRIGNOLE, Chiara, PERRI, Patrizia, RIBATTI, Domenico, PONZONI, Mirco, NICO, Beatrice, PASTORINO, Fabio, PEZZOLO, Annalisa, PICCARDI, Federica, CILLI, Michele, DI PAOLO, Daniela, PAGNAN, Gabriella, LONGO, Luca

“…Purpose: Vinblastine and rapamycin displayed synergistic inhibition of human neuroblastoma-related angiogenesis. Here, we studied the antitumor activity of…”
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