Search Results - "Perola, Markus"

Atlas of plasma NMR biomarkers for health and disease in 118,461 individuals from the UK Biobank by Julkunen, Heli, Cichońska, Anna, Tiainen, Mika, Koskela, Harri, Nybo, Kristian, Mäkelä, Valtteri, Nokso-Koivisto, Jussi, Kristiansson, Kati, Perola, Markus, Salomaa, Veikko, Jousilahti, Pekka, Lundqvist, Annamari, Kangas, Antti J., Soininen, Pasi, Barrett, Jeffrey C., Würtz, Peter

“…Blood lipids and metabolites are markers of current health and future disease risk. Here, we describe plasma nuclear magnetic resonance (NMR) biomarker data…”
Get full text

Taxonomic signatures of cause-specific mortality risk in human gut microbiome by Salosensaari, Aaro, Laitinen, Ville, Havulinna, Aki S., Meric, Guillaume, Cheng, Susan, Perola, Markus, Valsta, Liisa, Alfthan, Georg, Inouye, Michael, Watrous, Jeramie D., Long, Tao, Salido, Rodolfo A., Sanders, Karenina, Brennan, Caitriona, Humphrey, Gregory C., Sanders, Jon G., Jain, Mohit, Jousilahti, Pekka, Salomaa, Veikko, Knight, Rob, Lahti, Leo, Niiranen, Teemu

“…The collection of fecal material and developments in sequencing technologies have enabled standardised and non-invasive gut microbiome profiling. Microbiome…”
Get full text

Risks of Light and Moderate Alcohol Use in Fatty Liver Disease: Follow‐Up of Population Cohorts by Åberg, Fredrik, Puukka, Pauli, Salomaa, Veikko, Männistö, Satu, Lundqvist, Annamari, Valsta, Liisa, Perola, Markus, Färkkilä, Martti, Jula, Antti

“…Background and Aims The effects of alcohol use in nonalcoholic fatty liver disease are unclear. We investigated the impact of alcohol use in fatty liver…”
Get full text

Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu by Leitsalu, Liis, Haller, Toomas, Esko, Tõnu, Tammesoo, Mari-Liis, Alavere, Helene, Snieder, Harold, Perola, Markus, Ng, Pauline C, Mägi, Reedik, Milani, Lili, Fischer, Krista, Metspalu, Andres

“…The Estonian Biobank cohort is a volunteer-based sample of the Estonian resident adult population (aged ≥18 years). The current number of participants-close to…”
Get full text

Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors by Ahola-Olli, Ari V., Würtz, Peter, Havulinna, Aki S., Aalto, Kristiina, Pitkänen, Niina, Lehtimäki, Terho, Kähönen, Mika, Lyytikäinen, Leo-Pekka, Raitoharju, Emma, Seppälä, Ilkka, Sarin, Antti-Pekka, Ripatti, Samuli, Palotie, Aarne, Perola, Markus, Viikari, Jorma S., Jalkanen, Sirpa, Maksimow, Mikael, Salomaa, Veikko, Salmi, Marko, Kettunen, Johannes, Raitakari, Olli T.

“…Circulating cytokines and growth factors are regulators of inflammation and have been implicated in autoimmune and metabolic diseases. In this genome-wide…”
Get full text

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals by Deelen, Joris, Kettunen, Johannes, Fischer, Krista, van der Spek, Ashley, Trompet, Stella, Kastenmüller, Gabi, Boyd, Andy, Zierer, Jonas, van den Akker, Erik B., Ala-Korpela, Mika, Amin, Najaf, Demirkan, Ayse, Ghanbari, Mohsen, van Heemst, Diana, Ikram, M. Arfan, van Klinken, Jan Bert, Mooijaart, Simon P., Peters, Annette, Salomaa, Veikko, Sattar, Naveed, Spector, Tim D., Tiemeier, Henning, Verhoeven, Aswin, Waldenberger, Melanie, Würtz, Peter, Davey Smith, George, Metspalu, Andres, Perola, Markus, Menni, Cristina, Geleijnse, Johanna M., Drenos, Fotios, Beekman, Marian, Jukema, J. Wouter, van Duijn, Cornelia M., Slagboom, P. Eline

“…Predicting longer-term mortality risk requires collection of clinical data, which is often cumbersome. Therefore, we use a well-standardized metabolomics…”
Get full text

Genomic prediction of coronary heart disease by Abraham, Gad, Havulinna, Aki S, Bhalala, Oneil G, Byars, Sean G, De Livera, Alysha M, Yetukuri, Laxman, Tikkanen, Emmi, Perola, Markus, Schunkert, Heribert, Sijbrands, Eric J, Palotie, Aarno, Samani, Nilesh J, Salomaa, Veikko, Ripatti, Samuli, Inouye, Michael

“…Genetics plays an important role in coronary heart disease (CHD) but the clinical utility of genomic risk scores (GRSs) relative to clinical risk scores, such…”
Get full text

Evaluation of O2PLS in Omics data integration by Bouhaddani, Said El, Houwing-Duistermaat, Jeanine, Salo, Perttu, Perola, Markus, Jongbloed, Geurt, Uh, Hae-Won

“…Rapid computational and technological developments made large amounts of omics data available in different biological levels. It is becoming clear that…”
Get full text

Geographic Variation and Bias in the Polygenic Scores of Complex Diseases and Traits in Finland by Kerminen, Sini, Martin, Alicia R., Koskela, Jukka, Ruotsalainen, Sanni E., Havulinna, Aki S., Surakka, Ida, Palotie, Aarno, Perola, Markus, Salomaa, Veikko, Daly, Mark J., Ripatti, Samuli, Pirinen, Matti

“…Polygenic scores (PSs) are becoming a useful tool to identify individuals with high genetic risk for complex diseases, and several projects are currently…”
Get full text

An epigenome-wide association study of metabolic syndrome and its components by Nuotio, Marja-Liisa, Pervjakova, Natalia, Joensuu, Anni, Karhunen, Ville, Hiekkalinna, Tero, Milani, Lili, Kettunen, Johannes, Järvelin, Marjo-Riitta, Jousilahti, Pekka, Metspalu, Andres, Salomaa, Veikko, Kristiansson, Kati, Perola, Markus

“…The role of metabolic syndrome (MetS) as a preceding metabolic state for type 2 diabetes and cardiovascular disease is widely recognised. To accumulate…”
Get full text

Plasma N -Glycans as Emerging Biomarkers of Cardiometabolic Risk: A Prospective Investigation in the EPIC-Potsdam Cohort Study by Wittenbecher, Clemens, Štambuk, Tamara, Kuxhaus, Olga, Rudman, Najda, Vučković, Frano, Štambuk, Jerko, Schiborn, Catarina, Rahelić, Dario, Dietrich, Stefan, Gornik, Olga, Perola, Markus, Boeing, Heiner, Schulze, Matthias B, Lauc, Gordan

“…Plasma protein -glycan profiling integrates information on enzymatic protein glycosylation, which is a highly controlled ubiquitous posttranslational…”
Get full text

Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons by Fischer, Krista, Kettunen, Johannes, Würtz, Peter, Haller, Toomas, Havulinna, Aki S, Kangas, Antti J, Soininen, Pasi, Esko, Tõnu, Tammesoo, Mari-Liis, Mägi, Reedik, Smit, Steven, Palotie, Aarno, Ripatti, Samuli, Salomaa, Veikko, Ala-Korpela, Mika, Perola, Markus, Metspalu, Andres

“…Early identification of ambulatory persons at high short-term risk of death could benefit targeted prevention. To identify biomarkers for all-cause mortality…”
Get full text

Genome-wide association study identifies multiple loci influencing human serum metabolite levels by Kettunen, Johannes, Tukiainen, Taru, Sarin, Antti-Pekka, Ortega-Alonso, Alfredo, Tikkanen, Emmi, Lyytikäinen, Leo-Pekka, Kangas, Antti J, Soininen, Pasi, Würtz, Peter, Silander, Kaisa, Dick, Danielle M, Rose, Richard J, Savolainen, Markku J, Viikari, Jorma, Kähönen, Mika, Lehtimäki, Terho, Pietiläinen, Kirsi H, Inouye, Michael, McCarthy, Mark I, Jula, Antti, Eriksson, Johan, Raitakari, Olli T, Salomaa, Veikko, Kaprio, Jaakko, Järvelin, Marjo-Riitta, Peltonen, Leena, Perola, Markus, Freimer, Nelson B, Ala-Korpela, Mika, Palotie, Aarno, Ripatti, Samuli

“…Samuli Ripatti and colleagues report a genome-wide association study for human serum metabolites using NMR of serum samples from over 8,000 Finnish…”
Get full text

Editorial: Can population health be personalized? Estonia and Finland as examples by Kääriäinen, Helena, Metspalu, Andres, Perola, Markus

Get full text

A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses by Ripatti, Samuli, Dr, Tikkanen, Emmi, MSc, Orho-Melander, Marju, Prof, Havulinna, Aki S, MSc, Silander, Kaisa, PhD, Sharma, Amitabh, PhD, Guiducci, Candace, BS, Perola, Markus, Prof, Jula, Antti, MD, Sinisalo, Juha, MD, Lokki, Marja-Liisa, PhD, Nieminen, Markku S, Prof, Melander, Olle, MD, Salomaa, Veikko, Prof, Peltonen, Leena, Prof, Kathiresan, Sekar, MD

“…Summary Background Comparison of patients with coronary heart disease and controls in genome-wide association studies has revealed several single nucleotide…”
Get full text

IgG Glycome in Colorectal Cancer by Vučković, Frano, Theodoratou, Evropi, Thaçi, Kujtim, Timofeeva, Maria, Vojta, Aleksandar, Štambuk, Jerko, Pučić-Baković, Maja, Rudd, Pauline M, Đerek, Lovorka, Servis, Dražen, Wennerström, Annika, Farrington, Susan M, Perola, Markus, Aulchenko, Yurii, Dunlop, Malcolm G, Campbell, Harry, Lauc, Gordan

“…Alternative glycosylation has significant structural and functional consequences on IgG and consequently also on cancer immunosurveillance. Because of…”
Get full text

Apolipoprotein A-I concentrations and risk of coronary artery disease: A Mendelian randomization study by Karjalainen, Minna K., Holmes, Michael V., Wang, Qin, Anufrieva, Olga, Kähönen, Mika, Lehtimäki, Terho, Havulinna, Aki S., Kristiansson, Kati, Salomaa, Veikko, Perola, Markus, Viikari, Jorma S., Raitakari, Olli T., Järvelin, Marjo-Riitta, Ala-Korpela, Mika, Kettunen, Johannes

“…Apolipoprotein A-I (apoA-I) infusions represent a potential novel therapeutic approach for the prevention of coronary artery disease (CAD). Although…”
Get full text

Neolithic dairy farming at the extreme of agriculture in northern Europe by Cramp, Lucy J. E., Evershed, Richard P., Lavento, Mika, Halinen, Petri, Mannermaa, Kristiina, Oinonen, Markku, Kettunen, Johannes, Perola, Markus, Onkamo, Päivi, Heyd, Volker

“…The conventional ‘Neolithic package’ comprised animals and plants originally domesticated in the Near East. As farming spread on a generally northwest…”
Get full text

Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence by Wang, Qin, Würtz, Peter, Auro, Kirsi, Mäkinen, Ville-Petteri, Kangas, Antti J, Soininen, Pasi, Tiainen, Mika, Tynkkynen, Tuulia, Jokelainen, Jari, Santalahti, Kristiina, Salmi, Marko, Blankenberg, Stefan, Zeller, Tanja, Viikari, Jorma, Kähönen, Mika, Lehtimäki, Terho, Salomaa, Veikko, Perola, Markus, Jalkanen, Sirpa, Järvelin, Marjo-Riitta, Raitakari, Olli T, Kettunen, Johannes, Lawlor, Debbie A, Ala-Korpela, Mika

“…Pregnancy triggers well-known alterations in maternal glucose and lipid balance but its overall effects on systemic metabolism remain incompletely understood…”
Get full text

Intertumoral heterogeneity in patient-specific drug sensitivities in treatment-naïve glioblastoma by Skaga, Erlend, Kulesskiy, Evgeny, Fayzullin, Artem, Sandberg, Cecilie J, Potdar, Swapnil, Kyttälä, Aija, Langmoen, Iver A, Laakso, Aki, Gaál-Paavola, Emília, Perola, Markus, Wennerberg, Krister, Vik-Mo, Einar O

“…A major barrier to effective treatment of glioblastoma (GBM) is the large intertumoral heterogeneity at the genetic and cellular level. In early phase clinical…”
Get full text