Search Results - "Pernow, J."

The importance of endothelin-1 for vascular dysfunction in cardiovascular disease by BÖHM, Felix, PERNOW, John

“…Endothelin (ET)-1 is a potent vasoconstrictor peptide originally isolated from endothelial cells. Its production is stimulated in a variety of different cell…”
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Tissue‐specific up‐regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus by Pernow, J, Kiss, A, Tratsiakovich, Y, Climent, B

“…Background and Purpose Emerging evidence suggests a selective up‐regulation of arginase I in diabetes causing coronary artery disease; however, the mechanisms…”
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Arginase inhibition improves endothelial function in patients with familial hypercholesterolaemia irrespective of their cholesterol levels by Kovamees, O., Shemyakin, A., Eriksson, M., Angelin, B., Pernow, J.

“…Background Elevated LDL cholesterol is an important risk factor for atherosclerosis. Endothelial dysfunction, an early event in the development of…”
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Vagal nerve stimulation reduces infarct size via a mechanism involving the alpha‐7 nicotinic acetylcholine receptor and downregulation of cardiac and vascular arginase by Kiss, A., Tratsiakovich, Y., Mahdi, A., Yang, J., Gonon, A. T., Podesser, B. K., Pernow, J.

“…Aims Vagal nerve stimulation (VNS) protects from myocardial and vascular injury following myocardial ischaemia and reperfusion (IR) via a mechanism involving…”
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Hyperglycemia Induces Myocardial Dysfunction via Epigenetic Regulation of JunD by Hussain, Shafaat, Khan, Abdul Waheed, Akhmedov, Alexander, Suades, Rosa, Costantino, Sarah, Paneni, Francesco, Caidahl, Kenneth, Mohammed, Shafeeq A., Hage, Camilla, Gkolfos, Christos, Björck, Hanna, Pernow, John, Lund, Lars H., Lüscher, Thomas F., Cosentino, Francesco

“…RATIONALE.Hyperglycemia-induced reactive oxygen species (ROS) are key mediators of cardiac dysfunction. JunD, a member of the Activated Protein-1 (AP-1) family…”
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Arginase inhibition mediates cardioprotection during ischaemia–reperfusion by Jung, Christian, Gonon, Adrian T., Sjöquist, Per-Ove, Lundberg, Jon O., Pernow, John

“…Aims Nitric oxide (NO) is vital for the integrity of the cardiovascular system and protection against ischaemic heart disease. Arginase is up-regulated during…”
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Arginase inhibition improves endothelial function in patients with type 2 diabetes mellitus despite intensive glucose‐lowering therapy by Mahdi, A., Kövamees, O., Checa, A., Wheelock, C. E., Heijne, M., Alvarsson, M., Pernow, J.

“…Background Arginase is implicated in the pathogenesis behind endothelial dysfunction in type 2 diabetes mellitus (T2DM) by its inhibition of nitric oxide…”
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The endothelin receptor antagonist bosentan improves peripheral endothelial function in patients with type 2 diabetes mellitus and microalbuminuria: a randomised trial by Rafnsson, A., Böhm, F., Settergren, M., Gonon, A., Brismar, K., Pernow, J.

“…Aims/hypothesis Endothelial dysfunction is important in the development of vascular complications in diabetes. Patients with type 2 diabetes have increased…”
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The red blood cell as a mediator of endothelial dysfunction in patients with familial hypercholesterolemia and dyslipidemia by Mahdi, Ali, Wodaje, Tigist, Kövamees, Oskar, Tengbom, John, Zhao, Allan, Jiao, Tong, Henricsson, Marcus, Yang, Jiangning, Zhou, Zhichao, Nieminen, Anni I., Levin, Malin, Collado, Aida, Brinck, Jonas, Pernow, John

“…Background Patients with familial hypercholesterolemia (FH) display high levels of low‐density lipoprotein cholesterol (LDL‐c), endothelial dysfunction, and…”
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Effect of postconditioning on infarct size in patients with ST elevation myocardial infarction by Sörensson, Peder, Saleh, Nawzad, Bouvier, Frederic, Böhm, Felix, Settergren, Magnus, Caidahl, Kenneth, Tornvall, Per, Arheden, Håkan, Rydén, Lars, Pernow, John

“…Small studies suggest that postconditioning reperfusion interrupted by brief repetitive cycles of reocclusions, may protect the myocardium in the clinical…”
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Arginase inhibition improves coronary microvascular function and reduces infarct size following ischaemia-reperfusion in a rat model by Grönros, J., Kiss, A., Palmér, M., Jung, C., Berkowitz, D., Pernow, J.

“…Aim Ischaemia–reperfusion injury is associated with reduced bioavailability of nitric oxide (NO) and microvascular dysfunction. One emerging mechanism behind…”
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Tetraspanin CD151 and integrin 61 mediate platelet-enhanced endothelial colony forming cell angiogenesis by Huang, Z, Miao, X, Patarroyo, M, Nilsson, GP, Pernow, J, Li, N

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PAR1‐stimulated platelet releasate promotes angiogenic activities of endothelial progenitor cells more potently than PAR4‐stimulated platelet releasate by Huang, Z., Miao, X., Luan, Y., Zhu, L., Kong, F., Lu, Q., Pernow, J., Nilsson, G., Li, N.

“…Summary Background Endothelial progenitor cells (EPCs) are important for endothelial regeneration and angiogenesis. Thrombin protease‐activated receptor 1…”
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Tetraspanin CD151 and integrin α6β1 mediate platelet‐enhanced endothelial colony forming cell angiogenesis by Huang, Z., Miao, X., Patarroyo, M., Nilsson, G. P., Pernow, J., Li, N.

“…Essentials Platelet releasates (PRs) enhance endothelial colony forming cell (ECFC) angiogenesis. The impact of platelet membrane components on ECFC…”
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Arginase inhibition improves coronary microvascular function and reduces infarct size following ischaemiareperfusion in a rat model by Groenros, J, Kiss, A, Palmer, M, Jung, C, Berkowitz, D, Pernow, J

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Cholesterol lowering is more important than pleiotropic effects of statins for endothelial function in patients with dysglycaemia and coronary artery disease by Settergren, Magnus, Böhm, Felix, Rydén, Lars, Pernow, John

“…Aims The importance of pleiotropic effects of statins on endothelial function and inflammatory markers was investigated in patients with dysglycaemia and…”
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Adiponectin protects against myocardial ischaemia-reperfusion injury via AMP-activated protein kinase, Akt, and nitric oxide by Gonon, Adrian T., Widegren, Ulrika, Bulhak, Aliaksandr, Salehzadeh, Firoozeh, Persson, Jonas, Sjöquist, Per-Ove, Pernow, John

“…Aims Cardiovascular disease and type 2 diabetes mellitus are associated with low plasma concentration of adiponectin. The aim of this study was to investigate…”
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Myocardial microvascular dysfunction in asymptomatic patients with hereditary dyslipidemia by Wodaje, T, Venkateshvaran, A V, Mahdi, A M, Zenlander, R Z, Angelin, B A, Pernow, J P, Brinck, J B

“…Abstract Introduction Microvascular dysfunction underlies the pathophysiology of many cardiovascular disease (CVD) conditions and is strongly associated with…”
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l -Arginine and tetrahydrobiopterin protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease by Settergren, M, Böhm, F, Malmström, R.E, Channon, K.M, Pernow, J

“…Abstract Diminished levels of l -arginine and endothelial nitric oxide synthase (eNOS) uncoupling through deficiency of tetrahydrobiopterin (BH4 ) may…”
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Endothelin-1 increases superoxide production in human coronary artery bypass grafts by Cerrato, R., Cunnington, C., Crabtree, M.J., Antoniades, C., Pernow, J., Channon, K.M., Böhm, F.

“…Endothelin-1 (ET-1) has been shown to increase endothelial superoxide (O2−) production in experimental animal models. It is unclear whether ET-1 increases O2−…”
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