Search Results - "Pernot, Lucile"

Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism by Degiacomi, Matteo T, Iacovache, Ioan, Pernot, Lucile, Chami, Mohamed, Kudryashev, Misha, Stahlberg, Henning, van der Goot, F Gisou, Dal Peraro, Matteo

“…Near-atomistic models of the prepore and membrane-inserted pore conformations derived from a combination of crystallography, cryo-EM, single-particle analysis,…”
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Pore formation: An ancient yet complex form of attack by Iacovache, Ioan, van der Goot, F. Gisou, Pernot, Lucile

“…Bacteria, as well as higher organisms such as sea anemones or earthworms, have developed sophisticated virulence factors such as the pore-forming toxins (PFTs)…”
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A Bioorthogonal Chemical Reporter of Viral Infection by Neef, Anne B., Pernot, Lucile, Schreier, Verena N., Scapozza, Leonardo, Luedtke, Nathan W.

“…Pathogen‐selective labeling was achieved by using the novel gemcitabine metabolite analogue 2′‐deoxy‐2′,2′‐difluoro‐5‐ethynyluridine (dF‐EdU) and click…”
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Dual chaperone role of the C-terminal propeptide in folding and oligomerization of the pore-forming toxin aerolysin by Iacovache, Ioan, Degiacomi, Matteo T, Pernot, Lucile, Ho, Sylvia, Schiltz, Marc, Dal Peraro, Matteo, van der Goot, F Gisou

“…Throughout evolution, one of the most ancient forms of aggression between cells or organisms has been the production of proteins or peptides affecting the…”
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Crystal Structure of a Peptidoglycan Synthesis Regulatory Factor (PBP3) from Streptococcus pneumoniae by Morlot, Cécile, Pernot, Lucile, Le Gouellec, Audrey, Di Guilmi, Anne Marie, Vernet, Thierry, Dideberg, Otto, Dessen, Andréa

“…Penicillin-binding proteins (PBPs) are membrane-associated enzymes which perform critical functions in the bacterial cell division process. The single…”
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A PBP2x from a Clinical Isolate of Streptococcus pneumoniae Exhibits an Alternative Mechanism for Reduction of Susceptibility to β-Lactam Antibiotics by Pernot, Lucile, Chesnel, Laurent, Le Gouellec, Audrey, Croizé, Jacques, Vernet, Thierry, Dideberg, Otto, Dessen, Andréa

“…The human pathogen Streptococcus pneumoniae is one of the main causative agents of respiratory tract infections. At present, clinical isolates of S. pneumoniae…”
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A new N-methyl thymine derivative comprising a dihydroxyisobutenyl unit as ligand for thymidine kinase of herpes simplex virus type 1 (HSV-1 TK) by Krištafor, Svjetlana, Novaković, Ivana, Gazivoda Kraljević, Tatjana, Kraljević Pavelić, Sandra, Lučin, Pero, Westermaier, Yvonne, Pernot, Lucile, Scapozza, Leonardo, Ametamey, Simon M., Raić-Malić, Silvana

“…Molecular modeling and phosphorylation assay in vitro were employed to select a novel unsaturated 1,3-dihydroxyisobutenyl thymine derivative 6 as ligand for…”
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The Structural Modifications Induced by the M339F Substitution in PBP2x from Streptococcus pneumoniae Further Decreases the Susceptibility to β-Lactams of Resistant Strains by Chesnel, Laurent, Pernot, Lucile, Lemaire, David, Champelovier, Dominique, Croizé, Jacques, Dideberg, Otto, Vernet, Thierry, Zapun, André

“…PBP2x is a primary determinant of β-lactams resistance in Streptococcus pneumoniae. Altered PBP2x with multiple mutations have a reduced “affinity” for the…”
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Exploring hydrophobic sites in proteins with xenon or krypton by Prangé, Thierry, Schiltz, Marc, Pernot, Lucile, Colloc'h, Nathalie, Longhi, Sonia, Bourguet, William, Fourme, Roger

“…X‐ray diffraction is used to study the binding of xenon and krypton to a variety of crystallised proteins: porcine pancreatic elastase; subtilisin Carlsberg…”
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A Bioorthogonal Chemical Reporter of Viral Infection by Neef, Anne B., Pernot, Lucile, Schreier, Verena N., Scapozza, Leonardo, Luedtke, Nathan W.

“…Pathogen‐selective labeling was achieved by using the novel gemcitabine metabolite analogue 2′‐deoxy‐2′,2′‐difluoro‐5‐ethynyluridine (dF‐EdU) and click…”
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Synthesis, Crystal Structure, and in Vitro Biological Evaluation of C-6 Pyrimidine Derivatives: New Lead Structures for Monitoring Gene Expression in Vivo by Martić, Miljen, Pernot, Lucile, Westermaier, Yvonne, Perozzo, Remo, Kraljević, Tatjana Gazivoda, Krištafor, Svjetlana, Raić-Malić, Silvana, Scapozza, Leonardo, Ametamey, Simon

“…Novel C-6 substituted pyrimidine derivatives are good substrates of herpes simplex virus type 1 thymidine kinase (HSV1-TK). Enzyme kinetic experiments showed…”
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Structure of the imipenem-hydrolyzing class A β-­lactamase SME-1 from Serratia marcescens by Sougakoff, Wladimir, L'Hermite, Guillaume, Pernot, Lucile, Naas, Thierry, Guillet, Valérie, Nordmann, Patrice, Jarlier, Vincent, Delettré, Jean

“…The structure of the β‐lactamase SME‐1 from Serratia marcescens, a class A enzyme characterized by its significant activity against imipenem, has been…”
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Crystal structures of the class D β-lactamase OXA-13 in the native form and in complex with meropenem by Pernot, Lucile, Frénois, Frédéric, Rybkine, Tania, L’Hermite, Guillaume, Petrella, Stéphanie, Delettré, Jean, Jarlier, Vincent, Collatz, Ekkehard, Sougakoff, Wladimir

“…The therapeutic problems posed by class D β-lactamases, a family of serine enzymes that hydrolyse β-lactam antibiotics following an acylation-deacylation…”
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Preliminary crystallographic analysis of two oligomerization-deficient mutants of the aerolysin toxin, H132D and H132N, in their proteolyzed forms by Pernot, Lucile, Schiltz, Marc, Van Der Goot, F. Gisou

“…Aerolysin is a major virulence factor produced by the Gram‐negative bacterium Aeromonas hydrophila and is a member of the β‐pore‐forming toxin family. Two…”
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A PBP2x from a Clinical Isolate of Streptococcus pneumoniae Exhibits an Alternative Mechanism for Reduction of Susceptibility to β-Lactam Antibiotics by Lucile Pernot, Laurent Chesnel, Audrey Le Gouellec, Jacques CroizÃ, Thierry Vernet, Otto Dideberg, Andréa Dessen

“…The human pathogen Streptococcus pneumoniae is one of the main causative agents of respiratory tract infections. At present, clinical isolates of S. pneumoniae…”
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The Structural Modifications Induced by the M339F Substitution in PBP2x from Streptococcus pneumoniae Further Decreases the Susceptibility to β-Lactams of Resistant Strains by Laurent Chesnel, Lucile Pernot, David Lemaire, Dominique Champelovier, Jacques CroizÃ, Otto Dideberg, Thierry Vernet, André Zapun

“…PBP2x is a primary determinant of β-lactams resistance in Streptococcus pneumoniae . Altered PBP2x with multiple mutations have a reduced “affinity” for…”
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Molecular structure of the lipoamide dehydrogenase domain of a surface antigen from Neisseria meningitidis by de la Sierra, Inés Li, Pernot, Lucile, Prangé, Thierry, Saludjian, Pedro, Schiltz, Marc, Fourme, Roger, Padrón, Gabriel

“…The protein p64k from the surface of the Neisseria meningitidis bacteria has been characterized as a two-domain protein. It contains a dihydrolipoamide…”
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