Search Results - "Pero, Ralph"

Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils by Doyle, Alfred D., Jacobsen, Elizabeth A., Ochkur, Sergei I., Willetts, Lian, Shim, Kelly, Neely, Joseph, Kloeber, Jake, LeSuer, Will E., Pero, Ralph S., Lacy, Paige, Moqbel, Redwan, Lee, Nancy A., Lee, James J.

“…Cre‐recombinase expression in eoCRE mice generates a model system facilitating eosinophil‐specific knockouts, and/or, ectopic overexpression of heterologous…”
Get full text

Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells by Jacobsen, Elizabeth A, Ochkur, Sergei I, Pero, Ralph S, Taranova, Anna G, Protheroe, Cheryl A, Colbert, Dana C, Lee, Nancy A, Lee, James J

“…The current paradigm surrounding allergen-mediated T helper type 2 (Th2) immune responses in the lung suggests an almost hegemonic role for T cells. Our…”
Get full text

Mouse Eosinophils Possess Potent Antibacterial Properties In Vivo by Linch, Stefanie N, Kelly, Ann M, Danielson, Erin T, Pero, Ralph, Lee, James J, Gold, Jeffrey A

“…Eosinophils are best known as the predominant cellular infiltrate associated with asthma and parasitic infections. Recently, numerous studies have documented…”
Get full text

Coexpression of IL-5 and Eotaxin-2 in Mice Creates an Eosinophil-Dependent Model of Respiratory Inflammation with Characteristics of Severe Asthma by Ochkur, Sergei I, Jacobsen, Elizabeth A, Protheroe, Cheryl A, Biechele, Travis L, Pero, Ralph S, McGarry, Michael P, Wang, Huiying, O'Neill, Katie R, Colbert, Dana C, Colby, Thomas V, Shen, Huahao, Blackburn, Michael R, Irvin, Charles C, Lee, James J, Lee, Nancy A

“…Mouse models of allergen provocation and/or transgenic gene expression have provided significant insights regarding the cellular, molecular, and immune…”
Get full text

Pivotal Advance: Eosinophil infiltration of solid tumors is an early and persistent inflammatory host response by Cormier, Stephania A., Taranova, Anna G., Bedient, Carrie, Nguyen, Thanh, Protheroe, Cheryl, Pero, Ralph, Dimina, Dawn, Ochkur, Sergei I., O’Neill, Katie, Colbert, Dana, Lombari, Theresa R., Constant, Stephanie, McGarry, Michael P., Lee, James J., Lee, Nancy A.

“…Tumor‐associated eosinophilia has been observed in numerous human cancers and several tumor models in animals; however, the details surrounding this…”
Get full text

Post-translational Tyrosine Nitration of Eosinophil Granule Toxins Mediated by Eosinophil Peroxidase by Ulrich, Martina, Petre, Alina, Youhnovski, Nikolay, Prömm, Franziska, Schirle, Markus, Schumm, Michael, Pero, Ralph S., Doyle, Alfred, Checkel, James, Kita, Hirohito, Thiyagarajan, Nethaji, Acharya, K. Ravi, Schmid-Grendelmeier, Peter, Simon, Hans-Uwe, Schwarz, Heinz, Tsutsui, Masato, Shimokawa, Hiroaki, Bellon, Gabriel, Lee, James J., Przybylski, Michael, Döring, Gerd

“…Nitration of tyrosine residues has been observed during various acute and chronic inflammatory diseases. However, the mechanism of tyrosine nitration and the…”
Get full text

RAD51 Interacts with the Evolutionarily Conserved BRC Motifs in the Human Breast Cancer Susceptibility Gene brca2 by Wong, Alexander K.C., Pero, Ralph, Ormonde, Patricia A., Tavtigian, Sean V., Bartel, Paul L.

“…Recent work has shown that the murine BRCA2 tumor suppressor protein interacts with the murine RAD51 protein. This interaction suggests that BRCA2 participates…”
Get full text

A3 Adenosine Receptor Signaling Influences Pulmonary Inflammation and Fibrosis by Morschl, Eva, Molina, Jose G, Volmer, Jonathan B, Mohsenin, Amir, Pero, Ralph S, Hong, Jeong-Soo, Kheradmand, Farrah, Lee, James J, Blackburn, Michael R

“…Adenosine is a signaling molecule produced during conditions that cause cellular stress or damage. This signaling pathway is implicated in the regulation of…”
Get full text

The SNARE VAMP-7 Contributes To Eosinophil Degranulation, In Vivo by Lacy, Paige, Dr, Willetts, Lian, Dr, Jacobsen, Elizabeth, Dr, Condjella, Rachel, Dr, Zellner, Katie, Ms, Ochkur, Sergei, Dr, Lou, Hui, Mr, LeSuer, Will, Mr, Kim, John, Mr, Protheroe, Cheryl, Ms, Pero, Ralph, Mr, Lee, James J., Dr, Lee, Nancy A., Dr, Moqbel, Redwan, Dr

Get full text

Characterization of a carboxy-terminal BRCA1 interacting protein by WONG, A. K. C, ORMONDE, P. A, TAVTIGIAN, S. V, TENG, D. H.-F, BARTEL, P. L, PERO, R, YUAN CHEN, LUBING LIAN, SALADA, G, BERRY, S, LAWRENCE, Q, DAYANANTH, P, PHUONG HA

“…There are several lines of evidence indicating that the carboxy-terminal region of the tumor suppressor protein BRCA1 is a functionally significant domain…”
Get full text

Gαi2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation by Pero, Ralph S., Borchers, Michael T., Spicher, Karsten, Ochkur, Sergei I., Sikora, Lyudmila, Rao, Savita P., Abdala-Valencia, Hiam, O'Neill, Katie R., Shen, Huahao, McGarry, Michael P., Lee, Nancy A., Cook-Mills, Joan M., Sriramarao, P., Simon, Melvin I., Birnbaumer, Lutz, Lee, James J.

“…The trafficking of leukocytes from the blood to sites of inflammation is the cumulative result of receptor-ligand-mediated signaling events associated with the…”
Get full text

Defining a Link with Asthma in Mice Congenitally Deficient in Eosinophils by Lee, James J., Dimina, Dawn, Macias, MiMi P., Ochkur, Sergei I., McGarry, Michael P., O'Neill, Katie R., Protheroe, Cheryl, Pero, Ralph, Nguyen, Thanh, Cormier, Stephania A., Lenkiewicz, Elizabeth, Colbert, Dana, Rinaldi, Lisa, Ackerman, Steven J., Irvin, Charles G., Lee, Nancy A.

“…Eosinophils are often dominant inflammatory cells present in the lungs of asthma patients. Nonetheless, the role of these leukocytes remains poorly understood…”
Get full text

Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding by ADEY, N. B, LIWEN HUANG, ORMONDE, P. A, BAUMGARD, M. L, PERO, R, BYREDDY, D. V, TAVTIGIAN, S. V, BARREL, P. L

“…Two-hybrid searches with the tumor suppressor MMAC1/PTEN isolated the proteins hDLG and hMAST205. Further two-hybrid analysis and microtiter plate binding…”
Get full text

G[alpha]^sub i2^-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation by Pero, Ralph S, Borchers, Michael T, Spicher, Karsten, Ochkur, Sergei I

“…The trafficking of leukocytes from the blood to sites of inflammation is the cumulative result of receptor-ligand-mediated signaling events associated with the…”
Get full text

A 3 Adenosine Receptor Signaling Influences Pulmonary Inflammation and Fibrosis by Morschl, Eva, Molina, Jose G., Volmer, Jonathan B., Mohsenin, Amir, Pero, Ralph S., Hong, Jeong-Soo, Kheradmand, Farrah, Lee, James J., Blackburn, Michael R.

Get full text

A^sub 3^ Adenosine Receptor Signaling Influences Pulmonary Inflammation and Fibrosis by Morschl, Eva, Molina, Jose G, Volmer, Jonathan B, Mohsenin, Amir, Pero, Ralph S, Hong, Jeong-Soo, Kheradmand, Farrah, Lee, James J, Blackburn, Michael R

“…Adenosine is a signaling molecule produced during conditions that cause cellular stress or damage. This signaling pathway is implicated in the regulation of…”
Get full text

Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor by TENG, D. H.-F, PERRY, W. L, HU, R, JAMMULAPATI, S, JANECKI, T, LEAVITT, A, MITCHELL, J. T, PERO, R, SEXTON, D, SCHROEDER, M, SU, P.-H, SWEDLUND, B, HOGAN, J. K, KYRIAKIS, J. M, AVRUCH, J, BARTEL, P, WONG, A. K. C, OLIPHANT, A, THOMAS, A, SKOLNICK, M. H, TAVTIGIAN, S. V, BAUMGARD, M, BELL, R, BERRY, S, DAVIS, T, FRANK, D, FRYE, C, HATTIER, T

“…Mitogen-activated protein kinases function in signal transduction pathways that are involved in controlling key cellular processes in many organisms. A…”
Get full text

Galphai2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation by Pero, Ralph S, Borchers, Michael T, Spicher, Karsten, Ochkur, Sergei I, Sikora, Lyudmila, Rao, Savita P, Abdala-Valencia, Hiam, O'Neill, Katie R, Shen, Huahao, McGarry, Michael P, Lee, Nancy A, Cook-Mills, Joan M, Sriramarao, P, Simon, Melvin I, Birnbaumer, Lutz, Lee, James J

“…The trafficking of leukocytes from the blood to sites of inflammation is the cumulative result of receptor-ligand-mediated signaling events associated with the…”
Get full text

Gᵢ₂ Signaling Events in the Endothelium Are Involved in Controlling Leukocyte Extravasation by Pero, Ralph S., Borchers, Michael T., Spicher, Karsten, Ochkur, Sergei I., Sikora, Lyudmila, Rao, Savita P., Abdala-Valencia, Hiam, O'Neill, Katie R., Shen, Huahao, McGarry, Michael P., Lee, Nancy A., Cook-Mills, Joan M., Sriramarao, P., Simon, Melvin I., Birnbaumer, Lutz, Lee, James J.

“…The trafficking of leukocytes from the blood to sites of inflammation is the cumulative result of receptor-ligand-mediated signaling events associated with the…”
Get full text

G alpha sub(i2)-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation by Pero, Ralph S, Borchers, Michael T, Spicher, Karsten, Ochkur, Sergei I, Sikora, Lyudmila, Rao, Savita P, Abdala-Valencia, Hiam, O'Neill, Katie R, Shen, Huahao, McGarry, Michael P, Lee, Nancy A, Cook-Mills, Joan M, Sriramarao, P, Simon, Melvin I, Birnbaumer, Lutz, Lee, James J

“…The trafficking of leukocytes from the blood to sites of inflammation is the cumulative result of receptor-ligand-mediated signaling events associated with the…”
Get full text