Search Results - "Perper, Stuart J."

TWEAK Is a Novel Arthritogenic Mediator by Perper, Stuart J, Browning, Beth, Burkly, Linda C, Weng, Shawn, Gao, Cindy, Giza, Keith, Su, Lihe, Tarilonte, Leticia, Crowell, Thomas, Rajman, Luis, Runkel, Laura, Scott, Martin, Atkins, Gerald J, Findlay, David M, Zheng, Timothy S, Hess, Henry

“…TNF-like weak inducer of apoptosis (TWEAK) is a TNF family member with pleiotropic effects on a variety of cell types, one of which is the induction of…”
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Treatment with a CD40 Antagonist Antibody Reverses Severe Proteinuria and Loss of Saliva Production and Restores Glomerular Morphology in Murine Systemic Lupus Erythematosus by Perper, Stuart J, Westmoreland, Susan V, Karman, Jozsef, Twomey, Rachel, Seagal, Jane, Wang, Rui, McRae, Bradford L, Clarke, Stephen H

“…CD40 is a costimulatory receptor on APCs that is critical for the induction and maintenance of humoral and cell-mediated immunity. Accordingly, CD40 and its…”
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Therapeutic JAK1 Inhibition Reverses Lupus Nephritis in a Mouse Model and Demonstrates Transcriptional Changes Consistent With Human Disease by Twomey, Rachel E, Perper, Stuart J, Westmoreland, Susan V, Srinivasan, Swetha, Mathieu, Suzanne L, Frank, Kristine E, Karman, Jozsef, Long, Andrew J, Housley, William J, Clarke, Stephen H

“…Janus kinase family members are essential for signaling by multiple cytokines, including many implicated in systemic lupus erythematosus (SLE) pathogenesis. To…”
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Differential effects of treatment with a small-molecule VLA-4 antagonist before and after onset of relapsing EAE by Theien, Bradley E., Vanderlugt, Carol L., Nickerson-Nutter, Cheryl, Cornebise, Mark, Scott, Daniel M., Perper, Stuart J., Whalley, Eric T., Miller, Stephen D.

“…Interaction of very late antigen-4 (VLA-4) with its ligand vascular cell adhesion molecule-1 (VCAM-1) is required for central nervous system (CNS) migration of…”
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Anti-arthritic effects demonstrated by an interleukin-2 receptor-targeted cytotoxin (DAB486IL-2) in rat adjuvant arthritis by Bacha, P, Forte, S E, Perper, S J, Trentham, D E, Nichols, J C

“…DAB486IL-2 is an interleukin-2 receptor-specific cytotoxin which selectively targets and kills cells which bear the high-affinity form of the IL-2 receptor…”
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