Search Results - "Perrett, Hailee R."

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM by Antanasijevic, Aleksandar, Sewall, Leigh M., Cottrell, Christopher A., Carnathan, Diane G., Jimenez, Luis E., Ngo, Julia T., Silverman, Jennifer B., Groschel, Bettina, Georgeson, Erik, Bhiman, Jinal, Bastidas, Raiza, LaBranche, Celia, Allen, Joel D., Copps, Jeffrey, Perrett, Hailee R., Rantalainen, Kimmo, Cannac, Fabien, Yang, Yuhe R., de la Peña, Alba Torrents, Rocha, Rebeca Froes, Berndsen, Zachary T., Baker, David, King, Neil P., Sanders, Rogier W., Moore, John P., Crotty, Shane, Crispin, Max, Montefiori, David C., Burton, Dennis R., Schief, William R., Silvestri, Guido, Ward, Andrew B.

“…Engineered ectodomain trimer immunogens based on BG505 envelope glycoprotein are widely utilized as components of HIV vaccine development platforms. In this…”
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A Lassa virus mRNA vaccine confers protection but does not require neutralizing antibody in a guinea pig model of infection by Ronk, Adam J., Lloyd, Nicole M., Zhang, Min, Atyeo, Caroline, Perrett, Hailee R., Mire, Chad E., Hastie, Kathryn M., Sanders, Rogier W., Brouwer, Philip J. M., Saphire, Erica Olmann, Ward, Andrew B., Ksiazek, Thomas G., Alvarez Moreno, Juan Carlos, Thaker, Harshwardhan M., Alter, Galit, Himansu, Sunny, Carfi, Andrea, Bukreyev, Alexander

“…Lassa virus is a member of the Arenaviridae family, which causes human infections ranging from asymptomatic to severe hemorrhagic disease with a high case…”
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Defining bottlenecks and opportunities for Lassa virus neutralization by structural profiling of vaccine-induced polyclonal antibody responses by Brouwer, Philip J.M., Perrett, Hailee R., Beaumont, Tim, Nijhuis, Haye, Kruijer, Sabine, Burger, Judith A., Bontjer, Ilja, Lee, Wen-Hsin, Ferguson, James A., Schauflinger, Martin, Müller-Kräuter, Helena, Sanders, Rogier W., Strecker, Thomas, van Gils, Marit J., Ward, Andrew B.

“…Lassa fever continues to be a major public health burden in West Africa, yet effective therapies or vaccines are lacking. The isolation of protective…”
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Immune memory shapes human polyclonal antibody responses to H2N2 vaccination by Yang, Yuhe R., Han, Julianna, Perrett, Hailee R., Richey, Sara T., Rodriguez, Alesandra J., Jackson, Abigail M., Gillespie, Rebecca A., O’Connell, Sarah, Raab, Julie E., Cominsky, Lauren Y., Chopde, Ankita, Kanekiyo, Masaru, Houser, Katherine V., Chen, Grace L., McDermott, Adrian B., Andrews, Sarah F., Ward, Andrew B.

“…Influenza A virus subtype H2N2, which caused the 1957 influenza pandemic, remains a global threat. A recent phase 1 clinical trial investigating a ferritin…”
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Structural conservation of Lassa virus glycoproteins and recognition by neutralizing antibodies by Perrett, Hailee R., Brouwer, Philip J.M., Hurtado, Jonathan, Newby, Maddy L., Liu, Lin, Müller-Kräuter, Helena, Müller Aguirre, Sarah, Burger, Judith A., Bouhuijs, Joey H., Gibson, Grace, Messmer, Terrence, Schieffelin, John S., Antanasijevic, Aleksandar, Boons, Geert-Jan, Strecker, Thomas, Crispin, Max, Sanders, Rogier W., Briney, Bryan, Ward, Andrew B.

“…Lassa fever is an acute hemorrhagic fever caused by the zoonotic Lassa virus (LASV). The LASV glycoprotein complex (GPC) mediates viral entry and is the sole…”
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Structure and Dynamics Guiding Design of Antibody Therapeutics and Vaccines by Fernández-Quintero, Monica L, Pomarici, Nancy D, Fischer, Anna-Lena M, Hoerschinger, Valentin J, Kroell, Katharina B, Riccabona, Jakob R, Kamenik, Anna S, Loeffler, Johannes R, Ferguson, James A, Perrett, Hailee R, Liedl, Klaus R, Han, Julianna, Ward, Andrew B

“…Antibodies and other new antibody-like formats have emerged as one of the most rapidly growing classes of biotherapeutic proteins. Understanding the structural…”
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SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2 by Clausen, Thomas Mandel, Sandoval, Daniel R., Spliid, Charlotte B., Pihl, Jessica, Perrett, Hailee R., Painter, Chelsea D., Narayanan, Anoop, Majowicz, Sydney A., Kwong, Elizabeth M., McVicar, Rachael N., Thacker, Bryan E., Glass, Charles A., Yang, Zhang, Torres, Jonathan L., Golden, Gregory J., Bartels, Phillip L., Porell, Ryan N., Garretson, Aaron F., Laubach, Logan, Feldman, Jared, Yin, Xin, Pu, Yuan, Hauser, Blake M., Caradonna, Timothy M., Kellman, Benjamin P., Martino, Cameron, Gordts, Philip L.S.M., Chanda, Sumit K., Schmidt, Aaron G., Godula, Kamil, Leibel, Sandra L., Jose, Joyce, Corbett, Kevin D., Ward, Andrew B., Carlin, Aaron F., Esko, Jeffrey D.

“…We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and angiotensin-converting enzyme 2 (ACE2) through its receptor-binding…”
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Lassa virus glycoprotein nanoparticles elicit neutralizing antibody responses and protection by Brouwer, Philip J.M., Antanasijevic, Aleksandar, Ronk, Adam J., Müller-Kräuter, Helena, Watanabe, Yasunori, Claireaux, Mathieu, Perrett, Hailee R., Bijl, Tom P.L., Grobben, Marloes, Umotoy, Jeffrey C., Schriek, Angela I., Burger, Judith A., Tejjani, Khadija, Lloyd, Nicole M., Steijaert, Thijs H., van Haaren, Marlies M., Sliepen, Kwinten, de Taeye, Steven W., van Gils, Marit J., Crispin, Max, Strecker, Thomas, Bukreyev, Alexander, Ward, Andrew B., Sanders, Rogier W.

“…The Lassa virus is endemic in parts of West Africa, and it causes hemorrhagic fever with high mortality. The development of a recombinant protein vaccine has…”
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A cornucopia of Shigella phages from the Cornhusker State by Doore, Sarah M., Schrad, Jason R., Perrett, Hailee R., Schrad, Kevin P., Dean, William F., Parent, Kristin N.

“…Bacteriophages are abundant in the environment, yet the vast majority have not been discovered or described. Many characterized bacteriophages infect a small…”
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Cryo-Em structures of novel arenviral fusion glycoproteins reveal conserved sites of vulnerability by Perrett, Hailee R., Brouwer, Philip J.M., Antanasijevic, Aleksandar, King, Neil P., Sanders, Rogier W., Ward, Andrew B.

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Sugar, Ice, and Everything (Not So) Nice: Structural Interrogation of the Lassa Glycoprotein Complex and Its Recognition by the Humoral Immune System by Perrett, Hailee R

“…Recognized as a priority emerging pathogen by the World Health Organization due to its potential to cause a public health crisis and the absence of efficacious…”
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