Search Results - "Perreira, Jill M."

The IFITMs Inhibit Zika Virus Replication by Savidis, George, Perreira, Jill M., Portmann, Jocelyn M., Meraner, Paul, Guo, Zhiru, Green, Sharone, Brass, Abraham L.

“…Zika virus has emerged as a severe health threat with a rapidly expanding range. The IFITM family of restriction factors inhibits the replication of a broad…”
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Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics by Savidis, George, McDougall, William M., Meraner, Paul, Perreira, Jill M., Portmann, Jocelyn M., Trincucci, Gaia, John, Sinu P., Aker, Aaron M., Renzette, Nicholas, Robbins, Douglas R., Guo, Zhiru, Green, Sharone, Kowalik, Timothy F., Brass, Abraham L.

“…The flaviviruses dengue virus (DENV) and Zika virus (ZIKV) are severe health threats with rapidly expanding ranges. To identify the host cell dependencies of…”
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IFITMs Restrict the Replication of Multiple Pathogenic Viruses by Perreira, Jill M., Chin, Christopher R., Feeley, Eric M., Brass, Abraham L.

“…The interferon-inducible transmembrane protein (IFITM) family inhibits a growing number of pathogenic viruses, among them influenza A virus, dengue virus,…”
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Direct Visualization of HIV-1 Replication Intermediates Shows that Capsid and CPSF6 Modulate HIV-1 Intra-nuclear Invasion and Integration by Chin, Christopher R., Perreira, Jill M., Savidis, George, Portmann, Jocelyn M., Aker, Aaron M., Feeley, Eric M., Smith, Miles C., Brass, Abraham L.

“…Direct visualization of HIV-1 replication would improve our understanding of the viral life cycle. We adapted established technology and reagents to develop an…”
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The CD225 Domain of IFITM3 Is Required for both IFITM Protein Association and Inhibition of Influenza A Virus and Dengue Virus Replication by John, Sinu P, Chin, Christopher R, Perreira, Jill M, Feeley, Eric M, Aker, Aaron M, Savidis, George, Smith, Sarah E, Elia, Andrew E H, Everitt, Aaron R, Vora, Mehul, Pertel, Thomas, Elledge, Stephen J, Kellam, Paul, Brass, Abraham L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Amphotericin B Increases Influenza A Virus Infection by Preventing IFITM3-Mediated Restriction by Lin, Tsai-Yu, Chin, Christopher R., Everitt, Aaron R., Clare, Simon, Perreira, Jill M., Savidis, George, Aker, Aaron M., John, Sinu P., Sarlah, David, Carreira, Erick M., Elledge, Stephen J., Kellam, Paul, Brass, Abraham L.

“…The IFITMs inhibit influenza A virus (IAV) replication in vitro and in vivo. Here, we establish that the antimycotic heptaen, amphotericin B (AmphoB),…”
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RNASEK Is a V-ATPase-Associated Factor Required for Endocytosis and the Replication of Rhinovirus, Influenza A Virus, and Dengue Virus by Perreira, Jill M., Aker, Aaron M., Savidis, George, Chin, Christopher R., McDougall, William M., Portmann, Jocelyn M., Meraner, Paul, Smith, Miles C., Rahman, Motiur, Baker, Richard E., Gauthier, Annick, Franti, Michael, Brass, Abraham L.

“…Human rhinovirus (HRV) causes upper respiratory infections and asthma exacerbations. We screened multiple orthologous RNAi reagents and identified host…”
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Viral Infection or IFN-α Alters Mitotic Spindle Orientation by Modulating Pericentrin Levels by McDougall, William M, Perreira, Jill M, Hung, Hui-Fang, Vertii, Anastassiia, Xiaofei, E, Zimmerman, Wendy, Kowalik, Timothy F, Doxsey, Stephen, Brass, Abraham L

“…Congenital microcephaly occurs in utero during Zika virus (ZIKV) infection. The single-gene disorder, Majewski osteodysplastic primordial dwarfism type II…”
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OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism by Xiaofei, E, Meraner, Paul, Lu, Ping, Perreira, Jill M., Aker, Aaron M., McDougall, William M., Zhuge, Ronghua, Chan, Gary C., Gerstein, Rachel M., Caposio, Patrizia, Yurochko, Andrew D., Brass, Abraham L., Kowalik, Timothy F.

“…A human cytomegalovirus (HCMV) pentameric glycoprotein complex (PC), gH–gL–UL128–UL130–UL131A, is necessary for viral infection of clinically relevant cell…”
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Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration by Achuthan, Vasudevan, Perreira, Jill M., Sowd, Gregory A., Puray-Chavez, Maritza, McDougall, William M., Paulucci-Holthauzen, Adriana, Wu, Xiaolin, Fadel, Hind J., Poeschla, Eric M., Multani, Asha S., Hughes, Stephen H., Sarafianos, Stefan G., Brass, Abraham L., Engelman, Alan N.

“…HIV-1 integration into the host genome favors actively transcribed genes. Prior work indicated that the nuclear periphery provides the architectural basis for…”
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A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model by Yant, Stephen R., Mulato, Andrew, Hansen, Derek, Tse, Winston C., Niedziela-Majka, Anita, Zhang, Jennifer R., Stepan, George J., Jin, Debi, Wong, Melanie H., Perreira, Jill M., Singer, Eric, Papalia, Giuseppe A., Hu, Eric Y., Zheng, Jim, Lu, Bing, Schroeder, Scott D., Chou, Kevin, Ahmadyar, Shekeba, Liclican, Albert, Yu, Helen, Novikov, Nikolai, Paoli, Eric, Gonik, Daniel, Ram, Renee R., Hung, Magdeleine, McDougall, William M., Brass, Abraham L., Sundquist, Wesley I., Cihlar, Tomas, Link, John O.

“…People living with HIV (PLWH) have expressed concern about the life-long burden and stigma associated with taking pills daily and can experience medication…”
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Functional Genomic Strategies for Elucidating Human-Virus Interactions: Will CRISPR Knockout RNAi and Haploid Cells? by Perreira, Jill M, Meraner, Paul, Brass, Abraham L

“…Over the last several years a wealth of transformative human-virus interaction discoveries have been produced using loss-of-function functional genomics. These…”
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Discovery of Zika Virus Dependency and Restriction Factors Using Flow-Based Arrayed CRISPR Screening for Identification of Targets (FACS-IT) by McDougall, William M, Kandpal, Manish, Perreira, Jill M, Brass, Abraham L

“…The discovery and implementation of CRISPR/Cas9 tools in pooled genetic screens have allowed for the rapid, high-fidelity identification of host-virus…”
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CRISPR genetic screens to discover host–virus interactions by .McDougall, William M, Perreira, Jill M, Reynolds, Erin C, Brass, Abraham L

“…Viruses impose an immense burden on human health. With the goal of treating and preventing viral infections, researchers have carried out genetic screens to…”
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Direct Visualization of HIV-1 Replication Intermediates shows that Viral Capsid and CPSF6 Modulate HIV-1 Intra-nuclear Invasion and Integration by Chin, Christopher R., Perreira, Jill M., Savidis, George, Portmann, Jocelyn M., Aker, Aaron M., Feeley, Eric M., Smith, Miles C., Brass, Abraham L.

“…Direct visualization of HIV-1 replication would improve our understanding of the viral lifecycle. We adapted established technology and reagents to develop an…”
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